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Protein

Regulator of G-protein signaling 11

Gene

RGS11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

GO - Molecular functioni

  • G-protein beta-subunit binding Source: UniProtKB
  • GTPase activator activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 11
Short name:
RGS11
Gene namesi
Name:RGS11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000076344.15
HGNCiHGNC:9993 RGS11
MIMi603895 gene
neXtProtiNX_O94810

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi245S → A: Diminishes interaction with Gbeta5. 1 Publication1
Mutagenesisi274W → F: Diminishes interaction with Gbeta5. 1 Publication1

Organism-specific databases

DisGeNETi8786
OpenTargetsiENSG00000076344
PharmGKBiPA34363

Polymorphism and mutation databases

BioMutaiRGS11

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042101 – 467Regulator of G-protein signaling 11Add BLAST467

Proteomic databases

PaxDbiO94810
PRIDEiO94810
ProteomicsDBi50449
50450 [O94810-2]

PTM databases

iPTMnetiO94810
PhosphoSitePlusiO94810

Expressioni

Gene expression databases

BgeeiENSG00000076344
CleanExiHS_RGS11
ExpressionAtlasiO94810 baseline and differential
GenevisibleiO94810 HS

Organism-specific databases

HPAiHPA041692
HPA043039

Interactioni

Subunit structurei

Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity).By similarity

GO - Molecular functioni

  • G-protein beta-subunit binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114314, 4 interactors
IntActiO94810, 2 interactors
STRINGi9606.ENSP00000380876

Structurei

3D structure databases

ProteinModelPortaliO94810
SMRiO94810
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 107DEPPROSITE-ProRule annotationAdd BLAST76
Domaini219 – 282G protein gammaAdd BLAST64
Domaini299 – 414RGSPROSITE-ProRule annotationAdd BLAST116

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000119142
HOGENOMiHOG000220864
HOVERGENiHBG007404
InParanoidiO94810
KOiK16449
OMAiPHDPIMS
OrthoDBiEOG091G05MO
PhylomeDBiO94810
TreeFamiTF351956

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di1.10.10.10, 1 hit
4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF00631 G-gamma, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SM00224 GGL, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48097 SSF48097, 1 hit
SSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50132 RGS, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94810-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGPAPPPG RPRAQMPHLR KMERVVVSMQ DPDQGVKMRS QRLLVTVIPH
60 70 80 90 100
AVTGSDVVQW LAQKFCVSEE EALHLGAVLV QHGYIYPLRD PRSLMLRPDE
110 120 130 140 150
TPYRFQTPYF WTSTLRPAAE LDYAIYLAKK NIRKRGTLVD YEKDCYDRLH
160 170 180 190 200
KKINHAWDLV LMQAREQLRA AKQRSKGDRL VIACQEQTYW LVNRPPPGAP
210 220 230 240 250
DVLEQGPGRG SCAASRVLMT KSADFHKREI EYFRKALGRT RVKSSVCLEA
260 270 280 290 300
YLSFCGQRGP HDPLVSGCLP SNPWISDNDA YWVMNAPTVA APTKLRVERW
310 320 330 340 350
GFSFRELLED PVGRAHFMDF LGKEFSGENL SFWEACEELR YGAQAQVPTL
360 370 380 390 400
VDAVYEQFLA PGAAHWVNID SRTMEQTLEG LRQPHRYVLD DAQLHIYMLM
410 420 430 440 450
KKDSYPRFLK SDMYKALLAE AGIPLEMKRR VFPFTWRPRH SSPSPALLPT
460
PVEPTAACGP GGGDGVA
Length:467
Mass (Da):52,946
Last modified:July 15, 1999 - v2
Checksum:i46BEE11D77C2C5F7
GO
Isoform 2 (identifier: O94810-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-123: TPYFWTSTLRPAAELDY → VRLGGA

Show »
Length:456
Mass (Da):51,486
Checksum:iCC4FA2BBE9C4D806
GO
Isoform 3 (identifier: O94810-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.

Show »
Length:446
Mass (Da):50,727
Checksum:i87DEC7BDFE8E2693
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061770351V → M. Corresponds to variant dbSNP:rs9806942Ensembl.1
Natural variantiVAR_024606427M → T. Corresponds to variant dbSNP:rs739999Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0467241 – 21Missing in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_023497107 – 123TPYFW…AELDY → VRLGGA in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016929 mRNA Translation: BAA74751.1
AF035153 mRNA Translation: AAC69175.1
AF035154 mRNA Translation: AAC69176.1
AE006463 Genomic DNA Translation: AAK61221.1
Z69667, AC004754 Genomic DNA Translation: CAI95581.1
Z69667, AC004754 Genomic DNA Translation: CAI95582.1
CH471112 Genomic DNA Translation: EAW85839.1
CCDSiCCDS10403.1 [O94810-3]
CCDS42088.1 [O94810-1]
CCDS66884.1 [O94810-2]
RefSeqiNP_001273414.1, NM_001286485.1 [O94810-2]
NP_001273415.1, NM_001286486.1
NP_003825.1, NM_003834.2 [O94810-3]
NP_899180.1, NM_183337.2 [O94810-1]
UniGeneiHs.65756

Genome annotation databases

EnsembliENST00000316163; ENSP00000319069; ENSG00000076344 [O94810-3]
ENST00000359740; ENSP00000352778; ENSG00000076344 [O94810-2]
ENST00000397770; ENSP00000380876; ENSG00000076344 [O94810-1]
GeneIDi8786
KEGGihsa:8786
UCSCiuc002cgi.3 human [O94810-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRGS11_HUMAN
AccessioniPrimary (citable) accession number: O94810
Secondary accession number(s): O75883, Q4TT71, Q4TT72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: June 20, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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