UniProtKB - O94788 (AL1A2_HUMAN)
Protein
Retinal dehydrogenase 2
Gene
ALDH1A2
Organism
Homo sapiens (Human)
Status
Functioni
Converts retinaldehyde to retinoic acid (PubMed:29240402). Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal. Displays complete lack of activity with citral (By similarity).By similarity1 Publication
Catalytic activityi
- EC:1.2.1.361 Publication
: retinol metabolism Pathwayi
This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 187 | Transition state stabilizerBy similarity | 1 | |
Active sitei | 286 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Active sitei | 320 | NucleophilePROSITE-ProRule annotation1 Publication | 1 | |
Binding sitei | 417 | NADCombined sources1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 184 – 186 | NADCombined sources1 Publication | 3 | |
Nucleotide bindingi | 210 – 213 | NADCombined sources1 Publication | 4 | |
Nucleotide bindingi | 264 – 266 | NADCombined sources1 Publication | 3 | |
Nucleotide bindingi | 366 – 370 | NADCombined sources1 Publication | 5 |
GO - Molecular functioni
- 3-chloroallyl aldehyde dehydrogenase activity Source: UniProtKB
- aldehyde dehydrogenase (NAD+) activity Source: GO_Central
- retinal binding Source: UniProtKB
- retinal dehydrogenase activity Source: UniProtKB
GO - Biological processi
- 9-cis-retinoic acid biosynthetic process Source: Ensembl
- blood vessel development Source: Ensembl
- cardiac muscle tissue development Source: Ensembl
- cellular response to retinoic acid Source: Ensembl
- determination of bilateral symmetry Source: Ensembl
- embryonic camera-type eye development Source: Ensembl
- embryonic digestive tract development Source: Ensembl
- embryonic forelimb morphogenesis Source: Ensembl
- face development Source: Ensembl
- heart morphogenesis Source: Ensembl
- hindbrain development Source: Ensembl
- kidney development Source: Ensembl
- liver development Source: Ensembl
- lung development Source: Ensembl
- midgut development Source: Ensembl
- morphogenesis of embryonic epithelium Source: Ensembl
- negative regulation of cell population proliferation Source: UniProtKB
- neural crest cell development Source: Ensembl
- neural tube development Source: UniProtKB
- neuron differentiation Source: Ensembl
- pancreas development Source: Ensembl
- pituitary gland development Source: Ensembl
- positive regulation of apoptotic process Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of gene expression Source: Ensembl
- protein homotetramerization Source: UniProtKB
- proximal/distal pattern formation Source: Ensembl
- regulation of endothelial cell proliferation Source: Ensembl
- response to cytokine Source: UniProtKB
- response to estradiol Source: Ensembl
- response to vitamin A Source: Ensembl
- retinal metabolic process Source: Ensembl
- retinoic acid biosynthetic process Source: UniProtKB
- retinoic acid metabolic process Source: UniProtKB
- retinoic acid receptor signaling pathway involved in somitogenesis Source: Ensembl
- retinol metabolic process Source: UniProtKB-UniPathway
- ureter maturation Source: Ensembl
- vitamin A metabolic process Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
BioCyci | MetaCyc:HS05232-MONOMER |
PathwayCommonsi | O94788 |
Reactomei | R-HSA-5365859, RA biosynthesis pathway |
UniPathwayi | UPA00912 |
Names & Taxonomyi
Protein namesi | Recommended name: Retinal dehydrogenase 2 (EC:1.2.1.361 Publication)Short name: RALDH 2 Short name: RalDH21 Publication Alternative name(s): Aldehyde dehydrogenase family 1 member A2 Retinaldehyde-specific dehydrogenase type 2 Short name: RALDH(II) |
Gene namesi | Name:ALDH1A2 Synonyms:RALDH2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000128918.14 |
HGNCi | HGNC:15472, ALDH1A2 |
MIMi | 603687, gene |
neXtProti | NX_O94788 |
Subcellular locationi
Other locations
Cytosol
- cytosol Source: Reactome
Other locations
- cytoplasm Source: UniProtKB
- perinuclear region of cytoplasm Source: Ensembl
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 8854 |
OpenTargetsi | ENSG00000128918 |
PharmGKBi | PA24693 |
Miscellaneous databases
Pharosi | O94788, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3112384 |
DrugBanki | DB00157, NADH DB00755, Tretinoin DB00162, Vitamin A |
DrugCentrali | O94788 |
Polymorphism and mutation databases
BioMutai | ALDH1A2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056422 | 1 – 518 | Retinal dehydrogenase 2Add BLAST | 518 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 168 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 351 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O94788 |
jPOSTi | O94788 |
MassIVEi | O94788 |
MaxQBi | O94788 |
PaxDbi | O94788 |
PeptideAtlasi | O94788 |
PRIDEi | O94788 |
ProteomicsDBi | 26115 40109 50442 [O94788-1] 50443 [O94788-2] |
PTM databases
iPTMneti | O94788 |
PhosphoSitePlusi | O94788 |
Expressioni
Gene expression databases
Bgeei | ENSG00000128918, Expressed in adrenal tissue and 189 other tissues |
ExpressionAtlasi | O94788, baseline and differential |
Genevisiblei | O94788, HS |
Organism-specific databases
HPAi | ENSG00000128918, Low tissue specificity |
Interactioni
Subunit structurei
Homotetramer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 114379, 11 interactors |
IntActi | O94788, 6 interactors |
STRINGi | 9606.ENSP00000249750 |
Chemistry databases
BindingDBi | O94788 |
Miscellaneous databases
RNActi | O94788, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O94788 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the aldehyde dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | KOG2450, Eukaryota |
GeneTreei | ENSGT00940000158898 |
HOGENOMi | CLU_005391_0_0_1 |
InParanoidi | O94788 |
OMAi | ERWSPAC |
OrthoDBi | 153834at2759 |
PhylomeDBi | O94788 |
TreeFami | TF300455 |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O94788-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTSSKIEMPG EVKADPAALM ASLHLLPSPT PNLEIKYTKI FINNEWQNSE
60 70 80 90 100
SGRVFPVYNP ATGEQVCEVQ EADKADIDKA VQAARLAFSL GSVWRRMDAS
110 120 130 140 150
ERGRLLDKLA DLVERDRAVL ATMESLNGGK PFLQAFYVDL QGVIKTFRYY
160 170 180 190 200
AGWADKIHGM TIPVDGDYFT FTRHEPIGVC GQIIPWNFPL LMFAWKIAPA
210 220 230 240 250
LCCGNTVVIK PAEQTPLSAL YMGALIKEAG FPPGVINILP GYGPTAGAAI
260 270 280 290 300
ASHIGIDKIA FTGSTEVGKL IQEAAGRSNL KRVTLELGGK SPNIIFADAD
310 320 330 340 350
LDYAVEQAHQ GVFFNQGQCC TAGSRIFVEE SIYEEFVRRS VERAKRRVVG
360 370 380 390 400
SPFDPTTEQG PQIDKKQYNK ILELIQSGVA EGAKLECGGK GLGRKGFFIE
410 420 430 440 450
PTVFSNVTDD MRIAKEEIFG PVQEILRFKT MDEVIERANN SDFGLVAAVF
460 470 480 490 500
TNDINKALTV SSAMQAGTVW INCYNALNAQ SPFGGFKMSG NGREMGEFGL
510
REYSEVKTVT VKIPQKNS
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YMG7 | H0YMG7_HUMAN | Retinal dehydrogenase 2 | ALDH1A2 | 489 | Annotation score: | ||
H0YKL3 | H0YKL3_HUMAN | Retinal dehydrogenase 2 | ALDH1A2 | 85 | Annotation score: | ||
Q9UED3 | Q9UED3_HUMAN | RALDH2-T | ALDH1A2 RALDH2 | 25 | Annotation score: | ||
E9PF31 | E9PF31_HUMAN | Retinal dehydrogenase 2 | ALDH1A2 | 40 | Annotation score: | ||
H0YMT5 | H0YMT5_HUMAN | Retinal dehydrogenase 2 | ALDH1A2 | 24 | Annotation score: | ||
A0A0G2JL97 | A0A0G2JL97_HUMAN | Retinal dehydrogenase 2 | ALDH1A2 | 9 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 231 | F → L in BAG64174 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_025439 | 50 | E → G1 PublicationCorresponds to variant dbSNP:rs34266719Ensembl. | 1 | |
Natural variantiVAR_025440 | 110 | A → V1 PublicationCorresponds to variant dbSNP:rs35365164Ensembl. | 1 | |
Natural variantiVAR_025441 | 348 | V → I4 PublicationsCorresponds to variant dbSNP:rs4646626Ensembl. | 1 | |
Natural variantiVAR_025442 | 436 | E → K1 PublicationCorresponds to variant dbSNP:rs34744827Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047259 | 1 – 96 | Missing in isoform 4. 1 PublicationAdd BLAST | 96 | |
Alternative sequenceiVSP_044496 | 1 – 39 | MTSSK…IKYTK → MKNQCETVWLKSPIKLKL in isoform 3. 1 PublicationAdd BLAST | 39 | |
Alternative sequenceiVSP_017363 | 229 – 266 | Missing in isoform 2. 1 PublicationAdd BLAST | 38 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB015226 mRNA Translation: BAA34785.1 AB015227 mRNA Translation: BAA34786.1 AB015228 mRNA Translation: BAA34787.1 AK128709 mRNA Translation: BAG54714.1 AK303057 mRNA Translation: BAG64174.1 DQ322171 Genomic DNA Translation: ABC40749.1 AC012653 Genomic DNA No translation available. AC018904 Genomic DNA No translation available. AC025431 Genomic DNA No translation available. AC066616 Genomic DNA No translation available. AC084781 Genomic DNA No translation available. BC030589 mRNA Translation: AAH30589.1 AL110299 mRNA Translation: CAB53740.2 |
CCDSi | CCDS10163.1 [O94788-1] CCDS10164.1 [O94788-2] CCDS45266.1 [O94788-4] CCDS55968.1 [O94788-3] |
PIRi | T14799 |
RefSeqi | NP_001193826.1, NM_001206897.1 [O94788-3] NP_003879.2, NM_003888.3 [O94788-1] NP_733797.1, NM_170696.2 [O94788-2] NP_733798.1, NM_170697.2 [O94788-4] |
Genome annotation databases
Ensembli | ENST00000249750; ENSP00000249750; ENSG00000128918 [O94788-1] ENST00000347587; ENSP00000309623; ENSG00000128918 [O94788-2] ENST00000537372; ENSP00000438296; ENSG00000128918 [O94788-3] ENST00000559517; ENSP00000453408; ENSG00000128918 [O94788-4] |
GeneIDi | 8854 |
KEGGi | hsa:8854 |
UCSCi | uc002aew.4, human [O94788-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB015226 mRNA Translation: BAA34785.1 AB015227 mRNA Translation: BAA34786.1 AB015228 mRNA Translation: BAA34787.1 AK128709 mRNA Translation: BAG54714.1 AK303057 mRNA Translation: BAG64174.1 DQ322171 Genomic DNA Translation: ABC40749.1 AC012653 Genomic DNA No translation available. AC018904 Genomic DNA No translation available. AC025431 Genomic DNA No translation available. AC066616 Genomic DNA No translation available. AC084781 Genomic DNA No translation available. BC030589 mRNA Translation: AAH30589.1 AL110299 mRNA Translation: CAB53740.2 |
CCDSi | CCDS10163.1 [O94788-1] CCDS10164.1 [O94788-2] CCDS45266.1 [O94788-4] CCDS55968.1 [O94788-3] |
PIRi | T14799 |
RefSeqi | NP_001193826.1, NM_001206897.1 [O94788-3] NP_003879.2, NM_003888.3 [O94788-1] NP_733797.1, NM_170696.2 [O94788-2] NP_733798.1, NM_170697.2 [O94788-4] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4X2Q | X-ray | 2.94 | A/B/C/D | 21-518 | [»] | |
6ALJ | X-ray | 1.89 | A/B/C/D | 26-518 | [»] | |
6B5G | X-ray | 2.20 | A/B/C/D | 26-518 | [»] | |
6B5H | X-ray | 2.30 | A/B/C/D | 26-518 | [»] | |
6B5I | X-ray | 2.60 | A/B/C/D | 26-518 | [»] | |
SMRi | O94788 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114379, 11 interactors |
IntActi | O94788, 6 interactors |
STRINGi | 9606.ENSP00000249750 |
Chemistry databases
BindingDBi | O94788 |
ChEMBLi | CHEMBL3112384 |
DrugBanki | DB00157, NADH DB00755, Tretinoin DB00162, Vitamin A |
DrugCentrali | O94788 |
PTM databases
iPTMneti | O94788 |
PhosphoSitePlusi | O94788 |
Polymorphism and mutation databases
BioMutai | ALDH1A2 |
Proteomic databases
EPDi | O94788 |
jPOSTi | O94788 |
MassIVEi | O94788 |
MaxQBi | O94788 |
PaxDbi | O94788 |
PeptideAtlasi | O94788 |
PRIDEi | O94788 |
ProteomicsDBi | 26115 40109 50442 [O94788-1] 50443 [O94788-2] |
Protocols and materials databases
Antibodypediai | 2127, 342 antibodies |
DNASUi | 8854 |
Genome annotation databases
Ensembli | ENST00000249750; ENSP00000249750; ENSG00000128918 [O94788-1] ENST00000347587; ENSP00000309623; ENSG00000128918 [O94788-2] ENST00000537372; ENSP00000438296; ENSG00000128918 [O94788-3] ENST00000559517; ENSP00000453408; ENSG00000128918 [O94788-4] |
GeneIDi | 8854 |
KEGGi | hsa:8854 |
UCSCi | uc002aew.4, human [O94788-1] |
Organism-specific databases
CTDi | 8854 |
DisGeNETi | 8854 |
EuPathDBi | HostDB:ENSG00000128918.14 |
GeneCardsi | ALDH1A2 |
HGNCi | HGNC:15472, ALDH1A2 |
HPAi | ENSG00000128918, Low tissue specificity |
MIMi | 603687, gene |
neXtProti | NX_O94788 |
OpenTargetsi | ENSG00000128918 |
PharmGKBi | PA24693 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2450, Eukaryota |
GeneTreei | ENSGT00940000158898 |
HOGENOMi | CLU_005391_0_0_1 |
InParanoidi | O94788 |
OMAi | ERWSPAC |
OrthoDBi | 153834at2759 |
PhylomeDBi | O94788 |
TreeFami | TF300455 |
Enzyme and pathway databases
UniPathwayi | UPA00912 |
BioCyci | MetaCyc:HS05232-MONOMER |
PathwayCommonsi | O94788 |
Reactomei | R-HSA-5365859, RA biosynthesis pathway |
Miscellaneous databases
BioGRID-ORCSi | 8854, 3 hits in 848 CRISPR screens |
ChiTaRSi | ALDH1A2, human |
GeneWikii | ALDH1A2 |
GenomeRNAii | 8854 |
Pharosi | O94788, Tbio |
PROi | PR:O94788 |
RNActi | O94788, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000128918, Expressed in adrenal tissue and 189 other tissues |
ExpressionAtlasi | O94788, baseline and differential |
Genevisiblei | O94788, HS |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AL1A2_HUMAN | |
Accessioni | O94788Primary (citable) accession number: O94788 Secondary accession number(s): B3KY52 Q9UFY0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | March 7, 2006 | |
Last modified: | December 2, 2020 | |
This is version 185 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations