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Protein

Slit homolog 2 protein

Gene

SLIT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • GTPase inhibitor activity Source: UniProtKB
  • heparin binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • laminin-1 binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • proteoglycan binding Source: UniProtKB
  • Roundabout binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Heparin-binding
Biological processChemotaxis, Differentiation, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-373752 Netrin-1 signaling
R-HSA-376176 Signaling by ROBO receptors
R-HSA-428540 Activation of RAC1
R-HSA-428542 Regulation of commissural axon pathfinding by SLIT and ROBO
R-HSA-428543 Inactivation of CDC42 and RAC1
R-HSA-428890 Role of ABL in ROBO-SLIT signaling
R-HSA-8985586 SLIT2:ROBO1 increases RHOA activity
R-HSA-9010553 Regulation of expression of SLITs and ROBOs

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O94813

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Slit homolog 2 protein
Short name:
Slit-2
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLIT2
Synonyms:SLIL3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000145147.19

Human Gene Nomenclature Database

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HGNCi
HGNC:11086 SLIT2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603746 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O94813

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9353

Open Targets

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OpenTargetsi
ENSG00000145147

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA35939

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLIT2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000772531 – 1529Slit homolog 2 proteinAdd BLAST1499
ChainiPRO_000000772631 – 1121Slit homolog 2 protein N-productAdd BLAST1091
ChainiPRO_00000077271122 – 1529Slit homolog 2 protein C-productAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi277 ↔ 286
Disulfide bondi434 ↔ 457
Disulfide bondi436 ↔ 478
Disulfide bondi506 ↔ 512
Disulfide bondi510 ↔ 519
Glycosylationi564N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi623N-linked (GlcNAc...) asparagine1
Disulfide bondi668 ↔ 691
Disulfide bondi670 ↔ 712
Disulfide bondi727 ↔ 733
Disulfide bondi731 ↔ 740
Glycosylationi794N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi799N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi863 ↔ 886
Disulfide bondi865 ↔ 907
Disulfide bondi922 ↔ 933By similarity
Disulfide bondi927 ↔ 943By similarity
Disulfide bondi945 ↔ 954By similarity
Disulfide bondi961 ↔ 972By similarity
Disulfide bondi966 ↔ 984By similarity
Disulfide bondi986 ↔ 995By similarity
Disulfide bondi1002 ↔ 1013By similarity
Disulfide bondi1007 ↔ 1022By similarity
Glycosylationi1009N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1010N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1019N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1024 ↔ 1033By similarity
Disulfide bondi1040 ↔ 1053By similarity
Disulfide bondi1047 ↔ 1062By similarity
Disulfide bondi1064 ↔ 1073By similarity
Disulfide bondi1080 ↔ 1091By similarity
Disulfide bondi1085 ↔ 1100By similarity
Disulfide bondi1102 ↔ 1111By similarity
Disulfide bondi1125 ↔ 1136By similarity
Disulfide bondi1130 ↔ 1145By similarity
Disulfide bondi1147 ↔ 1156By similarity
Glycosylationi1183N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1266N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1300N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1307 ↔ 1333By similarity
Disulfide bondi1336 ↔ 1346By similarity
Disulfide bondi1341 ↔ 1356By similarity
Disulfide bondi1358 ↔ 1367By similarity
Disulfide bondi1375 ↔ 1385By similarity
Disulfide bondi1380 ↔ 1395By similarity
Disulfide bondi1397 ↔ 1406By similarity
Disulfide bondi1416 ↔ 1426By similarity
Disulfide bondi1421 ↔ 1436By similarity
Disulfide bondi1438 ↔ 1447By similarity
Disulfide bondi1453 ↔ 1492By similarity
Disulfide bondi1471 ↔ 1506By similarity
Disulfide bondi1482 ↔ 1522By similarity
Disulfide bondi1486 ↔ 1524By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1121 – 1122Cleavage2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O94813

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O94813

MaxQB - The MaxQuant DataBase

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MaxQBi
O94813

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O94813

PeptideAtlas

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PeptideAtlasi
O94813

PRoteomics IDEntifications database

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PRIDEi
O94813

ProteomicsDB human proteome resource

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ProteomicsDBi
50454
50455 [O94813-2]
50456 [O94813-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O94813

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O94813

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Fetal lung and kidney, and adult spinal cord. Weak expression in adult adrenal gland, thyroid, trachea and other tissues examined.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000145147 Expressed in 230 organ(s), highest expression level in upper lobe of lung

CleanEx database of gene expression profiles

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CleanExi
HS_SLIT2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O94813 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O94813 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB007590
HPA019511
HPA023088

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GREM1 (By similarity). Homodimer. Binds ROBO1 and ROBO2 with high affinity.By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114756, 18 interactors

Database of interacting proteins

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DIPi
DIP-38198N

Protein interaction database and analysis system

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IntActi
O94813, 10 interactors

Molecular INTeraction database

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MINTi
O94813

STRING: functional protein association networks

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STRINGi
9606.ENSP00000422591

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11529
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V70X-ray3.01A/B/C/D504-714[»]
2V9SX-ray2.00A/B/C/D271-480[»]
2V9TX-ray1.70B271-479[»]
2WFHX-ray1.80A/B726-907[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O94813

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O94813

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O94813

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 55LRRNTAdd BLAST25
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati56 – 77LRR 1Add BLAST22
Repeati80 – 101LRR 2Add BLAST22
Repeati104 – 125LRR 3Add BLAST22
Repeati128 – 149LRR 4Add BLAST22
Repeati152 – 173LRR 5Add BLAST22
Repeati176 – 197LRR 6Add BLAST22
Domaini209 – 259LRRCT 1Add BLAST51
Domaini264 – 300LRRNT 2Add BLAST37
Repeati301 – 322LRR 7Add BLAST22
Repeati325 – 346LRR 8Add BLAST22
Repeati349 – 370LRR 9Add BLAST22
Repeati373 – 394LRR 10Add BLAST22
Repeati397 – 418LRR 11Add BLAST22
Domaini430 – 480LRRCT 2Add BLAST51
Domaini497 – 533LRRNT 3Add BLAST37
Repeati534 – 555LRR 12Add BLAST22
Repeati559 – 580LRR 13Add BLAST22
Repeati583 – 604LRR 14Add BLAST22
Repeati607 – 628LRR 15Add BLAST22
Repeati631 – 652LRR 16Add BLAST22
Domaini664 – 714LRRCT 3Add BLAST51
Domaini718 – 754LRRNT 4Add BLAST37
Repeati755 – 777LRR 17Add BLAST23
Repeati778 – 799LRR 18Add BLAST22
Repeati802 – 823LRR 19Add BLAST22
Repeati826 – 847LRR 20Add BLAST22
Domaini859 – 909LRRCT 4Add BLAST51
Domaini918 – 955EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini957 – 996EGF-like 2PROSITE-ProRule annotationAdd BLAST40
Domaini998 – 1034EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1036 – 1074EGF-like 4PROSITE-ProRule annotationAdd BLAST39
Domaini1076 – 1112EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1121 – 1157EGF-like 6PROSITE-ProRule annotationAdd BLAST37
Domaini1160 – 1333Laminin G-likePROSITE-ProRule annotationAdd BLAST174
Domaini1332 – 1368EGF-like 7PROSITE-ProRule annotationAdd BLAST37
Domaini1453 – 1528CTCKPROSITE-ProRule annotationCuratedAdd BLAST76

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The leucine-rich repeat domain is sufficient for guiding both axon projection and neuronal migration, in vitro.1 Publication

Keywords - Domaini

EGF-like domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4237 Eukaryota
COG4886 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158402

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000116120

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG057959

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O94813

KEGG Orthology (KO)

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KOi
K06839

Database of Orthologous Groups

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OrthoDBi
28488at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O94813

TreeFam database of animal gene trees

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TreeFami
TF332887

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.80.10.10, 5 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000483 Cys-rich_flank_reg_C
IPR006207 Cys_knot_C
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR003645 Fol_N
IPR001791 Laminin_G
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT

Pfam protein domain database

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Pfami
View protein in Pfam
PF00008 EGF, 5 hits
PF12661 hEGF, 2 hits
PF00054 Laminin_G_1, 1 hit
PF13855 LRR_8, 7 hits
PF01463 LRRCT, 4 hits
PF01462 LRRNT, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00041 CT, 1 hit
SM00181 EGF, 9 hits
SM00179 EGF_CA, 7 hits
SM00274 FOLN, 3 hits
SM00282 LamG, 1 hit
SM00369 LRR_TYP, 17 hits
SM00082 LRRCT, 4 hits
SM00013 LRRNT, 4 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00022 EGF_1, 9 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 9 hits
PS01187 EGF_CA, 2 hits
PS50025 LAM_G_DOMAIN, 1 hit
PS51450 LRR, 20 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1Curated (identifier: O94813-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRGVGWQMLS LSLGLVLAIL NKVAPQACPA QCSCSGSTVD CHGLALRSVP
60 70 80 90 100
RNIPRNTERL DLNGNNITRI TKTDFAGLRH LRVLQLMENK ISTIERGAFQ
110 120 130 140 150
DLKELERLRL NRNHLQLFPE LLFLGTAKLY RLDLSENQIQ AIPRKAFRGA
160 170 180 190 200
VDIKNLQLDY NQISCIEDGA FRALRDLEVL TLNNNNITRL SVASFNHMPK
210 220 230 240 250
LRTFRLHSNN LYCDCHLAWL SDWLRQRPRV GLYTQCMGPS HLRGHNVAEV
260 270 280 290 300
QKREFVCSGH QSFMAPSCSV LHCPAACTCS NNIVDCRGKG LTEIPTNLPE
310 320 330 340 350
TITEIRLEQN TIKVIPPGAF SPYKKLRRID LSNNQISELA PDAFQGLRSL
360 370 380 390 400
NSLVLYGNKI TELPKSLFEG LFSLQLLLLN ANKINCLRVD AFQDLHNLNL
410 420 430 440 450
LSLYDNKLQT IAKGTFSPLR AIQTMHLAQN PFICDCHLKW LADYLHTNPI
460 470 480 490 500
ETSGARCTSP RRLANKRIGQ IKSKKFRCSA KEQYFIPGTE DYRSKLSGDC
510 520 530 540 550
FADLACPEKC RCEGTTVDCS NQKLNKIPEH IPQYTAELRL NNNEFTVLEA
560 570 580 590 600
TGIFKKLPQL RKINFSNNKI TDIEEGAFEG ASGVNEILLT SNRLENVQHK
610 620 630 640 650
MFKGLESLKT LMLRSNRITC VGNDSFIGLS SVRLLSLYDN QITTVAPGAF
660 670 680 690 700
DTLHSLSTLN LLANPFNCNC YLAWLGEWLR KKRIVTGNPR CQKPYFLKEI
710 720 730 740 750
PIQDVAIQDF TCDDGNDDNS CSPLSRCPTE CTCLDTVVRC SNKGLKVLPK
760 770 780 790 800
GIPRDVTELY LDGNQFTLVP KELSNYKHLT LIDLSNNRIS TLSNQSFSNM
810 820 830 840 850
TQLLTLILSY NRLRCIPPRT FDGLKSLRLL SLHGNDISVV PEGAFNDLSA
860 870 880 890 900
LSHLAIGANP LYCDCNMQWL SDWVKSEYKE PGIARCAGPG EMADKLLLTT
910 920 930 940 950
PSKKFTCQGP VDVNILAKCN PCLSNPCKND GTCNSDPVDF YRCTCPYGFK
960 970 980 990 1000
GQDCDVPIHA CISNPCKHGG TCHLKEGEED GFWCICADGF EGENCEVNVD
1010 1020 1030 1040 1050
DCEDNDCENN STCVDGINNY TCLCPPEYTG ELCEEKLDFC AQDLNPCQHD
1060 1070 1080 1090 1100
SKCILTPKGF KCDCTPGYVG EHCDIDFDDC QDNKCKNGAH CTDAVNGYTC
1110 1120 1130 1140 1150
ICPEGYSGLF CEFSPPMVLP RTSPCDNFDC QNGAQCIVRI NEPICQCLPG
1160 1170 1180 1190 1200
YQGEKCEKLV SVNFINKESY LQIPSAKVRP QTNITLQIAT DEDSGILLYK
1210 1220 1230 1240 1250
GDKDHIAVEL YRGRVRASYD TGSHPASAIY SVETINDGNF HIVELLALDQ
1260 1270 1280 1290 1300
SLSLSVDGGN PKIITNLSKQ STLNFDSPLY VGGMPGKSNV ASLRQAPGQN
1310 1320 1330 1340 1350
GTSFHGCIRN LYINSELQDF QKVPMQTGIL PGCEPCHKKV CAHGTCQPSS
1360 1370 1380 1390 1400
QAGFTCECQE GWMGPLCDQR TNDPCLGNKC VHGTCLPINA FSYSCKCLEG
1410 1420 1430 1440 1450
HGGVLCDEEE DLFNPCQAIK CKHGKCRLSG LGQPYCECSS GYTGDSCDRE
1460 1470 1480 1490 1500
ISCRGERIRD YYQKQQGYAA CQTTKKVSRL ECRGGCAGGQ CCGPLRSKRR
1510 1520
KYSFECTDGS SFVDEVEKVV KCGCTRCVS
Length:1,529
Mass (Da):169,870
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5D19CC5E7FD461BA
GO
Isoform 2Curated (identifier: O94813-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-258: S → SDEEE
     480-487: Missing.

Show »
Length:1,525
Mass (Da):169,395
Checksum:i56DE2356BB2E5CAD
GO
Isoform 3Curated (identifier: O94813-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     480-487: Missing.

Show »
Length:1,521
Mass (Da):168,893
Checksum:i7620F3C96DD4E534
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R3P0X6R3P0_HUMAN
Slit homolog 2 protein
SLIT2
1,542Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYV5A0A087WYV5_HUMAN
Slit homolog 2 protein
SLIT2
1,439Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9Z6H0Y9Z6_HUMAN
Slit homolog 2 protein
SLIT2
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H0U4F5H0U4_HUMAN
Slit homolog 2 protein
SLIT2
212Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y968H0Y968_HUMAN
Slit homolog 2 protein
SLIT2
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PCX4E9PCX4_HUMAN
Slit homolog 2 protein
SLIT2
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti226Q → K in AAD25539 (PubMed:10349621).Curated1
Sequence conflicti607 – 610SLKT → KPQN in AAD04309 (PubMed:10102268).Curated4
Sequence conflicti634L → M in AAD04309 (PubMed:10102268).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018098636S → P1 Publication1
Natural variantiVAR_0180991277S → F1 PublicationCorresponds to variant dbSNP:rs771375896Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_050035258S → SDEEE in isoform 2. 2 Publications1
Alternative sequenceiVSP_050036480 – 487Missing in isoform 2 and isoform 3. 4 Publications8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB017168 mRNA Translation: BAA35185.1
AF055585 mRNA Translation: AAD04309.1
AF133270 mRNA Translation: AAD25539.1
AC021118 Genomic DNA No translation available.
AC092577 Genomic DNA No translation available.
AC096718 Genomic DNA No translation available.
AC108011 Genomic DNA No translation available.
CH471069 Genomic DNA Translation: EAW92793.1
BC117190 mRNA Translation: AAI17191.1
BC143978 mRNA Translation: AAI43979.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3426.1 [O94813-1]
CCDS75110.1 [O94813-2]
CCDS75111.1 [O94813-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001276064.1, NM_001289135.2 [O94813-2]
NP_001276065.1, NM_001289136.2 [O94813-3]
NP_004778.1, NM_004787.3 [O94813-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.29802

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000503823; ENSP00000427548; ENSG00000145147 [O94813-3]
ENST00000503837; ENSP00000422261; ENSG00000145147 [O94813-2]
ENST00000504154; ENSP00000422591; ENSG00000145147 [O94813-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9353

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9353

UCSC genome browser

More...
UCSCi
uc003gpr.3 human [O94813-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017168 mRNA Translation: BAA35185.1
AF055585 mRNA Translation: AAD04309.1
AF133270 mRNA Translation: AAD25539.1
AC021118 Genomic DNA No translation available.
AC092577 Genomic DNA No translation available.
AC096718 Genomic DNA No translation available.
AC108011 Genomic DNA No translation available.
CH471069 Genomic DNA Translation: EAW92793.1
BC117190 mRNA Translation: AAI17191.1
BC143978 mRNA Translation: AAI43979.1
CCDSiCCDS3426.1 [O94813-1]
CCDS75110.1 [O94813-2]
CCDS75111.1 [O94813-3]
RefSeqiNP_001276064.1, NM_001289135.2 [O94813-2]
NP_001276065.1, NM_001289136.2 [O94813-3]
NP_004778.1, NM_004787.3 [O94813-1]
UniGeneiHs.29802

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V70X-ray3.01A/B/C/D504-714[»]
2V9SX-ray2.00A/B/C/D271-480[»]
2V9TX-ray1.70B271-479[»]
2WFHX-ray1.80A/B726-907[»]
ProteinModelPortaliO94813
SMRiO94813
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114756, 18 interactors
DIPiDIP-38198N
IntActiO94813, 10 interactors
MINTiO94813
STRINGi9606.ENSP00000422591

PTM databases

iPTMnetiO94813
PhosphoSitePlusiO94813

Polymorphism and mutation databases

BioMutaiSLIT2

Proteomic databases

EPDiO94813
jPOSTiO94813
MaxQBiO94813
PaxDbiO94813
PeptideAtlasiO94813
PRIDEiO94813
ProteomicsDBi50454
50455 [O94813-2]
50456 [O94813-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000503823; ENSP00000427548; ENSG00000145147 [O94813-3]
ENST00000503837; ENSP00000422261; ENSG00000145147 [O94813-2]
ENST00000504154; ENSP00000422591; ENSG00000145147 [O94813-1]
GeneIDi9353
KEGGihsa:9353
UCSCiuc003gpr.3 human [O94813-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9353
DisGeNETi9353
EuPathDBiHostDB:ENSG00000145147.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLIT2
HGNCiHGNC:11086 SLIT2
HPAiCAB007590
HPA019511
HPA023088
MIMi603746 gene
neXtProtiNX_O94813
OpenTargetsiENSG00000145147
PharmGKBiPA35939

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4237 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000158402
HOGENOMiHOG000116120
HOVERGENiHBG057959
InParanoidiO94813
KOiK06839
OrthoDBi28488at2759
PhylomeDBiO94813
TreeFamiTF332887

Enzyme and pathway databases

ReactomeiR-HSA-373752 Netrin-1 signaling
R-HSA-376176 Signaling by ROBO receptors
R-HSA-428540 Activation of RAC1
R-HSA-428542 Regulation of commissural axon pathfinding by SLIT and ROBO
R-HSA-428543 Inactivation of CDC42 and RAC1
R-HSA-428890 Role of ABL in ROBO-SLIT signaling
R-HSA-8985586 SLIT2:ROBO1 increases RHOA activity
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
SIGNORiO94813

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLIT2 human
EvolutionaryTraceiO94813

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLIT2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9353

Protein Ontology

More...
PROi
PR:O94813

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000145147 Expressed in 230 organ(s), highest expression level in upper lobe of lung
CleanExiHS_SLIT2
ExpressionAtlasiO94813 baseline and differential
GenevisibleiO94813 HS

Family and domain databases

Gene3Di3.80.10.10, 5 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000483 Cys-rich_flank_reg_C
IPR006207 Cys_knot_C
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR003645 Fol_N
IPR001791 Laminin_G
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF00008 EGF, 5 hits
PF12661 hEGF, 2 hits
PF00054 Laminin_G_1, 1 hit
PF13855 LRR_8, 7 hits
PF01463 LRRCT, 4 hits
PF01462 LRRNT, 4 hits
SMARTiView protein in SMART
SM00041 CT, 1 hit
SM00181 EGF, 9 hits
SM00179 EGF_CA, 7 hits
SM00274 FOLN, 3 hits
SM00282 LamG, 1 hit
SM00369 LRR_TYP, 17 hits
SM00082 LRRCT, 4 hits
SM00013 LRRNT, 4 hits
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00022 EGF_1, 9 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 9 hits
PS01187 EGF_CA, 2 hits
PS50025 LAM_G_DOMAIN, 1 hit
PS51450 LRR, 20 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLIT2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94813
Secondary accession number(s): A0A0A6YYB8
, B7ZLR5, O95710, Q17RU3, Q9Y5Q7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: May 1, 1999
Last modified: January 16, 2019
This is version 190 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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