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Protein

BAI1-associated protein 3

Gene

BAIAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans-Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters including NPY and serotonin and hormones like insulin (PubMed:28626000). Proposed to play a role in hypothalamic neuronal firing by modulating gamma-aminobutyric acid (GABA)ergic inhibitory neurotransmission (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • phospholipid binding Source: UniProtKB
  • SNARE binding Source: UniProtKB
  • syntaxin binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BAI1-associated protein 31 Publication
Short name:
BAP31 Publication
Alternative name(s):
Brain-specific angiogenesis inhibitor I-associated protein 31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BAIAP31 PublicationImported
Synonyms:KIAA07341 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000007516.13

Human Gene Nomenclature Database

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HGNCi
HGNC:948 BAIAP3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604009 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O94812

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endosome, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
8938

Open Targets

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OpenTargetsi
ENSG00000007516

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25252

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BAIAP3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000648191 – 1187BAI1-associated protein 3Add BLAST1187

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O94812

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O94812

PeptideAtlas

More...
PeptideAtlasi
O94812

PRoteomics IDEntifications database

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PRIDEi
O94812

ProteomicsDB human proteome resource

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ProteomicsDBi
50452
50453 [O94812-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O94812

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O94812

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in brain (PubMed:9790924). Also expressed in nonneural tissues such as breast and testes epithelium (PubMed:12498718).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000007516 Expressed in 158 organ(s), highest expression level in adenohypophysis

CleanEx database of gene expression profiles

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CleanExi
HS_BAIAP3

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O94812 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O94812 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA015627

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ADGRB1; this interaction is direct (PubMed:9790924). Interacts with endosomal SNARE proteins VAMP3, VAMP4, STX6 and STX16; this interaction is increased in the presence of calcium (PubMed:28626000).2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114450, 2 interactors

Protein interaction database and analysis system

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IntActi
O94812, 2 interactors

Molecular INTeraction database

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MINTi
O94812

STRING: functional protein association networks

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STRINGi
9606.ENSP00000324510

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O94812

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini182 – 317C2 1PROSITE-ProRule annotationAdd BLAST136
Domaini663 – 784MHD1PROSITE-ProRule annotationAdd BLAST122
Domaini888 – 996MHD2PROSITE-ProRule annotationAdd BLAST109
Domaini1012 – 1119C2 2PROSITE-ProRule annotationAdd BLAST108

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the unc-13 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1328 Eukaryota
ENOG410Z3Q9 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00730000110939

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230869

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050658

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O94812

KEGG Orthology (KO)

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KOi
K15621

Identification of Orthologs from Complete Genome Data

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OMAi
NTNGIQY

Database of Orthologous Groups

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OrthoDBi
72416at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O94812

TreeFam database of animal gene trees

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TreeFami
TF315526

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR014770 Munc13_1
IPR014772 Munc13_dom-2

Pfam protein domain database

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Pfami
View protein in Pfam
PF00168 C2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00239 C2, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 2 hits
PS51258 MHD1, 1 hit
PS51259 MHD2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94812-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPRGAAFAA GPPGDLHLGT AIGFAGAIWR SRSPAMSTLL DIKSSVLRQV
60 70 80 90 100
QVCPSFRRRT EQDPGSASAD PQEPATGAWK PGDGVEFFAH MRLMLKKGEG
110 120 130 140 150
RQGLPCLEVP LRSGSPAPPE PVDPSLGLRA LAPEEVEMLY EEALYTVLYR
160 170 180 190 200
AGTMGPDQVD DEEALLSYLQ QVFGTSLEEH TEAIERVRKA KAPTYALKVS
210 220 230 240 250
VMRAKNLLAK DPNGFSDPYC MLGILPASDA TREPRAQKEQ RFGFRKGSKR
260 270 280 290 300
GGPLPAKCIQ VTEVKSSTLN PVWKEHFLFE IEDVSTDQLH LDIWDHDDDV
310 320 330 340 350
SLVEACRKLN EVIGLKGMGR YFKQIVKSAR ANGTAGPTED HTDDFLGCLN
360 370 380 390 400
IPVREVPVAG VDRWFKLEPR SSASRVQGHC HLVLKLITTQ RDTAMSQRGR
410 420 430 440 450
SGFLSHLLLL SHLLRLEHSA EEPNSSSWRG ELSTPAATIL CLHGAQSNLS
460 470 480 490 500
PLQLAVLHWQ VSSRHHQTCT LDYSYLLGLL EDMQAHWEEA PSLPQEQEES
510 520 530 540 550
LADSLSAFSE FGLQLLRQLR DYFPATNSTA VHRLELLLKC LGKLQLFQPS
560 570 580 590 600
FEICPFESEL NMDIAAALKR GNREWYDRIL NDKSPREQPG PQRLPGLVVL
610 620 630 640 650
ADAVYDDLQF CYSVYASLFH SILNVDVFTL TFRQLERLVA EEAWVLTEEL
660 670 680 690 700
SPKMTLEVAS GLFELYLTLA DLQRFWDSIP GRDSRSLALA GIHAPFLPAV
710 720 730 740 750
KLWFQVLRDQ AKWRLQGAVD MDTLEPVDAS SRHSSSAATA GLCLSHIQEL
760 770 780 790 800
WVRLAWPDPA QAQGLGTQLG QDVCEATLFY TELLRKKVDT QPGAAGEAVS
810 820 830 840 850
EALCVVLNNV ELVRKAAGQA LKGLAWPEGA TGPEGVLPRP LLSCTQALDD
860 870 880 890 900
DLQREAHTVT AHLTSKMVGD IRKYVQHISL SPDSIQNDEA VAPLMKYLDE
910 920 930 940 950
KLALLNASLV KGNLSRVLEA LWELLLQAIL QALGANRDVS ADFYSRFHFT
960 970 980 990 1000
LEALVSFFHA EGQGLPLESL RDGSYKRLKE ELRLHKCSTR ECIEQFYLDK
1010 1020 1030 1040 1050
LKQRTLEQNR FGRLSVRCHY EAAEQRLAVE VLHAADLLPL DANGLSDPFV
1060 1070 1080 1090 1100
IVELGPPHLF PLVRSQRTQV KTRTLHPVYD ELFYFSVPAE ACRRRAACVL
1110 1120 1130 1140 1150
FTVMDHDWLS TNDFAGEAAL GLGGVTGVAR PQVGGGARAG QPVTLHLCRP
1160 1170 1180
RAQVRSALRR LEGRTSKEAQ EFVKKLKELE KCMEADP
Length:1,187
Mass (Da):131,901
Last modified:August 31, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE38EF36E91BE7DEB
GO
Isoform 2 (identifier: O94812-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.
     108-108: E → EAWGSPCRQSPHPGPHTQ

Note: No experimental confirmation available.Curated
Show »
Length:1,169
Mass (Da):130,210
Checksum:i3315DD206724B6DC
GO
Isoform 3 (identifier: O94812-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.
     136-158: Missing.

Note: No experimental confirmation available.
Show »
Length:1,129
Mass (Da):125,753
Checksum:i93D472F4072C6691
GO
Isoform 4 (identifier: O94812-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.
     136-163: Missing.

Note: No experimental confirmation available.
Show »
Length:1,124
Mass (Da):125,165
Checksum:iFE7C32EE04C7DFC9
GO
Isoform 5 (identifier: O94812-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Note: No experimental confirmation available.
Show »
Length:1,152
Mass (Da):128,385
Checksum:i9344A95B78938FFE
GO
Isoform 6 (identifier: O94812-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.
     355-390: Missing.

Note: No experimental confirmation available.
Show »
Length:1,116
Mass (Da):124,344
Checksum:i89F0D4B427ECD91B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BV46H3BV46_HUMAN
BAI1-associated protein 3
BAIAP3
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPP9H3BPP9_HUMAN
BAI1-associated protein 3
BAIAP3
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA34454 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAG57886 differs from that shown. Reason: Erroneous termination at position 717. Translated as Gly.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti216S → G in BAG61321 (PubMed:14702039).Curated1
Sequence conflicti248S → G in BAG57886 (PubMed:14702039).Curated1
Sequence conflicti318M → T in BAG61353 (PubMed:14702039).Curated1
Sequence conflicti422E → G in BAG61353 (PubMed:14702039).Curated1
Sequence conflicti599V → L in BAG61321 (PubMed:14702039).Curated1
Isoform 2 (identifier: O94812-2)
Sequence conflicti87P → T in CAH56376 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026667582D → A4 PublicationsCorresponds to variant dbSNP:rs1132356Ensembl.1
Natural variantiVAR_050687879S → I. Corresponds to variant dbSNP:rs36074509Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0192311 – 35Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST35
Alternative sequenceiVSP_019232108E → EAWGSPCRQSPHPGPHTQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_047000136 – 163Missing in isoform 4. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_044673136 – 158Missing in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_047001355 – 390Missing in isoform 6. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB017111 Genomic DNA Translation: BAA34710.1
AB018277 mRNA Translation: BAA34454.2 Different initiation.
AK294744 mRNA Translation: BAG57886.1 Sequence problems.
AK295645 mRNA Translation: BAG58515.1
AK299309 mRNA Translation: BAG61321.1
AK299358 mRNA Translation: BAG61353.1
AK315059 mRNA Translation: BAG37534.1
AL834321 mRNA Translation: CAH56376.1
AE006467 Genomic DNA Translation: AAK61275.1
AL031709 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85670.1
BC104966 mRNA Translation: AAI04967.1
BC112129 mRNA Translation: AAI12130.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10434.1 [O94812-1]
CCDS55978.1 [O94812-6]
CCDS55979.1 [O94812-7]
CCDS58402.1 [O94812-3]
CCDS58403.1 [O94812-5]
CCDS66894.1 [O94812-2]

Protein sequence database of the Protein Information Resource

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PIRi
JE0347

NCBI Reference Sequences

More...
RefSeqi
NP_001186025.1, NM_001199096.1 [O94812-7]
NP_001186026.1, NM_001199097.1 [O94812-6]
NP_001186027.1, NM_001199098.1 [O94812-3]
NP_001186028.1, NM_001199099.1 [O94812-5]
NP_001273393.1, NM_001286464.1
NP_003924.2, NM_003933.4 [O94812-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.458427

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000324385; ENSP00000324510; ENSG00000007516 [O94812-1]
ENST00000397488; ENSP00000380625; ENSG00000007516 [O94812-2]
ENST00000421665; ENSP00000409533; ENSG00000007516 [O94812-7]
ENST00000426824; ENSP00000407242; ENSG00000007516 [O94812-6]
ENST00000562208; ENSP00000458134; ENSG00000007516 [O94812-3]
ENST00000568887; ENSP00000457644; ENSG00000007516 [O94812-5]
ENST00000628027; ENSP00000487275; ENSG00000007516 [O94812-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8938

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8938

UCSC genome browser

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UCSCi
uc002clj.4 human [O94812-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017111 Genomic DNA Translation: BAA34710.1
AB018277 mRNA Translation: BAA34454.2 Different initiation.
AK294744 mRNA Translation: BAG57886.1 Sequence problems.
AK295645 mRNA Translation: BAG58515.1
AK299309 mRNA Translation: BAG61321.1
AK299358 mRNA Translation: BAG61353.1
AK315059 mRNA Translation: BAG37534.1
AL834321 mRNA Translation: CAH56376.1
AE006467 Genomic DNA Translation: AAK61275.1
AL031709 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85670.1
BC104966 mRNA Translation: AAI04967.1
BC112129 mRNA Translation: AAI12130.1
CCDSiCCDS10434.1 [O94812-1]
CCDS55978.1 [O94812-6]
CCDS55979.1 [O94812-7]
CCDS58402.1 [O94812-3]
CCDS58403.1 [O94812-5]
CCDS66894.1 [O94812-2]
PIRiJE0347
RefSeqiNP_001186025.1, NM_001199096.1 [O94812-7]
NP_001186026.1, NM_001199097.1 [O94812-6]
NP_001186027.1, NM_001199098.1 [O94812-3]
NP_001186028.1, NM_001199099.1 [O94812-5]
NP_001273393.1, NM_001286464.1
NP_003924.2, NM_003933.4 [O94812-1]
UniGeneiHs.458427

3D structure databases

ProteinModelPortaliO94812
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114450, 2 interactors
IntActiO94812, 2 interactors
MINTiO94812
STRINGi9606.ENSP00000324510

PTM databases

iPTMnetiO94812
PhosphoSitePlusiO94812

Polymorphism and mutation databases

BioMutaiBAIAP3

Proteomic databases

jPOSTiO94812
PaxDbiO94812
PeptideAtlasiO94812
PRIDEiO94812
ProteomicsDBi50452
50453 [O94812-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
8938
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324385; ENSP00000324510; ENSG00000007516 [O94812-1]
ENST00000397488; ENSP00000380625; ENSG00000007516 [O94812-2]
ENST00000421665; ENSP00000409533; ENSG00000007516 [O94812-7]
ENST00000426824; ENSP00000407242; ENSG00000007516 [O94812-6]
ENST00000562208; ENSP00000458134; ENSG00000007516 [O94812-3]
ENST00000568887; ENSP00000457644; ENSG00000007516 [O94812-5]
ENST00000628027; ENSP00000487275; ENSG00000007516 [O94812-2]
GeneIDi8938
KEGGihsa:8938
UCSCiuc002clj.4 human [O94812-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8938
DisGeNETi8938
EuPathDBiHostDB:ENSG00000007516.13

GeneCards: human genes, protein and diseases

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GeneCardsi
BAIAP3
HGNCiHGNC:948 BAIAP3
HPAiHPA015627
MIMi604009 gene
neXtProtiNX_O94812
OpenTargetsiENSG00000007516
PharmGKBiPA25252

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1328 Eukaryota
ENOG410Z3Q9 LUCA
GeneTreeiENSGT00730000110939
HOGENOMiHOG000230869
HOVERGENiHBG050658
InParanoidiO94812
KOiK15621
OMAiNTNGIQY
OrthoDBi72416at2759
PhylomeDBiO94812
TreeFamiTF315526

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
BAIAP3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8938

Protein Ontology

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PROi
PR:O94812

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000007516 Expressed in 158 organ(s), highest expression level in adenohypophysis
CleanExiHS_BAIAP3
ExpressionAtlasiO94812 baseline and differential
GenevisibleiO94812 HS

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR014770 Munc13_1
IPR014772 Munc13_dom-2
PfamiView protein in Pfam
PF00168 C2, 2 hits
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS51258 MHD1, 1 hit
PS51259 MHD2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBAIP3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94812
Secondary accession number(s): A2A2B2
, B2RCD7, B4DGS5, B4DIK3, B4DRK9, B4DRP1, E7EUB9, H3BUH8, H3BVI3, H7C2Q1, O94839, Q2M226, Q658J2, Q76N05, Q96RZ3, Q9UJK1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: January 16, 2019
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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