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UniProtKB - O94779 (CNTN5_HUMAN)

Entry version 156 (02 Dec 2020)
Sequence version 2 (01 Nov 1999)
Previous versions | rss
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Protein

Contactin-5

Gene

CNTN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O94779

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-163125, Post-translational modification: synthesis of GPI-anchored proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Contactin-5
Alternative name(s):
Neural recognition molecule NB-2
Short name:
hNB-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CNTN5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000149972.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:2175, CNTN5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607219, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O94779

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		53942

Open Targets

More...OpenTargetsi		ENSG00000149972

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26689

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O94779, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CNTN5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001471719 – 1072Contactin-5Add BLAST1054
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000147181073 – 1100Removed in mature formSequence analysisAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi123 ↔ 173PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi217 ↔ 269PROSITE-ProRule annotation
Disulfide bondi322 ↔ 369PROSITE-ProRule annotation
Glycosylationi397N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi411 ↔ 458PROSITE-ProRule annotation
Glycosylationi449N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi503 ↔ 551PROSITE-ProRule annotation
Glycosylationi540N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi593 ↔ 650PROSITE-ProRule annotation
Glycosylationi779N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi816N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi931N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1002N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi1072GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O94779

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O94779

PeptideAtlas

More...PeptideAtlasi		O94779

PRoteomics IDEntifications database

More...PRIDEi		O94779

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		21441
50439 [O94779-1]
50440 [O94779-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O94779, 9 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O94779

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O94779

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain and kidney and at very low level in placenta. Not expressed in other tissues. In brain, it is highly expressed in the occipital lobe, amygdala, cerebral cortex, frontal lobe, thalamus and temporal lobe. Expressed at moderate level in the cerebellum, substantia nigra, putamen, medulla and hippocampus. Weakly expressed in the spinal cord and caudate nucleus. Weakly or not expressed in the corpus callosum.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000149972, Expressed in adrenal tissue and 108 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O94779, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O94779, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000149972, Tissue enhanced (brain, pituitary gland, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PTPRG.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119823, 1 interactor

Protein interaction database and analysis system

More...IntActi		O94779, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000435637

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O94779, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11100
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O94779

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini99 – 190Ig-like C2-type 1Add BLAST92
Domaini196 – 282Ig-like C2-type 2Add BLAST87
Domaini300 – 385Ig-like C2-type 3Add BLAST86
Domaini390 – 474Ig-like C2-type 4Add BLAST85
Domaini480 – 567Ig-like C2-type 5Add BLAST88
Domaini571 – 660Ig-like C2-type 6Add BLAST90
Domaini673 – 771Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini776 – 873Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST98
Domaini878 – 972Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST95
Domaini977 – 1067Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST91

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily. Contactin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3513, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158183

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005756_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O94779

Identification of Orthologs from Complete Genome Data

More...OMAi		NGVPLWP

Database of Orthologous Groups

More...OrthoDBi		655902at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O94779

TreeFam database of animal gene trees

More...TreeFami		TF351103

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 4 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 10 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032989, Contactin-5
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2

The PANTHER Classification System

More...PANTHERi		PTHR44170:SF17, PTHR44170:SF17, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00041, fn3, 2 hits
PF07679, I-set, 4 hits
PF13895, Ig_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060, FN3, 4 hits
SM00409, IG, 6 hits
SM00408, IGc2, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 6 hits
SSF49265, SSF49265, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853, FN3, 4 hits
PS50835, IG_LIKE, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94779-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSWKLMLF LSVTMCLSEY SKSLPGLSTS YAALLRIKKS SSSSLFGSKT 
        60         70         80         90        100
RPRYSSPSLG TLSASSPSWL GAAQNYYSPI NLYHSSDAFK QDESVDYGPV 
       110        120        130        140        150
FVQEPDDIIF PTDSDEKKVA LNCEVRGNPV PSYRWLRNGT EIDLESDYRY 
       160        170        180        190        200
SLIDGTFIIS NPSEAKDSGH YQCLATNTVG SILSREATLQ FAYLGNFSGR 
       210        220        230        240        250
TRSAVSVREG QGVVLMCSPP PHSPEIIYSW VFNEFPSFVA EDSRRFISQE 
       260        270        280        290        300
TGNLYISKVQ TSDVGSYICL VKNTVTNARV LSPPTPLTLR NDGVMGEYEP 
       310        320        330        340        350
KIEVHFPFTV TAAKGTTVKM ECFALGNPVP TITWMKVNGY IPSKARLRKS 
       360        370        380        390        400
QAVLEIPNVQ LDDAGIYECR AENSRGKNSF RGQLQVYTYP HWVEKLNDTQ 
       410        420        430        440        450
LDSGSPLRWE CKATGKPRPT YRWLKNGVPL SPQSRVEMVN GVLMIHNVNQ 
       460        470        480        490        500
SDAGMYQCLA ENKYGAIYAS AELKILASAP TFALNQLKKT IIVTKDQEVV 
       510        520        530        540        550
IECKPQGSPK PTISWKKGDR AVRENKRIAI LPDGSLRILN ASKSDEGKYV 
       560        570        580        590        600
CRGENVFGSA EIIASLSVKE PTRIELTPKR TELTVGESIV LNCKAIHDAS 
       610        620        630        640        650
LDVTFYWTLK GQPIDFEEEG GHFESIRAQA SSADLMIRNI LLMHAGRYGC 
       660        670        680        690        700
RVQTTADSVS DEAELLVRGP PGPPGIVIVE EITESTATLS WSPAADNHSP 
       710        720        730        740        750
ISSYNLQARS PFSLGWQTVK TVPEIITGDM ESAMAVDLNP WVEYEFRVVA 
       760        770        780        790        800
TNPIGTGDPS TPSRMIRTNE AVPKTAPTNV SGRSGRRHEL VIAWEPVSEE 
       810        820        830        840        850
FQNGEGFGYI VAFRPNGTRG WKEKMVTSSE ASKFIYRDES VPPLTPFEVK 
       860        870        880        890        900
VGVYNNKGDG PFSQIVVICS AEGEPSAAPT DVKATSVSVS EILVAWKHIK 
       910        920        930        940        950
ESLGRPQGFE VGYWKDMEQE DTAETVKTRG NESFVILTGL EGNTLYHFTV 
       960        970        980        990       1000
RAYNGAGYGP PSSEVSATTK KSPPSQAPSN LRWEQQGSQV SLGWEPVIPL 
      1010       1020       1030       1040       1050
ANESEVVGYK VFYRQEGHSN SQVIETQKLQ AVVPLPDAGV YIIEVRAYSE 
      1060       1070       1080       1090       1100
GGDGTASSQI RVPSYSGGKI TSAQSTLHSL STSSSSVTLL LALMIPSTSW
Length:1,100
Mass (Da):120,686
Last modified:November 1, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5883575D84AD030E
GO
Isoform 2 (identifier: O94779-2) [UniParc]FASTAAdd to basket
Also known as: Short, HNB-2s

The sequence of this isoform differs from the canonical sequence as follows:
     19-92: Missing.

Show »
Length:1,026
Mass (Da):112,706
Checksum:i0C5EF6D543EB74D8
GO
Isoform 3 (identifier: O94779-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     912-1100: Missing.

Show »
Length:911
Mass (Da):100,327
Checksum:i23C1BE9D77447C59
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WTT8A0A087WTT8_HUMAN
Contactin-5
CNTN5
1,022Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQX5A0A0A0MQX5_HUMAN
Contactin-5
CNTN5
1,084Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH39255 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01990723S → A. Corresponds to variant dbSNP:rs10790978Ensembl.1
Natural variantiVAR_01990870L → R. Corresponds to variant dbSNP:rs7125822EnsemblClinVar.1
Natural variantiVAR_01990981N → S. Corresponds to variant dbSNP:rs10893933Ensembl.1
Natural variantiVAR_019910530I → V1 PublicationCorresponds to variant dbSNP:rs11223168Ensembl.1
Natural variantiVAR_0199111065Y → F. Corresponds to variant dbSNP:rs1944169EnsemblClinVar.1
Natural variantiVAR_0199121079S → T1 PublicationCorresponds to variant dbSNP:rs1216183Ensembl.1
Natural variantiVAR_0336101094M → V. Corresponds to variant dbSNP:rs35208161EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01196719 – 92Missing in isoform 2. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_045995912 – 1100Missing in isoform 3. 1 PublicationAdd BLAST189

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB013802 mRNA Translation: BAA36579.2
AB013803 mRNA Translation: BAA36580.2
AP000760 Genomic DNA No translation available.
AP000798 Genomic DNA No translation available.
AP000923 Genomic DNA No translation available.
AP001892 Genomic DNA No translation available.
AP001988 Genomic DNA No translation available.
AP002378 Genomic DNA No translation available.
AP002428 Genomic DNA No translation available.
AP002987 Genomic DNA No translation available.
AP003126 Genomic DNA No translation available.
AP003441 Genomic DNA No translation available.
AP003558 Genomic DNA No translation available.
AP004249 Genomic DNA No translation available.
BC039255 mRNA Translation: AAH39255.1 Sequence problems.
BC130619 mRNA Translation: AAI30620.1
BC144185 mRNA Translation: AAI44186.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS53696.1 [O94779-1]
CCDS53697.1 [O94779-2]
CCDS58168.1 [O94779-4]

NCBI Reference Sequences

More...RefSeqi		NP_001230199.1, NM_001243270.1 [O94779-1]
NP_001230200.1, NM_001243271.1 [O94779-4]
NP_055176.1, NM_014361.3 [O94779-1]
NP_780775.1, NM_175566.2 [O94779-2]
XP_011541173.1, XM_011542871.1 [O94779-2]
XP_016873415.1, XM_017017926.1 [O94779-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000418526; ENSP00000393229; ENSG00000149972 [O94779-2]
ENST00000524871; ENSP00000435637; ENSG00000149972 [O94779-1]
ENST00000527185; ENSP00000433575; ENSG00000149972 [O94779-4]
ENST00000528682; ENSP00000436185; ENSG00000149972 [O94779-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		53942

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:53942

UCSC genome browser

More...UCSCi		uc001pfz.4, human [O94779-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013802 mRNA Translation: BAA36579.2
AB013803 mRNA Translation: BAA36580.2
AP000760 Genomic DNA No translation available.
AP000798 Genomic DNA No translation available.
AP000923 Genomic DNA No translation available.
AP001892 Genomic DNA No translation available.
AP001988 Genomic DNA No translation available.
AP002378 Genomic DNA No translation available.
AP002428 Genomic DNA No translation available.
AP002987 Genomic DNA No translation available.
AP003126 Genomic DNA No translation available.
AP003441 Genomic DNA No translation available.
AP003558 Genomic DNA No translation available.
AP004249 Genomic DNA No translation available.
BC039255 mRNA Translation: AAH39255.1 Sequence problems.
BC130619 mRNA Translation: AAI30620.1
BC144185 mRNA Translation: AAI44186.1
CCDSiCCDS53696.1 [O94779-1]
CCDS53697.1 [O94779-2]
CCDS58168.1 [O94779-4]
RefSeqiNP_001230199.1, NM_001243270.1 [O94779-1]
NP_001230200.1, NM_001243271.1 [O94779-4]
NP_055176.1, NM_014361.3 [O94779-1]
NP_780775.1, NM_175566.2 [O94779-2]
XP_011541173.1, XM_011542871.1 [O94779-2]
XP_016873415.1, XM_017017926.1 [O94779-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4N68X-ray1.80A871-971[»]
5E52X-ray2.69A671-969[»]
SMRiO94779
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119823, 1 interactor
IntActiO94779, 3 interactors
STRINGi9606.ENSP00000435637

PTM databases

GlyGeniO94779, 9 sites
iPTMnetiO94779
PhosphoSitePlusiO94779

Polymorphism and mutation databases

BioMutaiCNTN5

Proteomic databases

MassIVEiO94779
PaxDbiO94779
PeptideAtlasiO94779
PRIDEiO94779
ProteomicsDBi21441
50439 [O94779-1]
50440 [O94779-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31696, 144 antibodies

Genome annotation databases

EnsembliENST00000418526; ENSP00000393229; ENSG00000149972 [O94779-2]
ENST00000524871; ENSP00000435637; ENSG00000149972 [O94779-1]
ENST00000527185; ENSP00000433575; ENSG00000149972 [O94779-4]
ENST00000528682; ENSP00000436185; ENSG00000149972 [O94779-1]
GeneIDi53942
KEGGihsa:53942
UCSCiuc001pfz.4, human [O94779-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		53942
DisGeNETi53942
EuPathDBiHostDB:ENSG00000149972.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		CNTN5
HGNCiHGNC:2175, CNTN5
HPAiENSG00000149972, Tissue enhanced (brain, pituitary gland, salivary gland)
MIMi607219, gene
neXtProtiNX_O94779
OpenTargetsiENSG00000149972
PharmGKBiPA26689

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3513, Eukaryota
GeneTreeiENSGT00940000158183
HOGENOMiCLU_005756_0_0_1
InParanoidiO94779
OMAiNGVPLWP
OrthoDBi655902at2759
PhylomeDBiO94779
TreeFamiTF351103

Enzyme and pathway databases

PathwayCommonsiO94779
ReactomeiR-HSA-163125, Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		53942, 2 hits in 841 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CNTN5, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		53942
PharosiO94779, Tbio

Protein Ontology

More...PROi		PR:O94779
RNActiO94779, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000149972, Expressed in adrenal tissue and 108 other tissues
ExpressionAtlasiO94779, baseline and differential
GenevisibleiO94779, HS

Family and domain databases

CDDicd00063, FN3, 4 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR032989, Contactin-5
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
PANTHERiPTHR44170:SF17, PTHR44170:SF17, 1 hit
PfamiView protein in Pfam
PF00041, fn3, 2 hits
PF07679, I-set, 4 hits
PF13895, Ig_2, 1 hit
SMARTiView protein in SMART
SM00060, FN3, 4 hits
SM00409, IG, 6 hits
SM00408, IGc2, 6 hits
SUPFAMiSSF48726, SSF48726, 6 hits
SSF49265, SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 4 hits
PS50835, IG_LIKE, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNTN5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94779
Secondary accession number(s): A1L4P0
, B7ZM07, E9PKE8, O94780, Q49AF3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 1, 1999
Last modified: December 2, 2020
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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