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Protein

Actin-like protein 6B

Gene

ACTL6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth (By similarity).2 PublicationsBy similarity

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: ProtInc
  • transcription coactivator activity Source: BHF-UCL

GO - Biological processi

  • chromatin organization Source: UniProtKB
  • chromatin remodeling Source: BHF-UCL
  • regulation of transcription by RNA polymerase II Source: BHF-UCL
  • spinal cord development Source: Ensembl
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator
Biological processNeurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214858 RMTs methylate histone arginines
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
SignaLinkiO94805
SIGNORiO94805

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-like protein 6B
Alternative name(s):
53 kDa BRG1-associated factor B
Actin-related protein Baf53b
ArpNalpha
BRG1-associated factor 53B
Short name:
BAF53B
Gene namesi
Name:ACTL6B
Synonyms:ACTL6, BAF53B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000077080.9
HGNCiHGNC:160 ACTL6B
MIMi612458 gene
neXtProtiNX_O94805

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51412
OpenTargetsiENSG00000077080
PharmGKBiPA24482

Polymorphism and mutation databases

BioMutaiACTL6B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000891351 – 426Actin-like protein 6BAdd BLAST426

Proteomic databases

EPDiO94805
MaxQBiO94805
PaxDbiO94805
PeptideAtlasiO94805
PRIDEiO94805
ProteomicsDBi50445

PTM databases

iPTMnetiO94805
PhosphoSitePlusiO94805

Expressioni

Gene expression databases

BgeeiENSG00000077080
CleanExiHS_ACTL6B
ExpressionAtlasiO94805 baseline and differential
GenevisibleiO94805 HS

Organism-specific databases

HPAiHPA045126

Interactioni

Subunit structurei

Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific (PubMed:22952240, PubMed:26601204). Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (PubMed:22952240, PubMed:26601204). Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A or SMARCD2/BAF60B or SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (ACTB). Note that the nBAF complex is polymorphic in regard to the ATPase, SMARCA2 and SMARCA4 occupying mutually exclusive positions. May be a component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin (PubMed:22952240, PubMed:26601204).2 PublicationsBy similarity

Protein-protein interaction databases

BioGridi119529, 32 interactors
CORUMiO94805
ELMiO94805
IntActiO94805, 10 interactors
MINTiO94805
STRINGi9606.ENSP00000160382

Structurei

3D structure databases

ProteinModelPortaliO94805
SMRiO94805
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni39 – 82Essential for mediating its function in dendritic development; may contribute to neuronal-specific targetingBy similarityAdd BLAST44

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0679 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00900000140992
HOGENOMiHOG000233340
HOVERGENiHBG003771
InParanoidiO94805
KOiK11652
OMAiSTMERRF
OrthoDBiEOG091G0A1S
PhylomeDBiO94805
TreeFamiTF312863

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00432 ACTINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

O94805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGVYGGDE VGALVFDIGS FSVRAGYAGE DCPKADFPTT VGLLAAEEGG
60 70 80 90 100
GLELEGDKEK KGKIFHIDTN ALHVPRDGAE VMSPLKNGMI EDWECFRAIL
110 120 130 140 150
DHTYSKHVKS EPNLHPVLMS EAPWNTRAKR EKLTELMFEQ YNIPAFFLCK
160 170 180 190 200
TAVLTAFANG RSTGLVLDSG ATHTTAIPVH DGYVLQQGIV KSPLAGDFIS
210 220 230 240 250
MQCRELFQEM AIDIIPPYMI AAKEPVREGA PPNWKKKEKL PQVSKSWHNY
260 270 280 290 300
MCNEVIQDFQ ASVLQVSDSP YDEQVAAQMP TVHYEMPNGY NTDYGAERLR
310 320 330 340 350
IPEGLFDPSN VKGLSGNTML GVGHVVTTSI GMCDIDIRPG LYGSVIVTGG
360 370 380 390 400
NTLLQGFTDR LNRELSQKTP PSMRLKLIAS NSTMERKFSP WIGGSILASL
410 420
GTFQQMWISK QEYEEGGKQC VERKCP
Length:426
Mass (Da):46,877
Last modified:May 1, 1999 - v1
Checksum:i6E9CEBABB8C81E64
GO

Sequence cautioni

The sequence AAC78795 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053356 Genomic DNA Translation: AAC78795.1 Sequence problems.
AB015906 mRNA Translation: BAA74576.1
AF041475 mRNA Translation: AAD54678.1
AK314940 mRNA Translation: BAG37446.1
AC099394 Genomic DNA Translation: AAP21874.1
CH236956 Genomic DNA Translation: EAL23823.1
CH471091 Genomic DNA Translation: EAW76502.1
BC020944 mRNA Translation: AAH20944.1
CCDSiCCDS5702.1
RefSeqiNP_057272.1, NM_016188.4
UniGeneiHs.259831

Genome annotation databases

EnsembliENST00000160382; ENSP00000160382; ENSG00000077080
GeneIDi51412
KEGGihsa:51412
UCSCiuc003uvy.4 human

Similar proteinsi

Entry informationi

Entry nameiACL6B_HUMAN
AccessioniPrimary (citable) accession number: O94805
Secondary accession number(s): A4D2D0, O75421
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 1999
Last modified: July 18, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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