UniProtKB - O94818 (NOL4_HUMAN)

BLAST

>sp|O94818|NOL4_HUMAN Nucleolar protein 4 OS=Homo sapiens OX=9606 GN=NOL4 PE=1 SV=2
MESERDMYRQFQDWCLRTYGDSGKTKTVTRKKYERIVQLLNGSESSSTDNAKFKFWVKSK
GFQLGQPDEVRGGGGGAKQVLYVPVKTTDGVGVDEKLSLRRVAVVEDFFDIIYSMHVETG
PNGEQIRKHAGQKRTYKAISESYAFLPREAVTRFLMSCSECQKRMHLNPDGTDHKDNGKP
PTLVTSMIDYNMPITMAYMKHMKLQLLNSQQDEDESSIESDEFDMSDSTRMSAVNSDLSS
NLEERMQSPQNLHGQQDDDSAAESFNGNETLGHSSIASGGTHSREMGDSNSDGKTGLEQD
EQPLNLSDSPLSAQLTSEYRIDDHNSNGKNKYKNLLISDLKMEREARENGSKSPAHSYSS
YDSGKNESVDRGAEDLSLNRGDEDEDDHEDHDDSEKVNETDGVEAERLKAFNMFVRLFVD
ENLDRMVPISKQPKEKIQAIIDSCRRQFPEYQERARKRIRTYLKSCRRMKRSGFEMSRPI
PSHLTSAVAESILASACESESRNAAKRMRLERQQDESAPADKQCKPEATQATYSTSAVPG
SQDVLYINGNGTYSYHSYRGLGGGLLNLNDASSSGPTDLSMKRQLATSSGSSSSSNSRPQ
LSPTEINAVRQLVAGYRESAAFLLRSADELENLILQQN

Align

Format
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History
Entry version 130 (07 Nov 2018)
Sequence version 2 (05 Apr 2011)
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Protein

Nucleolar protein 4

Gene

NOL4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

RNA binding
Source: ProtInc
Traceable author statementⁱ
- 9813152

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nucleolar protein 4 Alternative name(s): Nucleolar-localized protein
Gene namesⁱ	Name:NOL4 Synonyms:NOLP ORF Names:HRIHFB2255
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 18

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000101746.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7870 NOL4
MIMⁱ	603577 gene
neXtProtⁱ	NX_O94818

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8715
Open Targets More...OpenTargetsⁱ	ENSG00000101746
PharmGKBⁱ	PA31674

Polymorphism and mutation databases

BioMutaⁱ	NOL4

BioMutaⁱ

NOL4

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000096935	1 – 638	Nucleolar protein 4Add BLAST		638

Proteomic databases

EPDⁱ	O94818
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O94818
PaxDbⁱ	O94818
PeptideAtlas More...PeptideAtlasⁱ	O94818
PRIDEⁱ	O94818
ProteomicsDBⁱ	50459 50460 [O94818-2] 50461 [O94818-3]

PTM databases

iPTMnetⁱ	O94818
PhosphoSitePlusⁱ	O94818

Expressionⁱ

Tissue specificityⁱ

Expressed predominantly in fetal brain, adult brain and testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000101746 Expressed in 112 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_NOL4
ExpressionAtlasⁱ	O94818 baseline and differential
Genevisibleⁱ	O94818 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA046740

HPAⁱ

HPA046740

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CTBP1	Q13363-2	3	EBI-10190763,EBI-10171858
CTBP2	P56545	3	EBI-10190763,EBI-741533
CTBP2	P56545-3	3	EBI-10190763,EBI-10171902
FAM9B	Q8IZU0	3	EBI-10190763,EBI-10175124
SNAPC5	O75971	3	EBI-10190763,EBI-749483
TEX9	Q8N6V9	4	EBI-10190763,EBI-746341

Protein-protein interaction databases

BioGridⁱ	114256, 11 interactors
IntActⁱ	O94818, 14 interactors
Molecular INTeraction database More...MINTⁱ	O94818

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O94818
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	ENOG410IEBQ Eukaryota ENOG411245F LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017363
HOGENOMⁱ	HOG000220856
HOVERGENⁱ	HBG031438
InParanoidⁱ	O94818
OMAⁱ	NETVGHS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03G2
PhylomeDBⁱ	O94818
TreeFamⁱ	TF325594

Family and domain databases

InterProⁱ	View protein in InterPro IPR026747 NOL4 IPR039788 NOL4/NOL4L
PANTHERⁱ	PTHR12449 PTHR12449, 1 hit PTHR12449:SF17 PTHR12449:SF17, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O94818-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESERDMYRQ FQDWCLRTYG DSGKTKTVTR KKYERIVQLL NGSESSSTDN 
        60         70         80         90        100
AKFKFWVKSK GFQLGQPDEV RGGGGGAKQV LYVPVKTTDG VGVDEKLSLR 
       110        120        130        140        150
RVAVVEDFFD IIYSMHVETG PNGEQIRKHA GQKRTYKAIS ESYAFLPREA 
       160        170        180        190        200
VTRFLMSCSE CQKRMHLNPD GTDHKDNGKP PTLVTSMIDY NMPITMAYMK 
       210        220        230        240        250
HMKLQLLNSQ QDEDESSIES DEFDMSDSTR MSAVNSDLSS NLEERMQSPQ 
       260        270        280        290        300
NLHGQQDDDS AAESFNGNET LGHSSIASGG THSREMGDSN SDGKTGLEQD 
       310        320        330        340        350
EQPLNLSDSP LSAQLTSEYR IDDHNSNGKN KYKNLLISDL KMEREARENG 
       360        370        380        390        400
SKSPAHSYSS YDSGKNESVD RGAEDLSLNR GDEDEDDHED HDDSEKVNET 
       410        420        430        440        450
DGVEAERLKA FNMFVRLFVD ENLDRMVPIS KQPKEKIQAI IDSCRRQFPE 
       460        470        480        490        500
YQERARKRIR TYLKSCRRMK RSGFEMSRPI PSHLTSAVAE SILASACESE 
       510        520        530        540        550
SRNAAKRMRL ERQQDESAPA DKQCKPEATQ ATYSTSAVPG SQDVLYINGN 
       560        570        580        590        600
GTYSYHSYRG LGGGLLNLND ASSSGPTDLS MKRQLATSSG SSSSSNSRPQ 
       610        620        630 
LSPTEINAVR QLVAGYRESA AFLLRSADEL ENLILQQN

Length:638

Mass (Da):71,357

Last modified:April 5, 2011 - v2

Checksum:ⁱ02DF0130F10E0B3F

Isoform 2 (identifier: O94818-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
413-514: Missing.

« Hide

        10         20         30         40         50
MESERDMYRQ FQDWCLRTYG DSGKTKTVTR KKYERIVQLL NGSESSSTDN 
        60         70         80         90        100
AKFKFWVKSK GFQLGQPDEV RGGGGGAKQV LYVPVKTTDG VGVDEKLSLR 
       110        120        130        140        150
RVAVVEDFFD IIYSMHVETG PNGEQIRKHA GQKRTYKAIS ESYAFLPREA 
       160        170        180        190        200
VTRFLMSCSE CQKRMHLNPD GTDHKDNGKP PTLVTSMIDY NMPITMAYMK 
       210        220        230        240        250
HMKLQLLNSQ QDEDESSIES DEFDMSDSTR MSAVNSDLSS NLEERMQSPQ 
       260        270        280        290        300
NLHGQQDDDS AAESFNGNET LGHSSIASGG THSREMGDSN SDGKTGLEQD 
       310        320        330        340        350
EQPLNLSDSP LSAQLTSEYR IDDHNSNGKN KYKNLLISDL KMEREARENG 
       360        370        380        390        400
SKSPAHSYSS YDSGKNESVD RGAEDLSLNR GDEDEDDHED HDDSEKVNET 
       410        420        430        440        450
DGVEAERLKA FNDESAPADK QCKPEATQAT YSTSAVPGSQ DVLYINGNGT 
       460        470        480        490        500
YSYHSYRGLG GGLLNLNDAS SSGPTDLSMK RQLATSSGSS SSSNSRPQLS 
       510        520        530 
PTEINAVRQL VAGYRESAAF LLRSADELEN LILQQN

Show »

Length:536

Mass (Da):59,300

Checksum:ⁱ3264872F49A76C1C

Isoform 3 (identifier: O94818-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-87: MESERDMYRQ...KQVLYVPVKT → MADLMQETFLHHA

« Hide

        10         20         30         40         50
MADLMQETFL HHATDGVGVD EKLSLRRVAV VEDFFDIIYS MHVETGPNGE 
        60         70         80         90        100
QIRKHAGQKR TYKAISESYA FLPREAVTRF LMSCSECQKR MHLNPDGTDH 
       110        120        130        140        150
KDNGKPPTLV TSMIDYNMPI TMAYMKHMKL QLLNSQQDED ESSIESDEFD 
       160        170        180        190        200
MSDSTRMSAV NSDLSSNLEE RMQSPQNLHG QQDDDSAAES FNGNETLGHS 
       210        220        230        240        250
SIASGGTHSR EMGDSNSDGK TGLEQDEQPL NLSDSPLSAQ LTSEYRIDDH 
       260        270        280        290        300
NSNGKNKYKN LLISDLKMER EARENGSKSP AHSYSSYDSG KNESVDRGAE 
       310        320        330        340        350
DLSLNRGDED EDDHEDHDDS EKVNETDGVE AERLKAFNMF VRLFVDENLD 
       360        370        380        390        400
RMVPISKQPK EKIQAIIDSC RRQFPEYQER ARKRIRTYLK SCRRMKRSGF 
       410        420        430        440        450
EMSRPIPSHL TSAVAESILA SACESESRNA AKRMRLERQQ DESAPADKQC 
       460        470        480        490        500
KPEATQATYS TSAVPGSQDV LYINGNGTYS YHSYRGLGGG LLNLNDASSS 
       510        520        530        540        550
GPTDLSMKRQ LATSSGSSSS SNSRPQLSPT EINAVRQLVA GYRESAAFLL 
       560 
RSADELENLI LQQN

Note: No experimental confirmation available.

Show »

Length:564

Mass (Da):62,970

Checksum:ⁱF9F37733388F664D

Isoform 4 (identifier: O94818-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-285: Missing.

« Hide

        10         20         30         40         50
MGDSNSDGKT GLEQDEQPLN LSDSPLSAQL TSEYRIDDHN SNGKNKYKNL 
        60         70         80         90        100
LISDLKMERE ARENGSKSPA HSYSSYDSGK NESVDRGAED LSLNRGDEDE 
       110        120        130        140        150
DDHEDHDDSE KVNETDGVEA ERLKAFNMFV RLFVDENLDR MVPISKQPKE 
       160        170        180        190        200
KIQAIIDSCR RQFPEYQERA RKRIRTYLKS CRRMKRSGFE MSRPIPSHLT 
       210        220        230        240        250
SAVAESILAS ACESESRNAA KRMRLERQQD ESAPADKQCK PEATQATYST 
       260        270        280        290        300
SAVPGSQDVL YINGNGTYSY HSYRGLGGGL LNLNDASSSG PTDLSMKRQL 
       310        320        330        340        350
ATSSGSSSSS NSRPQLSPTE INAVRQLVAG YRESAAFLLR SADELENLIL 

QQN

Note: No experimental confirmation available.

Show »

Length:353

Mass (Da):39,293

Checksum:ⁱ3CF8C54C76B703FA

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EPC5	K7EPC5_HUMAN	Nucleolar protein 4 Nucleolar protein 4	NOL4	69	Annotation score:
K7ENM5	K7ENM5_HUMAN	Nucleolar protein 4 Nucleolar protein 4	NOL4	219	Annotation score:
K7EQ17	K7EQ17_HUMAN	Nucleolar protein 4 Nucleolar protein 4	NOL4	558	Annotation score:
K7EID6	K7EID6_HUMAN	Nucleolar protein 4 Nucleolar protein 4	NOL4	69	Annotation score:
K7EIK8	K7EIK8_HUMAN	Nucleolar protein 4 Nucleolar protein 4	NOL4	24	Annotation score:

Sequence cautionⁱ

The sequence AAH00313 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

The sequence BAA34576 differs from that shown. Reason: Frameshift at position 82.Curated

The sequence BAA34576 differs from that shown. Reason: Erroneous termination at position 38. Translated as Gln.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	637	Q → H in BAH12383 (PubMed:14702039).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_045836	1 – 285	Missing in isoform 4. 1 PublicationAdd BLAST	285
Alternative sequenceⁱVSP_043344	1 – 87	MESER…VPVKT → MADLMQETFLHHA in isoform 3. 1 PublicationAdd BLAST	87
Alternative sequenceⁱVSP_010080	413 – 514	Missing in isoform 2. 3 PublicationsAdd BLAST	102

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB017800 mRNA Translation: BAA34576.1 Sequence problems. AK296539 mRNA Translation: BAH12383.1 AK299850 mRNA Translation: BAG61712.1 AC010798 Genomic DNA No translation available. AC018972 Genomic DNA No translation available. AC087397 Genomic DNA No translation available. AC104985 Genomic DNA No translation available. BC000313 mRNA Translation: AAH00313.1 Sequence problems. BT006763 mRNA Translation: AAP35409.1 CR456730 mRNA Translation: CAG33011.1 AB015339 mRNA Translation: BAA34797.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11907.2 [O94818-1] CCDS56058.1 [O94818-4] CCDS56059.1 [O94818-3] CCDS59308.1 [O94818-2]
PIRⁱ	JE0335
NCBI Reference Sequences More...RefSeqⁱ	NP_001185475.1, NM_001198546.1 NP_001185476.1, NM_001198547.1 [O94818-3] NP_001185477.1, NM_001198548.1 [O94818-2] NP_001185478.1, NM_001198549.1 [O94818-4] NP_001269456.1, NM_001282527.1 NP_003778.2, NM_003787.4 [O94818-1] XP_006722626.1, XM_006722563.2 [O94818-1] XP_011524539.1, XM_011526237.1 [O94818-1] XP_011524540.1, XM_011526238.1 XP_016881548.1, XM_017026059.1 [O94818-4]
UniGeneⁱ	Hs.514795

Genome annotation databases

Ensemblⁱ	ENST00000261592; ENSP00000261592; ENSG00000101746 [O94818-1] ENST00000535384; ENSP00000445733; ENSG00000101746 [O94818-4] ENST00000538587; ENSP00000443472; ENSG00000101746 [O94818-3] ENST00000589544; ENSP00000465450; ENSG00000101746 [O94818-2]
GeneIDⁱ	8715
KEGGⁱ	hsa:8715
UCSC genome browser More...UCSCⁱ	uc002kxt.5 human [O94818-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O94818	NOL4 isoform 1		PANTR		638	UniRef100_O94818
Nucleolar protein 4		GORGO		638
UPI0000073F88		HUMAN		524
UPI0003EAFDE3		HUMAN		483
O94818-2	NOL4 isoform 4		PANTR		536	UniRef100_A0A2I3TQ35
Nucleolar protein 4		GORGO		536
O94818-3	NOL4 isoform 5		PANTR		564	UniRef100_A0A2I3TBX2
O94818-4	NOL4 isoform 2		PANTR		353	UniRef100_A0A2I3SA66
Uncharacterized protein		CERAT		353
Uncharacterized protein		RHIRO		353
Nucleolar protein 4		GORGO		353
Uncharacterized protein		MACFA		353
+5

Protein	Similar proteins		Species	Score	Length	Source
O94818	NOL4 isoform 1		PANTR		638	UniRef90_O94818
Nucleolar protein 4		GORGO		638
Uncharacterized protein		PELSI		640
Uncharacterized protein		SHEEP		639
Nucleolar protein 4 isoform 1		MACMU		638
+239
O94818-2	NOL4 isoform 4		PANTR		536	UniRef90_A0A2I3TQ35
Nucleolar protein 4		GORGO		536
Nucleolar protein 4		SAIBB		536
Uncharacterized protein		Cebus capucinus imitator		536
Uncharacterized protein		CALJA		536
+47
O94818-4	NOL4 isoform 2		PANTR		353	UniRef90_A0A2I3SA66
Uncharacterized protein		CERAT		353
Uncharacterized protein		RHIRO		353
Nucleolar protein 4		GORGO		353
Uncharacterized protein		MACFA		353
+16

Protein	Similar proteins		Species	Score	Length	Source
O94818	NOL4 isoform 1		PANTR		638	UniRef50_O94818
Nucleolar protein 4		GORGO		638
Uncharacterized protein		PELSI		640
Uncharacterized protein		SHEEP		639
Nucleolar protein 4 isoform 1		MACMU		638
+618
O94818-2	Uncharacterized protein		CHICK		518	UniRef50_E1C508
Uncharacterized protein		PROCO		481
nucleolar protein 4 isoform X1		TARSY		419
Nucleolar protein 4		MYODS		614
Uncharacterized protein		ALLMI		570
+96

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB017800 mRNA Translation: BAA34576.1 Sequence problems. AK296539 mRNA Translation: BAH12383.1 AK299850 mRNA Translation: BAG61712.1 AC010798 Genomic DNA No translation available. AC018972 Genomic DNA No translation available. AC087397 Genomic DNA No translation available. AC104985 Genomic DNA No translation available. BC000313 mRNA Translation: AAH00313.1 Sequence problems. BT006763 mRNA Translation: AAP35409.1 CR456730 mRNA Translation: CAG33011.1 AB015339 mRNA Translation: BAA34797.1
CCDSⁱ	CCDS11907.2 [O94818-1] CCDS56058.1 [O94818-4] CCDS56059.1 [O94818-3] CCDS59308.1 [O94818-2]
PIRⁱ	JE0335
RefSeqⁱ	NP_001185475.1, NM_001198546.1 NP_001185476.1, NM_001198547.1 [O94818-3] NP_001185477.1, NM_001198548.1 [O94818-2] NP_001185478.1, NM_001198549.1 [O94818-4] NP_001269456.1, NM_001282527.1 NP_003778.2, NM_003787.4 [O94818-1] XP_006722626.1, XM_006722563.2 [O94818-1] XP_011524539.1, XM_011526237.1 [O94818-1] XP_011524540.1, XM_011526238.1 XP_016881548.1, XM_017026059.1 [O94818-4]
UniGeneⁱ	Hs.514795

3D structure databases

ProteinModelPortalⁱ	O94818
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114256, 11 interactors
IntActⁱ	O94818, 14 interactors
MINTⁱ	O94818

PTM databases

iPTMnetⁱ	O94818
PhosphoSitePlusⁱ	O94818

Polymorphism and mutation databases

BioMutaⁱ	NOL4

BioMutaⁱ

NOL4

Proteomic databases

EPDⁱ	O94818
MaxQBⁱ	O94818
PaxDbⁱ	O94818
PeptideAtlasⁱ	O94818
PRIDEⁱ	O94818
ProteomicsDBⁱ	50459 50460 [O94818-2] 50461 [O94818-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8715
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000261592; ENSP00000261592; ENSG00000101746 [O94818-1] ENST00000535384; ENSP00000445733; ENSG00000101746 [O94818-4] ENST00000538587; ENSP00000443472; ENSG00000101746 [O94818-3] ENST00000589544; ENSP00000465450; ENSG00000101746 [O94818-2]
GeneIDⁱ	8715
KEGGⁱ	hsa:8715
UCSCⁱ	uc002kxt.5 human [O94818-1]

Organism-specific databases

CTDⁱ	8715
DisGeNETⁱ	8715
EuPathDBⁱ	HostDB:ENSG00000101746.15
GeneCardsⁱ	NOL4
HGNCⁱ	HGNC:7870 NOL4
HPAⁱ	HPA046740
MIMⁱ	603577 gene
neXtProtⁱ	NX_O94818
OpenTargetsⁱ	ENSG00000101746
PharmGKBⁱ	PA31674
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEBQ Eukaryota ENOG411245F LUCA
GeneTreeⁱ	ENSGT00390000017363
HOGENOMⁱ	HOG000220856
HOVERGENⁱ	HBG031438
InParanoidⁱ	O94818
OMAⁱ	NETVGHS
OrthoDBⁱ	EOG091G03G2
PhylomeDBⁱ	O94818
TreeFamⁱ	TF325594

Miscellaneous databases

ChiTaRSⁱ	NOL4 human
GenomeRNAiⁱ	8715
Protein Ontology More...PROⁱ	PR:O94818
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000101746 Expressed in 112 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_NOL4
ExpressionAtlasⁱ	O94818 baseline and differential
Genevisibleⁱ	O94818 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR026747 NOL4 IPR039788 NOL4/NOL4L
PANTHERⁱ	PTHR12449 PTHR12449, 1 hit PTHR12449:SF17 PTHR12449:SF17, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NOL4_HUMAN
Accessionⁱ	O94818Primary (citable) accession number: O94818 Secondary accession number(s): B4DSQ0 , B7Z3Z7, F5H1E3, Q6IBS2, Q9BWF1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
	Last sequence update:	April 5, 2011
	Last modified:	November 7, 2018
	This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - O94818 (NOL4_HUMAN)

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Nucleolar protein 4

NOL4

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ