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Protein

BAI1-associated protein 3

Gene

BAIAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans-Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters including NPY and serotonin and hormones like insulin (PubMed:28626000). Proposed to play a role in hypothalamic neuronal firing by modulating gamma-aminobutyric acid (GABA)ergic inhibitory neurotransmission (By similarity).By similarity1 Publication

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • phospholipid binding Source: UniProtKB
  • SNARE binding Source: UniProtKB
  • syntaxin binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processExocytosis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
BAI1-associated protein 31 Publication
Short name:
BAP31 Publication
Alternative name(s):
Brain-specific angiogenesis inhibitor I-associated protein 31 Publication
Gene namesi
Name:BAIAP31 PublicationImported
Synonyms:KIAA07341 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000007516.13
HGNCiHGNC:948 BAIAP3
MIMi604009 gene
neXtProtiNX_O94812

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8938
OpenTargetsiENSG00000007516
PharmGKBiPA25252

Polymorphism and mutation databases

BioMutaiBAIAP3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000648191 – 1187BAI1-associated protein 3Add BLAST1187

Proteomic databases

PaxDbiO94812
PeptideAtlasiO94812
PRIDEiO94812
ProteomicsDBi50452
50453 [O94812-2]

PTM databases

iPTMnetiO94812
PhosphoSitePlusiO94812

Expressioni

Tissue specificityi

Predominantly expressed in brain (PubMed:9790924). Also expressed in nonneural tissues such as breast and testes epithelium (PubMed:12498718).2 Publications

Gene expression databases

BgeeiENSG00000007516 Expressed in 158 organ(s), highest expression level in adenohypophysis
CleanExiHS_BAIAP3
ExpressionAtlasiO94812 baseline and differential
GenevisibleiO94812 HS

Organism-specific databases

HPAiHPA015627

Interactioni

Subunit structurei

Interacts with ADGRB1; this interaction is direct (PubMed:9790924). Interacts with endosomal SNARE proteins VAMP3, VAMP4, STX6 and STX16; this interaction is increased in the presence of calcium (PubMed:28626000).2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114450, 2 interactors
IntActiO94812, 2 interactors
MINTiO94812
STRINGi9606.ENSP00000324510

Structurei

3D structure databases

ProteinModelPortaliO94812
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 317C2 1PROSITE-ProRule annotationAdd BLAST136
Domaini663 – 784MHD1PROSITE-ProRule annotationAdd BLAST122
Domaini888 – 996MHD2PROSITE-ProRule annotationAdd BLAST109
Domaini1012 – 1119C2 2PROSITE-ProRule annotationAdd BLAST108

Sequence similaritiesi

Belongs to the unc-13 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1328 Eukaryota
ENOG410Z3Q9 LUCA
GeneTreeiENSGT00730000110939
HOGENOMiHOG000230869
HOVERGENiHBG050658
InParanoidiO94812
KOiK15621
OMAiNTNGIQY
OrthoDBiEOG091G024N
PhylomeDBiO94812
TreeFamiTF315526

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR014770 Munc13_1
IPR014772 Munc13_dom-2
IPR019558 Munc13_subgr_dom-2
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF10540 Membr_traf_MHD, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS51258 MHD1, 1 hit
PS51259 MHD2, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94812-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPRGAAFAA GPPGDLHLGT AIGFAGAIWR SRSPAMSTLL DIKSSVLRQV
60 70 80 90 100
QVCPSFRRRT EQDPGSASAD PQEPATGAWK PGDGVEFFAH MRLMLKKGEG
110 120 130 140 150
RQGLPCLEVP LRSGSPAPPE PVDPSLGLRA LAPEEVEMLY EEALYTVLYR
160 170 180 190 200
AGTMGPDQVD DEEALLSYLQ QVFGTSLEEH TEAIERVRKA KAPTYALKVS
210 220 230 240 250
VMRAKNLLAK DPNGFSDPYC MLGILPASDA TREPRAQKEQ RFGFRKGSKR
260 270 280 290 300
GGPLPAKCIQ VTEVKSSTLN PVWKEHFLFE IEDVSTDQLH LDIWDHDDDV
310 320 330 340 350
SLVEACRKLN EVIGLKGMGR YFKQIVKSAR ANGTAGPTED HTDDFLGCLN
360 370 380 390 400
IPVREVPVAG VDRWFKLEPR SSASRVQGHC HLVLKLITTQ RDTAMSQRGR
410 420 430 440 450
SGFLSHLLLL SHLLRLEHSA EEPNSSSWRG ELSTPAATIL CLHGAQSNLS
460 470 480 490 500
PLQLAVLHWQ VSSRHHQTCT LDYSYLLGLL EDMQAHWEEA PSLPQEQEES
510 520 530 540 550
LADSLSAFSE FGLQLLRQLR DYFPATNSTA VHRLELLLKC LGKLQLFQPS
560 570 580 590 600
FEICPFESEL NMDIAAALKR GNREWYDRIL NDKSPREQPG PQRLPGLVVL
610 620 630 640 650
ADAVYDDLQF CYSVYASLFH SILNVDVFTL TFRQLERLVA EEAWVLTEEL
660 670 680 690 700
SPKMTLEVAS GLFELYLTLA DLQRFWDSIP GRDSRSLALA GIHAPFLPAV
710 720 730 740 750
KLWFQVLRDQ AKWRLQGAVD MDTLEPVDAS SRHSSSAATA GLCLSHIQEL
760 770 780 790 800
WVRLAWPDPA QAQGLGTQLG QDVCEATLFY TELLRKKVDT QPGAAGEAVS
810 820 830 840 850
EALCVVLNNV ELVRKAAGQA LKGLAWPEGA TGPEGVLPRP LLSCTQALDD
860 870 880 890 900
DLQREAHTVT AHLTSKMVGD IRKYVQHISL SPDSIQNDEA VAPLMKYLDE
910 920 930 940 950
KLALLNASLV KGNLSRVLEA LWELLLQAIL QALGANRDVS ADFYSRFHFT
960 970 980 990 1000
LEALVSFFHA EGQGLPLESL RDGSYKRLKE ELRLHKCSTR ECIEQFYLDK
1010 1020 1030 1040 1050
LKQRTLEQNR FGRLSVRCHY EAAEQRLAVE VLHAADLLPL DANGLSDPFV
1060 1070 1080 1090 1100
IVELGPPHLF PLVRSQRTQV KTRTLHPVYD ELFYFSVPAE ACRRRAACVL
1110 1120 1130 1140 1150
FTVMDHDWLS TNDFAGEAAL GLGGVTGVAR PQVGGGARAG QPVTLHLCRP
1160 1170 1180
RAQVRSALRR LEGRTSKEAQ EFVKKLKELE KCMEADP
Length:1,187
Mass (Da):131,901
Last modified:August 31, 2004 - v2
Checksum:iE38EF36E91BE7DEB
GO
Isoform 2 (identifier: O94812-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.
     108-108: E → EAWGSPCRQSPHPGPHTQ

Note: No experimental confirmation available.Curated
Show »
Length:1,169
Mass (Da):130,210
Checksum:i3315DD206724B6DC
GO
Isoform 3 (identifier: O94812-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.
     136-158: Missing.

Note: No experimental confirmation available.
Show »
Length:1,129
Mass (Da):125,753
Checksum:i93D472F4072C6691
GO
Isoform 4 (identifier: O94812-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.
     136-163: Missing.

Note: No experimental confirmation available.
Show »
Length:1,124
Mass (Da):125,165
Checksum:iFE7C32EE04C7DFC9
GO
Isoform 5 (identifier: O94812-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Note: No experimental confirmation available.
Show »
Length:1,152
Mass (Da):128,385
Checksum:i9344A95B78938FFE
GO
Isoform 6 (identifier: O94812-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.
     355-390: Missing.

Note: No experimental confirmation available.
Show »
Length:1,116
Mass (Da):124,344
Checksum:i89F0D4B427ECD91B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BV46H3BV46_HUMAN
BAI1-associated protein 3
BAIAP3
217Annotation score:
H3BPP9H3BPP9_HUMAN
BAI1-associated protein 3
BAIAP3
191Annotation score:

Sequence cautioni

The sequence BAA34454 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAG57886 differs from that shown. Reason: Erroneous termination at position 717. Translated as Gly.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti216S → G in BAG61321 (PubMed:14702039).Curated1
Sequence conflicti248S → G in BAG57886 (PubMed:14702039).Curated1
Sequence conflicti318M → T in BAG61353 (PubMed:14702039).Curated1
Sequence conflicti422E → G in BAG61353 (PubMed:14702039).Curated1
Sequence conflicti599V → L in BAG61321 (PubMed:14702039).Curated1
Isoform 2 (identifier: O94812-2)
Sequence conflicti87P → T in CAH56376 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026667582D → A4 PublicationsCorresponds to variant dbSNP:rs1132356Ensembl.1
Natural variantiVAR_050687879S → I. Corresponds to variant dbSNP:rs36074509Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0192311 – 35Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST35
Alternative sequenceiVSP_019232108E → EAWGSPCRQSPHPGPHTQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_047000136 – 163Missing in isoform 4. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_044673136 – 158Missing in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_047001355 – 390Missing in isoform 6. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017111 Genomic DNA Translation: BAA34710.1
AB018277 mRNA Translation: BAA34454.2 Different initiation.
AK294744 mRNA Translation: BAG57886.1 Sequence problems.
AK295645 mRNA Translation: BAG58515.1
AK299309 mRNA Translation: BAG61321.1
AK299358 mRNA Translation: BAG61353.1
AK315059 mRNA Translation: BAG37534.1
AL834321 mRNA Translation: CAH56376.1
AE006467 Genomic DNA Translation: AAK61275.1
AL031709 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85670.1
BC104966 mRNA Translation: AAI04967.1
BC112129 mRNA Translation: AAI12130.1
CCDSiCCDS10434.1 [O94812-1]
CCDS55978.1 [O94812-6]
CCDS55979.1 [O94812-7]
CCDS58402.1 [O94812-3]
CCDS58403.1 [O94812-5]
CCDS66894.1 [O94812-2]
PIRiJE0347
RefSeqiNP_001186025.1, NM_001199096.1 [O94812-7]
NP_001186026.1, NM_001199097.1 [O94812-6]
NP_001186027.1, NM_001199098.1 [O94812-3]
NP_001186028.1, NM_001199099.1 [O94812-5]
NP_001273393.1, NM_001286464.1
NP_003924.2, NM_003933.4 [O94812-1]
UniGeneiHs.458427

Genome annotation databases

EnsembliENST00000324385; ENSP00000324510; ENSG00000007516 [O94812-1]
ENST00000397488; ENSP00000380625; ENSG00000007516 [O94812-2]
ENST00000421665; ENSP00000409533; ENSG00000007516 [O94812-7]
ENST00000426824; ENSP00000407242; ENSG00000007516 [O94812-6]
ENST00000562208; ENSP00000458134; ENSG00000007516 [O94812-3]
ENST00000568887; ENSP00000457644; ENSG00000007516 [O94812-5]
ENST00000628027; ENSP00000487275; ENSG00000007516 [O94812-2]
GeneIDi8938
KEGGihsa:8938
UCSCiuc002clj.4 human [O94812-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017111 Genomic DNA Translation: BAA34710.1
AB018277 mRNA Translation: BAA34454.2 Different initiation.
AK294744 mRNA Translation: BAG57886.1 Sequence problems.
AK295645 mRNA Translation: BAG58515.1
AK299309 mRNA Translation: BAG61321.1
AK299358 mRNA Translation: BAG61353.1
AK315059 mRNA Translation: BAG37534.1
AL834321 mRNA Translation: CAH56376.1
AE006467 Genomic DNA Translation: AAK61275.1
AL031709 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85670.1
BC104966 mRNA Translation: AAI04967.1
BC112129 mRNA Translation: AAI12130.1
CCDSiCCDS10434.1 [O94812-1]
CCDS55978.1 [O94812-6]
CCDS55979.1 [O94812-7]
CCDS58402.1 [O94812-3]
CCDS58403.1 [O94812-5]
CCDS66894.1 [O94812-2]
PIRiJE0347
RefSeqiNP_001186025.1, NM_001199096.1 [O94812-7]
NP_001186026.1, NM_001199097.1 [O94812-6]
NP_001186027.1, NM_001199098.1 [O94812-3]
NP_001186028.1, NM_001199099.1 [O94812-5]
NP_001273393.1, NM_001286464.1
NP_003924.2, NM_003933.4 [O94812-1]
UniGeneiHs.458427

3D structure databases

ProteinModelPortaliO94812
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114450, 2 interactors
IntActiO94812, 2 interactors
MINTiO94812
STRINGi9606.ENSP00000324510

PTM databases

iPTMnetiO94812
PhosphoSitePlusiO94812

Polymorphism and mutation databases

BioMutaiBAIAP3

Proteomic databases

PaxDbiO94812
PeptideAtlasiO94812
PRIDEiO94812
ProteomicsDBi50452
50453 [O94812-2]

Protocols and materials databases

DNASUi8938
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324385; ENSP00000324510; ENSG00000007516 [O94812-1]
ENST00000397488; ENSP00000380625; ENSG00000007516 [O94812-2]
ENST00000421665; ENSP00000409533; ENSG00000007516 [O94812-7]
ENST00000426824; ENSP00000407242; ENSG00000007516 [O94812-6]
ENST00000562208; ENSP00000458134; ENSG00000007516 [O94812-3]
ENST00000568887; ENSP00000457644; ENSG00000007516 [O94812-5]
ENST00000628027; ENSP00000487275; ENSG00000007516 [O94812-2]
GeneIDi8938
KEGGihsa:8938
UCSCiuc002clj.4 human [O94812-1]

Organism-specific databases

CTDi8938
DisGeNETi8938
EuPathDBiHostDB:ENSG00000007516.13
GeneCardsiBAIAP3
HGNCiHGNC:948 BAIAP3
HPAiHPA015627
MIMi604009 gene
neXtProtiNX_O94812
OpenTargetsiENSG00000007516
PharmGKBiPA25252
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1328 Eukaryota
ENOG410Z3Q9 LUCA
GeneTreeiENSGT00730000110939
HOGENOMiHOG000230869
HOVERGENiHBG050658
InParanoidiO94812
KOiK15621
OMAiNTNGIQY
OrthoDBiEOG091G024N
PhylomeDBiO94812
TreeFamiTF315526

Miscellaneous databases

GeneWikiiBAIAP3
GenomeRNAii8938
PROiPR:O94812
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000007516 Expressed in 158 organ(s), highest expression level in adenohypophysis
CleanExiHS_BAIAP3
ExpressionAtlasiO94812 baseline and differential
GenevisibleiO94812 HS

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR014770 Munc13_1
IPR014772 Munc13_dom-2
IPR019558 Munc13_subgr_dom-2
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF10540 Membr_traf_MHD, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS51258 MHD1, 1 hit
PS51259 MHD2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBAIP3_HUMAN
AccessioniPrimary (citable) accession number: O94812
Secondary accession number(s): A2A2B2
, B2RCD7, B4DGS5, B4DIK3, B4DRK9, B4DRP1, E7EUB9, H3BUH8, H3BVI3, H7C2Q1, O94839, Q2M226, Q658J2, Q76N05, Q96RZ3, Q9UJK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: November 7, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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