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Entry version 189 (13 Feb 2019)
Sequence version 2 (30 Aug 2002)
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Protein

ATP-dependent DNA helicase Q5

Gene

RECQL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination.7 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi52 – 59ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent 3'-5' DNA helicase activity Source: GO_Central
  • DNA binding Source: GO_Central
  • DNA helicase activity Source: UniProtKB
  • four-way junction helicase activity Source: GO_Central
  • identical protein binding Source: IntAct
  • RNA polymerase II complex binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase
Biological processCell cycle, Cell division, DNA damage, DNA repair, DNA replication
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-dependent DNA helicase Q5 (EC:3.6.4.12)
Alternative name(s):
DNA helicase, RecQ-like type 5
Short name:
RecQ5
RecQ protein-like 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RECQL5
Synonyms:RECQ5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000108469.14

Human Gene Nomenclature Database

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HGNCi
HGNC:9950 RECQL5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603781 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O94762

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi157D → A: Abolishes helicase activity. 1
Mutagenesisi504W → A: Abolishes interaction with POLR2A. 1
Mutagenesisi508Y → A: Abolishes interaction with POLR2A. 1
Mutagenesisi515R → E: Abolishes interaction with POLR2A. 1
Mutagenesisi516K → E: Abolishes interaction with POLR2A. 1
Mutagenesisi550R → A: Impairs protein folding and abolishes interaction with POLR2A. 1 Publication1
Mutagenesisi552H → A: Abolishes interaction with POLR2A. 1
Mutagenesisi556L → E: Abolishes interaction with POLR2A. 1
Mutagenesisi584E → A or D: Abolishes interaction with POLR2A. 1 Publication1
Mutagenesisi597Y → A: Reduces interaction with POLR2A. 1 Publication1
Mutagenesisi598K → E: Abolishes interaction with POLR2A. 1
Mutagenesisi602L → D or E: Abolishes interaction with POLR2A. 1 Publication1
Mutagenesisi603K → E: Abolishes interaction with POLR2A. 1
Mutagenesisi666F → A: Abolishes interaction with RAD51. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9400

Open Targets

More...
OpenTargetsi
ENSG00000108469

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA34317

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RECQL5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002050551 – 991ATP-dependent DNA helicase Q5Add BLAST991

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei488PhosphoserineBy similarity1
Modified residuei491PhosphoserineCombined sources1
Modified residuei727PhosphoserineCombined sources1
Modified residuei815PhosphoserineCombined sources1
Modified residuei839PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O94762

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O94762

MaxQB - The MaxQuant DataBase

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MaxQBi
O94762

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O94762

PeptideAtlas

More...
PeptideAtlasi
O94762

PRoteomics IDEntifications database

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PRIDEi
O94762

ProteomicsDB human proteome resource

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ProteomicsDBi
50425
50426 [O94762-2]
50427 [O94762-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O94762

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O94762

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000108469 Expressed in 164 organ(s), highest expression level in lower esophagus mucosa

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O94762 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O94762 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA029971

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Interacts with TOP2A, TOP3A and TOP3B. Isoform beta interacts with RNA polymerase II subunit POLR2A. Identified in a complex with the RNA polymerase II core bound to DNA. Isoform beta interacts with RAD51.5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
POLR2AP249288EBI-15710057,EBI-295301

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114797, 59 interactors

Database of interacting proteins

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DIPi
DIP-32964N

Protein interaction database and analysis system

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IntActi
O94762, 33 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000317636

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1991
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BK0X-ray1.90A/B515-620[»]
5LB3X-ray1.80B/E11-453[»]
5LB5X-ray2.00A/B/C/D11-453[»]
5LB8X-ray3.40A/D11-526[»]
5LBAX-ray2.50A/B/C/D11-453[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O94762

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O94762

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 213Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST175
Domaini241 – 403Helicase C-terminalPROSITE-ProRule annotationAdd BLAST163

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni490 – 620Interaction with POLR2AAdd BLAST131
Regioni652 – 725Interaction with RAD51Add BLAST74

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi157 – 160DEAH box4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. RecQ subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0352 Eukaryota
COG0514 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157800

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000206773

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG061479

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O94762

KEGG Orthology (KO)

More...
KOi
K10902

Identification of Orthologs from Complete Genome Data

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OMAi
PACTKGC

Database of Orthologous Groups

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OrthoDBi
445763at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O94762

TreeFam database of animal gene trees

More...
TreeFami
TF317614

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00079 HELICc, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR004589 DNA_helicase_ATP-dep_RecQ
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR010716 RECQ5
IPR032284 RecQ_Zn-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF06959 RecQ5, 1 hit
PF16124 RecQ_Zn_bind, 1 hit

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD120154 RecQ_helicase-like_5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00614 recQ_fam, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform Beta (identifier: O94762-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSHHTTFPF DPERRVRSTL KKVFGFDSFK TPLQESATMA VVKGNKDVFV
60 70 80 90 100
CMPTGAGKSL CYQLPALLAK GITIVVSPLI ALIQDQVDHL LTLKVRVSSL
110 120 130 140 150
NSKLSAQERK ELLADLEREK PQTKILYITP EMAASSSFQP TLNSLVSRHL
160 170 180 190 200
LSYLVVDEAH CVSQWGHDFR PDYLRLGALR SRLGHAPCVA LTATATPQVQ
210 220 230 240 250
EDVFAALHLK KPVAIFKTPC FRANLFYDVQ FKELISDPYG NLKDFCLKAL
260 270 280 290 300
GQEADKGLSG CGIVYCRTRE ACEQLAIELS CRGVNAKAYH AGLKASERTL
310 320 330 340 350
VQNDWMEEKV PVIVATISFG MGVDKANVRF VAHWNIAKSM AGYYQESGRA
360 370 380 390 400
GRDGKPSWCR LYYSRNDRDQ VSFLIRKEVA KLQEKRGNKA SDKATIMAFD
410 420 430 440 450
ALVTFCEELG CRHAAIAKYF GDALPACAKG CDHCQNPTAV RRRLEALERS
460 470 480 490 500
SSWSKTCIGP SQGNGFDPEL YEGGRKGYGD FSRYDEGSGG SGDEGRDEAH
510 520 530 540 550
KREWNLFYQK QMQLRKGKDP KIEEFVPPDE NCPLKEASSR RIPRLTVKAR
560 570 580 590 600
EHCLRLLEEA LSSNRQSTRT ADEADLRAKA VELEHETFRN AKVANLYKAS
610 620 630 640 650
VLKKVADIHR ASKDGQPYDM GGSAKSCSAQ AEPPEPNEYD IPPASHVYSL
660 670 680 690 700
KPKRVGAGFP KGSCPFQTAT ELMETTRIRE QAPQPERGGE HEPPSRPCGL
710 720 730 740 750
LDEDGSEPLP GPRGEVPGGS AHYGGPSPEK KAKSSSGGSS LAKGRASKKQ
760 770 780 790 800
QLLATAAHKD SQSIARFFCR RVESPALLAS APEAEGACPS CEGVQGPPMA
810 820 830 840 850
PEKYTGEEDG AGGHSPAPPQ TEECLRERPS TCPPRDQGTP EVQPTPAKDT
860 870 880 890 900
WKGKRPRSQQ ENPESQPQKR PRPSAKPSVV AEVKGSVSAS EQGTLNPTAQ
910 920 930 940 950
DPFQLSAPGV SLKEAANVVV KCLTPFYKEG KFASKELFKG FARHLSHLLT
960 970 980 990
QKTSPGRSVK EEAQNLIRHF FHGRARCESE ADWHGLCGPQ R
Length:991
Mass (Da):108,858
Last modified:August 30, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i983668133DED865A
GO
Isoform Alpha (identifier: O94762-2) [UniParc]FASTAAdd to basket
Also known as: RecQ5b

The sequence of this isoform differs from the canonical sequence as follows:
     411-991: Missing.

Show »
Length:410
Mass (Da):45,679
Checksum:i4B3035ED9892A112
GO
Isoform Gamma (identifier: O94762-3) [UniParc]FASTAAdd to basket
Also known as: RecQ5a

The sequence of this isoform differs from the canonical sequence as follows:
     411-435: CRHAAIAKYFGDALPACAKGCDHCQ → RWGRGHGKSLRAAWCSQVVSRHAEL
     436-991: Missing.

Show »
Length:435
Mass (Da):48,509
Checksum:i00EC15408C5D09AA
GO
Isoform 4 (identifier: O94762-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-69: Missing.

Note: No experimental confirmation available.
Show »
Length:964
Mass (Da):106,051
Checksum:i333A7E6A073D1AF0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KTQ2J3KTQ2_HUMAN
ATP-dependent DNA helicase
RECQL5
480Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLU0J3QLU0_HUMAN
ATP-dependent DNA helicase Q5
RECQL5
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSL7J3KSL7_HUMAN
ATP-dependent DNA helicase Q5
RECQL5
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSV9J3KSV9_HUMAN
ATP-dependent DNA helicase Q5
RECQL5
206Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS37J3KS37_HUMAN
ATP-dependent DNA helicase Q5
RECQL5
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRM6J3KRM6_HUMAN
ATP-dependent DNA helicase Q5
RECQL5
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024272480D → G. Corresponds to variant dbSNP:rs820196Ensembl.1
Natural variantiVAR_051733628S → N. Corresponds to variant dbSNP:rs35566780Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05743143 – 69Missing in isoform 4. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_005568411 – 991Missing in isoform Alpha. 3 PublicationsAdd BLAST581
Alternative sequenceiVSP_005569411 – 435CRHAA…CDHCQ → RWGRGHGKSLRAAWCSQVVS RHAEL in isoform Gamma. 3 PublicationsAdd BLAST25
Alternative sequenceiVSP_005570436 – 991Missing in isoform Gamma. 3 PublicationsAdd BLAST556

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB006533 mRNA Translation: BAA74454.1
AF135183 mRNA Translation: AAD43061.1
AF135183 mRNA Translation: AAD43062.1
AB042823 mRNA Translation: BAA95952.1
AB042824 mRNA Translation: BAA95953.1
AB042825 mRNA Translation: BAA95954.1
AC087749 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89292.1
BC016911 mRNA Translation: AAH16911.1
BC063440 mRNA Translation: AAH63440.1
AL136869 mRNA Translation: CAB66803.3

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32735.1 [O94762-3]
CCDS42380.1 [O94762-1]
CCDS45777.1 [O94762-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001003715.1, NM_001003715.3 [O94762-3]
NP_001003716.1, NM_001003716.3 [O94762-2]
NP_004250.4, NM_004259.6 [O94762-1]
XP_016880832.1, XM_017025343.1
XP_016880833.1, XM_017025344.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.632229

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000317905; ENSP00000317636; ENSG00000108469 [O94762-1]
ENST00000340830; ENSP00000341983; ENSG00000108469 [O94762-3]
ENST00000420326; ENSP00000414933; ENSG00000108469 [O94762-2]
ENST00000423245; ENSP00000394820; ENSG00000108469 [O94762-4]
ENST00000584999; ENSP00000462248; ENSG00000108469 [O94762-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9400

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9400

UCSC genome browser

More...
UCSCi
uc002joz.5 human [O94762-1]
uc060jzt.1 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006533 mRNA Translation: BAA74454.1
AF135183 mRNA Translation: AAD43061.1
AF135183 mRNA Translation: AAD43062.1
AB042823 mRNA Translation: BAA95952.1
AB042824 mRNA Translation: BAA95953.1
AB042825 mRNA Translation: BAA95954.1
AC087749 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89292.1
BC016911 mRNA Translation: AAH16911.1
BC063440 mRNA Translation: AAH63440.1
AL136869 mRNA Translation: CAB66803.3
CCDSiCCDS32735.1 [O94762-3]
CCDS42380.1 [O94762-1]
CCDS45777.1 [O94762-2]
RefSeqiNP_001003715.1, NM_001003715.3 [O94762-3]
NP_001003716.1, NM_001003716.3 [O94762-2]
NP_004250.4, NM_004259.6 [O94762-1]
XP_016880832.1, XM_017025343.1
XP_016880833.1, XM_017025344.1
UniGeneiHs.632229

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BK0X-ray1.90A/B515-620[»]
5LB3X-ray1.80B/E11-453[»]
5LB5X-ray2.00A/B/C/D11-453[»]
5LB8X-ray3.40A/D11-526[»]
5LBAX-ray2.50A/B/C/D11-453[»]
ProteinModelPortaliO94762
SMRiO94762
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114797, 59 interactors
DIPiDIP-32964N
IntActiO94762, 33 interactors
STRINGi9606.ENSP00000317636

PTM databases

iPTMnetiO94762
PhosphoSitePlusiO94762

Polymorphism and mutation databases

BioMutaiRECQL5

Proteomic databases

EPDiO94762
jPOSTiO94762
MaxQBiO94762
PaxDbiO94762
PeptideAtlasiO94762
PRIDEiO94762
ProteomicsDBi50425
50426 [O94762-2]
50427 [O94762-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317905; ENSP00000317636; ENSG00000108469 [O94762-1]
ENST00000340830; ENSP00000341983; ENSG00000108469 [O94762-3]
ENST00000420326; ENSP00000414933; ENSG00000108469 [O94762-2]
ENST00000423245; ENSP00000394820; ENSG00000108469 [O94762-4]
ENST00000584999; ENSP00000462248; ENSG00000108469 [O94762-3]
GeneIDi9400
KEGGihsa:9400
UCSCiuc002joz.5 human [O94762-1]
uc060jzt.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9400
DisGeNETi9400
EuPathDBiHostDB:ENSG00000108469.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RECQL5
HGNCiHGNC:9950 RECQL5
HPAiHPA029971
MIMi603781 gene
neXtProtiNX_O94762
OpenTargetsiENSG00000108469
PharmGKBiPA34317

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0352 Eukaryota
COG0514 LUCA
GeneTreeiENSGT00940000157800
HOGENOMiHOG000206773
HOVERGENiHBG061479
InParanoidiO94762
KOiK10902
OMAiPACTKGC
OrthoDBi445763at2759
PhylomeDBiO94762
TreeFamiTF317614

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RECQL5 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RECQL5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9400

Protein Ontology

More...
PROi
PR:O94762

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000108469 Expressed in 164 organ(s), highest expression level in lower esophagus mucosa
ExpressionAtlasiO94762 baseline and differential
GenevisibleiO94762 HS

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR004589 DNA_helicase_ATP-dep_RecQ
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR010716 RECQ5
IPR032284 RecQ_Zn-bd
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF06959 RecQ5, 1 hit
PF16124 RecQ_Zn_bind, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD120154 RecQ_helicase-like_5, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00614 recQ_fam, 1 hit
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRECQ5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94762
Secondary accession number(s): Q6P4G0
, Q9H0B1, Q9P1W7, Q9UNC8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 30, 2002
Last modified: February 13, 2019
This is version 189 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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