ALDH1A2

Functionⁱ

Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity).By similarity

Catalytic activityⁱ

Retinal + NAD⁺ + H₂O = retinoate + NADH.

Pathwayⁱ: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	187	Transition state stabilizerBy similarity	1
Active siteⁱ	286	Proton acceptorPROSITE-ProRule annotation	1
Active siteⁱ	320	NucleophilePROSITE-ProRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	263 – 268	NADBy similarity		6

GO - Molecular functionⁱ

3-chloroallyl aldehyde dehydrogenase activity Source: UniProtKB
aldehyde dehydrogenase (NAD) activity Source: GO_Central
retinal binding Source: UniProtKB
retinal dehydrogenase activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

9-cis-retinoic acid biosynthetic process Source: Ensembl
blood vessel development Source: Ensembl
cardiac muscle tissue development Source: Ensembl
cellular response to retinoic acid Source: Ensembl
determination of bilateral symmetry Source: Ensembl
embryonic camera-type eye development Source: Ensembl
embryonic digestive tract development Source: Ensembl
embryonic forelimb morphogenesis Source: Ensembl
face development Source: Ensembl
heart morphogenesis Source: Ensembl
hindbrain development Source: Ensembl
kidney development Source: Ensembl
liver development Source: Ensembl
lung development Source: Ensembl
midgut development Source: Ensembl
morphogenesis of embryonic epithelium Source: Ensembl
negative regulation of cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 16166285
neural crest cell development Source: Ensembl
neural tube development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16237707
neuron differentiation Source: Ensembl
pancreas development Source: Ensembl
pituitary gland development Source: Ensembl
positive regulation of apoptotic process Source: Ensembl
positive regulation of cell proliferation Source: Ensembl
positive regulation of gene expression Source: Ensembl
proximal/distal pattern formation Source: Ensembl
regulation of endothelial cell proliferation Source: Ensembl
response to cytokine
Source: UniProtKB
Inferred from direct assayⁱ
- 18495959
response to estradiol Source: Ensembl
response to vitamin A Source: Ensembl
retinal metabolic process Source: Ensembl
retinoic acid metabolic process Source: UniProtKB
retinoic acid receptor signaling pathway involved in somitogenesis Source: Ensembl
retinol metabolic process Source: UniProtKB-UniPathway
ureter maturation Source: Ensembl
vitamin A metabolic process
Source: UniProtKB
Non-traceable author statementⁱ
- 8663198

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	NAD

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS05232-MONOMER
Reactomeⁱ	R-HSA-5365859 RA biosynthesis pathway
UniPathwayⁱ	UPA00912

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Retinal dehydrogenase 2 (EC:1.2.1.36) Short name: RALDH 2 Short name: RalDH2 Alternative name(s): Aldehyde dehydrogenase family 1 member A2 Retinaldehyde-specific dehydrogenase type 2 Short name: RALDH(II)
Gene namesⁱ	Name:ALDH1A2 Synonyms:RALDH2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000128918.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15472 ALDH1A2
MIMⁱ	603687 gene
neXtProtⁱ	NX_O94788

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8854
Open Targets More...OpenTargetsⁱ	ENSG00000128918
PharmGKBⁱ	PA24693

Chemistry databases

ChEMBLⁱ	CHEMBL3112384
Drug and drug target database More...DrugBankⁱ	DB00157 NADH DB00755 Tretinoin DB00162 Vitamin A

Polymorphism and mutation databases

BioMutaⁱ	ALDH1A2

BioMutaⁱ

ALDH1A2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000056422	1 – 518	Retinal dehydrogenase 2Add BLAST		518

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	168	PhosphotyrosineCombined sources		1
Modified residueⁱ	351	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O94788
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O94788
PaxDbⁱ	O94788
PeptideAtlas More...PeptideAtlasⁱ	O94788
PRIDEⁱ	O94788
ProteomicsDBⁱ	50442 50443 [O94788-2]

PTM databases

iPTMnetⁱ	O94788
PhosphoSitePlusⁱ	O94788

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000128918 Expressed in 168 organ(s), highest expression level in adrenal tissue
CleanExⁱ	HS_ALDH1A2
ExpressionAtlasⁱ	O94788 baseline and differential
Genevisibleⁱ	O94788 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA010022

HPAⁱ

HPA010022

Interactionⁱ

Subunit structureⁱ

Homotetramer.By similarity

Protein-protein interaction databases

BioGridⁱ	114379, 5 interactors
IntActⁱ	O94788, 3 interactors
STRINGⁱ	9606.ENSP00000249750

Chemistry databases

BindingDBⁱ

O94788

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	39 – 42	Combined sources	4
Beta strandⁱ	45 – 47	Combined sources	3
Beta strandⁱ	54 – 58	Combined sources	5
Turnⁱ	60 – 62	Combined sources	3
Beta strandⁱ	65 – 70	Combined sources	6
Helixⁱ	74 – 87	Combined sources	14
Helixⁱ	93 – 96	Combined sources	4
Helixⁱ	99 – 115	Combined sources	17
Helixⁱ	117 – 128	Combined sources	12
Helixⁱ	132 – 137	Combined sources	6
Helixⁱ	139 – 151	Combined sources	13
Helixⁱ	154 – 156	Combined sources	3
Beta strandⁱ	159 – 162	Combined sources	4
Beta strandⁱ	165 – 176	Combined sources	12
Beta strandⁱ	178 – 183	Combined sources	6
Beta strandⁱ	186 – 188	Combined sources	3
Helixⁱ	189 – 202	Combined sources	14
Beta strandⁱ	206 – 210	Combined sources	5
Beta strandⁱ	213 – 215	Combined sources	3
Helixⁱ	217 – 229	Combined sources	13
Beta strandⁱ	235 – 238	Combined sources	4
Turnⁱ	243 – 245	Combined sources	3
Helixⁱ	246 – 251	Combined sources	6
Beta strandⁱ	258 – 263	Combined sources	6
Helixⁱ	265 – 277	Combined sources	13
Beta strandⁱ	282 – 286	Combined sources	5
Beta strandⁱ	292 – 295	Combined sources	4
Helixⁱ	301 – 313	Combined sources	13
Helixⁱ	314 – 317	Combined sources	4
Beta strandⁱ	325 – 329	Combined sources	5
Helixⁱ	330 – 346	Combined sources	17
Helixⁱ	365 – 380	Combined sources	16
Beta strandⁱ	384 – 387	Combined sources	4
Beta strandⁱ	393 – 396	Combined sources	4
Beta strandⁱ	402 – 406	Combined sources	5
Helixⁱ	412 – 415	Combined sources	4
Beta strandⁱ	420 – 428	Combined sources	9
Helixⁱ	431 – 439	Combined sources	9
Beta strandⁱ	441 – 450	Combined sources	10
Helixⁱ	454 – 463	Combined sources	10
Beta strandⁱ	466 – 472	Combined sources	7
Beta strandⁱ	479 – 481	Combined sources	3
Beta strandⁱ	490 – 492	Combined sources	3
Helixⁱ	498 – 503	Combined sources	6
Beta strandⁱ	504 – 512	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	O94788
SMRⁱ	O94788
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2450 Eukaryota COG1012 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118999
HOGENOMⁱ	HOG000271505
HOVERGENⁱ	HBG000097
InParanoidⁱ	O94788
KEGG Orthology (KO) More...KOⁱ	K07249
OMAⁱ	RHVMIKH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05E8
PhylomeDBⁱ	O94788
TreeFamⁱ	TF300455

Family and domain databases

Gene3Dⁱ	3.40.309.10, 1 hit 3.40.605.10, 2 hits
InterProⁱ	View protein in InterPro IPR016161 Ald_DH/histidinol_DH IPR016163 Ald_DH_C IPR016160 Ald_DH_CS_CYS IPR029510 Ald_DH_CS_GLU IPR016162 Ald_DH_N IPR015590 Aldehyde_DH_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00171 Aldedh, 1 hit
SUPFAMⁱ	SSF53720 SSF53720, 1 hit
PROSITEⁱ	View protein in PROSITE PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O94788-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSSKIEMPG EVKADPAALM ASLHLLPSPT PNLEIKYTKI FINNEWQNSE 
        60         70         80         90        100
SGRVFPVYNP ATGEQVCEVQ EADKADIDKA VQAARLAFSL GSVWRRMDAS 
       110        120        130        140        150
ERGRLLDKLA DLVERDRAVL ATMESLNGGK PFLQAFYVDL QGVIKTFRYY 
       160        170        180        190        200
AGWADKIHGM TIPVDGDYFT FTRHEPIGVC GQIIPWNFPL LMFAWKIAPA 
       210        220        230        240        250
LCCGNTVVIK PAEQTPLSAL YMGALIKEAG FPPGVINILP GYGPTAGAAI 
       260        270        280        290        300
ASHIGIDKIA FTGSTEVGKL IQEAAGRSNL KRVTLELGGK SPNIIFADAD 
       310        320        330        340        350
LDYAVEQAHQ GVFFNQGQCC TAGSRIFVEE SIYEEFVRRS VERAKRRVVG 
       360        370        380        390        400
SPFDPTTEQG PQIDKKQYNK ILELIQSGVA EGAKLECGGK GLGRKGFFIE 
       410        420        430        440        450
PTVFSNVTDD MRIAKEEIFG PVQEILRFKT MDEVIERANN SDFGLVAAVF 
       460        470        480        490        500
TNDINKALTV SSAMQAGTVW INCYNALNAQ SPFGGFKMSG NGREMGEFGL 
       510 
REYSEVKTVT VKIPQKNS

Length:518

Mass (Da):56,724

Last modified:March 7, 2006 - v3

Checksum:ⁱAAEE7A886951373F

GO

Isoform 2 (identifier: O94788-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
229-266: Missing.

« Hide

        10         20         30         40         50
MTSSKIEMPG EVKADPAALM ASLHLLPSPT PNLEIKYTKI FINNEWQNSE 
        60         70         80         90        100
SGRVFPVYNP ATGEQVCEVQ EADKADIDKA VQAARLAFSL GSVWRRMDAS 
       110        120        130        140        150
ERGRLLDKLA DLVERDRAVL ATMESLNGGK PFLQAFYVDL QGVIKTFRYY 
       160        170        180        190        200
AGWADKIHGM TIPVDGDYFT FTRHEPIGVC GQIIPWNFPL LMFAWKIAPA 
       210        220        230        240        250
LCCGNTVVIK PAEQTPLSAL YMGALIKEVG KLIQEAAGRS NLKRVTLELG 
       260        270        280        290        300
GKSPNIIFAD ADLDYAVEQA HQGVFFNQGQ CCTAGSRIFV EESIYEEFVR 
       310        320        330        340        350
RSVERAKRRV VGSPFDPTTE QGPQIDKKQY NKILELIQSG VAEGAKLECG 
       360        370        380        390        400
GKGLGRKGFF IEPTVFSNVT DDMRIAKEEI FGPVQEILRF KTMDEVIERA 
       410        420        430        440        450
NNSDFGLVAA VFTNDINKAL TVSSAMQAGT VWINCYNALN AQSPFGGFKM 
       460        470        480
SGNGREMGEF GLREYSEVKT VTVKIPQKNS

Note: No experimental confirmation available.

Show »

Length:480

Mass (Da):53,060

Checksum:ⁱ5AC931BE5ED26AA4

GO

Isoform 3 (identifier: O94788-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-39: MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTK → MKNQCETVWLKSPIKLKL

« Hide

        10         20         30         40         50
MKNQCETVWL KSPIKLKLIF INNEWQNSES GRVFPVYNPA TGEQVCEVQE 
        60         70         80         90        100
ADKADIDKAV QAARLAFSLG SVWRRMDASE RGRLLDKLAD LVERDRAVLA 
       110        120        130        140        150
TMESLNGGKP FLQAFYVDLQ GVIKTFRYYA GWADKIHGMT IPVDGDYFTF 
       160        170        180        190        200
TRHEPIGVCG QIIPWNFPLL MFAWKIAPAL CCGNTVVIKP AEQTPLSALY 
       210        220        230        240        250
MGALIKEAGF PPGVINILPG YGPTAGAAIA SHIGIDKIAF TGSTEVGKLI 
       260        270        280        290        300
QEAAGRSNLK RVTLELGGKS PNIIFADADL DYAVEQAHQG VFFNQGQCCT 
       310        320        330        340        350
AGSRIFVEES IYEEFVRRSV ERAKRRVVGS PFDPTTEQGP QIDKKQYNKI 
       360        370        380        390        400
LELIQSGVAE GAKLECGGKG LGRKGFFIEP TVFSNVTDDM RIAKEEIFGP 
       410        420        430        440        450
VQEILRFKTM DEVIERANNS DFGLVAAVFT NDINKALTVS SAMQAGTVWI 
       460        470        480        490 
NCYNALNAQS PFGGFKMSGN GREMGEFGLR EYSEVKTVTV KIPQKNS

Note: No experimental confirmation available.

Show »

Length:497

Mass (Da):54,673

Checksum:ⁱ27E8A8307A680BB7

GO

Isoform 4 (identifier: O94788-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-96: Missing.

« Hide

        10         20         30         40         50
MDASERGRLL DKLADLVERD RAVLATMESL NGGKPFLQAF YVDLQGVIKT 
        60         70         80         90        100
FRYYAGWADK IHGMTIPVDG DYFTFTRHEP IGVCGQIIPW NFPLLMFAWK 
       110        120        130        140        150
IAPALCCGNT VVIKPAEQTP LSALYMGALI KEAGFPPGVI NILPGYGPTA 
       160        170        180        190        200
GAAIASHIGI DKIAFTGSTE VGKLIQEAAG RSNLKRVTLE LGGKSPNIIF 
       210        220        230        240        250
ADADLDYAVE QAHQGVFFNQ GQCCTAGSRI FVEESIYEEF VRRSVERAKR 
       260        270        280        290        300
RVVGSPFDPT TEQGPQIDKK QYNKILELIQ SGVAEGAKLE CGGKGLGRKG 
       310        320        330        340        350
FFIEPTVFSN VTDDMRIAKE EIFGPVQEIL RFKTMDEVIE RANNSDFGLV 
       360        370        380        390        400
AAVFTNDINK ALTVSSAMQA GTVWINCYNA LNAQSPFGGF KMSGNGREMG 
       410        420 
EFGLREYSEV KTVTVKIPQK NS

Show »

Length:422

Mass (Da):46,137

Checksum:ⁱ4927D07BDD3BAC5D

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YMG7	H0YMG7_HUMAN	Retinal dehydrogenase 2 Retinal dehydrogenase 2	ALDH1A2	489	Annotation score:
H0YKL3	H0YKL3_HUMAN	Retinal dehydrogenase 2 Retinal dehydrogenase 2	ALDH1A2	85	Annotation score:
Q9UED3	Q9UED3_HUMAN	RALDH2-T RALDH2-T (Retinal dehydrogenase 2)	ALDH1A2 RALDH2	25	Annotation score:
E9PF31	E9PF31_HUMAN	Retinal dehydrogenase 2 Retinal dehydrogenase 2	ALDH1A2	40	Annotation score:
H0YMT5	H0YMT5_HUMAN	Retinal dehydrogenase 2 Retinal dehydrogenase 2	ALDH1A2	24	Annotation score:
A0A0G2JL97	A0A0G2JL97_HUMAN	Retinal dehydrogenase 2 Retinal dehydrogenase 2	ALDH1A2	9	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	231	F → L in BAG64174 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_025439	50	E → G1 PublicationCorresponds to variant dbSNP:rs34266719Ensembl.	1
Natural variantⁱVAR_025440	110	A → V1 PublicationCorresponds to variant dbSNP:rs35365164Ensembl.	1
Natural variantⁱVAR_025441	348	V → I4 PublicationsCorresponds to variant dbSNP:rs4646626Ensembl.	1
Natural variantⁱVAR_025442	436	E → K1 PublicationCorresponds to variant dbSNP:rs34744827Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_047259	1 – 96	Missing in isoform 4. 1 PublicationAdd BLAST	96
Alternative sequenceⁱVSP_044496	1 – 39	MTSSK…IKYTK → MKNQCETVWLKSPIKLKL in isoform 3. 1 PublicationAdd BLAST	39
Alternative sequenceⁱVSP_017363	229 – 266	Missing in isoform 2. 1 PublicationAdd BLAST	38

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB015226 mRNA Translation: BAA34785.1 AB015227 mRNA Translation: BAA34786.1 AB015228 mRNA Translation: BAA34787.1 AK128709 mRNA Translation: BAG54714.1 AK303057 mRNA Translation: BAG64174.1 DQ322171 Genomic DNA Translation: ABC40749.1 AC012653 Genomic DNA No translation available. AC018904 Genomic DNA No translation available. AC025431 Genomic DNA No translation available. AC066616 Genomic DNA No translation available. AC084781 Genomic DNA No translation available. BC030589 mRNA Translation: AAH30589.1 AL110299 mRNA Translation: CAB53740.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10163.1 [O94788-1] CCDS10164.1 [O94788-2] CCDS45266.1 [O94788-4] CCDS55968.1 [O94788-3]
PIRⁱ	T14799
NCBI Reference Sequences More...RefSeqⁱ	NP_001193826.1, NM_001206897.1 [O94788-3] NP_003879.2, NM_003888.3 [O94788-1] NP_733797.1, NM_170696.2 [O94788-2] NP_733798.1, NM_170697.2 [O94788-4]
UniGeneⁱ	Hs.643455

Genome annotation databases

Ensemblⁱ	ENST00000249750; ENSP00000249750; ENSG00000128918 [O94788-1] ENST00000347587; ENSP00000309623; ENSG00000128918 [O94788-2] ENST00000537372; ENSP00000438296; ENSG00000128918 [O94788-3] ENST00000559517; ENSP00000453408; ENSG00000128918 [O94788-4]
GeneIDⁱ	8854
KEGGⁱ	hsa:8854
UCSC genome browser More...UCSCⁱ	uc002aew.4 human [O94788-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O94788	Retinal dehydrogenase 2 (Fragment)		HUMAN		85	UniRef100_O94788
Isoform 4 of Retinal dehydrogenase 2		HUMAN		422
UPI000C71CA24		HUMAN		493

Protein	Similar proteins		Species	Score	Length	Source
O94788	Retinal dehydrogenase 2		MOUSE		518	UniRef90_Q62148
Retinal dehydrogenase 2		CHICK		518
Retinal dehydrogenase 2	)	RAT		518
Retinal dehydrogenase 2		TAEGU		517
Uncharacterized protein		RABIT		590
+276
O94788-2	ALDH1A2 isoform 16		PANTR		480	UniRef90_O94788-2
Aldehyde dehydrogenase 1 family member A2		SAIBB		480
Uncharacterized protein		MACMU		480
Uncharacterized protein		CERAT		480
Uncharacterized protein		FELCA		480
+66

Protein	Similar proteins		Species	Score	Length	Source
O94788	Retinal dehydrogenase 2		MOUSE		518	UniRef50_Q62148
Retinal dehydrogenase 2		CHICK		518
Retinal dehydrogenase 2	)	RAT		518
Retinal dehydrogenase 2		TAEGU		517
Aldehyde dehydrogenase, mitochondrial		HORSE		500
+613
O94788-2	retinal dehydrogenase 2 isoform X3		ODORO		480	UniRef50_O94788-2
retinal dehydrogenase 2 isoform X2		Enhydra lutris kenyoni		480
ALDH1A2 isoform 16		PANTR		480
Aldehyde dehydrogenase 1 family member A2		SAIBB		480
Uncharacterized protein		MACMU		480
+104

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB015226 mRNA Translation: BAA34785.1 AB015227 mRNA Translation: BAA34786.1 AB015228 mRNA Translation: BAA34787.1 AK128709 mRNA Translation: BAG54714.1 AK303057 mRNA Translation: BAG64174.1 DQ322171 Genomic DNA Translation: ABC40749.1 AC012653 Genomic DNA No translation available. AC018904 Genomic DNA No translation available. AC025431 Genomic DNA No translation available. AC066616 Genomic DNA No translation available. AC084781 Genomic DNA No translation available. BC030589 mRNA Translation: AAH30589.1 AL110299 mRNA Translation: CAB53740.2
CCDSⁱ	CCDS10163.1 [O94788-1] CCDS10164.1 [O94788-2] CCDS45266.1 [O94788-4] CCDS55968.1 [O94788-3]
PIRⁱ	T14799
RefSeqⁱ	NP_001193826.1, NM_001206897.1 [O94788-3] NP_003879.2, NM_003888.3 [O94788-1] NP_733797.1, NM_170696.2 [O94788-2] NP_733798.1, NM_170697.2 [O94788-4]
UniGeneⁱ	Hs.643455

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4X2Q	X-ray	2.94	A/B/C/D	21-518	[»]
	6ALJ	X-ray	1.89	A/B/C/D	26-518	[»]
	6B5G	X-ray	2.20	A/B/C/D	26-518	[»]
	6B5H	X-ray	2.30	A/B/C/D	26-518	[»]
	6B5I	X-ray	2.60	A/B/C/D	26-518	[»]
ProteinModelPortalⁱ	O94788
SMRⁱ	O94788
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114379, 5 interactors
IntActⁱ	O94788, 3 interactors
STRINGⁱ	9606.ENSP00000249750

Chemistry databases

BindingDBⁱ	O94788
ChEMBLⁱ	CHEMBL3112384
DrugBankⁱ	DB00157 NADH DB00755 Tretinoin DB00162 Vitamin A

PTM databases

iPTMnetⁱ	O94788
PhosphoSitePlusⁱ	O94788

Polymorphism and mutation databases

BioMutaⁱ	ALDH1A2

BioMutaⁱ

ALDH1A2

Proteomic databases

EPDⁱ	O94788
MaxQBⁱ	O94788
PaxDbⁱ	O94788
PeptideAtlasⁱ	O94788
PRIDEⁱ	O94788
ProteomicsDBⁱ	50442 50443 [O94788-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8854
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000249750; ENSP00000249750; ENSG00000128918 [O94788-1] ENST00000347587; ENSP00000309623; ENSG00000128918 [O94788-2] ENST00000537372; ENSP00000438296; ENSG00000128918 [O94788-3] ENST00000559517; ENSP00000453408; ENSG00000128918 [O94788-4]
GeneIDⁱ	8854
KEGGⁱ	hsa:8854
UCSCⁱ	uc002aew.4 human [O94788-1]

Organism-specific databases

CTDⁱ	8854
DisGeNETⁱ	8854
EuPathDBⁱ	HostDB:ENSG00000128918.14
GeneCardsⁱ	ALDH1A2
H-InvDBⁱ	HIX0038341
HGNCⁱ	HGNC:15472 ALDH1A2
HPAⁱ	HPA010022
MIMⁱ	603687 gene
neXtProtⁱ	NX_O94788
OpenTargetsⁱ	ENSG00000128918
PharmGKBⁱ	PA24693
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2450 Eukaryota COG1012 LUCA
GeneTreeⁱ	ENSGT00760000118999
HOGENOMⁱ	HOG000271505
HOVERGENⁱ	HBG000097
InParanoidⁱ	O94788
KOⁱ	K07249
OMAⁱ	RHVMIKH
OrthoDBⁱ	EOG091G05E8
PhylomeDBⁱ	O94788
TreeFamⁱ	TF300455

Enzyme and pathway databases

UniPathwayⁱ	UPA00912
BioCycⁱ	MetaCyc:HS05232-MONOMER
Reactomeⁱ	R-HSA-5365859 RA biosynthesis pathway

Miscellaneous databases

ChiTaRSⁱ	ALDH1A2 human
GeneWikiⁱ	ALDH1A2
GenomeRNAiⁱ	8854
Protein Ontology More...PROⁱ	PR:O94788
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000128918 Expressed in 168 organ(s), highest expression level in adrenal tissue
CleanExⁱ	HS_ALDH1A2
ExpressionAtlasⁱ	O94788 baseline and differential
Genevisibleⁱ	O94788 HS

Family and domain databases

Gene3Dⁱ	3.40.309.10, 1 hit 3.40.605.10, 2 hits
InterProⁱ	View protein in InterPro IPR016161 Ald_DH/histidinol_DH IPR016163 Ald_DH_C IPR016160 Ald_DH_CS_CYS IPR029510 Ald_DH_CS_GLU IPR016162 Ald_DH_N IPR015590 Aldehyde_DH_dom
Pfamⁱ	View protein in Pfam PF00171 Aldedh, 1 hit
SUPFAMⁱ	SSF53720 SSF53720, 1 hit
PROSITEⁱ	View protein in PROSITE PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AL1A2_HUMAN
Accessionⁱ	O94788Primary (citable) accession number: O94788 Secondary accession number(s): B3KY52 Q9UFY0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	March 7, 2006
	Last modified:	September 12, 2018
	This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - O94788 (AL1A2_HUMAN)

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Retinal dehydrogenase 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: retinol metabolism

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GO - Biological processi

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

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Protein-protein interaction databases

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3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: retinol metabolism

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ