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Protein

Kelch repeat and BTB domain-containing protein 11

Gene

KBTBD11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch repeat and BTB domain-containing protein 11
Alternative name(s):
Chronic myelogenous leukemia-associated protein
Kelch domain-containing protein 7B
Gene namesi
Name:KBTBD11
Synonyms:CMLAP, KIAA0711, KLHDC7C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000176595.3
HGNCiHGNC:29104 KBTBD11
neXtProtiNX_O94819

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176595
PharmGKBiPA142671642

Polymorphism and mutation databases

BioMutaiKBTBD11

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190901 – 623Kelch repeat and BTB domain-containing protein 11Add BLAST623

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64PhosphoserineBy similarity1
Modified residuei67PhosphoserineBy similarity1
Modified residuei87PhosphoserineCombined sources1
Modified residuei107PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO94819
MaxQBiO94819
PaxDbiO94819
PeptideAtlasiO94819
PRIDEiO94819
ProteomicsDBi50462

PTM databases

iPTMnetiO94819
PhosphoSitePlusiO94819
SwissPalmiO94819

Expressioni

Gene expression databases

BgeeiENSG00000176595
CleanExiHS_KBTBD11
GenevisibleiO94819 HS

Organism-specific databases

HPAiHPA051159

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000321544

Structurei

3D structure databases

ProteinModelPortaliO94819
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini140 – 196BTBPROSITE-ProRule annotationAdd BLAST57
Repeati311 – 359Kelch 1Add BLAST49
Repeati360 – 412Kelch 2Add BLAST53
Repeati413 – 455Kelch 3Add BLAST43
Repeati458 – 500Kelch 4Add BLAST43

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG1072 Eukaryota
ENOG4110X8D LUCA
GeneTreeiENSGT00900000140914
HOGENOMiHOG000246990
HOVERGENiHBG081849
InParanoidiO94819
KOiK10476
OMAiCNGEIYV
OrthoDBiEOG091G02D9
PhylomeDBiO94819
TreeFamiTF328485

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF01344 Kelch_1, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00612 Kelch, 3 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

O94819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHAVAPCVL YPGTEPGAAG ESESEGAASP AQTPCSLGAS LCFSSGEESP
60 70 80 90 100
PQSLASAAEG AATSPPSSGG PRVVERQWEA GSAGAASPEE LASPEERACP
110 120 130 140 150
EEPAAPSPEP RVWLEDPASP EEPGEPAPVP PGFGAVYGEP DLVLEVSGRR
160 170 180 190 200
LRAHKAVLAA RSDYFRARAS RDVLRVQGVS LTALRLLLAD AYSGRMAGVR
210 220 230 240 250
PDNVAEVVAG ARRLQLPGAA QRATDAVGPQ LSLANCYEVL SAAKRQRLNE
260 270 280 290 300
LRDAAYCFMS DHYLEVLREP AVFGRLSGAE RDLLLRRRLR AGRAHLLAAA
310 320 330 340 350
LGPAGERAGS RPQSPSGDAD ARGDAAVYCF HAAAGEWREL TRLPEGAPAR
360 370 380 390 400
GCGLCVLYNY LFVAGGVAPA GPDGRARPSD QVFCYNPATD SWSAVRPLRQ
410 420 430 440 450
ARSQLRLLAL DGHLYAVGGE CLLSVERYDP RADRWAPVAP LPRGAFAVAH
460 470 480 490 500
EATTCHGEIY VSGGSLFYRL LKYDPRRDEW QECPCSSSRE RSADMVALDG
510 520 530 540 550
FIYRFDLSGS RGEAQAAGPS GVSVSRYHCL AKQWSPCVAP LRLPGGPTGL
560 570 580 590 600
QPFRCAALDG AIYCVSRAGT WRFQPAREGE AGGDAGQGGG FEALGAPLDV
610 620
RGVLIPFALS LPEKPPRGEQ GAP
Length:623
Mass (Da):65,720
Last modified:May 1, 1999 - v1
Checksum:i1044C753A8F478C6
GO

Sequence cautioni

The sequence BAA34431 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY762229 mRNA Translation: AAW83120.1
AB018254 mRNA Translation: BAA34431.2 Different initiation.
CH471181 Genomic DNA Translation: EAW51487.1
CCDSiCCDS34795.1
RefSeqiNP_055682.1, NM_014867.2
XP_011533073.1, XM_011534771.2
XP_011533074.1, XM_011534772.2
XP_016869603.1, XM_017014114.1
XP_016869604.1, XM_017014115.1
XP_016869605.1, XM_017014116.1
XP_016869606.1, XM_017014117.1
UniGeneiHs.5333

Genome annotation databases

EnsembliENST00000320248; ENSP00000321544; ENSG00000176595
ENST00000617214; ENSP00000481889; ENSG00000273645
GeneIDi9920
KEGGihsa:9920
UCSCiuc003wpw.5 human

Similar proteinsi

Entry informationi

Entry nameiKBTBB_HUMAN
AccessioniPrimary (citable) accession number: O94819
Secondary accession number(s): Q3L1I0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: June 20, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM

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