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Protein

Extracellular matrix protein 2

Gene

ECM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Promotes matrix assembly and cell adhesiveness.By similarity

GO - Molecular functioni

  • collagen V binding Source: GO_Central
  • heparin binding Source: GO_Central
  • integrin binding Source: ProtInc

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular matrix protein 2
Alternative name(s):
Matrix glycoprotein SC1/ECM2
Gene namesi
Name:ECM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000106823.12
HGNCiHGNC:3154 ECM2
MIMi603479 gene
neXtProtiNX_O94769

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1842
OpenTargetsiENSG00000106823
PharmGKBiPA27599

Polymorphism and mutation databases

BioMutaiECM2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003273121 – 699Extracellular matrix protein 2Add BLAST679

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi378N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi449N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi506N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO94769
PeptideAtlasiO94769
PRIDEiO94769
ProteomicsDBi50433
50434 [O94769-2]

PTM databases

GlyConnecti1229
iPTMnetiO94769
PhosphoSitePlusiO94769

Expressioni

Tissue specificityi

Expressed predominantly in adipose tissue as well as female-specific organs such as mammary gland, ovary, and uterus.

Gene expression databases

BgeeiENSG00000106823 Expressed in 207 organ(s), highest expression level in adipose tissue
CleanExiHS_ECM2
ExpressionAtlasiO94769 baseline and differential
GenevisibleiO94769 HS

Organism-specific databases

HPAiHPA035347

Interactioni

Subunit structurei

Interacts with numerous extracellular matrix proteins.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiO94769, 1 interactor
STRINGi9606.ENSP00000344758

Structurei

3D structure databases

ProteinModelPortaliO94769
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 158VWFCPROSITE-ProRule annotationAdd BLAST58
Domaini307 – 344LRRNTAdd BLAST38
Repeati368 – 388LRR 1Add BLAST21
Repeati394 – 415LRR 2Add BLAST22
Repeati416 – 436LRR 3Add BLAST21
Repeati439 – 459LRR 4Add BLAST21
Repeati465 – 484LRR 5Add BLAST20
Repeati486 – 507LRR 6Add BLAST22
Repeati510 – 530LRR 7Add BLAST21
Repeati536 – 557LRR 8Add BLAST22
Repeati558 – 578LRR 9Add BLAST21
Repeati582 – 602LRR 10Add BLAST21
Repeati609 – 630LRR 11Add BLAST22
Repeati632 – 653LRR 12Add BLAST22
Repeati661 – 684LRR 13Add BLAST24

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi294 – 296Cell attachment siteSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi270 – 281Poly-GluAdd BLAST12

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118969
HOGENOMiHOG000112319
HOVERGENiHBG031529
InParanoidiO94769
KOiK08119
OMAiVWSPKPC
OrthoDBiEOG091G03L1
PhylomeDBiO94769
TreeFamiTF330031

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR001007 VWF_dom
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
PF00093 VWC, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 12 hits
SM00214 VWC, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 12 hits
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O94769-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKIAVLFCFF LLIIFQTDFG KNEEIPRKQR RKIYHRRLRK SSTSHKHRSN
60 70 80 90 100
RQLGIQQTTV FTPVARLPIV NFDYSMEEKF ESFSSFPGVE SSYNVLPGKK
110 120 130 140 150
GHCLVKGITM YNKAVWSPEP CTTCLCSDGR VLCDETMCHP QRCPQTVIPE
160 170 180 190 200
GECCPVCSAT VSYSLLSGIA LNDRNEFSGD SSEQREPTNL LHKQLPPPQV
210 220 230 240 250
GMDRIVRKEA LQSEEDEEVK EEDTEQKRET PESRNQGQLY SEGDSRGGDR
260 270 280 290 300
KQRPGEERRL AHQQQRQGRE EEEDEEEEGE EGEEDEEDEE DPVRGDMFRM
310 320 330 340 350
PSRSPLPAPP RGTLRLPSGC SLSYRTISCI NAMLTQIPPL TAPQITSLEL
360 370 380 390 400
TGNSIASIPD EAFNGLPNLE RLDLSKNNIT SSGIGPKAFK LLKKLMRLNM
410 420 430 440 450
DGNNLIQIPS QLPSTLEELK VNENNLQAID EESLSDLNQL VTLELEGNNL
460 470 480 490 500
SEANVNPLAF KPLKSLAYLR LGKNKFRIIP QGLPGSIEEL YLENNQIEEI
510 520 530 540 550
TEICFNHTRK INVIVLRYNK IEENRIAPLA WINQENLESI DLSYNKLYHV
560 570 580 590 600
PSYLPKSLLH LVLLGNQIER IPGYVFGHME PGLEYLYLSF NKLADDGMDR
610 620 630 640 650
VSFYGAYHSL RELFLDHNDL KSIPPGIQEM KALHFLRLNN NKIRNILPEE
660 670 680 690
ICNAEEDDDS NLEHLHLENN YIKIREIPSY TFSCIRSYSS IVLKPQNIK
Length:699
Mass (Da):79,789
Last modified:May 1, 1999 - v1
Checksum:iE44E76A40A5C2742
GO
Isoform 2 (identifier: O94769-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-182: Missing.
     645-699: NILPEEICNA...SIVLKPQNIK → CVSDAVLETVTNRSDVAFPLW

Show »
Length:643
Mass (Da):73,348
Checksum:i7F7C9722614F657A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T9F4Q5T9F4_HUMAN
Extracellular matrix protein 2
ECM2
160Annotation score:
Q5T9F3Q5T9F3_HUMAN
Extracellular matrix protein 2
ECM2
164Annotation score:

Sequence cautioni

The sequence CAD97940 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02464656Q → P1 PublicationCorresponds to variant dbSNP:rs10120210Ensembl.1
Natural variantiVAR_052010109T → S. Corresponds to variant dbSNP:rs35496743Ensembl.1
Natural variantiVAR_052011204R → Q. Corresponds to variant dbSNP:rs34758505Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039114161 – 182Missing in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_039115645 – 699NILPE…PQNIK → CVSDAVLETVTNRSDVAFPL W in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011792 mRNA Translation: BAA33958.1
AK312820 mRNA Translation: BAG35677.1
BX537976 mRNA Translation: CAD97940.1 Different initiation.
AL137848 Genomic DNA No translation available.
AL157827 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62824.1
BC107493 mRNA Translation: AAI07494.1
CCDSiCCDS56578.1 [O94769-2]
CCDS6698.1 [O94769-1]
RefSeqiNP_001184224.1, NM_001197295.1
NP_001184225.1, NM_001197296.1 [O94769-2]
NP_001384.1, NM_001393.3 [O94769-1]
UniGeneiHs.117060

Genome annotation databases

EnsembliENST00000344604; ENSP00000344758; ENSG00000106823 [O94769-1]
ENST00000444490; ENSP00000393971; ENSG00000106823 [O94769-2]
GeneIDi1842
KEGGihsa:1842
UCSCiuc004asf.5 human [O94769-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011792 mRNA Translation: BAA33958.1
AK312820 mRNA Translation: BAG35677.1
BX537976 mRNA Translation: CAD97940.1 Different initiation.
AL137848 Genomic DNA No translation available.
AL157827 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62824.1
BC107493 mRNA Translation: AAI07494.1
CCDSiCCDS56578.1 [O94769-2]
CCDS6698.1 [O94769-1]
RefSeqiNP_001184224.1, NM_001197295.1
NP_001184225.1, NM_001197296.1 [O94769-2]
NP_001384.1, NM_001393.3 [O94769-1]
UniGeneiHs.117060

3D structure databases

ProteinModelPortaliO94769
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO94769, 1 interactor
STRINGi9606.ENSP00000344758

PTM databases

GlyConnecti1229
iPTMnetiO94769
PhosphoSitePlusiO94769

Polymorphism and mutation databases

BioMutaiECM2

Proteomic databases

PaxDbiO94769
PeptideAtlasiO94769
PRIDEiO94769
ProteomicsDBi50433
50434 [O94769-2]

Protocols and materials databases

DNASUi1842
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344604; ENSP00000344758; ENSG00000106823 [O94769-1]
ENST00000444490; ENSP00000393971; ENSG00000106823 [O94769-2]
GeneIDi1842
KEGGihsa:1842
UCSCiuc004asf.5 human [O94769-1]

Organism-specific databases

CTDi1842
DisGeNETi1842
EuPathDBiHostDB:ENSG00000106823.12
GeneCardsiECM2
HGNCiHGNC:3154 ECM2
HPAiHPA035347
MIMi603479 gene
neXtProtiNX_O94769
OpenTargetsiENSG00000106823
PharmGKBiPA27599
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118969
HOGENOMiHOG000112319
HOVERGENiHBG031529
InParanoidiO94769
KOiK08119
OMAiVWSPKPC
OrthoDBiEOG091G03L1
PhylomeDBiO94769
TreeFamiTF330031

Miscellaneous databases

GeneWikiiECM2
GenomeRNAii1842
PROiPR:O94769
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106823 Expressed in 207 organ(s), highest expression level in adipose tissue
CleanExiHS_ECM2
ExpressionAtlasiO94769 baseline and differential
GenevisibleiO94769 HS

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR001007 VWF_dom
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
PF00093 VWC, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 12 hits
SM00214 VWC, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 12 hits
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiECM2_HUMAN
AccessioniPrimary (citable) accession number: O94769
Secondary accession number(s): B2R730
, E2PU11, Q5T9F2, Q7Z3D0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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