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Protein

Metastasis-associated protein MTA2

Gene

MTA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri367 – 394GATA-type; atypicalAdd BLAST28

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-3214815 HDACs deacetylate histones
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-6804758 Regulation of TP53 Activity through Acetylation
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-8943724 Regulation of PTEN gene transcription
SIGNORiO94776

Names & Taxonomyi

Protein namesi
Recommended name:
Metastasis-associated protein MTA2
Alternative name(s):
Metastasis-associated 1-like 1
Short name:
MTA1-L1 protein
p53 target protein in deacetylase complex
Gene namesi
Name:MTA2
Synonyms:MTA1L1, PID
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149480.6
HGNCiHGNC:7411 MTA2
MIMi603947 gene
neXtProtiNX_O94776

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9219
OpenTargetsiENSG00000149480
PharmGKBiPA31219

Polymorphism and mutation databases

BioMutaiMTA2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000834961 – 668Metastasis-associated protein MTA2Add BLAST668

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52PhosphoserineCombined sources1
Modified residuei54PhosphoserineCombined sources1
Modified residuei152N6-acetyllysineCombined sources1
Modified residuei433PhosphoserineCombined sources1
Modified residuei435PhosphoserineCombined sources1
Modified residuei460N6-acetyllysineBy similarity1
Cross-linki492Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3); alternateCurated
Cross-linki492Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki508Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei522N6-acetyllysineBy similarity1
Modified residuei531N6-acetyllysineBy similarity1
Modified residuei534PhosphothreonineCombined sources1
Modified residuei548PhosphoserineCombined sources1
Cross-linki559Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki595Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO94776
MaxQBiO94776
PaxDbiO94776
PeptideAtlasiO94776
PRIDEiO94776
ProteomicsDBi50436

PTM databases

iPTMnetiO94776
PhosphoSitePlusiO94776

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000149480
CleanExiHS_MTA2
ExpressionAtlasiO94776 baseline and differential
GenevisibleiO94776 HS

Organism-specific databases

HPAiCAB005315
CAB017522
HPA006214

Interactioni

Subunit structurei

Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with HDAC7, p53/TP53, MINT and MBD3 (By similarity). Interacts with PIMREG. Interacts with NACC2.By similarity3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • histone deacetylase binding Source: Ensembl
  • RNA polymerase II repressing transcription factor binding Source: BHF-UCL
  • RNA polymerase II transcription factor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi114652, 146 interactors
ComplexPortaliCPX-880 MBD2/NuRD nucleosome remodeling and deacetylase complex
CPX-922 MBD3/NuRD nucleosome remodeling and deacetylase complex
CORUMiO94776
DIPiDIP-46519N
IntActiO94776, 63 interactors
MINTiO94776
STRINGi9606.ENSP00000278823

Structurei

3D structure databases

ProteinModelPortaliO94776
SMRiO94776
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 144BAHPROSITE-ProRule annotationAdd BLAST144
Domaini145 – 256ELM2PROSITE-ProRule annotationAdd BLAST112
Domaini263 – 315SANTPROSITE-ProRule annotationAdd BLAST53

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri367 – 394GATA-type; atypicalAdd BLAST28

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3554 Eukaryota
ENOG410XSAJ LUCA
GeneTreeiENSGT00580000081398
HOGENOMiHOG000045387
HOVERGENiHBG002598
InParanoidiO94776
KOiK11660
OMAiGPPTPIN
OrthoDBiEOG091G04Z4
PhylomeDBiO94776
TreeFamiTF106444

Family and domain databases

InterProiView protein in InterPro
IPR001025 BAH_dom
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR035170 MTA1_R1
IPR037964 MTA2
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR000679 Znf_GATA
PANTHERiPTHR10865:SF4 PTHR10865:SF4, 1 hit
PfamiView protein in Pfam
PF01426 BAH, 1 hit
PF01448 ELM2, 1 hit
PF00320 GATA, 1 hit
PF17226 MTA_R1, 1 hit
SMARTiView protein in SMART
SM00439 BAH, 1 hit
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00401 ZnF_GATA, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51038 BAH, 1 hit
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O94776-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAANMYRVGD YVYFENSSSN PYLVRRIEEL NKTANGNVEA KVVCLFRRRD
60 70 80 90 100
ISSSLNSLAD SNAREFEEES KQPGVSEQQR HQLKHRELFL SRQFESLPAT
110 120 130 140 150
HIRGKCSVTL LNETDILSQY LEKEDCFFYS LVFDPVQKTL LADQGEIRVG
160 170 180 190 200
CKYQAEIPDR LVEGESDNRN QQKMEMKVWD PDNPLTDRQI DQFLVVARAV
210 220 230 240 250
GTFARALDCS SSIRQPSLHM SAAAASRDIT LFHAMDTLQR NGYDLAKAMS
260 270 280 290 300
TLVPQGGPVL CRDEMEEWSA SEAMLFEEAL EKYGKDFNDI RQDFLPWKSL
310 320 330 340 350
ASIVQFYYMW KTTDRYIQQK RLKAAEADSK LKQVYIPTYT KPNPNQIISV
360 370 380 390 400
GSKPGMNGAG FQKGLTCESC HTTQSAQWYA WGPPNMQCRL CASCWIYWKK
410 420 430 440 450
YGGLKTPTQL EGATRGTTEP HSRGHLSRPE AQSLSPYTTS ANRAKLLAKN
460 470 480 490 500
RQTFLLQTTK LTRLARRMCR DLLQPRRAAR RPYAPINANA IKAECSIRLP
510 520 530 540 550
KAAKTPLKIH PLVRLPLATI VKDLVAQAPL KPKTPRGTKT PINRNQLSQN
560 570 580 590 600
RGLGGIMVKR AYETMAGAGV PFSANGRPLA SGIRSSSQPA AKRQKLNPAD
610 620 630 640 650
APNPVVFVAT KDTRALRKAL THLEMRRAAR RPNLPLKVKP TLIAVRPPVP
660
LPAPSHPAST NEPIVLED
Length:668
Mass (Da):75,023
Last modified:May 1, 1999 - v1
Checksum:i65087AF798BA64EC
GO
Isoform 2 (identifier: O94776-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-173: Missing.

Note: No experimental confirmation available.
Show »
Length:495
Mass (Da):55,037
Checksum:iF6072C422C0F80C6
GO

Sequence cautioni

The sequence AAH23656 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75V → M in BAA36707 (PubMed:9929979).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0550831 – 173Missing in isoform 2. 2 PublicationsAdd BLAST173

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012922 Genomic DNA Translation: BAA36562.1
AB016591 mRNA Translation: BAA36707.1
AF295807 mRNA Translation: AAG02241.1
AK301569 mRNA Translation: BAG63063.1
CR749481 mRNA Translation: CAH18309.1
AP001458 Genomic DNA No translation available.
BC023656 mRNA Translation: AAH23656.1 Sequence problems.
BC053650 mRNA Translation: AAH53650.1
CCDSiCCDS8022.1 [O94776-1]
CCDS81576.1 [O94776-2]
RefSeqiNP_001317221.1, NM_001330292.1 [O94776-2]
NP_004730.2, NM_004739.3 [O94776-1]
UniGeneiHs.173043

Genome annotation databases

EnsembliENST00000278823; ENSP00000278823; ENSG00000149480 [O94776-1]
ENST00000524902; ENSP00000431346; ENSG00000149480 [O94776-2]
ENST00000527204; ENSP00000431797; ENSG00000149480 [O94776-2]
GeneIDi9219
KEGGihsa:9219
UCSCiuc001ntq.3 human [O94776-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMTA2_HUMAN
AccessioniPrimary (citable) accession number: O94776
Secondary accession number(s): Q68DB1, Q9UQB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: May 1, 1999
Last modified: July 18, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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