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Entry version 156 (02 Jun 2021)
Sequence version 3 (23 Jan 2007)
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Protein

Dolichol phosphate-mannose biosynthesis regulatory protein

Gene

DPM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates the biosynthesis of dolichol phosphate-mannose (PubMed:10835346).

Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1 (PubMed:10835346).

Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis (PubMed:16162815).

May act by regulating the GPI-GNT complex (PubMed:10944123).

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:ENSG00000136908-MONOMER

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O94777

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-162699, Synthesis of dolichyl-phosphate mannose
R-HSA-162710, Synthesis of glycosylphosphatidylinositol (GPI)
R-HSA-4717374, Defective DPM1 causes DPM1-CDG (CDG-1e)
R-HSA-4719360, Defective DPM3 causes DPM3-CDG (CDG-1o)
R-HSA-4719377, Defective DPM2 causes DPM2-CDG (CDG-1u)

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O94777

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00378

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dolichol phosphate-mannose biosynthesis regulatory proteinCurated
Alternative name(s):
Dolichol-phosphate mannose synthase subunit 2
Short name:
DPM synthase subunit 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DPM2Imported
ORF Names:My026
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3006, DPM2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603564, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O94777

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000136908.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Congenital disorder of glycosylation 1U (CDG1U)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of congenital disorder of glycosylation, a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Some CDG1U patients have dystrophic changes seen on muscle biopsy and reduced O-mannosyl glycans on alpha-dystroglycan.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06974523Y → C in CDG1U. 1 PublicationCorresponds to variant dbSNP:rs397514503EnsemblClinVar.1

Keywords - Diseasei

Congenital disorder of glycosylation, Congenital muscular dystrophy, Disease variant, Dystroglycanopathy

Organism-specific databases

DisGeNET

More...
DisGeNETi
8818

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
DPM2

MalaCards human disease database

More...
MalaCardsi
DPM2
MIMi615042, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000136908

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
329178, Congenital muscular dystrophy with intellectual disability and severe epilepsy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27464

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O94777, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DPM2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002208732 – 84Dolichol phosphate-mannose biosynthesis regulatory proteinAdd BLAST83

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O94777

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94777

PeptideAtlas

More...
PeptideAtlasi
O94777

PRoteomics IDEntifications database

More...
PRIDEi
O94777

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
50437

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
O94777

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136908, Expressed in endometrium epithelium and 219 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O94777, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O94777, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000136908, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3 (PubMed:10835346).

Component of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex composed at least by PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY and DPM2 (PubMed:16162815).

Interacts with PIGA, PIGC and PIGQ (PubMed:10944123).

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
114345, 5 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O94777

Protein interaction database and analysis system

More...
IntActi
O94777, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000322181

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O94777, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O94777

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DPM2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3488, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001098

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_150144_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O94777

Identification of Orthologs from Complete Genome Data

More...
OMAi
WTLFMPF

Database of Orthologous Groups

More...
OrthoDBi
1605216at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O94777

TreeFam database of animal gene trees

More...
TreeFami
TF300257

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009914, DPM2

The PANTHER Classification System

More...
PANTHERi
PTHR15039, PTHR15039, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07297, DPM2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O94777-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATGTDQVVG LGLVAVSLII FTYYTAWVIL LPFIDSQHVI HKYFLPRAYA
60 70 80
VAIPLAAGLL LLLFVGLFIS YVMLKTKRVT KKAQ
Length:84
Mass (Da):9,312
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0247A0843A711EE9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T9C7Q5T9C7_HUMAN
Dolichol phosphate-mannose biosynth...
DPM2
130Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06974523Y → C in CDG1U. 1 PublicationCorresponds to variant dbSNP:rs397514503EnsemblClinVar.1
Natural variantiVAR_03389576T → S3 PublicationsCorresponds to variant dbSNP:rs7997EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB013361 mRNA Translation: BAA33974.1
AF061729 mRNA Translation: AAG43140.1
CR542134 mRNA Translation: CAG46931.1
AB451329 mRNA Translation: BAG70143.1
AB451473 mRNA Translation: BAG70287.1
AL157935 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87730.1
BC015233 mRNA Translation: AAH15233.1
BC107863 mRNA Translation: AAI07864.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6886.1

NCBI Reference Sequences

More...
RefSeqi
NP_003854.1, NM_003863.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314392; ENSP00000322181; ENSG00000136908

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8818

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8818

UCSC genome browser

More...
UCSCi
uc004bsv.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013361 mRNA Translation: BAA33974.1
AF061729 mRNA Translation: AAG43140.1
CR542134 mRNA Translation: CAG46931.1
AB451329 mRNA Translation: BAG70143.1
AB451473 mRNA Translation: BAG70287.1
AL157935 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87730.1
BC015233 mRNA Translation: AAH15233.1
BC107863 mRNA Translation: AAI07864.1
CCDSiCCDS6886.1
RefSeqiNP_003854.1, NM_003863.3

3D structure databases

SMRiO94777
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114345, 5 interactors
CORUMiO94777
IntActiO94777, 3 interactors
STRINGi9606.ENSP00000322181

Genetic variation databases

BioMutaiDPM2

Proteomic databases

MassIVEiO94777
PaxDbiO94777
PeptideAtlasiO94777
PRIDEiO94777
ProteomicsDBi50437
TopDownProteomicsiO94777

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
44831, 43 antibodies

The DNASU plasmid repository

More...
DNASUi
8818

Genome annotation databases

EnsembliENST00000314392; ENSP00000322181; ENSG00000136908
GeneIDi8818
KEGGihsa:8818
UCSCiuc004bsv.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8818
DisGeNETi8818

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DPM2
GeneReviewsiDPM2
HGNCiHGNC:3006, DPM2
HPAiENSG00000136908, Low tissue specificity
MalaCardsiDPM2
MIMi603564, gene
615042, phenotype
neXtProtiNX_O94777
OpenTargetsiENSG00000136908
Orphaneti329178, Congenital muscular dystrophy with intellectual disability and severe epilepsy
PharmGKBiPA27464
VEuPathDBiHostDB:ENSG00000136908.17

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3488, Eukaryota
GeneTreeiENSGT00390000001098
HOGENOMiCLU_150144_2_1_1
InParanoidiO94777
OMAiWTLFMPF
OrthoDBi1605216at2759
PhylomeDBiO94777
TreeFamiTF300257

Enzyme and pathway databases

UniPathwayiUPA00378
BioCyciMetaCyc:ENSG00000136908-MONOMER
PathwayCommonsiO94777
ReactomeiR-HSA-162699, Synthesis of dolichyl-phosphate mannose
R-HSA-162710, Synthesis of glycosylphosphatidylinositol (GPI)
R-HSA-4717374, Defective DPM1 causes DPM1-CDG (CDG-1e)
R-HSA-4719360, Defective DPM3 causes DPM3-CDG (CDG-1o)
R-HSA-4719377, Defective DPM2 causes DPM2-CDG (CDG-1u)
SIGNORiO94777

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
8818, 167 hits in 993 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DPM2, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DPM2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8818
PharosiO94777, Tdark

Protein Ontology

More...
PROi
PR:O94777
RNActiO94777, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000136908, Expressed in endometrium epithelium and 219 other tissues
ExpressionAtlasiO94777, baseline and differential
GenevisibleiO94777, HS

Family and domain databases

InterProiView protein in InterPro
IPR009914, DPM2
PANTHERiPTHR15039, PTHR15039, 1 hit
PfamiView protein in Pfam
PF07297, DPM2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPM2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94777
Secondary accession number(s): Q5XKK9, Q6FGH3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: June 2, 2021
This is version 156 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families
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