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Entry version 158 (23 Feb 2022)
Sequence version 1 (01 May 1999)
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Protein

Leucine aminopeptidase 2

Gene

lap2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA4 but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B4 as the product compared to the homologous mammalian enzyme (in vitro).

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi294Zinc; catalyticPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei295Proton acceptorPROSITE-ProRule annotation1
Metal bindingi298Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi317Zinc; catalyticPROSITE-ProRule annotation1
Active sitei382Proton donorPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-2142691, Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-SPO-6798695, Neutrophil degranulation
R-SPO-9018676, Biosynthesis of D-series resolvins
R-SPO-9018681, Biosynthesis of protectins
R-SPO-9018896, Biosynthesis of E-series 18(S)-resolvins
R-SPO-9020265, Biosynthesis of aspirin-triggered D-series resolvins
R-SPO-9023661, Biosynthesis of E-series 18(R)-resolvins

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M01.034

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine aminopeptidase 2 (EC:3.4.11.-)
Alternative name(s):
Epoxide hydrolase (EC:3.3.2.10)
Leukotriene A-4 hydrolase homolog
Short name:
LTA-4 hydrolase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lap2
ORF Names:SPCC1322.05c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPCC1322.05c, lap2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPCC1322.05c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000951281 – 612Leucine aminopeptidase 2Add BLAST612

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O94544

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94544

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O94544

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
275494, 2 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPCC1322.05c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O94544

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni136 – 138Substrate bindingBy similarity3
Regioni265 – 270Substrate bindingBy similarity6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1047, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014505_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O94544

Identification of Orthologs from Complete Genome Data

More...
OMAi
CTALQWM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O94544

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09599, M1_LTA4H, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.390.10, 1 hit
1.25.40.320, 1 hit
2.60.40.1730, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR045357, Aminopeptidase_N-like_N
IPR042097, Aminopeptidase_N-like_N_sf
IPR016024, ARM-type_fold
IPR012777, LTA4H
IPR038502, M1_LTA-4_hydro/amino_C_sf
IPR034015, M1_LTA4H
IPR001930, Peptidase_M1
IPR015211, Peptidase_M1_C
IPR014782, Peptidase_M1_dom
IPR027268, Peptidase_M4/M1_CTD_sf

The PANTHER Classification System

More...
PANTHERi
PTHR45726, PTHR45726, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09127, Leuk-A4-hydro_C, 1 hit
PF01433, Peptidase_M1, 1 hit
PF17900, Peptidase_M1_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00756, ALADIPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01263, Leuk-A4-hydro_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF63737, SSF63737, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02411, leuko_A4_hydro, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00142, ZINC_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O94544-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLRLDPSTQ SNYHDVSISK LDWHARIDFD QELLHGKVSF VIQSARVSQA
60 70 80 90 100
LSHIILDTSY LEIKNVTIND IPTPFRVDKR RGFLGSALHI VPADEIPSSK
110 120 130 140 150
SCILTILYST TKDCTALQFL KPEQTIGGKF PYVFSECQAI HARSFIPCQD
160 170 180 190 200
TPSVKVPCTF KIRSKLPVIA SGIPCGTANF CNGSLEYLFE QKNPIPSYLF
210 220 230 240 250
CILSGDLAST NIGPRSSVYT EPGNLLACKY EFEHDMENFM EAAEQLTLPY
260 270 280 290 300
CWTRYDFVIL PPSFPYGGME NPNATFATPT LIAGDRSNVN VIAHELAHSW
310 320 330 340 350
SGNLVTNESW QCFWLNEGMT VFLERKILGR LYGEPTRQFE AIIGWGELEE
360 370 380 390 400
SVKLLGEDSE YTKLIQNLEG RDPDDAFSTV PYEKGSNFLY EIERVIGGPS
410 420 430 440 450
VFEPFLPFYF RKFAKSTVNE VKFKHALYEY FSPLGLASKL DSIDWDTWYH
460 470 480 490 500
APGMPPVKPH FDTTLADPCY KLAESWTNSA KNSDDPSKFS SKDIENWSAG
510 520 530 540 550
QKSLFLDVVY EAVSFPHNYI KRMGDVYSFA ESKNAELSFR FFKLALKSKY
560 570 580 590 600
KPLYNTIAER VGSVGRMKFV RPIFRLLNEA DRAFAIETFE KYKHFYHKIC
610
ASQVEKDLGL SE
Length:612
Mass (Da):69,522
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i19D3DFFC5CE2A341
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA22858.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T40936

NCBI Reference Sequences

More...
RefSeqi
NP_588133.1, NM_001023123.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPCC1322.05c.1; SPCC1322.05c.1:pep; SPCC1322.05c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2538917

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPCC1322.05c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA22858.1
PIRiT40936
RefSeqiNP_588133.1, NM_001023123.2

3D structure databases

SMRiO94544
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi275494, 2 interactors
STRINGi4896.SPCC1322.05c.1

Protein family/group databases

MEROPSiM01.034

PTM databases

iPTMnetiO94544

Proteomic databases

MaxQBiO94544
PaxDbiO94544

Genome annotation databases

EnsemblFungiiSPCC1322.05c.1; SPCC1322.05c.1:pep; SPCC1322.05c
GeneIDi2538917
KEGGispo:SPCC1322.05c

Organism-specific databases

PomBaseiSPCC1322.05c, lap2
VEuPathDBiFungiDB:SPCC1322.05c

Phylogenomic databases

eggNOGiKOG1047, Eukaryota
HOGENOMiCLU_014505_1_2_1
InParanoidiO94544
OMAiCTALQWM
PhylomeDBiO94544

Enzyme and pathway databases

ReactomeiR-SPO-2142691, Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-SPO-6798695, Neutrophil degranulation
R-SPO-9018676, Biosynthesis of D-series resolvins
R-SPO-9018681, Biosynthesis of protectins
R-SPO-9018896, Biosynthesis of E-series 18(S)-resolvins
R-SPO-9020265, Biosynthesis of aspirin-triggered D-series resolvins
R-SPO-9023661, Biosynthesis of E-series 18(R)-resolvins

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O94544

Family and domain databases

CDDicd09599, M1_LTA4H, 1 hit
Gene3Di1.10.390.10, 1 hit
1.25.40.320, 1 hit
2.60.40.1730, 1 hit
InterProiView protein in InterPro
IPR045357, Aminopeptidase_N-like_N
IPR042097, Aminopeptidase_N-like_N_sf
IPR016024, ARM-type_fold
IPR012777, LTA4H
IPR038502, M1_LTA-4_hydro/amino_C_sf
IPR034015, M1_LTA4H
IPR001930, Peptidase_M1
IPR015211, Peptidase_M1_C
IPR014782, Peptidase_M1_dom
IPR027268, Peptidase_M4/M1_CTD_sf
PANTHERiPTHR45726, PTHR45726, 1 hit
PfamiView protein in Pfam
PF09127, Leuk-A4-hydro_C, 1 hit
PF01433, Peptidase_M1, 1 hit
PF17900, Peptidase_M1_N, 1 hit
PRINTSiPR00756, ALADIPTASE
SMARTiView protein in SMART
SM01263, Leuk-A4-hydro_C, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF63737, SSF63737, 1 hit
TIGRFAMsiTIGR02411, leuko_A4_hydro, 1 hit
PROSITEiView protein in PROSITE
PS00142, ZINC_PROTEASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLKHA4_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94544
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: May 1, 1999
Last modified: February 23, 2022
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
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