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Entry version 187 (25 May 2022)
Sequence version 1 (01 May 1999)
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Protein

Ubiquitin carboxyl-terminal hydrolase 1

Gene

USP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335).

Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995).

Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029).

4 Publications

Miscellaneous

HEK293T cells expressing reduced levels of USP1 show a higher level of ubiquitinated PCNA and an increase in point mutations upon UV irradiation.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.7 µM for ubiquitin vinyl sulfone (in presence of WDR48)1 Publication
  2. KM=1.4 µM for ubiquitin vinyl sulfone (in absence of WDR48)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei90Nucleophile3 Publications1
Active sitei593Proton acceptorPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processDNA damage, DNA repair, Ubl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O94782

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-110314, Recognition of DNA damage by PCNA-containing replication complex
R-HSA-6783310, Fanconi Anemia Pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O94782

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O94782

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C19.019

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 1 (EC:3.4.19.125 Publications)
Alternative name(s):
Deubiquitinating enzyme 1
Short name:
hUBP
Ubiquitin thioesterase 1
Ubiquitin-specific-processing protease 1
Cleaved into the following chain:
Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12607, USP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603478, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O94782

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000162607

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi90C → S: Loss of catalytic activity including autolysis. 3 Publications1
Mutagenesisi444E → K: Strongly reduces interaction with WDR48 and activation by WDR48. 1 Publication1
Mutagenesisi670 – 671GG → AA: Loss of autolysis-mediated degradation upon UV irradiation. No effect on catalytic activity. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
7398

Open Targets

More...
OpenTargetsi
ENSG00000162607

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37233

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O94782, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1795087

DrugCentral

More...
DrugCentrali
O94782

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2428

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
USP1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000806151 – 785Ubiquitin carboxyl-terminal hydrolase 1Add BLAST785
ChainiPRO_00004531621 – 671Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragmentAdd BLAST671

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei16PhosphoserineCombined sources1
Modified residuei42PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei313PhosphoserineCombined sources1
Modified residuei475PhosphoserineCombined sources1
Modified residuei768PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autocatalytic cleavage of USP1 following UV irradiation inactivates it leading to an increase in ubiquitinated PCNA, recruitment of POLH and translesion synthesis.2 Publications
Ubiquitinated by the CRL2(KLHDC2) complex following autocatalytic cleavage, leading to its degradation: the CRL2(KLHDC2) complex recognizes the diglycine (Gly-Gly) at the C-terminus.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei671 – 672Cleavage; by autolysis1 Publication2

Keywords - PTMi

Autocatalytic cleavage, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-952

Encyclopedia of Proteome Dynamics

More...
EPDi
O94782

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O94782

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O94782

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O94782

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94782

PeptideAtlas

More...
PeptideAtlasi
O94782

PRoteomics IDEntifications database

More...
PRIDEi
O94782

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
50441

2D gel databases

USC-OGP 2-DE database

More...
OGPi
O94782

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O94782

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O94782

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Cell cycle-regulated. Highest level during S phase.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated following DNA damage.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162607, Expressed in secondary oocyte and 252 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O94782, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O94782, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000162607, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FANCD2 and PCNA (PubMed:15694335, PubMed:16531995).

Interacts with WDR48 (PubMed:18082604, PubMed:26388029).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
113241, 99 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O94782

Database of interacting proteins

More...
DIPi
DIP-53609N

Protein interaction database and analysis system

More...
IntActi
O94782, 37 interactors

Molecular INTeraction database

More...
MINTi
O94782

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000343526

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O94782

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O94782, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1785
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
O94782

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O94782

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini81 – 785USPAdd BLAST705

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 21DisorderedSequence analysisAdd BLAST21
Regioni33 – 52DisorderedSequence analysisAdd BLAST20
Regioni258 – 336DisorderedSequence analysisAdd BLAST79
Regioni693 – 723DisorderedSequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi258 – 310Basic and acidic residuesSequence analysisAdd BLAST53
Compositional biasi704 – 718Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1864, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00910000144243

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_019874_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O94782

Identification of Orthologs from Complete Genome Data

More...
OMAi
HAIQDVN

Database of Orthologous Groups

More...
OrthoDBi
439300at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O94782

TreeFam database of animal gene trees

More...
TreeFami
TF331057

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02671, Peptidase_C19O, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR033815, USP1
IPR018200, USP_CS
IPR028889, USP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00443, UCH, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O94782-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGVIPSESN GLSRGSPSKK NRLSLKFFQK KETKRALDFT DSQENEEKAS
60 70 80 90 100
EYRASEIDQV VPAAQSSPIN CEKRENLLPF VGLNNLGNTC YLNSILQVLY
110 120 130 140 150
FCPGFKSGVK HLFNIISRKK EALKDEANQK DKGNCKEDSL ASYELICSLQ
160 170 180 190 200
SLIISVEQLQ ASFLLNPEKY TDELATQPRR LLNTLRELNP MYEGYLQHDA
210 220 230 240 250
QEVLQCILGN IQETCQLLKK EEVKNVAELP TKVEEIPHPK EEMNGINSIE
260 270 280 290 300
MDSMRHSEDF KEKLPKGNGK RKSDTEFGNM KKKVKLSKEH QSLEENQRQT
310 320 330 340 350
RSKRKATSDT LESPPKIIPK YISENESPRP SQKKSRVKIN WLKSATKQPS
360 370 380 390 400
ILSKFCSLGK ITTNQGVKGQ SKENECDPEE DLGKCESDNT TNGCGLESPG
410 420 430 440 450
NTVTPVNVNE VKPINKGEEQ IGFELVEKLF QGQLVLRTRC LECESLTERR
460 470 480 490 500
EDFQDISVPV QEDELSKVEE SSEISPEPKT EMKTLRWAIS QFASVERIVG
510 520 530 540 550
EDKYFCENCH HYTEAERSLL FDKMPEVITI HLKCFAASGL EFDCYGGGLS
560 570 580 590 600
KINTPLLTPL KLSLEEWSTK PTNDSYGLFA VVMHSGITIS SGHYTASVKV
610 620 630 640 650
TDLNSLELDK GNFVVDQMCE IGKPEPLNEE EARGVVENYN DEEVSIRVGG
660 670 680 690 700
NTQPSKVLNK KNVEAIGLLG GQKSKADYEL YNKASNPDKV ASTAFAENRN
710 720 730 740 750
SETSDTTGTH ESDRNKESSD QTGINISGFE NKISYVVQSL KEYEGKWLLF
760 770 780
DDSEVKVTEE KDFLNSLSPS TSPTSTPYLL FYKKL
Length:785
Mass (Da):88,207
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i50AA2817A60810AF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JC88C9JC88_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP1
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWX4C9JWX4_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP1
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH18745 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH32364 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAD92130 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti621I → M in AAD11441 (Ref. 2) Curated1

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB014458 mRNA Translation: BAA34703.1
AF117386 mRNA Translation: AAD11441.1
AL117575 mRNA Translation: CAB55999.1
AL117503 mRNA Translation: CAB55967.1
AB208893 mRNA Translation: BAD92130.1 Frameshift.
CH471059 Genomic DNA Translation: EAX06585.1
CH471059 Genomic DNA Translation: EAX06586.1
BC050525 mRNA Translation: AAH50525.1
BC018745 mRNA Translation: AAH18745.1 Sequence problems.
BC032364 mRNA Translation: AAH32364.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS621.1

Protein sequence database of the Protein Information Resource

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PIRi
T17309

NCBI Reference Sequences

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RefSeqi
NP_001017415.1, NM_001017415.1
NP_001017416.1, NM_001017416.1
NP_003359.3, NM_003368.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000339950.5; ENSP00000343526.4; ENSG00000162607.13
ENST00000371146.5; ENSP00000360188.1; ENSG00000162607.13

Database of genes from NCBI RefSeq genomes

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GeneIDi
7398

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7398

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

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MANE-Selecti
ENST00000339950.5; ENSP00000343526.4; NM_003368.5; NP_003359.3

UCSC genome browser

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UCSCi
uc001daj.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014458 mRNA Translation: BAA34703.1
AF117386 mRNA Translation: AAD11441.1
AL117575 mRNA Translation: CAB55999.1
AL117503 mRNA Translation: CAB55967.1
AB208893 mRNA Translation: BAD92130.1 Frameshift.
CH471059 Genomic DNA Translation: EAX06585.1
CH471059 Genomic DNA Translation: EAX06586.1
BC050525 mRNA Translation: AAH50525.1
BC018745 mRNA Translation: AAH18745.1 Sequence problems.
BC032364 mRNA Translation: AAH32364.1 Sequence problems.
CCDSiCCDS621.1
PIRiT17309
RefSeqiNP_001017415.1, NM_001017415.1
NP_001017416.1, NM_001017416.1
NP_003359.3, NM_003368.4

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6DO5X-ray2.50C/D666-671[»]
7AY0X-ray3.60B/D67-785[»]
7AY1electron microscopy3.70D1-785[»]
7AY2X-ray3.20B/E67-785[»]
AlphaFoldDBiO94782
SMRiO94782
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113241, 99 interactors
CORUMiO94782
DIPiDIP-53609N
IntActiO94782, 37 interactors
MINTiO94782
STRINGi9606.ENSP00000343526

Chemistry databases

BindingDBiO94782
ChEMBLiCHEMBL1795087
DrugCentraliO94782
GuidetoPHARMACOLOGYi2428

Protein family/group databases

MEROPSiC19.019

PTM databases

iPTMnetiO94782
PhosphoSitePlusiO94782

Genetic variation databases

BioMutaiUSP1

2D gel databases

OGPiO94782

Proteomic databases

CPTACiCPTAC-952
EPDiO94782
jPOSTiO94782
MassIVEiO94782
MaxQBiO94782
PaxDbiO94782
PeptideAtlasiO94782
PRIDEiO94782
ProteomicsDBi50441

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
33332, 345 antibodies from 34 providers

The DNASU plasmid repository

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DNASUi
7398

Genome annotation databases

EnsembliENST00000339950.5; ENSP00000343526.4; ENSG00000162607.13
ENST00000371146.5; ENSP00000360188.1; ENSG00000162607.13
GeneIDi7398
KEGGihsa:7398
MANE-SelectiENST00000339950.5; ENSP00000343526.4; NM_003368.5; NP_003359.3
UCSCiuc001daj.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7398
DisGeNETi7398

GeneCards: human genes, protein and diseases

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GeneCardsi
USP1
HGNCiHGNC:12607, USP1
HPAiENSG00000162607, Low tissue specificity
MIMi603478, gene
neXtProtiNX_O94782
OpenTargetsiENSG00000162607
PharmGKBiPA37233
VEuPathDBiHostDB:ENSG00000162607

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1864, Eukaryota
GeneTreeiENSGT00910000144243
HOGENOMiCLU_019874_0_0_1
InParanoidiO94782
OMAiHAIQDVN
OrthoDBi439300at2759
PhylomeDBiO94782
TreeFamiTF331057

Enzyme and pathway databases

PathwayCommonsiO94782
ReactomeiR-HSA-110314, Recognition of DNA damage by PCNA-containing replication complex
R-HSA-6783310, Fanconi Anemia Pathway
SignaLinkiO94782
SIGNORiO94782

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
7398, 140 hits in 1123 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
USP1, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
USP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7398
PharosiO94782, Tchem

Protein Ontology

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PROi
PR:O94782
RNActiO94782, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162607, Expressed in secondary oocyte and 252 other tissues
ExpressionAtlasiO94782, baseline and differential
GenevisibleiO94782, HS

Family and domain databases

CDDicd02671, Peptidase_C19O, 1 hit
InterProiView protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR033815, USP1
IPR018200, USP_CS
IPR028889, USP_dom
PfamiView protein in Pfam
PF00443, UCH, 2 hits
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94782
Secondary accession number(s): A0PJ95
, D3DQ57, Q05BX7, Q59H66, Q9UFR0, Q9UNJ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: May 25, 2022
This is version 187 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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