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Entry version 108 (11 Dec 2019)
Sequence version 4 (20 Feb 2007)
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Protein

Ergothioneine biosynthesis protein 1

Gene

egt1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine and subsequent conjugation with cysteine and oxygen to form hercynylcysteine sulfoxide, the first two steps in the biosynthesis pathway of ergothioneine (PubMed:24828577). May play a role in meiosis (PubMed:16303567).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per monomer.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: ergothioneine biosynthesis

This protein is involved in the pathway ergothioneine biosynthesis, which is part of Amino-acid biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in the pathway ergothioneine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei51L-histidineBy similarity1
Binding sitei85S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
Binding sitei91S-adenosyl-L-methionineBy similarity1
Binding sitei112S-adenosyl-L-methionineBy similarity1
Binding sitei172L-histidineBy similarity1
Binding sitei212L-histidineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi382Iron; via tele nitrogenBy similarity1
Metal bindingi476Iron; via tele nitrogenBy similarity1
Metal bindingi480Iron; via tele nitrogenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Monooxygenase, Oxidoreductase, Transferase
Biological processMeiosis
LigandIron, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA01014

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ergothioneine biosynthesis protein 11 Publication
Alternative name(s):
Meiotically up-regulated gene 158 protein1 Publication
Including the following 2 domains:
L-histidine N(alpha)-methyltransferaseBy similarity (EC:2.1.1.44By similarity)
Hercynylcysteine S-oxide synthaseBy similarity (EC:1.14.99.51By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:egt11 Publication
Synonyms:mug1581 Publication
ORF Names:SPBC1604.01Imported, SPBC1677.01c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPBC1604.01

Schizosaccharomyces pombe database

More...
PomBasei
SPBC1604.01 egt1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Completely lacks ergothioneine and its precursors (trimethyl histidine/hercynine and hercynylcysteine sulfoxide).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002785111 – 773Ergothioneine biosynthesis protein 1Add BLAST773

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O94632

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94632

PRoteomics IDEntifications database

More...
PRIDEi
O94632

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4896.SPBC1604.01.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O94632

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni16 – 322L-histidine N(alpha)-methyltransferaseCuratedAdd BLAST307
Regioni142 – 143S-adenosyl-L-methionine bindingBy similarity2
Regioni287 – 289L-histidine bindingBy similarity3
Regioni347 – 772Hercynylcysteine S-oxide synthaseCuratedAdd BLAST426

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the methyltransferase superfamily. EgtD family.Curated
In the C-terminal section; belongs to the EgtB family.Curated

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O94632

KEGG Orthology (KO)

More...
KOi
K20246

Identification of Orthologs from Complete Genome Data

More...
OMAi
HIPAFLD

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O94632

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.1580.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016187 CTDL_fold
IPR019257 MeTrfase_dom
IPR029063 SAM-dependent_MTases
IPR017805 SAM_MeTrfase_EasF-type_put
IPR005532 SUMF_dom
IPR042095 SUMF_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03781 FGE-sulfatase, 1 hit
PF10017 Methyltransf_33, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335 SSF53335, 1 hit
SSF56436 SSF56436, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03439 methyl_EasF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O94632-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEIENIGAL EVLFSPESIE QSLKRCQLPS TLLYDEKGLR LFDEITNLKE
60 70 80 90 100
YYLYESELDI LKKFSDSIAN QLLSPDLPNT VIELGCGNMR KTKLLLDAFE
110 120 130 140 150
KKGCDVHFYA LDLNEAELQK GLQELRQTTN YQHVKVSGIC GCFERLLQCL
160 170 180 190 200
DRFRSEPNSR ISMLYLGASI GNFDRKSAAS FLRSFASRLN IHDNLLISFD
210 220 230 240 250
HRNKAELVQL AYDDPYRITE KFEKNILASV NAVFGENLFD ENDWEYKSVY
260 270 280 290 300
DEDLGVHRAY LQAKNEVTVI KGPMFFQFKP SHLILIEESW KNSDQECRQI
310 320 330 340 350
IEKGDFKLVS KYESTIADYS TYVITKQFPA MLQLPLQPCP SLAEWDALRK
360 370 380 390 400
VWLFITNKLL NKDNMYTAWI PLRHPPIFYI GHVPVFNDIY LTKIVKNKAT
410 420 430 440 450
ANKKHFWEWF QRGIDPDIED PSKCHWHSEV PESWPSPDQL REYEKESWEY
460 470 480 490 500
HIVKLCKAMD ELSTSEKRIL WLCYEHVAMH VETTLYIYVQ SFQNANQTVS
510 520 530 540 550
ICGSLPEPAE KLTKAPLWVN VPETEIAVGM PLTTQYTSVG SNLQSSDLSA
560 570 580 590 600
HENTDELFYF AWDNEKPMRK KLVSSFSIAN RPISNGEYLD FINKKSKTER
610 620 630 640 650
VYPKQWAEID GTLYIRTMYG LLPLDDYLGW PVMTSYDDLN NYASSQGCRL
660 670 680 690 700
PTEDELNCFY DRVLERTDEP YVSTEGKATG FQQLHPLALS DNSSNQIFTG
710 720 730 740 750
AWEWTSTVLE KHEDFEPEEL YPDYTRDFFD GKHNVVLGGS FATATRISNR
760 770
RSFRNFYQAG YKYAWIGARL VKN
Length:773
Mass (Da):89,714
Last modified:February 20, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E9EF9AC7A4D89C7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA22334.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T39513

NCBI Reference Sequences

More...
RefSeqi
NP_596639.2, NM_001022560.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC1604.01.1; SPBC1604.01.1:pep; SPBC1604.01

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2539656

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC1604.01

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA22334.1
PIRiT39513
RefSeqiNP_596639.2, NM_001022560.3

3D structure databases

SMRiO94632
ModBaseiSearch...

Protein-protein interaction databases

STRINGi4896.SPBC1604.01.1

Proteomic databases

MaxQBiO94632
PaxDbiO94632
PRIDEiO94632

Genome annotation databases

EnsemblFungiiSPBC1604.01.1; SPBC1604.01.1:pep; SPBC1604.01
GeneIDi2539656
KEGGispo:SPBC1604.01

Organism-specific databases

EuPathDBiFungiDB:SPBC1604.01
PomBaseiSPBC1604.01 egt1

Phylogenomic databases

InParanoidiO94632
KOiK20246
OMAiHIPAFLD
PhylomeDBiO94632

Enzyme and pathway databases

UniPathwayiUPA01014

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O94632

Family and domain databases

Gene3Di3.90.1580.10, 1 hit
InterProiView protein in InterPro
IPR016187 CTDL_fold
IPR019257 MeTrfase_dom
IPR029063 SAM-dependent_MTases
IPR017805 SAM_MeTrfase_EasF-type_put
IPR005532 SUMF_dom
IPR042095 SUMF_sf
PfamiView protein in Pfam
PF03781 FGE-sulfatase, 1 hit
PF10017 Methyltransf_33, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
SSF56436 SSF56436, 1 hit
TIGRFAMsiTIGR03439 methyl_EasF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEGT1_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94632
Secondary accession number(s): O94367, Q1MTP5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: December 11, 2019
This is version 108 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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