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Protein

Nucleolar protein 4

Gene

NOL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 4
Alternative name(s):
Nucleolar-localized protein
Gene namesi
Name:NOL4
Synonyms:NOLP
ORF Names:HRIHFB2255
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000101746.15
HGNCiHGNC:7870 NOL4
MIMi603577 gene
neXtProtiNX_O94818

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8715
OpenTargetsiENSG00000101746
PharmGKBiPA31674

Polymorphism and mutation databases

BioMutaiNOL4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000969351 – 638Nucleolar protein 4Add BLAST638

Proteomic databases

EPDiO94818
MaxQBiO94818
PaxDbiO94818
PeptideAtlasiO94818
PRIDEiO94818
ProteomicsDBi50459
50460 [O94818-2]
50461 [O94818-3]

PTM databases

iPTMnetiO94818
PhosphoSitePlusiO94818

Expressioni

Tissue specificityi

Expressed predominantly in fetal brain, adult brain and testis.1 Publication

Gene expression databases

BgeeiENSG00000101746 Expressed in 112 organ(s), highest expression level in frontal cortex
CleanExiHS_NOL4
ExpressionAtlasiO94818 baseline and differential
GenevisibleiO94818 HS

Organism-specific databases

HPAiHPA046740

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi114256, 11 interactors
IntActiO94818, 14 interactors
MINTiO94818

Structurei

3D structure databases

ProteinModelPortaliO94818
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IEBQ Eukaryota
ENOG411245F LUCA
GeneTreeiENSGT00390000017363
HOGENOMiHOG000220856
HOVERGENiHBG031438
InParanoidiO94818
OMAiNETVGHS
OrthoDBiEOG091G03G2
PhylomeDBiO94818
TreeFamiTF325594

Family and domain databases

InterProiView protein in InterPro
IPR026747 NOL4
IPR039788 NOL4/NOL4L
PANTHERiPTHR12449 PTHR12449, 1 hit
PTHR12449:SF17 PTHR12449:SF17, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94818-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESERDMYRQ FQDWCLRTYG DSGKTKTVTR KKYERIVQLL NGSESSSTDN
60 70 80 90 100
AKFKFWVKSK GFQLGQPDEV RGGGGGAKQV LYVPVKTTDG VGVDEKLSLR
110 120 130 140 150
RVAVVEDFFD IIYSMHVETG PNGEQIRKHA GQKRTYKAIS ESYAFLPREA
160 170 180 190 200
VTRFLMSCSE CQKRMHLNPD GTDHKDNGKP PTLVTSMIDY NMPITMAYMK
210 220 230 240 250
HMKLQLLNSQ QDEDESSIES DEFDMSDSTR MSAVNSDLSS NLEERMQSPQ
260 270 280 290 300
NLHGQQDDDS AAESFNGNET LGHSSIASGG THSREMGDSN SDGKTGLEQD
310 320 330 340 350
EQPLNLSDSP LSAQLTSEYR IDDHNSNGKN KYKNLLISDL KMEREARENG
360 370 380 390 400
SKSPAHSYSS YDSGKNESVD RGAEDLSLNR GDEDEDDHED HDDSEKVNET
410 420 430 440 450
DGVEAERLKA FNMFVRLFVD ENLDRMVPIS KQPKEKIQAI IDSCRRQFPE
460 470 480 490 500
YQERARKRIR TYLKSCRRMK RSGFEMSRPI PSHLTSAVAE SILASACESE
510 520 530 540 550
SRNAAKRMRL ERQQDESAPA DKQCKPEATQ ATYSTSAVPG SQDVLYINGN
560 570 580 590 600
GTYSYHSYRG LGGGLLNLND ASSSGPTDLS MKRQLATSSG SSSSSNSRPQ
610 620 630
LSPTEINAVR QLVAGYRESA AFLLRSADEL ENLILQQN
Length:638
Mass (Da):71,357
Last modified:April 5, 2011 - v2
Checksum:i02DF0130F10E0B3F
GO
Isoform 2 (identifier: O94818-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     413-514: Missing.

Show »
Length:536
Mass (Da):59,300
Checksum:i3264872F49A76C1C
GO
Isoform 3 (identifier: O94818-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: MESERDMYRQ...KQVLYVPVKT → MADLMQETFLHHA

Note: No experimental confirmation available.
Show »
Length:564
Mass (Da):62,970
Checksum:iF9F37733388F664D
GO
Isoform 4 (identifier: O94818-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-285: Missing.

Note: No experimental confirmation available.
Show »
Length:353
Mass (Da):39,293
Checksum:i3CF8C54C76B703FA
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EPC5K7EPC5_HUMAN
Nucleolar protein 4
NOL4
69Annotation score:
K7ENM5K7ENM5_HUMAN
Nucleolar protein 4
NOL4
219Annotation score:
K7EQ17K7EQ17_HUMAN
Nucleolar protein 4
NOL4
558Annotation score:
K7EID6K7EID6_HUMAN
Nucleolar protein 4
NOL4
69Annotation score:
K7EIK8K7EIK8_HUMAN
Nucleolar protein 4
NOL4
24Annotation score:

Sequence cautioni

The sequence AAH00313 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence BAA34576 differs from that shown. Reason: Frameshift at position 82.Curated
The sequence BAA34576 differs from that shown. Reason: Erroneous termination at position 38. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti637Q → H in BAH12383 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0458361 – 285Missing in isoform 4. 1 PublicationAdd BLAST285
Alternative sequenceiVSP_0433441 – 87MESER…VPVKT → MADLMQETFLHHA in isoform 3. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_010080413 – 514Missing in isoform 2. 3 PublicationsAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017800 mRNA Translation: BAA34576.1 Sequence problems.
AK296539 mRNA Translation: BAH12383.1
AK299850 mRNA Translation: BAG61712.1
AC010798 Genomic DNA No translation available.
AC018972 Genomic DNA No translation available.
AC087397 Genomic DNA No translation available.
AC104985 Genomic DNA No translation available.
BC000313 mRNA Translation: AAH00313.1 Sequence problems.
BT006763 mRNA Translation: AAP35409.1
CR456730 mRNA Translation: CAG33011.1
AB015339 mRNA Translation: BAA34797.1
CCDSiCCDS11907.2 [O94818-1]
CCDS56058.1 [O94818-4]
CCDS56059.1 [O94818-3]
CCDS59308.1 [O94818-2]
PIRiJE0335
RefSeqiNP_001185475.1, NM_001198546.1
NP_001185476.1, NM_001198547.1 [O94818-3]
NP_001185477.1, NM_001198548.1 [O94818-2]
NP_001185478.1, NM_001198549.1 [O94818-4]
NP_001269456.1, NM_001282527.1
NP_003778.2, NM_003787.4 [O94818-1]
XP_006722626.1, XM_006722563.2 [O94818-1]
XP_011524539.1, XM_011526237.1 [O94818-1]
XP_011524540.1, XM_011526238.1
XP_016881548.1, XM_017026059.1 [O94818-4]
UniGeneiHs.514795

Genome annotation databases

EnsembliENST00000261592; ENSP00000261592; ENSG00000101746 [O94818-1]
ENST00000535384; ENSP00000445733; ENSG00000101746 [O94818-4]
ENST00000538587; ENSP00000443472; ENSG00000101746 [O94818-3]
ENST00000589544; ENSP00000465450; ENSG00000101746 [O94818-2]
GeneIDi8715
KEGGihsa:8715
UCSCiuc002kxt.5 human [O94818-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017800 mRNA Translation: BAA34576.1 Sequence problems.
AK296539 mRNA Translation: BAH12383.1
AK299850 mRNA Translation: BAG61712.1
AC010798 Genomic DNA No translation available.
AC018972 Genomic DNA No translation available.
AC087397 Genomic DNA No translation available.
AC104985 Genomic DNA No translation available.
BC000313 mRNA Translation: AAH00313.1 Sequence problems.
BT006763 mRNA Translation: AAP35409.1
CR456730 mRNA Translation: CAG33011.1
AB015339 mRNA Translation: BAA34797.1
CCDSiCCDS11907.2 [O94818-1]
CCDS56058.1 [O94818-4]
CCDS56059.1 [O94818-3]
CCDS59308.1 [O94818-2]
PIRiJE0335
RefSeqiNP_001185475.1, NM_001198546.1
NP_001185476.1, NM_001198547.1 [O94818-3]
NP_001185477.1, NM_001198548.1 [O94818-2]
NP_001185478.1, NM_001198549.1 [O94818-4]
NP_001269456.1, NM_001282527.1
NP_003778.2, NM_003787.4 [O94818-1]
XP_006722626.1, XM_006722563.2 [O94818-1]
XP_011524539.1, XM_011526237.1 [O94818-1]
XP_011524540.1, XM_011526238.1
XP_016881548.1, XM_017026059.1 [O94818-4]
UniGeneiHs.514795

3D structure databases

ProteinModelPortaliO94818
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114256, 11 interactors
IntActiO94818, 14 interactors
MINTiO94818

PTM databases

iPTMnetiO94818
PhosphoSitePlusiO94818

Polymorphism and mutation databases

BioMutaiNOL4

Proteomic databases

EPDiO94818
MaxQBiO94818
PaxDbiO94818
PeptideAtlasiO94818
PRIDEiO94818
ProteomicsDBi50459
50460 [O94818-2]
50461 [O94818-3]

Protocols and materials databases

DNASUi8715
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261592; ENSP00000261592; ENSG00000101746 [O94818-1]
ENST00000535384; ENSP00000445733; ENSG00000101746 [O94818-4]
ENST00000538587; ENSP00000443472; ENSG00000101746 [O94818-3]
ENST00000589544; ENSP00000465450; ENSG00000101746 [O94818-2]
GeneIDi8715
KEGGihsa:8715
UCSCiuc002kxt.5 human [O94818-1]

Organism-specific databases

CTDi8715
DisGeNETi8715
EuPathDBiHostDB:ENSG00000101746.15
GeneCardsiNOL4
HGNCiHGNC:7870 NOL4
HPAiHPA046740
MIMi603577 gene
neXtProtiNX_O94818
OpenTargetsiENSG00000101746
PharmGKBiPA31674
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEBQ Eukaryota
ENOG411245F LUCA
GeneTreeiENSGT00390000017363
HOGENOMiHOG000220856
HOVERGENiHBG031438
InParanoidiO94818
OMAiNETVGHS
OrthoDBiEOG091G03G2
PhylomeDBiO94818
TreeFamiTF325594

Miscellaneous databases

ChiTaRSiNOL4 human
GenomeRNAii8715
PROiPR:O94818
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101746 Expressed in 112 organ(s), highest expression level in frontal cortex
CleanExiHS_NOL4
ExpressionAtlasiO94818 baseline and differential
GenevisibleiO94818 HS

Family and domain databases

InterProiView protein in InterPro
IPR026747 NOL4
IPR039788 NOL4/NOL4L
PANTHERiPTHR12449 PTHR12449, 1 hit
PTHR12449:SF17 PTHR12449:SF17, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNOL4_HUMAN
AccessioniPrimary (citable) accession number: O94818
Secondary accession number(s): B4DSQ0
, B7Z3Z7, F5H1E3, Q6IBS2, Q9BWF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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