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Entry version 172 (07 Oct 2020)
Sequence version 1 (01 May 1999)
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Protein

Ubiquitin-like protein ATG12

Gene

ATG12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes.5 Publications
(Microbial infection) May act as a proviral factor. In association with ATG5, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for the initiation of HCV replication, but not required once infection is established (PubMed:19666601).2 Publications

Miscellaneous

Small amount of ATG5-ATG12 conjugate is enough to perform normal autophagy.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Atg8 ligase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy, Host-virus interaction, Ubl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
O94817

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1632852, Macroautophagy
R-HSA-5205685, PINK1-PRKN Mediated Mitophagy
R-HSA-8934903, Receptor Mediated Mitophagy
R-HSA-936440, Negative regulators of DDX58/IFIH1 signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O94817

Protein family/group databases

Transport Classification Database

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TCDBi
9.A.15.2.1, the autophagy-related phagophore-formation transporter (apt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin-like protein ATG12
Alternative name(s):
Autophagy-related protein 12
Short name:
APG12-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATG12
Synonyms:APG12, APG12L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000145782.12

Human Gene Nomenclature Database

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HGNCi
HGNC:588, ATG12

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609608, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O94817

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi54K → D: Impairs E3 activity of the ATG12-ATG5 conjugate. 1 Publication1
Mutagenesisi62V → R: Impairs E3 activity of the ATG12-ATG5 conjugate. 1 Publication1
Mutagenesisi63G → D: Impairs E3 activity of the ATG12-ATG5 conjugate. 1 Publication1
Mutagenesisi72K → D: Impairs E3 activity of the ATG12-ATG5 conjugate. 1 Publication1
Mutagenesisi73W → A: Impairs E3 activity of the ATG12-ATG5 conjugate. 1 Publication1
Mutagenesisi108F → A, D or R: Impairs ATG12 stability. 1 Publication1
Mutagenesisi113D → V: Impairs E3 activity of the ATG12-ATG5 conjugate. 1 Publication1
Mutagenesisi122C → W: Impairs E3 activity of the ATG12-ATG5 conjugate. 1 Publication1
Mutagenesisi123F → D: Impairs ATG12 stability. 1 Publication1
Mutagenesisi138A → R: Impairs E3 activity of the ATG12-ATG5 conjugate. 1 Publication1
Mutagenesisi139W → F or Y: Impairs E3 activity of the ATG12-ATG5 conjugate. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9140

Open Targets

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OpenTargetsi
ENSG00000145782

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA24879

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O94817, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATG12

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002124711 – 140Ubiquitin-like protein ATG12Add BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki140Glycyl lysine isopeptide (Gly-Lys) (interchain with K-130 in ATG5)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylated by EP300.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O94817

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O94817

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O94817

MaxQB - The MaxQuant DataBase

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MaxQBi
O94817

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94817

PeptideAtlas

More...
PeptideAtlasi
O94817

PRoteomics IDEntifications database

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PRIDEi
O94817

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
50457 [O94817-1]
50458 [O94817-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O94817

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O94817

SwissPalm database of S-palmitoylation events

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SwissPalmi
O94817

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is induced by mitochondrial DNA deletions, chloramphenicol and nicotinamide.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000145782, Expressed in corpus callosum and 251 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O94817, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O94817, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000145782, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a conjugate with ATG5 (PubMed:11096062, PubMed:12207896, PubMed:11825910, PubMed:17709747, PubMed:26812546, PubMed:23202584). The ATG12-ATG5 conjugate forms a complex with several units of ATG16L1 (PubMed:23202584).

Forms an 800-kDa complex composed of ATG12-ATG5 and ATG16L2 (By similarity).

Interacts with DHX58/RIG-1, IFIH1/MDA5 and MAVS/IPS-1 in monomeric form as well as in ATG12-ATG5 conjugate. The interaction with MAVS is further enhanced upon vesicular stomatitis virus (VSV) infection (PubMed:17709747).

Interacts with ATG3 and ATG7 (PubMed:11096062, PubMed:12207896, PubMed:11825910, PubMed:23202584).

Interacts with ATG10 (By similarity).

Interacts with TECPR1 (PubMed:22342342).

By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
114587, 37 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-200, ATG12-ATG5-ATG16L1 complex
CPX-354, ATG12-ATG5-ATG16L2 complex
CPX-356, ATG5-ATG12 complex
CPX-358, ATG5-ATG12-TECPR1 complex

Database of interacting proteins

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DIPi
DIP-46466N

Protein interaction database and analysis system

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IntActi
O94817, 30 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000425107

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
O94817, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1140
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O94817

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Shares weak sequence similarity with ubiquitin family, but contains an 'ubiquitin superfold' and the C-terminal Gly is required for isopeptide linkage.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATG12 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3439, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000016654

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_106795_3_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O94817

KEGG Orthology (KO)

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KOi
K08336

Identification of Orthologs from Complete Genome Data

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OMAi
GNLWRCF

Database of Orthologous Groups

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OrthoDBi
1525971at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O94817

TreeFam database of animal gene trees

More...
TreeFami
TF325131

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007242, Atg12
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

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PANTHERi
PTHR13385, PTHR13385, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF04110, APG12, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54236, SSF54236, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94817-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEEPQSVLQ LPTSIAAGGE GLTDVSPETT TPEPPSSAAV SPGTEEPAGD
60 70 80 90 100
TKKKIDILLK AVGDTPIMKT KKWAVERTRT IQGLIDFIKK FLKLVASEQL
110 120 130 140
FIYVNQSFAP SPDQEVGTLY ECFGSDGKLV LHYCKSQAWG
Length:140
Mass (Da):15,113
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i109258521C2D194F
GO
Isoform 2 (identifier: O94817-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-74: DILLKAVGDTPIMKTKKWA → YLCESVLCSFPRPRSWNSL
     75-140: Missing.

Show »
Length:74
Mass (Da):7,746
Checksum:i21346AAD91E00D16
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BYD7H7BYD7_HUMAN
Ubiquitin-like protein ATG12
ATG12
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RB14D6RB14_HUMAN
Ubiquitin-like protein ATG12
ATG12
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9W4H0Y9W4_HUMAN
Ubiquitin-like protein ATG12
ATG12
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YA29H0YA29_HUMAN
Ubiquitin-like protein ATG12
ATG12
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH12266 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01810456 – 74DILLK…TKKWA → YLCESVLCSFPRPRSWNSL in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_01810575 – 140Missing in isoform 2. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB017507 mRNA Translation: BAA36493.1
AC026449 Genomic DNA No translation available.
BC011033 mRNA Translation: AAH11033.1
BC012266 mRNA Translation: AAH12266.2 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4122.2 [O94817-1]
CCDS64222.1 [O94817-4]

NCBI Reference Sequences

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RefSeqi
NP_001264712.1, NM_001277783.1 [O94817-4]
NP_004698.3, NM_004707.3 [O94817-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000500945; ENSP00000425164; ENSG00000145782 [O94817-4]
ENST00000509910; ENSP00000425107; ENSG00000145782 [O94817-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9140

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9140

UCSC genome browser

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UCSCi
uc003krh.4, human [O94817-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017507 mRNA Translation: BAA36493.1
AC026449 Genomic DNA No translation available.
BC011033 mRNA Translation: AAH11033.1
BC012266 mRNA Translation: AAH12266.2 Different initiation.
CCDSiCCDS4122.2 [O94817-1]
CCDS64222.1 [O94817-4]
RefSeqiNP_001264712.1, NM_001277783.1 [O94817-4]
NP_004698.3, NM_004707.3 [O94817-1]

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GDKX-ray2.70A/D52-140[»]
4GDLX-ray2.88A52-140[»]
4NAWX-ray2.20A/E/I/M52-140[»]
SMRiO94817
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114587, 37 interactors
ComplexPortaliCPX-200, ATG12-ATG5-ATG16L1 complex
CPX-354, ATG12-ATG5-ATG16L2 complex
CPX-356, ATG5-ATG12 complex
CPX-358, ATG5-ATG12-TECPR1 complex
DIPiDIP-46466N
IntActiO94817, 30 interactors
STRINGi9606.ENSP00000425107

Protein family/group databases

TCDBi9.A.15.2.1, the autophagy-related phagophore-formation transporter (apt) family

PTM databases

iPTMnetiO94817
PhosphoSitePlusiO94817
SwissPalmiO94817

Polymorphism and mutation databases

BioMutaiATG12

Proteomic databases

EPDiO94817
jPOSTiO94817
MassIVEiO94817
MaxQBiO94817
PaxDbiO94817
PeptideAtlasiO94817
PRIDEiO94817
ProteomicsDBi50457 [O94817-1]
50458 [O94817-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
4593, 767 antibodies

Genome annotation databases

EnsembliENST00000500945; ENSP00000425164; ENSG00000145782 [O94817-4]
ENST00000509910; ENSP00000425107; ENSG00000145782 [O94817-1]
GeneIDi9140
KEGGihsa:9140
UCSCiuc003krh.4, human [O94817-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9140
DisGeNETi9140
EuPathDBiHostDB:ENSG00000145782.12

GeneCards: human genes, protein and diseases

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GeneCardsi
ATG12
HGNCiHGNC:588, ATG12
HPAiENSG00000145782, Low tissue specificity
MIMi609608, gene
neXtProtiNX_O94817
OpenTargetsiENSG00000145782
PharmGKBiPA24879

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3439, Eukaryota
GeneTreeiENSGT00390000016654
HOGENOMiCLU_106795_3_0_1
InParanoidiO94817
KOiK08336
OMAiGNLWRCF
OrthoDBi1525971at2759
PhylomeDBiO94817
TreeFamiTF325131

Enzyme and pathway databases

PathwayCommonsiO94817
ReactomeiR-HSA-1632852, Macroautophagy
R-HSA-5205685, PINK1-PRKN Mediated Mitophagy
R-HSA-8934903, Receptor Mediated Mitophagy
R-HSA-936440, Negative regulators of DDX58/IFIH1 signaling
SIGNORiO94817

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
9140, 10 hits in 879 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ATG12, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ATG12

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9140
PharosiO94817, Tbio

Protein Ontology

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PROi
PR:O94817
RNActiO94817, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000145782, Expressed in corpus callosum and 251 other tissues
ExpressionAtlasiO94817, baseline and differential
GenevisibleiO94817, HS

Family and domain databases

InterProiView protein in InterPro
IPR007242, Atg12
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR13385, PTHR13385, 1 hit
PfamiView protein in Pfam
PF04110, APG12, 1 hit
SUPFAMiSSF54236, SSF54236, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATG12_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94817
Secondary accession number(s): Q6PJV2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 1, 1999
Last modified: October 7, 2020
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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