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Protein

Slit homolog 2 protein

Gene

SLIT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.6 Publications

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • GTPase inhibitor activity Source: UniProtKB
  • heparin binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • laminin-1 binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • proteoglycan binding Source: UniProtKB
  • Roundabout binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Heparin-binding
Biological processChemotaxis, Differentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-HSA-373752 Netrin-1 signaling
R-HSA-376176 Signaling by ROBO receptors
R-HSA-428540 Activation of RAC1
R-HSA-428542 Regulation of commissural axon pathfinding by SLIT and ROBO
R-HSA-428543 Inactivation of CDC42 and RAC1
R-HSA-428890 Role of ABL in ROBO-SLIT signaling
R-HSA-8985586 SLIT2:ROBO1 increases RHOA activity
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
SIGNORiO94813

Names & Taxonomyi

Protein namesi
Recommended name:
Slit homolog 2 protein
Short name:
Slit-2
Cleaved into the following 2 chains:
Gene namesi
Name:SLIT2
Synonyms:SLIL3
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000145147.19
HGNCiHGNC:11086 SLIT2
MIMi603746 gene
neXtProtiNX_O94813

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi9353
OpenTargetsiENSG00000145147
PharmGKBiPA35939

Polymorphism and mutation databases

BioMutaiSLIT2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000000772531 – 1529Slit homolog 2 proteinAdd BLAST1499
ChainiPRO_000000772631 – 1121Slit homolog 2 protein N-productAdd BLAST1091
ChainiPRO_00000077271122 – 1529Slit homolog 2 protein C-productAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi277 ↔ 286
Disulfide bondi434 ↔ 457
Disulfide bondi436 ↔ 478
Disulfide bondi506 ↔ 512
Disulfide bondi510 ↔ 519
Glycosylationi564N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi623N-linked (GlcNAc...) asparagine1
Disulfide bondi668 ↔ 691
Disulfide bondi670 ↔ 712
Disulfide bondi727 ↔ 733
Disulfide bondi731 ↔ 740
Glycosylationi794N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi799N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi863 ↔ 886
Disulfide bondi865 ↔ 907
Disulfide bondi922 ↔ 933By similarity
Disulfide bondi927 ↔ 943By similarity
Disulfide bondi945 ↔ 954By similarity
Disulfide bondi961 ↔ 972By similarity
Disulfide bondi966 ↔ 984By similarity
Disulfide bondi986 ↔ 995By similarity
Disulfide bondi1002 ↔ 1013By similarity
Disulfide bondi1007 ↔ 1022By similarity
Glycosylationi1009N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1010N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1019N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1024 ↔ 1033By similarity
Disulfide bondi1040 ↔ 1053By similarity
Disulfide bondi1047 ↔ 1062By similarity
Disulfide bondi1064 ↔ 1073By similarity
Disulfide bondi1080 ↔ 1091By similarity
Disulfide bondi1085 ↔ 1100By similarity
Disulfide bondi1102 ↔ 1111By similarity
Disulfide bondi1125 ↔ 1136By similarity
Disulfide bondi1130 ↔ 1145By similarity
Disulfide bondi1147 ↔ 1156By similarity
Glycosylationi1183N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1266N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1300N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1307 ↔ 1333By similarity
Disulfide bondi1336 ↔ 1346By similarity
Disulfide bondi1341 ↔ 1356By similarity
Disulfide bondi1358 ↔ 1367By similarity
Disulfide bondi1375 ↔ 1385By similarity
Disulfide bondi1380 ↔ 1395By similarity
Disulfide bondi1397 ↔ 1406By similarity
Disulfide bondi1416 ↔ 1426By similarity
Disulfide bondi1421 ↔ 1436By similarity
Disulfide bondi1438 ↔ 1447By similarity
Disulfide bondi1453 ↔ 1492By similarity
Disulfide bondi1471 ↔ 1506By similarity
Disulfide bondi1482 ↔ 1522By similarity
Disulfide bondi1486 ↔ 1524By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1121 – 1122Cleavage2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO94813
MaxQBiO94813
PaxDbiO94813
PeptideAtlasiO94813
PRIDEiO94813
ProteomicsDBi50454
50455 [O94813-2]
50456 [O94813-3]

PTM databases

iPTMnetiO94813
PhosphoSitePlusiO94813

Expressioni

Tissue specificityi

Fetal lung and kidney, and adult spinal cord. Weak expression in adult adrenal gland, thyroid, trachea and other tissues examined.2 Publications

Gene expression databases

BgeeiENSG00000145147 Expressed in 230 organ(s), highest expression level in upper lobe of lung
CleanExiHS_SLIT2
ExpressionAtlasiO94813 baseline and differential
GenevisibleiO94813 HS

Organism-specific databases

HPAiCAB007590
HPA019511
HPA023088

Interactioni

Subunit structurei

Interacts with GREM1 (By similarity). Homodimer. Binds ROBO1 and ROBO2 with high affinity.By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114756, 18 interactors
DIPiDIP-38198N
IntActiO94813, 10 interactors
MINTiO94813
STRINGi9606.ENSP00000422591

Structurei

Secondary structure

11529
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO94813
SMRiO94813
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO94813

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 55LRRNTAdd BLAST25
Repeati56 – 77LRR 1Add BLAST22
Repeati80 – 101LRR 2Add BLAST22
Repeati104 – 125LRR 3Add BLAST22
Repeati128 – 149LRR 4Add BLAST22
Repeati152 – 173LRR 5Add BLAST22
Repeati176 – 197LRR 6Add BLAST22
Domaini209 – 259LRRCT 1Add BLAST51
Domaini264 – 300LRRNT 2Add BLAST37
Repeati301 – 322LRR 7Add BLAST22
Repeati325 – 346LRR 8Add BLAST22
Repeati349 – 370LRR 9Add BLAST22
Repeati373 – 394LRR 10Add BLAST22
Repeati397 – 418LRR 11Add BLAST22
Domaini430 – 480LRRCT 2Add BLAST51
Domaini497 – 533LRRNT 3Add BLAST37
Repeati534 – 555LRR 12Add BLAST22
Repeati559 – 580LRR 13Add BLAST22
Repeati583 – 604LRR 14Add BLAST22
Repeati607 – 628LRR 15Add BLAST22
Repeati631 – 652LRR 16Add BLAST22
Domaini664 – 714LRRCT 3Add BLAST51
Domaini718 – 754LRRNT 4Add BLAST37
Repeati755 – 777LRR 17Add BLAST23
Repeati778 – 799LRR 18Add BLAST22
Repeati802 – 823LRR 19Add BLAST22
Repeati826 – 847LRR 20Add BLAST22
Domaini859 – 909LRRCT 4Add BLAST51
Domaini918 – 955EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini957 – 996EGF-like 2PROSITE-ProRule annotationAdd BLAST40
Domaini998 – 1034EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1036 – 1074EGF-like 4PROSITE-ProRule annotationAdd BLAST39
Domaini1076 – 1112EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1121 – 1157EGF-like 6PROSITE-ProRule annotationAdd BLAST37
Domaini1160 – 1333Laminin G-likePROSITE-ProRule annotationAdd BLAST174
Domaini1332 – 1368EGF-like 7PROSITE-ProRule annotationAdd BLAST37
Domaini1453 – 1528CTCKPROSITE-ProRule annotationCuratedAdd BLAST76

Domaini

The leucine-rich repeat domain is sufficient for guiding both axon projection and neuronal migration, in vitro.1 Publication

Keywords - Domaini

EGF-like domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG4237 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00910000144018
HOGENOMiHOG000116120
HOVERGENiHBG057959
InParanoidiO94813
KOiK06839
PhylomeDBiO94813
TreeFamiTF332887

Family and domain databases

Gene3Di3.80.10.10, 5 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000483 Cys-rich_flank_reg_C
IPR006207 Cys_knot_C
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR003645 Fol_N
IPR001791 Laminin_G
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF00008 EGF, 5 hits
PF12661 hEGF, 2 hits
PF00054 Laminin_G_1, 1 hit
PF13855 LRR_8, 7 hits
PF01463 LRRCT, 4 hits
PF01462 LRRNT, 4 hits
SMARTiView protein in SMART
SM00041 CT, 1 hit
SM00181 EGF, 9 hits
SM00179 EGF_CA, 7 hits
SM00274 FOLN, 3 hits
SM00282 LamG, 1 hit
SM00369 LRR_TYP, 17 hits
SM00082 LRRCT, 4 hits
SM00013 LRRNT, 4 hits
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00022 EGF_1, 9 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 9 hits
PS01187 EGF_CA, 2 hits
PS50025 LAM_G_DOMAIN, 1 hit
PS51450 LRR, 20 hits

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.iShow all

Isoform 1Curated (identifier: O94813-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRGVGWQMLS LSLGLVLAIL NKVAPQACPA QCSCSGSTVD CHGLALRSVP
60 70 80 90 100
RNIPRNTERL DLNGNNITRI TKTDFAGLRH LRVLQLMENK ISTIERGAFQ
110 120 130 140 150
DLKELERLRL NRNHLQLFPE LLFLGTAKLY RLDLSENQIQ AIPRKAFRGA
160 170 180 190 200
VDIKNLQLDY NQISCIEDGA FRALRDLEVL TLNNNNITRL SVASFNHMPK
210 220 230 240 250
LRTFRLHSNN LYCDCHLAWL SDWLRQRPRV GLYTQCMGPS HLRGHNVAEV
260 270 280 290 300
QKREFVCSGH QSFMAPSCSV LHCPAACTCS NNIVDCRGKG LTEIPTNLPE
310 320 330 340 350
TITEIRLEQN TIKVIPPGAF SPYKKLRRID LSNNQISELA PDAFQGLRSL
360 370 380 390 400
NSLVLYGNKI TELPKSLFEG LFSLQLLLLN ANKINCLRVD AFQDLHNLNL
410 420 430 440 450
LSLYDNKLQT IAKGTFSPLR AIQTMHLAQN PFICDCHLKW LADYLHTNPI
460 470 480 490 500
ETSGARCTSP RRLANKRIGQ IKSKKFRCSA KEQYFIPGTE DYRSKLSGDC
510 520 530 540 550
FADLACPEKC RCEGTTVDCS NQKLNKIPEH IPQYTAELRL NNNEFTVLEA
560 570 580 590 600
TGIFKKLPQL RKINFSNNKI TDIEEGAFEG ASGVNEILLT SNRLENVQHK
610 620 630 640 650
MFKGLESLKT LMLRSNRITC VGNDSFIGLS SVRLLSLYDN QITTVAPGAF
660 670 680 690 700
DTLHSLSTLN LLANPFNCNC YLAWLGEWLR KKRIVTGNPR CQKPYFLKEI
710 720 730 740 750
PIQDVAIQDF TCDDGNDDNS CSPLSRCPTE CTCLDTVVRC SNKGLKVLPK
760 770 780 790 800
GIPRDVTELY LDGNQFTLVP KELSNYKHLT LIDLSNNRIS TLSNQSFSNM
810 820 830 840 850
TQLLTLILSY NRLRCIPPRT FDGLKSLRLL SLHGNDISVV PEGAFNDLSA
860 870 880 890 900
LSHLAIGANP LYCDCNMQWL SDWVKSEYKE PGIARCAGPG EMADKLLLTT
910 920 930 940 950
PSKKFTCQGP VDVNILAKCN PCLSNPCKND GTCNSDPVDF YRCTCPYGFK
960 970 980 990 1000
GQDCDVPIHA CISNPCKHGG TCHLKEGEED GFWCICADGF EGENCEVNVD
1010 1020 1030 1040 1050
DCEDNDCENN STCVDGINNY TCLCPPEYTG ELCEEKLDFC AQDLNPCQHD
1060 1070 1080 1090 1100
SKCILTPKGF KCDCTPGYVG EHCDIDFDDC QDNKCKNGAH CTDAVNGYTC
1110 1120 1130 1140 1150
ICPEGYSGLF CEFSPPMVLP RTSPCDNFDC QNGAQCIVRI NEPICQCLPG
1160 1170 1180 1190 1200
YQGEKCEKLV SVNFINKESY LQIPSAKVRP QTNITLQIAT DEDSGILLYK
1210 1220 1230 1240 1250
GDKDHIAVEL YRGRVRASYD TGSHPASAIY SVETINDGNF HIVELLALDQ
1260 1270 1280 1290 1300
SLSLSVDGGN PKIITNLSKQ STLNFDSPLY VGGMPGKSNV ASLRQAPGQN
1310 1320 1330 1340 1350
GTSFHGCIRN LYINSELQDF QKVPMQTGIL PGCEPCHKKV CAHGTCQPSS
1360 1370 1380 1390 1400
QAGFTCECQE GWMGPLCDQR TNDPCLGNKC VHGTCLPINA FSYSCKCLEG
1410 1420 1430 1440 1450
HGGVLCDEEE DLFNPCQAIK CKHGKCRLSG LGQPYCECSS GYTGDSCDRE
1460 1470 1480 1490 1500
ISCRGERIRD YYQKQQGYAA CQTTKKVSRL ECRGGCAGGQ CCGPLRSKRR
1510 1520
KYSFECTDGS SFVDEVEKVV KCGCTRCVS
Length:1,529
Mass (Da):169,870
Last modified:May 1, 1999 - v1
Checksum:i5D19CC5E7FD461BA
GO
Isoform 2Curated (identifier: O94813-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-258: S → SDEEE
     480-487: Missing.

Show »
Length:1,525
Mass (Da):169,395
Checksum:i56DE2356BB2E5CAD
GO
Isoform 3Curated (identifier: O94813-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     480-487: Missing.

Show »
Length:1,521
Mass (Da):168,893
Checksum:i7620F3C96DD4E534
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R3P0X6R3P0_HUMAN
Slit homolog 2 protein
SLIT2
1,542Annotation score:
A0A087WYV5A0A087WYV5_HUMAN
Slit homolog 2 protein
SLIT2
1,439Annotation score:
H0Y9Z6H0Y9Z6_HUMAN
Slit homolog 2 protein
SLIT2
196Annotation score:
F5H0U4F5H0U4_HUMAN
Slit homolog 2 protein
SLIT2
212Annotation score:
H0Y968H0Y968_HUMAN
Slit homolog 2 protein
SLIT2
82Annotation score:
E9PCX4E9PCX4_HUMAN
Slit homolog 2 protein
SLIT2
146Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti226Q → K in AAD25539 (PubMed:10349621).Curated1
Sequence conflicti607 – 610SLKT → KPQN in AAD04309 (PubMed:10102268).Curated4
Sequence conflicti634L → M in AAD04309 (PubMed:10102268).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018098636S → P1 Publication1
Natural variantiVAR_0180991277S → F1 PublicationCorresponds to variant dbSNP:rs771375896Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_050035258S → SDEEE in isoform 2. 2 Publications1
Alternative sequenceiVSP_050036480 – 487Missing in isoform 2 and isoform 3. 4 Publications8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017168 mRNA Translation: BAA35185.1
AF055585 mRNA Translation: AAD04309.1
AF133270 mRNA Translation: AAD25539.1
AC021118 Genomic DNA No translation available.
AC092577 Genomic DNA No translation available.
AC096718 Genomic DNA No translation available.
AC108011 Genomic DNA No translation available.
CH471069 Genomic DNA Translation: EAW92793.1
BC117190 mRNA Translation: AAI17191.1
BC143978 mRNA Translation: AAI43979.1
CCDSiCCDS3426.1 [O94813-1]
CCDS75110.1 [O94813-2]
CCDS75111.1 [O94813-3]
RefSeqiNP_001276064.1, NM_001289135.2 [O94813-2]
NP_001276065.1, NM_001289136.2 [O94813-3]
NP_004778.1, NM_004787.3 [O94813-1]
UniGeneiHs.29802

Genome annotation databases

EnsembliENST00000503823; ENSP00000427548; ENSG00000145147 [O94813-3]
ENST00000503837; ENSP00000422261; ENSG00000145147 [O94813-2]
ENST00000504154; ENSP00000422591; ENSG00000145147 [O94813-1]
GeneIDi9353
KEGGihsa:9353
UCSCiuc003gpr.3 human [O94813-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017168 mRNA Translation: BAA35185.1
AF055585 mRNA Translation: AAD04309.1
AF133270 mRNA Translation: AAD25539.1
AC021118 Genomic DNA No translation available.
AC092577 Genomic DNA No translation available.
AC096718 Genomic DNA No translation available.
AC108011 Genomic DNA No translation available.
CH471069 Genomic DNA Translation: EAW92793.1
BC117190 mRNA Translation: AAI17191.1
BC143978 mRNA Translation: AAI43979.1
CCDSiCCDS3426.1 [O94813-1]
CCDS75110.1 [O94813-2]
CCDS75111.1 [O94813-3]
RefSeqiNP_001276064.1, NM_001289135.2 [O94813-2]
NP_001276065.1, NM_001289136.2 [O94813-3]
NP_004778.1, NM_004787.3 [O94813-1]
UniGeneiHs.29802

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V70X-ray3.01A/B/C/D504-714[»]
2V9SX-ray2.00A/B/C/D271-480[»]
2V9TX-ray1.70B271-479[»]
2WFHX-ray1.80A/B726-907[»]
ProteinModelPortaliO94813
SMRiO94813
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114756, 18 interactors
DIPiDIP-38198N
IntActiO94813, 10 interactors
MINTiO94813
STRINGi9606.ENSP00000422591

PTM databases

iPTMnetiO94813
PhosphoSitePlusiO94813

Polymorphism and mutation databases

BioMutaiSLIT2

Proteomic databases

EPDiO94813
MaxQBiO94813
PaxDbiO94813
PeptideAtlasiO94813
PRIDEiO94813
ProteomicsDBi50454
50455 [O94813-2]
50456 [O94813-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000503823; ENSP00000427548; ENSG00000145147 [O94813-3]
ENST00000503837; ENSP00000422261; ENSG00000145147 [O94813-2]
ENST00000504154; ENSP00000422591; ENSG00000145147 [O94813-1]
GeneIDi9353
KEGGihsa:9353
UCSCiuc003gpr.3 human [O94813-1]

Organism-specific databases

CTDi9353
DisGeNETi9353
EuPathDBiHostDB:ENSG00000145147.19
GeneCardsiSLIT2
HGNCiHGNC:11086 SLIT2
HPAiCAB007590
HPA019511
HPA023088
MIMi603746 gene
neXtProtiNX_O94813
OpenTargetsiENSG00000145147
PharmGKBiPA35939
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4237 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00910000144018
HOGENOMiHOG000116120
HOVERGENiHBG057959
InParanoidiO94813
KOiK06839
PhylomeDBiO94813
TreeFamiTF332887

Enzyme and pathway databases

ReactomeiR-HSA-373752 Netrin-1 signaling
R-HSA-376176 Signaling by ROBO receptors
R-HSA-428540 Activation of RAC1
R-HSA-428542 Regulation of commissural axon pathfinding by SLIT and ROBO
R-HSA-428543 Inactivation of CDC42 and RAC1
R-HSA-428890 Role of ABL in ROBO-SLIT signaling
R-HSA-8985586 SLIT2:ROBO1 increases RHOA activity
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
SIGNORiO94813

Miscellaneous databases

ChiTaRSiSLIT2 human
EvolutionaryTraceiO94813
GeneWikiiSLIT2
GenomeRNAii9353
PROiPR:O94813
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145147 Expressed in 230 organ(s), highest expression level in upper lobe of lung
CleanExiHS_SLIT2
ExpressionAtlasiO94813 baseline and differential
GenevisibleiO94813 HS

Family and domain databases

Gene3Di3.80.10.10, 5 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000483 Cys-rich_flank_reg_C
IPR006207 Cys_knot_C
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR003645 Fol_N
IPR001791 Laminin_G
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF00008 EGF, 5 hits
PF12661 hEGF, 2 hits
PF00054 Laminin_G_1, 1 hit
PF13855 LRR_8, 7 hits
PF01463 LRRCT, 4 hits
PF01462 LRRNT, 4 hits
SMARTiView protein in SMART
SM00041 CT, 1 hit
SM00181 EGF, 9 hits
SM00179 EGF_CA, 7 hits
SM00274 FOLN, 3 hits
SM00282 LamG, 1 hit
SM00369 LRR_TYP, 17 hits
SM00082 LRRCT, 4 hits
SM00013 LRRNT, 4 hits
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00022 EGF_1, 9 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 9 hits
PS01187 EGF_CA, 2 hits
PS50025 LAM_G_DOMAIN, 1 hit
PS51450 LRR, 20 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSLIT2_HUMAN
AccessioniPrimary (citable) accession number: O94813
Secondary accession number(s): A0A0A6YYB8
, B7ZLR5, O95710, Q17RU3, Q9Y5Q7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 187 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health

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