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Protein

Tubulin polymerization-promoting protein

Gene

TPPP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.3 Publications

Miscellaneous

Unstructured protein. Interacts with aggregated SNCA and may have a pro-aggregatory role in synucleinopathies.

GO - Molecular functioni

  • microtubule binding Source: HGNC
  • tubulin binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin polymerization-promoting protein
Short name:
TPPP
Alternative name(s):
25 kDa brain-specific protein
TPPP/p25
p24
p25-alpha
Gene namesi
Name:TPPP
Synonyms:TPPP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000171368.11
HGNCiHGNC:24164 TPPP
MIMi608773 gene
neXtProtiNX_O94811

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11076
OpenTargetsiENSG00000171368
PharmGKBiPA162406809

Polymorphism and mutation databases

BioMutaiTPPP

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002211351 – 219Tubulin polymerization-promoting proteinAdd BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14Phosphothreonine; by CDK5; in vitroCombined sources1 Publication1
Modified residuei18Phosphoserine; by CDK5 and MAPK1; in vitroCombined sources1 Publication1
Modified residuei32Phosphoserine; by PKA; in vitroCombined sources1 Publication1
Modified residuei35PhosphoserineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei92Phosphothreonine; by PKA; in vitro1 Publication1
Glycosylationi152O-linked (GlcNAc) serineBy similarity1
Modified residuei159Phosphoserine; by PKA; in vitroCombined sources1 Publication1
Modified residuei160Phosphoserine; by CDK5 and MAPK1; in vitro1 Publication1

Post-translational modificationi

Poor substrate for GSK3 (By similarity). Phosphorylated by LIMK1 on serine residues. Phosphorylation may alter the tubulin polymerization activity.By similarity2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO94811
PaxDbiO94811
PeptideAtlasiO94811
PRIDEiO94811
ProteomicsDBi50451

2D gel databases

UCD-2DPAGEiO94811

PTM databases

iPTMnetiO94811
PhosphoSitePlusiO94811

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000171368 Expressed in 207 organ(s), highest expression level in Brodmann (1909) area 23
CleanExiHS_TPPP
ExpressionAtlasiO94811 baseline and differential
GenevisibleiO94811 HS

Organism-specific databases

HPAiHPA036575
HPA036576

Interactioni

Subunit structurei

Homodimer. Binds tubulin; binding is inhibited by GTP (By similarity). Interacts with GSK3 (By similarity). Interacts with MAPK1 (By similarity). Interacts with GAPDH; the interaction is direct (By similarity). Interacts with LIMK1 (via the PDZ domain); the interaction is direct.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116259, 12 interactors
IntActiO94811, 3 interactors
MINTiO94811
STRINGi9606.ENSP00000353785

Chemistry databases

BindingDBiO94811

Structurei

3D structure databases

ProteinModelPortaliO94811
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 116Mediates interaction with LIMK11 PublicationAdd BLAST116

Sequence similaritiesi

Belongs to the TPPP family.Curated

Phylogenomic databases

eggNOGiKOG4070 Eukaryota
ENOG4111H9J LUCA
GeneTreeiENSGT00390000014993
HOGENOMiHOG000260314
HOVERGENiHBG036683
InParanoidiO94811
OMAiCHVIDGK
OrthoDBiEOG091G0PC4
PhylomeDBiO94811
TreeFamiTF314440

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR008907 P25-alpha
IPR030792 TPPP1
PANTHERiPTHR12932 PTHR12932, 1 hit
PTHR12932:SF18 PTHR12932:SF18, 1 hit
PfamiView protein in Pfam
PF05517 p25-alpha, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit

Sequencei

Sequence statusi: Complete.

O94811-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADKAKPAKA ANRTPPKSPG DPSKDRAAKR LSLESEGAGE GAAASPELSA
60 70 80 90 100
LEEAFRRFAV HGDARATGRE MHGKNWSKLC KDCQVIDGRN VTVTDVDIVF
110 120 130 140 150
SKIKGKSCRT ITFEQFQEAL EELAKKRFKD KSSEEAVREV HRLIEGKAPI
160 170 180 190 200
ISGVTKAISS PTVSRLTDTT KFTGSHKERF DPSGKGKGKA GRVDLVDESG
210
YVSGYKHAGT YDQKVQGGK
Length:219
Mass (Da):23,694
Last modified:May 1, 1999 - v1
Checksum:iF8B2C814EA59129A
GO

Sequence cautioni

The sequence AAH40496 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017016 mRNA Translation: BAA36164.1
BT020035 mRNA Translation: AAV38838.1
BC040496 mRNA Translation: AAH40496.1 Different initiation.
CCDSiCCDS3856.1
RefSeqiNP_008961.1, NM_007030.2
XP_005248294.2, XM_005248237.3
XP_016864483.1, XM_017008994.1
UniGeneiHs.481466

Genome annotation databases

EnsembliENST00000360578; ENSP00000353785; ENSG00000171368
GeneIDi11076
KEGGihsa:11076

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017016 mRNA Translation: BAA36164.1
BT020035 mRNA Translation: AAV38838.1
BC040496 mRNA Translation: AAH40496.1 Different initiation.
CCDSiCCDS3856.1
RefSeqiNP_008961.1, NM_007030.2
XP_005248294.2, XM_005248237.3
XP_016864483.1, XM_017008994.1
UniGeneiHs.481466

3D structure databases

ProteinModelPortaliO94811
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116259, 12 interactors
IntActiO94811, 3 interactors
MINTiO94811
STRINGi9606.ENSP00000353785

Chemistry databases

BindingDBiO94811

PTM databases

iPTMnetiO94811
PhosphoSitePlusiO94811

Polymorphism and mutation databases

BioMutaiTPPP

2D gel databases

UCD-2DPAGEiO94811

Proteomic databases

EPDiO94811
PaxDbiO94811
PeptideAtlasiO94811
PRIDEiO94811
ProteomicsDBi50451

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360578; ENSP00000353785; ENSG00000171368
GeneIDi11076
KEGGihsa:11076

Organism-specific databases

CTDi11076
DisGeNETi11076
EuPathDBiHostDB:ENSG00000171368.11
GeneCardsiTPPP
HGNCiHGNC:24164 TPPP
HPAiHPA036575
HPA036576
MIMi608773 gene
neXtProtiNX_O94811
OpenTargetsiENSG00000171368
PharmGKBiPA162406809
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4070 Eukaryota
ENOG4111H9J LUCA
GeneTreeiENSGT00390000014993
HOGENOMiHOG000260314
HOVERGENiHBG036683
InParanoidiO94811
OMAiCHVIDGK
OrthoDBiEOG091G0PC4
PhylomeDBiO94811
TreeFamiTF314440

Miscellaneous databases

ChiTaRSiTPPP human
GeneWikiiTPPP
GenomeRNAii11076
PROiPR:O94811
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171368 Expressed in 207 organ(s), highest expression level in Brodmann (1909) area 23
CleanExiHS_TPPP
ExpressionAtlasiO94811 baseline and differential
GenevisibleiO94811 HS

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR008907 P25-alpha
IPR030792 TPPP1
PANTHERiPTHR12932 PTHR12932, 1 hit
PTHR12932:SF18 PTHR12932:SF18, 1 hit
PfamiView protein in Pfam
PF05517 p25-alpha, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPPP_HUMAN
AccessioniPrimary (citable) accession number: O94811
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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