UniProtKB - O94818 (NOL4_HUMAN)
Protein
Nucleolar protein 4
Gene
NOL4
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: ProtInc
Enzyme and pathway databases
PathwayCommonsi | O94818 |
Names & Taxonomyi
Protein namesi | Recommended name: Nucleolar protein 4Alternative name(s): Nucleolar-localized protein |
Gene namesi | Name:NOL4 Synonyms:NOLP ORF Names:HRIHFB2255 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7870, NOL4 |
MIMi | 603577, gene |
neXtProti | NX_O94818 |
VEuPathDBi | HostDB:ENSG00000101746.15 |
Subcellular locationi
Nucleus
- nucleolus 2 Publications
Nucleus
- nucleolus Source: ProtInc
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 8715 |
OpenTargetsi | ENSG00000101746 |
PharmGKBi | PA31674 |
Miscellaneous databases
Pharosi | O94818, Tbio |
Genetic variation databases
BioMutai | NOL4 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000096935 | 1 – 638 | Nucleolar protein 4Add BLAST | 638 |
Proteomic databases
EPDi | O94818 |
jPOSTi | O94818 |
MassIVEi | O94818 |
MaxQBi | O94818 |
PaxDbi | O94818 |
PeptideAtlasi | O94818 |
PRIDEi | O94818 |
ProteomicsDBi | 25628 50459 [O94818-1] 50460 [O94818-2] 50461 [O94818-3] |
PTM databases
iPTMneti | O94818 |
PhosphoSitePlusi | O94818 |
Expressioni
Tissue specificityi
Expressed predominantly in fetal brain, adult brain and testis.1 Publication
Gene expression databases
Bgeei | ENSG00000101746, Expressed in cortical plate and 138 other tissues |
ExpressionAtlasi | O94818, baseline and differential |
Genevisiblei | O94818, HS |
Organism-specific databases
HPAi | ENSG00000101746, Group enriched (brain, testis) |
Interactioni
Binary interactionsi
Hide detailsIsoform 2 [O94818-2]
Protein-protein interaction databases
BioGRIDi | 114256, 19 interactors |
IntActi | O94818, 14 interactors |
MINTi | O94818 |
STRINGi | 9606.ENSP00000261592 |
Miscellaneous databases
RNActi | O94818, protein |
Family & Domainsi
Phylogenomic databases
eggNOGi | ENOG502QR3R, Eukaryota |
GeneTreei | ENSGT00940000159992 |
HOGENOMi | CLU_020587_0_0_1 |
InParanoidi | O94818 |
OMAi | CREMGDT |
OrthoDBi | 1009964at2759 |
PhylomeDBi | O94818 |
TreeFami | TF325594 |
Family and domain databases
InterProi | View protein in InterPro IPR026747, NOL4 IPR039788, NOL4/NOL4L |
PANTHERi | PTHR12449, PTHR12449, 1 hit PTHR12449:SF17, PTHR12449:SF17, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O94818-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MESERDMYRQ FQDWCLRTYG DSGKTKTVTR KKYERIVQLL NGSESSSTDN
60 70 80 90 100
AKFKFWVKSK GFQLGQPDEV RGGGGGAKQV LYVPVKTTDG VGVDEKLSLR
110 120 130 140 150
RVAVVEDFFD IIYSMHVETG PNGEQIRKHA GQKRTYKAIS ESYAFLPREA
160 170 180 190 200
VTRFLMSCSE CQKRMHLNPD GTDHKDNGKP PTLVTSMIDY NMPITMAYMK
210 220 230 240 250
HMKLQLLNSQ QDEDESSIES DEFDMSDSTR MSAVNSDLSS NLEERMQSPQ
260 270 280 290 300
NLHGQQDDDS AAESFNGNET LGHSSIASGG THSREMGDSN SDGKTGLEQD
310 320 330 340 350
EQPLNLSDSP LSAQLTSEYR IDDHNSNGKN KYKNLLISDL KMEREARENG
360 370 380 390 400
SKSPAHSYSS YDSGKNESVD RGAEDLSLNR GDEDEDDHED HDDSEKVNET
410 420 430 440 450
DGVEAERLKA FNMFVRLFVD ENLDRMVPIS KQPKEKIQAI IDSCRRQFPE
460 470 480 490 500
YQERARKRIR TYLKSCRRMK RSGFEMSRPI PSHLTSAVAE SILASACESE
510 520 530 540 550
SRNAAKRMRL ERQQDESAPA DKQCKPEATQ ATYSTSAVPG SQDVLYINGN
560 570 580 590 600
GTYSYHSYRG LGGGLLNLND ASSSGPTDLS MKRQLATSSG SSSSSNSRPQ
610 620 630
LSPTEINAVR QLVAGYRESA AFLLRSADEL ENLILQQN
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7ENM5 | K7ENM5_HUMAN | Nucleolar protein 4 | NOL4 | 219 | Annotation score: | ||
K7EQ17 | K7EQ17_HUMAN | Nucleolar protein 4 | NOL4 | 558 | Annotation score: | ||
K7EPC5 | K7EPC5_HUMAN | Nucleolar protein 4 | NOL4 | 69 | Annotation score: | ||
K7EID6 | K7EID6_HUMAN | Nucleolar protein 4 | NOL4 | 69 | Annotation score: | ||
K7EIK8 | K7EIK8_HUMAN | Nucleolar protein 4 | NOL4 | 24 | Annotation score: |
Sequence cautioni
The sequence AAH00313 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence BAA34576 differs from that shown. Reason: Frameshift.Curated
The sequence BAA34576 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 637 | Q → H in BAH12383 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045836 | 1 – 285 | Missing in isoform 4. 1 PublicationAdd BLAST | 285 | |
Alternative sequenceiVSP_043344 | 1 – 87 | MESER…VPVKT → MADLMQETFLHHA in isoform 3. 1 PublicationAdd BLAST | 87 | |
Alternative sequenceiVSP_010080 | 413 – 514 | Missing in isoform 2. 3 PublicationsAdd BLAST | 102 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000261592; ENSP00000261592; ENSG00000101746 [O94818-1] ENST00000535384; ENSP00000445733; ENSG00000101746 [O94818-4] ENST00000538587; ENSP00000443472; ENSG00000101746 [O94818-3] ENST00000589544; ENSP00000465450; ENSG00000101746 [O94818-2] |
GeneIDi | 8715 |
KEGGi | hsa:8715 |
UCSCi | uc002kxt.5, human [O94818-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 114256, 19 interactors |
IntActi | O94818, 14 interactors |
MINTi | O94818 |
STRINGi | 9606.ENSP00000261592 |
PTM databases
iPTMneti | O94818 |
PhosphoSitePlusi | O94818 |
Genetic variation databases
BioMutai | NOL4 |
Proteomic databases
EPDi | O94818 |
jPOSTi | O94818 |
MassIVEi | O94818 |
MaxQBi | O94818 |
PaxDbi | O94818 |
PeptideAtlasi | O94818 |
PRIDEi | O94818 |
ProteomicsDBi | 25628 50459 [O94818-1] 50460 [O94818-2] 50461 [O94818-3] |
Protocols and materials databases
Antibodypediai | 8389, 118 antibodies |
DNASUi | 8715 |
Genome annotation databases
Ensembli | ENST00000261592; ENSP00000261592; ENSG00000101746 [O94818-1] ENST00000535384; ENSP00000445733; ENSG00000101746 [O94818-4] ENST00000538587; ENSP00000443472; ENSG00000101746 [O94818-3] ENST00000589544; ENSP00000465450; ENSG00000101746 [O94818-2] |
GeneIDi | 8715 |
KEGGi | hsa:8715 |
UCSCi | uc002kxt.5, human [O94818-1] |
Organism-specific databases
CTDi | 8715 |
DisGeNETi | 8715 |
GeneCardsi | NOL4 |
HGNCi | HGNC:7870, NOL4 |
HPAi | ENSG00000101746, Group enriched (brain, testis) |
MIMi | 603577, gene |
neXtProti | NX_O94818 |
OpenTargetsi | ENSG00000101746 |
PharmGKBi | PA31674 |
VEuPathDBi | HostDB:ENSG00000101746.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QR3R, Eukaryota |
GeneTreei | ENSGT00940000159992 |
HOGENOMi | CLU_020587_0_0_1 |
InParanoidi | O94818 |
OMAi | CREMGDT |
OrthoDBi | 1009964at2759 |
PhylomeDBi | O94818 |
TreeFami | TF325594 |
Enzyme and pathway databases
PathwayCommonsi | O94818 |
Miscellaneous databases
BioGRID-ORCSi | 8715, 3 hits in 991 CRISPR screens |
ChiTaRSi | NOL4, human |
GenomeRNAii | 8715 |
Pharosi | O94818, Tbio |
PROi | PR:O94818 |
RNActi | O94818, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101746, Expressed in cortical plate and 138 other tissues |
ExpressionAtlasi | O94818, baseline and differential |
Genevisiblei | O94818, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026747, NOL4 IPR039788, NOL4/NOL4L |
PANTHERi | PTHR12449, PTHR12449, 1 hit PTHR12449:SF17, PTHR12449:SF17, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NOL4_HUMAN | |
Accessioni | O94818Primary (citable) accession number: O94818 Secondary accession number(s): B4DSQ0 Q9BWF1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | April 5, 2011 | |
Last modified: | April 7, 2021 | |
This is version 148 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot