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Protein

Aquaporin-8

Gene

AQP8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea.

GO - Molecular functioni

GO - Biological processi

  • cellular response to cAMP Source: UniProtKB
  • water transport Source: Reactome

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-432047 Passive transport by Aquaporins

Protein family/group databases

TCDBi1.A.8.10.15 the major intrinsic protein (mip) family

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-8
Short name:
AQP-8
Gene namesi
Name:AQP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103375.10
HGNCiHGNC:642 AQP8
MIMi603750 gene
neXtProtiNX_O94778

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Topological domaini58 – 84ExtracellularSequence analysisAdd BLAST27
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 107CytoplasmicSequence analysis2
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 156ExtracellularSequence analysisAdd BLAST28
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Topological domaini178 – 183CytoplasmicSequence analysis6
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 228ExtracellularSequence analysisAdd BLAST24
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 261CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi343
OpenTargetsiENSG00000103375
PharmGKBiPA24926

Polymorphism and mutation databases

BioMutaiAQP8

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639611 – 261Aquaporin-8Add BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO94778
PeptideAtlasiO94778
PRIDEiO94778
ProteomicsDBi50438

Expressioni

Tissue specificityi

Expressed only in pancreas and colon.

Gene expression databases

BgeeiENSG00000103375 Expressed in 70 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_AQP8
ExpressionAtlasiO94778 baseline and differential
GenevisibleiO94778 HS

Organism-specific databases

HPAiHPA046259

Interactioni

Protein-protein interaction databases

IntActiO94778, 6 interactors
STRINGi9606.ENSP00000219660

Structurei

3D structure databases

ProteinModelPortaliO94778
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi92 – 94NPA 13
Motifi210 – 212NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223 Eukaryota
COG0580 LUCA
GeneTreeiENSGT00760000119223
HOGENOMiHOG000288286
HOVERGENiHBG100478
InParanoidiO94778
KOiK09869
OMAiVANHWDF
OrthoDBiEOG091G166T
PhylomeDBiO94778
TreeFamiTF312940

Family and domain databases

Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR023277 Aquaporin_8
IPR034294 Aquaporin_transptr
IPR000425 MIP
IPR022357 MIP_CS
PANTHERiPTHR19139 PTHR19139, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR02020 AQUAPORIN8
PR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O94778-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGEIAMCEP EFGNDKAREP SVGGRWRVSW YERFVQPCLV ELLGSALFIF
60 70 80 90 100
IGCLSVIENG TDTGLLQPAL AHGLALGLVI ATLGNISGGH FNPAVSLAAM
110 120 130 140 150
LIGGLNLVML LPYWVSQLLG GMLGAALAKA VSPEERFWNA SGAAFVTVQE
160 170 180 190 200
QGQVAGALVA EIILTTLLAL AVCMGAINEK TKGPLAPFSI GFAVTVDILA
210 220 230 240 250
GGPVSGGCMN PARAFGPAVV ANHWNFHWIY WLGPLLAGLL VGLLIRCFIG
260
DGKTRLILKA R
Length:261
Mass (Da):27,381
Last modified:May 10, 2004 - v2
Checksum:iB5328B07A2049B3B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGL6A0A0C4DGL6_HUMAN
Aquaporin-8
AQP8
255Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130A → V in BAA34223 (PubMed:9806845).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036484229I → M in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_021933260A → P. Corresponds to variant dbSNP:rs2287798Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013456 mRNA Translation: BAA34223.1
AF067797 mRNA Translation: AAF19050.1
BC040630 mRNA Translation: AAH40630.1
CCDSiCCDS10626.1
RefSeqiNP_001160.2, NM_001169.2
UniGeneiHs.176658

Genome annotation databases

EnsembliENST00000219660; ENSP00000219660; ENSG00000103375
GeneIDi343
KEGGihsa:343
UCSCiuc002doc.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013456 mRNA Translation: BAA34223.1
AF067797 mRNA Translation: AAF19050.1
BC040630 mRNA Translation: AAH40630.1
CCDSiCCDS10626.1
RefSeqiNP_001160.2, NM_001169.2
UniGeneiHs.176658

3D structure databases

ProteinModelPortaliO94778
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO94778, 6 interactors
STRINGi9606.ENSP00000219660

Protein family/group databases

TCDBi1.A.8.10.15 the major intrinsic protein (mip) family

Polymorphism and mutation databases

BioMutaiAQP8

Proteomic databases

PaxDbiO94778
PeptideAtlasiO94778
PRIDEiO94778
ProteomicsDBi50438

Protocols and materials databases

DNASUi343
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219660; ENSP00000219660; ENSG00000103375
GeneIDi343
KEGGihsa:343
UCSCiuc002doc.4 human

Organism-specific databases

CTDi343
DisGeNETi343
EuPathDBiHostDB:ENSG00000103375.10
GeneCardsiAQP8
HGNCiHGNC:642 AQP8
HPAiHPA046259
MIMi603750 gene
neXtProtiNX_O94778
OpenTargetsiENSG00000103375
PharmGKBiPA24926
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0223 Eukaryota
COG0580 LUCA
GeneTreeiENSGT00760000119223
HOGENOMiHOG000288286
HOVERGENiHBG100478
InParanoidiO94778
KOiK09869
OMAiVANHWDF
OrthoDBiEOG091G166T
PhylomeDBiO94778
TreeFamiTF312940

Enzyme and pathway databases

ReactomeiR-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-432047 Passive transport by Aquaporins

Miscellaneous databases

GeneWikiiAQP8
GenomeRNAii343
PROiPR:O94778
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103375 Expressed in 70 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_AQP8
ExpressionAtlasiO94778 baseline and differential
GenevisibleiO94778 HS

Family and domain databases

Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR023277 Aquaporin_8
IPR034294 Aquaporin_transptr
IPR000425 MIP
IPR022357 MIP_CS
PANTHERiPTHR19139 PTHR19139, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR02020 AQUAPORIN8
PR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAQP8_HUMAN
AccessioniPrimary (citable) accession number: O94778
Secondary accession number(s): Q8IUU3, Q9UIA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 10, 2004
Last modified: November 7, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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