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Protein

Ubiquitin carboxyl-terminal hydrolase 1

Gene

USP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029).4 Publications

Miscellaneous

HEK293T cells expressing reduced levels of USP1 show a higher level of ubiquitinated PCNA and an increase in point mutations upon UV irradiation.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.7 µM for ubiquitin vinyl sulfone (in presence of WDR48)1 Publication
  2. KM=1.4 µM for ubiquitin vinyl sulfone (in absence of WDR48)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei90Nucleophile3 Publications1
    Active sitei593Proton acceptorPROSITE-ProRule annotation1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • cysteine-type endopeptidase activity Source: GO_Central
    • peptidase activity Source: Reactome
    • thiol-dependent ubiquitin-specific protease activity Source: UniProtKB
    • thiol-dependent ubiquitinyl hydrolase activity Source: UniProtKB

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Protease, Thiol protease
    Biological processDNA damage, DNA repair, Ubl conjugation pathway

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex
    R-HSA-6783310 Fanconi Anemia Pathway

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    C19.019

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 1 (EC:3.4.19.125 Publications)
    Alternative name(s):
    Deubiquitinating enzyme 1
    Short name:
    hUBP
    Ubiquitin thioesterase 1
    Ubiquitin-specific-processing protease 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:USP1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000162607.12

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:12607 USP1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    603478 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_O94782

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi90C → S: Loss of catalytic activity including autolysis. 3 Publications1
    Mutagenesisi444E → K: Strongly reduces interaction with WDR48 and activation by WDR48. 1 Publication1
    Mutagenesisi670 – 671GG → AA: Loss of autolysis-mediated degradation upon UV irradiation. No effect on catalytic activity. 1 Publication2

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    7398

    Open Targets

    More...
    OpenTargetsi
    ENSG00000162607

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA37233

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL1795087

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    2428

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    USP1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000806151 – 785Ubiquitin carboxyl-terminal hydrolase 1Add BLAST785

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei16PhosphoserineCombined sources1
    Modified residuei42PhosphoserineCombined sources1
    Modified residuei67PhosphoserineCombined sources1
    Modified residuei313PhosphoserineCombined sources1
    Modified residuei475PhosphoserineCombined sources1
    Modified residuei768PhosphoserineBy similarity1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Autocatalytic cleavage of USP1 following UV irradiation inactivates it leading to an increase in ubiquitinated PCNA, recruitment of POLH and translesion synthesis.2 Publications
    Ubiquitinated; leading to its subsequent proteasomal degradation.By similarity

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei671 – 672Cleavage; by autolysis1 Publication2

    Keywords - PTMi

    Autocatalytic cleavage, Phosphoprotein, Ubl conjugation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    O94782

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    O94782

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    O94782

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    O94782

    PeptideAtlas

    More...
    PeptideAtlasi
    O94782

    PRoteomics IDEntifications database

    More...
    PRIDEi
    O94782

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    50441

    2D gel databases

    USC-OGP 2-DE database

    More...
    OGPi
    O94782

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    O94782

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    O94782

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

    Cell cycle-regulated. Highest level during S phase.1 Publication

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Down-regulated following DNA damage.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000162607 Expressed in 241 organ(s), highest expression level in secondary oocyte

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_USP1

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    O94782 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    O94782 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA028387
    HPA028440

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with FANCD2 and PCNA (PubMed:15694335, PubMed:16531995). Interacts with WDR48 (PubMed:18082604, PubMed:26388029).4 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    WithEntry#Exp.IntActNotes
    WDR48Q8TAF3-12EBI-2513396,EBI-16178048

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    113241, 69 interactors

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    O94782

    Database of interacting proteins

    More...
    DIPi
    DIP-53609N

    Protein interaction database and analysis system

    More...
    IntActi
    O94782, 34 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000343526

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    O94782

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    O94782

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    O94782

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini81 – 785USPAdd BLAST705

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1864 Eukaryota
    ENOG410XQ81 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00910000144243

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG017288

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    O94782

    KEGG Orthology (KO)

    More...
    KOi
    K11832

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    KWAISQF

    Database of Orthologous Groups

    More...
    OrthoDBi
    439300at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    O94782

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF331057

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd02671 Peptidase_C19O, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR038765 Papain_like_cys_pep_sf
    IPR001394 Peptidase_C19_UCH
    IPR033815 USP1
    IPR018200 USP_CS
    IPR028889 USP_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00443 UCH, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF54001 SSF54001, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00972 USP_1, 1 hit
    PS00973 USP_2, 1 hit
    PS50235 USP_3, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

    O94782-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MPGVIPSESN GLSRGSPSKK NRLSLKFFQK KETKRALDFT DSQENEEKAS
    60 70 80 90 100
    EYRASEIDQV VPAAQSSPIN CEKRENLLPF VGLNNLGNTC YLNSILQVLY
    110 120 130 140 150
    FCPGFKSGVK HLFNIISRKK EALKDEANQK DKGNCKEDSL ASYELICSLQ
    160 170 180 190 200
    SLIISVEQLQ ASFLLNPEKY TDELATQPRR LLNTLRELNP MYEGYLQHDA
    210 220 230 240 250
    QEVLQCILGN IQETCQLLKK EEVKNVAELP TKVEEIPHPK EEMNGINSIE
    260 270 280 290 300
    MDSMRHSEDF KEKLPKGNGK RKSDTEFGNM KKKVKLSKEH QSLEENQRQT
    310 320 330 340 350
    RSKRKATSDT LESPPKIIPK YISENESPRP SQKKSRVKIN WLKSATKQPS
    360 370 380 390 400
    ILSKFCSLGK ITTNQGVKGQ SKENECDPEE DLGKCESDNT TNGCGLESPG
    410 420 430 440 450
    NTVTPVNVNE VKPINKGEEQ IGFELVEKLF QGQLVLRTRC LECESLTERR
    460 470 480 490 500
    EDFQDISVPV QEDELSKVEE SSEISPEPKT EMKTLRWAIS QFASVERIVG
    510 520 530 540 550
    EDKYFCENCH HYTEAERSLL FDKMPEVITI HLKCFAASGL EFDCYGGGLS
    560 570 580 590 600
    KINTPLLTPL KLSLEEWSTK PTNDSYGLFA VVMHSGITIS SGHYTASVKV
    610 620 630 640 650
    TDLNSLELDK GNFVVDQMCE IGKPEPLNEE EARGVVENYN DEEVSIRVGG
    660 670 680 690 700
    NTQPSKVLNK KNVEAIGLLG GQKSKADYEL YNKASNPDKV ASTAFAENRN
    710 720 730 740 750
    SETSDTTGTH ESDRNKESSD QTGINISGFE NKISYVVQSL KEYEGKWLLF
    760 770 780
    DDSEVKVTEE KDFLNSLSPS TSPTSTPYLL FYKKL
    Length:785
    Mass (Da):88,207
    Last modified:May 1, 1999 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i50AA2817A60810AF
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    C9JC88C9JC88_HUMAN
    Ubiquitin carboxyl-terminal hydrola...
    USP1
    186Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    C9JWX4C9JWX4_HUMAN
    Ubiquitin carboxyl-terminal hydrola...
    USP1
    87Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAH18745 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
    The sequence AAH32364 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
    The sequence BAD92130 differs from that shown. Reason: Frameshift at position 230.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti621I → M in AAD11441 (Ref. 2) Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB014458 mRNA Translation: BAA34703.1
    AF117386 mRNA Translation: AAD11441.1
    AL117575 mRNA Translation: CAB55999.1
    AL117503 mRNA Translation: CAB55967.1
    AB208893 mRNA Translation: BAD92130.1 Frameshift.
    CH471059 Genomic DNA Translation: EAX06585.1
    CH471059 Genomic DNA Translation: EAX06586.1
    BC050525 mRNA Translation: AAH50525.1
    BC018745 mRNA Translation: AAH18745.1 Sequence problems.
    BC032364 mRNA Translation: AAH32364.1 Sequence problems.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS621.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    T17309

    NCBI Reference Sequences

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    RefSeqi
    NP_001017415.1, NM_001017415.1
    NP_001017416.1, NM_001017416.1
    NP_003359.3, NM_003368.4

    UniGene gene-oriented nucleotide sequence clusters

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    UniGenei
    Hs.35086

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

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    Ensembli
    ENST00000339950; ENSP00000343526; ENSG00000162607
    ENST00000371146; ENSP00000360188; ENSG00000162607

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    7398

    KEGG: Kyoto Encyclopedia of Genes and Genomes

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    KEGGi
    hsa:7398

    UCSC genome browser

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    UCSCi
    uc001daj.3 human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB014458 mRNA Translation: BAA34703.1
    AF117386 mRNA Translation: AAD11441.1
    AL117575 mRNA Translation: CAB55999.1
    AL117503 mRNA Translation: CAB55967.1
    AB208893 mRNA Translation: BAD92130.1 Frameshift.
    CH471059 Genomic DNA Translation: EAX06585.1
    CH471059 Genomic DNA Translation: EAX06586.1
    BC050525 mRNA Translation: AAH50525.1
    BC018745 mRNA Translation: AAH18745.1 Sequence problems.
    BC032364 mRNA Translation: AAH32364.1 Sequence problems.
    CCDSiCCDS621.1
    PIRiT17309
    RefSeqiNP_001017415.1, NM_001017415.1
    NP_001017416.1, NM_001017416.1
    NP_003359.3, NM_003368.4
    UniGeneiHs.35086

    3D structure databases

    ProteinModelPortaliO94782
    SMRiO94782
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi113241, 69 interactors
    CORUMiO94782
    DIPiDIP-53609N
    IntActiO94782, 34 interactors
    STRINGi9606.ENSP00000343526

    Chemistry databases

    BindingDBiO94782
    ChEMBLiCHEMBL1795087
    GuidetoPHARMACOLOGYi2428

    Protein family/group databases

    MEROPSiC19.019

    PTM databases

    iPTMnetiO94782
    PhosphoSitePlusiO94782

    Polymorphism and mutation databases

    BioMutaiUSP1

    2D gel databases

    OGPiO94782

    Proteomic databases

    EPDiO94782
    jPOSTiO94782
    MaxQBiO94782
    PaxDbiO94782
    PeptideAtlasiO94782
    PRIDEiO94782
    ProteomicsDBi50441

    Protocols and materials databases

    The DNASU plasmid repository

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    DNASUi
    7398
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000339950; ENSP00000343526; ENSG00000162607
    ENST00000371146; ENSP00000360188; ENSG00000162607
    GeneIDi7398
    KEGGihsa:7398
    UCSCiuc001daj.3 human

    Organism-specific databases

    Comparative Toxicogenomics Database

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    CTDi
    7398
    DisGeNETi7398
    EuPathDBiHostDB:ENSG00000162607.12

    GeneCards: human genes, protein and diseases

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    GeneCardsi
    USP1

    H-Invitational Database, human transcriptome db

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    H-InvDBi
    HIX0159950
    HGNCiHGNC:12607 USP1
    HPAiHPA028387
    HPA028440
    MIMi603478 gene
    neXtProtiNX_O94782
    OpenTargetsiENSG00000162607
    PharmGKBiPA37233

    GenAtlas: human gene database

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    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1864 Eukaryota
    ENOG410XQ81 LUCA
    GeneTreeiENSGT00910000144243
    HOVERGENiHBG017288
    InParanoidiO94782
    KOiK11832
    OMAiKWAISQF
    OrthoDBi439300at2759
    PhylomeDBiO94782
    TreeFamiTF331057

    Enzyme and pathway databases

    ReactomeiR-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex
    R-HSA-6783310 Fanconi Anemia Pathway

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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    ChiTaRSi
    USP1 human

    The Gene Wiki collection of pages on human genes and proteins

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    GeneWikii
    USP1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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    GenomeRNAii
    7398

    Protein Ontology

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    PROi
    PR:O94782

    The Stanford Online Universal Resource for Clones and ESTs

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    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000162607 Expressed in 241 organ(s), highest expression level in secondary oocyte
    CleanExiHS_USP1
    ExpressionAtlasiO94782 baseline and differential
    GenevisibleiO94782 HS

    Family and domain databases

    CDDicd02671 Peptidase_C19O, 1 hit
    InterProiView protein in InterPro
    IPR038765 Papain_like_cys_pep_sf
    IPR001394 Peptidase_C19_UCH
    IPR033815 USP1
    IPR018200 USP_CS
    IPR028889 USP_dom
    PfamiView protein in Pfam
    PF00443 UCH, 1 hit
    SUPFAMiSSF54001 SSF54001, 1 hit
    PROSITEiView protein in PROSITE
    PS00972 USP_1, 1 hit
    PS00973 USP_2, 1 hit
    PS50235 USP_3, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBP1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94782
    Secondary accession number(s): A0PJ95
    , D3DQ57, Q05BX7, Q59H66, Q9UFR0, Q9UNJ3
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1999
    Last modified: January 16, 2019
    This is version 168 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
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