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Protein

Kelch repeat and BTB domain-containing protein 11

Gene

KBTBD11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kelch repeat and BTB domain-containing protein 11
Alternative name(s):
Chronic myelogenous leukemia-associated protein
Kelch domain-containing protein 7B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KBTBD11
Synonyms:CMLAP, KIAA0711, KLHDC7C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000176595.3

Human Gene Nomenclature Database

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HGNCi
HGNC:29104 KBTBD11

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O94819

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000176595

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671642

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KBTBD11

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001190901 – 623Kelch repeat and BTB domain-containing protein 11Add BLAST623

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei64PhosphoserineBy similarity1
Modified residuei67PhosphoserineBy similarity1
Modified residuei87PhosphoserineCombined sources1
Modified residuei107PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O94819

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O94819

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O94819

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94819

PeptideAtlas

More...
PeptideAtlasi
O94819

PRoteomics IDEntifications database

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PRIDEi
O94819

ProteomicsDB human proteome resource

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ProteomicsDBi
50462

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O94819

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O94819

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O94819

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000176595 Expressed in 176 organ(s), highest expression level in Brodmann (1909) area 10

CleanEx database of gene expression profiles

More...
CleanExi
HS_KBTBD11

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O94819 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051159

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000321544

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O94819

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini140 – 196BTBPROSITE-ProRule annotationAdd BLAST57
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati311 – 359Kelch 1Add BLAST49
Repeati360 – 412Kelch 2Add BLAST53
Repeati413 – 455Kelch 3Add BLAST43
Repeati458 – 500Kelch 4Add BLAST43

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1072 Eukaryota
ENOG4110X8D LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161983

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000246990

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG081849

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O94819

KEGG Orthology (KO)

More...
KOi
K10476

Identification of Orthologs from Complete Genome Data

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OMAi
CNGEIYV

Database of Orthologous Groups

More...
OrthoDBi
594274at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O94819

TreeFam database of animal gene trees

More...
TreeFami
TF328485

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00651 BTB, 1 hit
PF01344 Kelch_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00225 BTB, 1 hit
SM00612 Kelch, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097 BTB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O94819-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHAVAPCVL YPGTEPGAAG ESESEGAASP AQTPCSLGAS LCFSSGEESP
60 70 80 90 100
PQSLASAAEG AATSPPSSGG PRVVERQWEA GSAGAASPEE LASPEERACP
110 120 130 140 150
EEPAAPSPEP RVWLEDPASP EEPGEPAPVP PGFGAVYGEP DLVLEVSGRR
160 170 180 190 200
LRAHKAVLAA RSDYFRARAS RDVLRVQGVS LTALRLLLAD AYSGRMAGVR
210 220 230 240 250
PDNVAEVVAG ARRLQLPGAA QRATDAVGPQ LSLANCYEVL SAAKRQRLNE
260 270 280 290 300
LRDAAYCFMS DHYLEVLREP AVFGRLSGAE RDLLLRRRLR AGRAHLLAAA
310 320 330 340 350
LGPAGERAGS RPQSPSGDAD ARGDAAVYCF HAAAGEWREL TRLPEGAPAR
360 370 380 390 400
GCGLCVLYNY LFVAGGVAPA GPDGRARPSD QVFCYNPATD SWSAVRPLRQ
410 420 430 440 450
ARSQLRLLAL DGHLYAVGGE CLLSVERYDP RADRWAPVAP LPRGAFAVAH
460 470 480 490 500
EATTCHGEIY VSGGSLFYRL LKYDPRRDEW QECPCSSSRE RSADMVALDG
510 520 530 540 550
FIYRFDLSGS RGEAQAAGPS GVSVSRYHCL AKQWSPCVAP LRLPGGPTGL
560 570 580 590 600
QPFRCAALDG AIYCVSRAGT WRFQPAREGE AGGDAGQGGG FEALGAPLDV
610 620
RGVLIPFALS LPEKPPRGEQ GAP
Length:623
Mass (Da):65,720
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1044C753A8F478C6
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA34431 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY762229 mRNA Translation: AAW83120.1
AB018254 mRNA Translation: BAA34431.2 Different initiation.
CH471181 Genomic DNA Translation: EAW51487.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34795.1

NCBI Reference Sequences

More...
RefSeqi
NP_055682.1, NM_014867.2
XP_011533073.1, XM_011534771.2
XP_011533074.1, XM_011534772.2
XP_016869603.1, XM_017014114.1
XP_016869604.1, XM_017014115.1
XP_016869605.1, XM_017014116.1
XP_016869606.1, XM_017014117.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.5333

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000320248; ENSP00000321544; ENSG00000176595
ENST00000617214; ENSP00000481889; ENSG00000273645

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9920

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9920

UCSC genome browser

More...
UCSCi
uc003wpw.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY762229 mRNA Translation: AAW83120.1
AB018254 mRNA Translation: BAA34431.2 Different initiation.
CH471181 Genomic DNA Translation: EAW51487.1
CCDSiCCDS34795.1
RefSeqiNP_055682.1, NM_014867.2
XP_011533073.1, XM_011534771.2
XP_011533074.1, XM_011534772.2
XP_016869603.1, XM_017014114.1
XP_016869604.1, XM_017014115.1
XP_016869605.1, XM_017014116.1
XP_016869606.1, XM_017014117.1
UniGeneiHs.5333

3D structure databases

ProteinModelPortaliO94819
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000321544

PTM databases

iPTMnetiO94819
PhosphoSitePlusiO94819
SwissPalmiO94819

Polymorphism and mutation databases

BioMutaiKBTBD11

Proteomic databases

EPDiO94819
jPOSTiO94819
MaxQBiO94819
PaxDbiO94819
PeptideAtlasiO94819
PRIDEiO94819
ProteomicsDBi50462

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320248; ENSP00000321544; ENSG00000176595
ENST00000617214; ENSP00000481889; ENSG00000273645
GeneIDi9920
KEGGihsa:9920
UCSCiuc003wpw.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9920
EuPathDBiHostDB:ENSG00000176595.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KBTBD11
HGNCiHGNC:29104 KBTBD11
HPAiHPA051159
neXtProtiNX_O94819
OpenTargetsiENSG00000176595
PharmGKBiPA142671642

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1072 Eukaryota
ENOG4110X8D LUCA
GeneTreeiENSGT00940000161983
HOGENOMiHOG000246990
HOVERGENiHBG081849
InParanoidiO94819
KOiK10476
OMAiCNGEIYV
OrthoDBi594274at2759
PhylomeDBiO94819
TreeFamiTF328485

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9920

Protein Ontology

More...
PROi
PR:O94819

Gene expression databases

BgeeiENSG00000176595 Expressed in 176 organ(s), highest expression level in Brodmann (1909) area 10
CleanExiHS_KBTBD11
GenevisibleiO94819 HS

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF01344 Kelch_1, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00612 Kelch, 3 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKBTBB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94819
Secondary accession number(s): Q3L1I0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: January 16, 2019
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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