UniProtKB - O94779 (CNTN5_HUMAN)
Protein
Contactin-5
Gene
CNTN5
Organism
Homo sapiens (Human)
Status
Functioni
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system (By similarity).By similarity
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
- presynapse assembly Source: Ensembl
- sensory perception of sound Source: Ensembl
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | O94779 |
Reactomei | R-HSA-163125, Post-translational modification: synthesis of GPI-anchored proteins |
Names & Taxonomyi
Protein namesi | Recommended name: Contactin-5Alternative name(s): Neural recognition molecule NB-2 Short name: hNB-2 |
Gene namesi | Name:CNTN5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000149972.10 |
HGNCi | HGNC:2175, CNTN5 |
MIMi | 607219, gene |
neXtProti | NX_O94779 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; GPI-anchor By similarity
Extracellular region or secreted
- extracellular region Source: Reactome
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- anchored component of membrane Source: UniProtKB-KW
- GABA-ergic synapse Source: Ensembl
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 53942 |
OpenTargetsi | ENSG00000149972 |
PharmGKBi | PA26689 |
Miscellaneous databases
Pharosi | O94779, Tbio |
Polymorphism and mutation databases
BioMutai | CNTN5 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000014717 | 19 – 1072 | Contactin-5Add BLAST | 1054 | |
PropeptideiPRO_0000014718 | 1073 – 1100 | Removed in mature formSequence analysisAdd BLAST | 28 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 123 ↔ 173 | PROSITE-ProRule annotation | ||
Glycosylationi | 138 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 196 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 217 ↔ 269 | PROSITE-ProRule annotation | ||
Disulfide bondi | 322 ↔ 369 | PROSITE-ProRule annotation | ||
Glycosylationi | 397 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 411 ↔ 458 | PROSITE-ProRule annotation | ||
Glycosylationi | 449 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 503 ↔ 551 | PROSITE-ProRule annotation | ||
Glycosylationi | 540 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 593 ↔ 650 | PROSITE-ProRule annotation | ||
Glycosylationi | 779 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 816 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 931 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1002 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 1072 | GPI-anchor amidated serineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, LipoproteinProteomic databases
MassIVEi | O94779 |
PaxDbi | O94779 |
PeptideAtlasi | O94779 |
PRIDEi | O94779 |
ProteomicsDBi | 21441 50439 [O94779-1] 50440 [O94779-2] |
PTM databases
GlyGeni | O94779, 9 sites |
iPTMneti | O94779 |
PhosphoSitePlusi | O94779 |
Expressioni
Tissue specificityi
Expressed in brain and kidney and at very low level in placenta. Not expressed in other tissues. In brain, it is highly expressed in the occipital lobe, amygdala, cerebral cortex, frontal lobe, thalamus and temporal lobe. Expressed at moderate level in the cerebellum, substantia nigra, putamen, medulla and hippocampus. Weakly expressed in the spinal cord and caudate nucleus. Weakly or not expressed in the corpus callosum.1 Publication
Gene expression databases
Bgeei | ENSG00000149972, Expressed in adrenal tissue and 108 other tissues |
ExpressionAtlasi | O94779, baseline and differential |
Genevisiblei | O94779, HS |
Organism-specific databases
HPAi | ENSG00000149972, Tissue enhanced (brain, pituitary gland, salivary gland) |
Interactioni
Subunit structurei
Interacts with PTPRG.
1 PublicationProtein-protein interaction databases
BioGRIDi | 119823, 1 interactor |
IntActi | O94779, 3 interactors |
STRINGi | 9606.ENSP00000435637 |
Miscellaneous databases
RNActi | O94779, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O94779 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 99 – 190 | Ig-like C2-type 1Add BLAST | 92 | |
Domaini | 196 – 282 | Ig-like C2-type 2Add BLAST | 87 | |
Domaini | 300 – 385 | Ig-like C2-type 3Add BLAST | 86 | |
Domaini | 390 – 474 | Ig-like C2-type 4Add BLAST | 85 | |
Domaini | 480 – 567 | Ig-like C2-type 5Add BLAST | 88 | |
Domaini | 571 – 660 | Ig-like C2-type 6Add BLAST | 90 | |
Domaini | 673 – 771 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 99 | |
Domaini | 776 – 873 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 878 – 972 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 977 – 1067 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 91 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, SignalPhylogenomic databases
eggNOGi | KOG3513, Eukaryota |
GeneTreei | ENSGT00940000158183 |
HOGENOMi | CLU_005756_0_0_1 |
InParanoidi | O94779 |
OMAi | NGVPLWP |
OrthoDBi | 655902at2759 |
PhylomeDBi | O94779 |
TreeFami | TF351103 |
Family and domain databases
CDDi | cd00063, FN3, 4 hits |
Gene3Di | 2.60.40.10, 10 hits |
InterProi | View protein in InterPro IPR032989, Contactin-5 IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 |
PANTHERi | PTHR44170:SF17, PTHR44170:SF17, 1 hit |
Pfami | View protein in Pfam PF00041, fn3, 2 hits PF07679, I-set, 4 hits PF13895, Ig_2, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 4 hits SM00409, IG, 6 hits SM00408, IGc2, 6 hits |
SUPFAMi | SSF48726, SSF48726, 6 hits SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 4 hits PS50835, IG_LIKE, 6 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O94779-1) [UniParc]FASTAAdd to basket
Also known as: Long
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASSWKLMLF LSVTMCLSEY SKSLPGLSTS YAALLRIKKS SSSSLFGSKT
60 70 80 90 100
RPRYSSPSLG TLSASSPSWL GAAQNYYSPI NLYHSSDAFK QDESVDYGPV
110 120 130 140 150
FVQEPDDIIF PTDSDEKKVA LNCEVRGNPV PSYRWLRNGT EIDLESDYRY
160 170 180 190 200
SLIDGTFIIS NPSEAKDSGH YQCLATNTVG SILSREATLQ FAYLGNFSGR
210 220 230 240 250
TRSAVSVREG QGVVLMCSPP PHSPEIIYSW VFNEFPSFVA EDSRRFISQE
260 270 280 290 300
TGNLYISKVQ TSDVGSYICL VKNTVTNARV LSPPTPLTLR NDGVMGEYEP
310 320 330 340 350
KIEVHFPFTV TAAKGTTVKM ECFALGNPVP TITWMKVNGY IPSKARLRKS
360 370 380 390 400
QAVLEIPNVQ LDDAGIYECR AENSRGKNSF RGQLQVYTYP HWVEKLNDTQ
410 420 430 440 450
LDSGSPLRWE CKATGKPRPT YRWLKNGVPL SPQSRVEMVN GVLMIHNVNQ
460 470 480 490 500
SDAGMYQCLA ENKYGAIYAS AELKILASAP TFALNQLKKT IIVTKDQEVV
510 520 530 540 550
IECKPQGSPK PTISWKKGDR AVRENKRIAI LPDGSLRILN ASKSDEGKYV
560 570 580 590 600
CRGENVFGSA EIIASLSVKE PTRIELTPKR TELTVGESIV LNCKAIHDAS
610 620 630 640 650
LDVTFYWTLK GQPIDFEEEG GHFESIRAQA SSADLMIRNI LLMHAGRYGC
660 670 680 690 700
RVQTTADSVS DEAELLVRGP PGPPGIVIVE EITESTATLS WSPAADNHSP
710 720 730 740 750
ISSYNLQARS PFSLGWQTVK TVPEIITGDM ESAMAVDLNP WVEYEFRVVA
760 770 780 790 800
TNPIGTGDPS TPSRMIRTNE AVPKTAPTNV SGRSGRRHEL VIAWEPVSEE
810 820 830 840 850
FQNGEGFGYI VAFRPNGTRG WKEKMVTSSE ASKFIYRDES VPPLTPFEVK
860 870 880 890 900
VGVYNNKGDG PFSQIVVICS AEGEPSAAPT DVKATSVSVS EILVAWKHIK
910 920 930 940 950
ESLGRPQGFE VGYWKDMEQE DTAETVKTRG NESFVILTGL EGNTLYHFTV
960 970 980 990 1000
RAYNGAGYGP PSSEVSATTK KSPPSQAPSN LRWEQQGSQV SLGWEPVIPL
1010 1020 1030 1040 1050
ANESEVVGYK VFYRQEGHSN SQVIETQKLQ AVVPLPDAGV YIIEVRAYSE
1060 1070 1080 1090 1100
GGDGTASSQI RVPSYSGGKI TSAQSTLHSL STSSSSVTLL LALMIPSTSW
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WTT8 | A0A087WTT8_HUMAN | Contactin-5 | CNTN5 | 1,022 | Annotation score: | ||
A0A0A0MQX5 | A0A0A0MQX5_HUMAN | Contactin-5 | CNTN5 | 1,084 | Annotation score: |
Sequence cautioni
The sequence AAH39255 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019907 | 23 | S → A. Corresponds to variant dbSNP:rs10790978Ensembl. | 1 | |
Natural variantiVAR_019908 | 70 | L → R. Corresponds to variant dbSNP:rs7125822EnsemblClinVar. | 1 | |
Natural variantiVAR_019909 | 81 | N → S. Corresponds to variant dbSNP:rs10893933Ensembl. | 1 | |
Natural variantiVAR_019910 | 530 | I → V1 PublicationCorresponds to variant dbSNP:rs11223168Ensembl. | 1 | |
Natural variantiVAR_019911 | 1065 | Y → F. Corresponds to variant dbSNP:rs1944169EnsemblClinVar. | 1 | |
Natural variantiVAR_019912 | 1079 | S → T1 PublicationCorresponds to variant dbSNP:rs1216183Ensembl. | 1 | |
Natural variantiVAR_033610 | 1094 | M → V. Corresponds to variant dbSNP:rs35208161EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011967 | 19 – 92 | Missing in isoform 2. 1 PublicationAdd BLAST | 74 | |
Alternative sequenceiVSP_045995 | 912 – 1100 | Missing in isoform 3. 1 PublicationAdd BLAST | 189 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB013802 mRNA Translation: BAA36579.2 AB013803 mRNA Translation: BAA36580.2 AP000760 Genomic DNA No translation available. AP000798 Genomic DNA No translation available. AP000923 Genomic DNA No translation available. AP001892 Genomic DNA No translation available. AP001988 Genomic DNA No translation available. AP002378 Genomic DNA No translation available. AP002428 Genomic DNA No translation available. AP002987 Genomic DNA No translation available. AP003126 Genomic DNA No translation available. AP003441 Genomic DNA No translation available. AP003558 Genomic DNA No translation available. AP004249 Genomic DNA No translation available. BC039255 mRNA Translation: AAH39255.1 Sequence problems. BC130619 mRNA Translation: AAI30620.1 BC144185 mRNA Translation: AAI44186.1 |
CCDSi | CCDS53696.1 [O94779-1] CCDS53697.1 [O94779-2] CCDS58168.1 [O94779-4] |
RefSeqi | NP_001230199.1, NM_001243270.1 [O94779-1] NP_001230200.1, NM_001243271.1 [O94779-4] NP_055176.1, NM_014361.3 [O94779-1] NP_780775.1, NM_175566.2 [O94779-2] XP_011541173.1, XM_011542871.1 [O94779-2] XP_016873415.1, XM_017017926.1 [O94779-1] |
Genome annotation databases
Ensembli | ENST00000418526; ENSP00000393229; ENSG00000149972 [O94779-2] ENST00000524871; ENSP00000435637; ENSG00000149972 [O94779-1] ENST00000527185; ENSP00000433575; ENSG00000149972 [O94779-4] ENST00000528682; ENSP00000436185; ENSG00000149972 [O94779-1] |
GeneIDi | 53942 |
KEGGi | hsa:53942 |
UCSCi | uc001pfz.4, human [O94779-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB013802 mRNA Translation: BAA36579.2 AB013803 mRNA Translation: BAA36580.2 AP000760 Genomic DNA No translation available. AP000798 Genomic DNA No translation available. AP000923 Genomic DNA No translation available. AP001892 Genomic DNA No translation available. AP001988 Genomic DNA No translation available. AP002378 Genomic DNA No translation available. AP002428 Genomic DNA No translation available. AP002987 Genomic DNA No translation available. AP003126 Genomic DNA No translation available. AP003441 Genomic DNA No translation available. AP003558 Genomic DNA No translation available. AP004249 Genomic DNA No translation available. BC039255 mRNA Translation: AAH39255.1 Sequence problems. BC130619 mRNA Translation: AAI30620.1 BC144185 mRNA Translation: AAI44186.1 |
CCDSi | CCDS53696.1 [O94779-1] CCDS53697.1 [O94779-2] CCDS58168.1 [O94779-4] |
RefSeqi | NP_001230199.1, NM_001243270.1 [O94779-1] NP_001230200.1, NM_001243271.1 [O94779-4] NP_055176.1, NM_014361.3 [O94779-1] NP_780775.1, NM_175566.2 [O94779-2] XP_011541173.1, XM_011542871.1 [O94779-2] XP_016873415.1, XM_017017926.1 [O94779-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4N68 | X-ray | 1.80 | A | 871-971 | [»] | |
5E52 | X-ray | 2.69 | A | 671-969 | [»] | |
SMRi | O94779 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119823, 1 interactor |
IntActi | O94779, 3 interactors |
STRINGi | 9606.ENSP00000435637 |
PTM databases
GlyGeni | O94779, 9 sites |
iPTMneti | O94779 |
PhosphoSitePlusi | O94779 |
Polymorphism and mutation databases
BioMutai | CNTN5 |
Proteomic databases
MassIVEi | O94779 |
PaxDbi | O94779 |
PeptideAtlasi | O94779 |
PRIDEi | O94779 |
ProteomicsDBi | 21441 50439 [O94779-1] 50440 [O94779-2] |
Protocols and materials databases
Antibodypediai | 31696, 144 antibodies |
Genome annotation databases
Ensembli | ENST00000418526; ENSP00000393229; ENSG00000149972 [O94779-2] ENST00000524871; ENSP00000435637; ENSG00000149972 [O94779-1] ENST00000527185; ENSP00000433575; ENSG00000149972 [O94779-4] ENST00000528682; ENSP00000436185; ENSG00000149972 [O94779-1] |
GeneIDi | 53942 |
KEGGi | hsa:53942 |
UCSCi | uc001pfz.4, human [O94779-1] |
Organism-specific databases
CTDi | 53942 |
DisGeNETi | 53942 |
EuPathDBi | HostDB:ENSG00000149972.10 |
GeneCardsi | CNTN5 |
HGNCi | HGNC:2175, CNTN5 |
HPAi | ENSG00000149972, Tissue enhanced (brain, pituitary gland, salivary gland) |
MIMi | 607219, gene |
neXtProti | NX_O94779 |
OpenTargetsi | ENSG00000149972 |
PharmGKBi | PA26689 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3513, Eukaryota |
GeneTreei | ENSGT00940000158183 |
HOGENOMi | CLU_005756_0_0_1 |
InParanoidi | O94779 |
OMAi | NGVPLWP |
OrthoDBi | 655902at2759 |
PhylomeDBi | O94779 |
TreeFami | TF351103 |
Enzyme and pathway databases
PathwayCommonsi | O94779 |
Reactomei | R-HSA-163125, Post-translational modification: synthesis of GPI-anchored proteins |
Miscellaneous databases
BioGRID-ORCSi | 53942, 2 hits in 841 CRISPR screens |
ChiTaRSi | CNTN5, human |
GenomeRNAii | 53942 |
Pharosi | O94779, Tbio |
PROi | PR:O94779 |
RNActi | O94779, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000149972, Expressed in adrenal tissue and 108 other tissues |
ExpressionAtlasi | O94779, baseline and differential |
Genevisiblei | O94779, HS |
Family and domain databases
CDDi | cd00063, FN3, 4 hits |
Gene3Di | 2.60.40.10, 10 hits |
InterProi | View protein in InterPro IPR032989, Contactin-5 IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 |
PANTHERi | PTHR44170:SF17, PTHR44170:SF17, 1 hit |
Pfami | View protein in Pfam PF00041, fn3, 2 hits PF07679, I-set, 4 hits PF13895, Ig_2, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 4 hits SM00409, IG, 6 hits SM00408, IGc2, 6 hits |
SUPFAMi | SSF48726, SSF48726, 6 hits SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 4 hits PS50835, IG_LIKE, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CNTN5_HUMAN | |
Accessioni | O94779Primary (citable) accession number: O94779 Secondary accession number(s): A1L4P0 Q49AF3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations