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Entry version 106 (29 Sep 2021)
Sequence version 1 (01 May 1999)
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Protein

Putative endoplasmic reticulum metallopeptidase 1

Gene

erm1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi161Zinc 1; catalyticBy similarity1
Metal bindingi173Zinc 1; catalyticBy similarity1
Metal bindingi173Zinc 2; catalyticBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei207Proton acceptorBy similarity1
Metal bindingi208Zinc 2; catalyticBy similarity1
Metal bindingi234Zinc 1; catalyticBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei306Transition state stabilizerBy similarity1
Metal bindingi307Zinc 2; catalyticBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • proteolysis Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative endoplasmic reticulum metallopeptidase 1By similarity (EC:3.4.-.-Curated)
Alternative name(s):
FXNA-like proteaseCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:erm1Imported
ORF Names:SPCC1259.02cImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPCC1259.02c, erm1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPCC1259.02c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 14CytoplasmicCuratedAdd BLAST14
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei15 – 35Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini36 – 365LumenalCuratedAdd BLAST330
Transmembranei366 – 384Helical; Name=2Sequence analysisAdd BLAST19
Topological domaini385 – 392CytoplasmicCurated8
Transmembranei393 – 413Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini414 – 431LumenalCuratedAdd BLAST18
Transmembranei432 – 452Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini453 – 463CytoplasmicCuratedAdd BLAST11
Transmembranei464 – 484Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini485LumenalCurated1
Transmembranei486 – 506Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini507 – 514CytoplasmicCurated8
Transmembranei515 – 535Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini536 – 547LumenalCuratedAdd BLAST12
Transmembranei548 – 568Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini569 – 575CytoplasmicCurated7
Transmembranei576 – 596Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini597 – 822LumenalCuratedAdd BLAST226

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003723861 – 822Putative endoplasmic reticulum metallopeptidase 1Add BLAST822

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi146N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi291N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi617N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi682N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi706N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi758N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O94702

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94702

PRoteomics IDEntifications database

More...
PRIDEi
O94702

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O94702

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
275613, 2 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M28 family. M28B subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2194, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015120_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O94702

Identification of Orthologs from Complete Genome Data

More...
OMAi
HAEGHNI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O94702

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007484, Peptidase_M28

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04389, Peptidase_M28, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O94702-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLVCASSSK CKRNTFLQLA MVLFAVVMAR IALYFHNHLD EPLVDPYDAN
60 70 80 90 100
GNPQFSEANA LKHVIHLSDD IGYRILGTIE QERAREYIMN EVLALQKQLQ
110 120 130 140 150
DGPNADIHQM EVSLESGDGA HRFDFMNKYV IKKYQNLKNI VVRLSNGTEA
160 170 180 190 200
CKEEAVLINA HVDSTLPSPG ATDDALAVAI LLEAIRIFIS RPVPLTHSIV
210 220 230 240 250
FLFNDAEESL QDASHMFITQ SPLRDTIKCV VNLEACGTTG SEILFQATSN
260 270 280 290 300
EMIKAYSHVP HPFGTVLADD VFRTGLILSD TDFRQFVQYG NLTGLDMAVV
310 320 330 340 350
KNSYLYHTKK DLAPYISPGT PQNFGENILA ILTYLVSPEA DLNNMKSSGT
360 370 380 390 400
VYFSVFNSLF FMYSKLTSKI LNTLVGGLGI LLTLRGSEGS FTVALIAQVI
410 420 430 440 450
SIAGIFVIPN IWAYILGNVL DCGMSWFRNE YWPLFIYLPA IFASLFFTES
460 470 480 490 500
LFKRSEHLAL RATIFIFSLL TFIPLPSAYL FTIIDFFMVF ALFLNDKILA
510 520 530 540 550
KPGTVHPLTY FIGSIGAMTV GFESAINLLE IFVPLTGRIG TDKVADNVVA
560 570 580 590 600
TVCVCGFNIY FPLMSPWIQR FRSRCCFRLG LLFSIFVVGF SSFILAKQDT
610 620 630 640 650
YYDSLHPRRI FVQRMENITS NEVSLHIASA DSAPGFDKLS SDLSSLLTDE
660 670 680 690 700
PVVKTEMDDW NSDWDTVYPF SQFLGSYRIP LNDTVDVTTL PSIKFSNKVV
710 720 730 740 750
KDNVVNVTVT VEHPGLIWTV VSFDADVLSW SLPEVPSTVR RHHVREVSAY
760 770 780 790 800
GLDSYSFNMS YLEAPIYFDF VGVDGVGHYP SKASEGRDRA SIQLCEKLTN
810 820
DYLPDWTDTL CIGVVSGNFK LE
Length:822
Mass (Da):91,843
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFBB4DAE6857E671F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA22540.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T40891

NCBI Reference Sequences

More...
RefSeqi
NP_588058.1, NM_001023050.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPCC1259.02c.1; SPCC1259.02c.1:pep; SPCC1259.02c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA22540.1
PIRiT40891
RefSeqiNP_588058.1, NM_001023050.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi275613, 2 interactors

PTM databases

SwissPalmiO94702

Proteomic databases

MaxQBiO94702
PaxDbiO94702
PRIDEiO94702

Genome annotation databases

EnsemblFungiiSPCC1259.02c.1; SPCC1259.02c.1:pep; SPCC1259.02c

Organism-specific databases

PomBaseiSPCC1259.02c, erm1
VEuPathDBiFungiDB:SPCC1259.02c

Phylogenomic databases

eggNOGiKOG2194, Eukaryota
HOGENOMiCLU_015120_0_0_1
InParanoidiO94702
OMAiHAEGHNI
PhylomeDBiO94702

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O94702

Family and domain databases

InterProiView protein in InterPro
IPR007484, Peptidase_M28
PfamiView protein in Pfam
PF04389, Peptidase_M28, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERMP1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94702
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 1, 1999
Last modified: September 29, 2021
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
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