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Entry version 137 (29 Sep 2021)
Sequence version 1 (01 May 1999)
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Protein

DNA-directed RNA polymerase III subunit rpc1

Gene

rpc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi66Zinc 1By similarity1
Metal bindingi69Zinc 1By similarity1
Metal bindingi76Zinc 1By similarity1
Metal bindingi79Zinc 1By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi109Zinc 2By similarity1
Metal bindingi153Zinc 2By similarity1
Metal bindingi493Magnesium; catalyticBy similarity1
Metal bindingi495Magnesium; catalyticBy similarity1
Metal bindingi497Magnesium; catalyticBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription
LigandMagnesium, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-SPO-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit rpc1 (EC:2.7.7.6)
Short name:
RNA polymerase III subunit C1
Alternative name(s):
DNA-directed RNA polymerase III largest subunit
RPC158
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rpc1
ORF Names:SPBC651.08c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPBC651.08c, rpc1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPBC651.08c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000739511 – 1405DNA-directed RNA polymerase III subunit rpc1Add BLAST1405

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O94666

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94666

PRoteomics IDEntifications database

More...
PRIDEi
O94666

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
277609, 5 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPBC651.08c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni838 – 850Bridging helixBy similarityAdd BLAST13

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0261, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000487_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O94666

Identification of Orthologs from Complete Genome Data

More...
OMAi
AVCPPYN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O94666

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02736, RNAP_III_Rpc1_C, 1 hit
cd02583, RNAP_III_RPC1_N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.132.30, 1 hit
1.10.274.100, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000722, RNA_pol_asu
IPR006592, RNA_pol_N
IPR007080, RNA_pol_Rpb1_1
IPR007066, RNA_pol_Rpb1_3
IPR042102, RNA_pol_Rpb1_3_sf
IPR007083, RNA_pol_Rpb1_4
IPR007081, RNA_pol_Rpb1_5
IPR035698, RNAP_III_Rpc1_C
IPR035697, RNAP_III_RPC1_N
IPR038120, Rpb1_funnel_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04997, RNA_pol_Rpb1_1, 1 hit
PF00623, RNA_pol_Rpb1_2, 1 hit
PF04983, RNA_pol_Rpb1_3, 1 hit
PF05000, RNA_pol_Rpb1_4, 1 hit
PF04998, RNA_pol_Rpb1_5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00663, RPOLA_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O94666-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDPIDDQIP KRIKHLQFGI NGPEEFVKDG TVEVSRRDLY TMTDRSPAEH
60 70 80 90 100
GALDLHMGTS NKQINCATCG ESMADCMGHF GYVKLALPVF HIGYFKATLT
110 120 130 140 150
ILQNICKDCS SVLLSDQEKR QFLKDLRRPG IDNLRRSQIC KRINDHCKKM
160 170 180 190 200
RRCSKCDAMQ GVVKKAGPLK IIHERFRYVR KSQDDEENFR HSFDEALKTI
210 220 230 240 250
PELKMHLSKA HDDLNPLKVL NLFKQITPVD CELLGMDPEH GRPENLLWRY
260 270 280 290 300
VPAPPVCIRP SVAQEGATTE DDLTVKITEI IWTSSLIRAA LSKGTPISNL
310 320 330 340 350
MEQWEFMQLS IAMYINSEMP GLRPSDMPSK PIRGFCQRLK GKQGRFRGNL
360 370 380 390 400
SGKRVDFSGR TVISPDPNLR IDQVAVPYRI AKILTFPERV TTQNKKHLQD
410 420 430 440 450
CIRNGPDVHP GANYVIDRES GFKRFLRFGN RNRIADDLKI GDIVERHLHD
460 470 480 490 500
NDVVLFNRQP SLHKLSIMAH LVKVRPWRTL RFNECVCGPY NADFDGDEMN
510 520 530 540 550
LHVPQTEEAK TEALELMGIK NNLVSPRNGE PIIAATQDFI TAAYLLSLKD
560 570 580 590 600
TFLDRKSISN ICCYMMDAST HIDLPPPAII KPRCLWTGKQ VFTVLMKPNR
610 620 630 640 650
FSKVLVNLDA KTRSFSRIKS KTPEMCPKDG YLMIRNSEII AGVVDKSVVG
660 670 680 690 700
DGKKDSLFYV ILRDYGALEA AEAITRLSKM CARFLGNRGF SIGIEDVQPG
710 720 730 740 750
KSLSSQKEIL VNKAYATSDD FIMQYAKGIL ECQPGMDQEA TLEAKISSTL
760 770 780 790 800
SKVRDDVGEI CMDELGPANS PLIMATCGSK GSKINVSQMV ACVGQQIISG
810 820 830 840 850
KRVPDGFQDR SLPHFHKNSK HPLAKGFVSN SFYSGLTPTE FLFHAISGRE
860 870 880 890 900
GLVDTAVKTA ETGYMSRRLM KSLEDLSSAY DGTVRSSNSD VVQFVYGDDG
910 920 930 940 950
LDPTYMEGDG QAVEFKRTWI HSVNLNYDRH DSAMLPYEII DYVNRALDDP
960 970 980 990 1000
KFLTNCNRDF IETIRTFVIE NIAKYLASVR ERRDLAPMLE EPDMDDLDDM
1010 1020 1030 1040 1050
EGDEFAPVAK RKSVENIIRV TEKQLRSFVD RCWEKYMRAK VEPGTAVGAI
1060 1070 1080 1090 1100
GAQSIGEPGT QMTLKTFHFA GVAAQTTLGV PRIKEIINAA KTISTPIITG
1110 1120 1130 1140 1150
QLINDRDERS ARVVKGRIEK TYLKDVTSYI EEVYGPVTTY LSIQVNFDTI
1160 1170 1180 1190 1200
SKLQLDITLA DIAAAIWNTP KLKIPSQQVT VNNTLQQIHV HTSSDGKSSE
1210 1220 1230 1240 1250
TEVYYRLQTY KRVLPDVVVA GIPTINRSVI NQESGKIELF MEGTGLQAVM
1260 1270 1280 1290 1300
NTEGIVGTKT STNHVMEMKD VLGIEAARYS IISEIGYTMA KHGLTVDPRH
1310 1320 1330 1340 1350
IMLLGDVMTC KGEVLGITRF GVAKMKDSVL ALASFEKTTD HLFNAAARFA
1360 1370 1380 1390 1400
KDSIEGISEC IVLGKLAPIG TNVFQLIRRT EEEEEQKPKE LLFDTPSLHQ

LEITA
Length:1,405
Mass (Da):157,562
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i104B1AC4145A3B7B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ156227 mRNA Translation: ABA54855.1
CU329671 Genomic DNA Translation: CAB37604.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T40607

NCBI Reference Sequences

More...
RefSeqi
NP_595506.1, NM_001021416.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC651.08c.1; SPBC651.08c.1:pep; SPBC651.08c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2541094

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC651.08c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ156227 mRNA Translation: ABA54855.1
CU329671 Genomic DNA Translation: CAB37604.1
PIRiT40607
RefSeqiNP_595506.1, NM_001021416.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi277609, 5 interactors
STRINGi4896.SPBC651.08c.1

Proteomic databases

MaxQBiO94666
PaxDbiO94666
PRIDEiO94666

Genome annotation databases

EnsemblFungiiSPBC651.08c.1; SPBC651.08c.1:pep; SPBC651.08c
GeneIDi2541094
KEGGispo:SPBC651.08c

Organism-specific databases

PomBaseiSPBC651.08c, rpc1
VEuPathDBiFungiDB:SPBC651.08c

Phylogenomic databases

eggNOGiKOG0261, Eukaryota
HOGENOMiCLU_000487_3_0_1
InParanoidiO94666
OMAiAVCPPYN
PhylomeDBiO94666

Enzyme and pathway databases

ReactomeiR-SPO-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-SPO-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O94666

Family and domain databases

CDDicd02736, RNAP_III_Rpc1_C, 1 hit
cd02583, RNAP_III_RPC1_N, 1 hit
Gene3Di1.10.132.30, 1 hit
1.10.274.100, 1 hit
InterProiView protein in InterPro
IPR000722, RNA_pol_asu
IPR006592, RNA_pol_N
IPR007080, RNA_pol_Rpb1_1
IPR007066, RNA_pol_Rpb1_3
IPR042102, RNA_pol_Rpb1_3_sf
IPR007083, RNA_pol_Rpb1_4
IPR007081, RNA_pol_Rpb1_5
IPR035698, RNAP_III_Rpc1_C
IPR035697, RNAP_III_RPC1_N
IPR038120, Rpb1_funnel_sf
PfamiView protein in Pfam
PF04997, RNA_pol_Rpb1_1, 1 hit
PF00623, RNA_pol_Rpb1_2, 1 hit
PF04983, RNA_pol_Rpb1_3, 1 hit
PF05000, RNA_pol_Rpb1_4, 1 hit
PF04998, RNA_pol_Rpb1_5, 1 hit
SMARTiView protein in SMART
SM00663, RPOLA_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPC1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94666
Secondary accession number(s): Q0QYE3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: September 29, 2021
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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