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Entry version 144 (08 May 2019)
Sequence version 2 (01 Nov 1999)
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Protein

Contactin-5

Gene

CNTN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Contactin-5
Alternative name(s):
Neural recognition molecule NB-2
Short name:
hNB-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CNTN5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2175 CNTN5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607219 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O94779

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
53942

Open Targets

More...
OpenTargetsi
ENSG00000149972

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26689

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CNTN5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001471719 – 1072Contactin-5Add BLAST1054
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000147181073 – 1100Removed in mature formSequence analysisAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi123 ↔ 173PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi217 ↔ 269PROSITE-ProRule annotation
Disulfide bondi322 ↔ 369PROSITE-ProRule annotation
Glycosylationi397N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi411 ↔ 458PROSITE-ProRule annotation
Glycosylationi449N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi503 ↔ 551PROSITE-ProRule annotation
Glycosylationi540N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi593 ↔ 650PROSITE-ProRule annotation
Glycosylationi779N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi816N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi931N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1002N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi1072GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O94779

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O94779

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94779

PeptideAtlas

More...
PeptideAtlasi
O94779

PRoteomics IDEntifications database

More...
PRIDEi
O94779

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50439
50440 [O94779-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O94779

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O94779

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain and kidney and at very low level in placenta. Not expressed in other tissues. In brain, it is highly expressed in the occipital lobe, amygdala, cerebral cortex, frontal lobe, thalamus and temporal lobe. Expressed at moderate level in the cerebellum, substantia nigra, putamen, medulla and hippocampus. Weakly expressed in the spinal cord and caudate nucleus. Weakly or not expressed in the corpus callosum.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000149972 Expressed in 84 organ(s), highest expression level in adrenal tissue

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O94779 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O94779 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039492
HPA041223

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PTPRG.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119823, 1 interactor

Protein interaction database and analysis system

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IntActi
O94779, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000435637

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11100
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4N68X-ray1.80A871-971[»]
5E52X-ray2.69A671-969[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O94779

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini99 – 190Ig-like C2-type 1Add BLAST92
Domaini196 – 282Ig-like C2-type 2Add BLAST87
Domaini300 – 385Ig-like C2-type 3Add BLAST86
Domaini390 – 474Ig-like C2-type 4Add BLAST85
Domaini480 – 567Ig-like C2-type 5Add BLAST88
Domaini571 – 660Ig-like C2-type 6Add BLAST90
Domaini673 – 771Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini776 – 873Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST98
Domaini878 – 972Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST95
Domaini977 – 1067Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST91

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3513 Eukaryota
ENOG410XSVG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158183

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000059617

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O94779

KEGG Orthology (KO)

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KOi
K06763

Identification of Orthologs from Complete Genome Data

More...
OMAi
VPSYRWL

Database of Orthologous Groups

More...
OrthoDBi
655902at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O94779

TreeFam database of animal gene trees

More...
TreeFami
TF351103

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 4 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 10 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032989 Contactin-5
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2

The PANTHER Classification System

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PANTHERi
PTHR44170:SF17 PTHR44170:SF17, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 4 hits
SM00409 IG, 6 hits
SM00408 IGc2, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 4 hits
PS50835 IG_LIKE, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94779-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSWKLMLF LSVTMCLSEY SKSLPGLSTS YAALLRIKKS SSSSLFGSKT
60 70 80 90 100
RPRYSSPSLG TLSASSPSWL GAAQNYYSPI NLYHSSDAFK QDESVDYGPV
110 120 130 140 150
FVQEPDDIIF PTDSDEKKVA LNCEVRGNPV PSYRWLRNGT EIDLESDYRY
160 170 180 190 200
SLIDGTFIIS NPSEAKDSGH YQCLATNTVG SILSREATLQ FAYLGNFSGR
210 220 230 240 250
TRSAVSVREG QGVVLMCSPP PHSPEIIYSW VFNEFPSFVA EDSRRFISQE
260 270 280 290 300
TGNLYISKVQ TSDVGSYICL VKNTVTNARV LSPPTPLTLR NDGVMGEYEP
310 320 330 340 350
KIEVHFPFTV TAAKGTTVKM ECFALGNPVP TITWMKVNGY IPSKARLRKS
360 370 380 390 400
QAVLEIPNVQ LDDAGIYECR AENSRGKNSF RGQLQVYTYP HWVEKLNDTQ
410 420 430 440 450
LDSGSPLRWE CKATGKPRPT YRWLKNGVPL SPQSRVEMVN GVLMIHNVNQ
460 470 480 490 500
SDAGMYQCLA ENKYGAIYAS AELKILASAP TFALNQLKKT IIVTKDQEVV
510 520 530 540 550
IECKPQGSPK PTISWKKGDR AVRENKRIAI LPDGSLRILN ASKSDEGKYV
560 570 580 590 600
CRGENVFGSA EIIASLSVKE PTRIELTPKR TELTVGESIV LNCKAIHDAS
610 620 630 640 650
LDVTFYWTLK GQPIDFEEEG GHFESIRAQA SSADLMIRNI LLMHAGRYGC
660 670 680 690 700
RVQTTADSVS DEAELLVRGP PGPPGIVIVE EITESTATLS WSPAADNHSP
710 720 730 740 750
ISSYNLQARS PFSLGWQTVK TVPEIITGDM ESAMAVDLNP WVEYEFRVVA
760 770 780 790 800
TNPIGTGDPS TPSRMIRTNE AVPKTAPTNV SGRSGRRHEL VIAWEPVSEE
810 820 830 840 850
FQNGEGFGYI VAFRPNGTRG WKEKMVTSSE ASKFIYRDES VPPLTPFEVK
860 870 880 890 900
VGVYNNKGDG PFSQIVVICS AEGEPSAAPT DVKATSVSVS EILVAWKHIK
910 920 930 940 950
ESLGRPQGFE VGYWKDMEQE DTAETVKTRG NESFVILTGL EGNTLYHFTV
960 970 980 990 1000
RAYNGAGYGP PSSEVSATTK KSPPSQAPSN LRWEQQGSQV SLGWEPVIPL
1010 1020 1030 1040 1050
ANESEVVGYK VFYRQEGHSN SQVIETQKLQ AVVPLPDAGV YIIEVRAYSE
1060 1070 1080 1090 1100
GGDGTASSQI RVPSYSGGKI TSAQSTLHSL STSSSSVTLL LALMIPSTSW
Length:1,100
Mass (Da):120,686
Last modified:November 1, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5883575D84AD030E
GO
Isoform 2 (identifier: O94779-2) [UniParc]FASTAAdd to basket
Also known as: Short, HNB-2s

The sequence of this isoform differs from the canonical sequence as follows:
     19-92: Missing.

Show »
Length:1,026
Mass (Da):112,706
Checksum:i0C5EF6D543EB74D8
GO
Isoform 3 (identifier: O94779-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     912-1100: Missing.

Note: No experimental confirmation available.
Show »
Length:911
Mass (Da):100,327
Checksum:i23C1BE9D77447C59
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WTT8A0A087WTT8_HUMAN
Contactin-5
CNTN5
1,022Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQX5A0A0A0MQX5_HUMAN
Contactin-5
CNTN5
1,084Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH39255 differs from that shown. Reason: Erroneous termination at position 223. Translated as Ser.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01990723S → A. Corresponds to variant dbSNP:rs10790978Ensembl.1
Natural variantiVAR_01990870L → R. Corresponds to variant dbSNP:rs7125822Ensembl.1
Natural variantiVAR_01990981N → S. Corresponds to variant dbSNP:rs10893933Ensembl.1
Natural variantiVAR_019910530I → V1 PublicationCorresponds to variant dbSNP:rs11223168Ensembl.1
Natural variantiVAR_0199111065Y → F. Corresponds to variant dbSNP:rs1944169Ensembl.1
Natural variantiVAR_0199121079S → T1 PublicationCorresponds to variant dbSNP:rs1216183Ensembl.1
Natural variantiVAR_0336101094M → V. Corresponds to variant dbSNP:rs35208161Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01196719 – 92Missing in isoform 2. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_045995912 – 1100Missing in isoform 3. 1 PublicationAdd BLAST189

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB013802 mRNA Translation: BAA36579.2
AB013803 mRNA Translation: BAA36580.2
AP000760 Genomic DNA No translation available.
AP000798 Genomic DNA No translation available.
AP000923 Genomic DNA No translation available.
AP001892 Genomic DNA No translation available.
AP001988 Genomic DNA No translation available.
AP002378 Genomic DNA No translation available.
AP002428 Genomic DNA No translation available.
AP002987 Genomic DNA No translation available.
AP003126 Genomic DNA No translation available.
AP003441 Genomic DNA No translation available.
AP003558 Genomic DNA No translation available.
AP004249 Genomic DNA No translation available.
BC039255 mRNA Translation: AAH39255.1 Sequence problems.
BC130619 mRNA Translation: AAI30620.1
BC144185 mRNA Translation: AAI44186.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS53696.1 [O94779-1]
CCDS53697.1 [O94779-2]
CCDS58168.1 [O94779-4]

NCBI Reference Sequences

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RefSeqi
NP_001230199.1, NM_001243270.1 [O94779-1]
NP_001230200.1, NM_001243271.1 [O94779-4]
NP_055176.1, NM_014361.3 [O94779-1]
NP_780775.1, NM_175566.2 [O94779-2]
XP_011541173.1, XM_011542871.1 [O94779-2]
XP_016873415.1, XM_017017926.1 [O94779-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000418526; ENSP00000393229; ENSG00000149972 [O94779-2]
ENST00000524871; ENSP00000435637; ENSG00000149972 [O94779-1]
ENST00000527185; ENSP00000433575; ENSG00000149972 [O94779-4]
ENST00000528682; ENSP00000436185; ENSG00000149972 [O94779-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
53942

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:53942

UCSC genome browser

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UCSCi
uc001pfz.4 human [O94779-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013802 mRNA Translation: BAA36579.2
AB013803 mRNA Translation: BAA36580.2
AP000760 Genomic DNA No translation available.
AP000798 Genomic DNA No translation available.
AP000923 Genomic DNA No translation available.
AP001892 Genomic DNA No translation available.
AP001988 Genomic DNA No translation available.
AP002378 Genomic DNA No translation available.
AP002428 Genomic DNA No translation available.
AP002987 Genomic DNA No translation available.
AP003126 Genomic DNA No translation available.
AP003441 Genomic DNA No translation available.
AP003558 Genomic DNA No translation available.
AP004249 Genomic DNA No translation available.
BC039255 mRNA Translation: AAH39255.1 Sequence problems.
BC130619 mRNA Translation: AAI30620.1
BC144185 mRNA Translation: AAI44186.1
CCDSiCCDS53696.1 [O94779-1]
CCDS53697.1 [O94779-2]
CCDS58168.1 [O94779-4]
RefSeqiNP_001230199.1, NM_001243270.1 [O94779-1]
NP_001230200.1, NM_001243271.1 [O94779-4]
NP_055176.1, NM_014361.3 [O94779-1]
NP_780775.1, NM_175566.2 [O94779-2]
XP_011541173.1, XM_011542871.1 [O94779-2]
XP_016873415.1, XM_017017926.1 [O94779-1]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4N68X-ray1.80A871-971[»]
5E52X-ray2.69A671-969[»]
SMRiO94779
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119823, 1 interactor
IntActiO94779, 2 interactors
STRINGi9606.ENSP00000435637

PTM databases

iPTMnetiO94779
PhosphoSitePlusiO94779

Polymorphism and mutation databases

BioMutaiCNTN5

Proteomic databases

EPDiO94779
jPOSTiO94779
PaxDbiO94779
PeptideAtlasiO94779
PRIDEiO94779
ProteomicsDBi50439
50440 [O94779-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000418526; ENSP00000393229; ENSG00000149972 [O94779-2]
ENST00000524871; ENSP00000435637; ENSG00000149972 [O94779-1]
ENST00000527185; ENSP00000433575; ENSG00000149972 [O94779-4]
ENST00000528682; ENSP00000436185; ENSG00000149972 [O94779-1]
GeneIDi53942
KEGGihsa:53942
UCSCiuc001pfz.4 human [O94779-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
53942
DisGeNETi53942

GeneCards: human genes, protein and diseases

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GeneCardsi
CNTN5
HGNCiHGNC:2175 CNTN5
HPAiHPA039492
HPA041223
MIMi607219 gene
neXtProtiNX_O94779
OpenTargetsiENSG00000149972
PharmGKBiPA26689

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3513 Eukaryota
ENOG410XSVG LUCA
GeneTreeiENSGT00940000158183
HOGENOMiHOG000059617
InParanoidiO94779
KOiK06763
OMAiVPSYRWL
OrthoDBi655902at2759
PhylomeDBiO94779
TreeFamiTF351103

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CNTN5 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
53942

Protein Ontology

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PROi
PR:O94779

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000149972 Expressed in 84 organ(s), highest expression level in adrenal tissue
ExpressionAtlasiO94779 baseline and differential
GenevisibleiO94779 HS

Family and domain databases

CDDicd00063 FN3, 4 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR032989 Contactin-5
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PANTHERiPTHR44170:SF17 PTHR44170:SF17, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 4 hits
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SM00409 IG, 6 hits
SM00408 IGc2, 6 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS50835 IG_LIKE, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNTN5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94779
Secondary accession number(s): A1L4P0
, B7ZM07, E9PKE8, O94780, Q49AF3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 1, 1999
Last modified: May 8, 2019
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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