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Entry version 101 (02 Jun 2021)
Sequence version 1 (01 May 1999)
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Protein

Uncharacterized membrane protein C1322.03

Gene

SPCC1322.03

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium channel activity Source: PomBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.4.9.4, the transient receptor potential ca(2+) channel (trp-cc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized membrane protein C1322.03
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:SPCC1322.03
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPCC1322.03

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPCC1322.03

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 61LumenalSequence analysisAdd BLAST36
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 187CytoplasmicSequence analysisAdd BLAST105
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 230LumenalSequence analysisAdd BLAST22
Transmembranei231 – 250HelicalSequence analysisAdd BLAST20
Topological domaini251 – 256CytoplasmicSequence analysis6
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Topological domaini278 – 329LumenalSequence analysisAdd BLAST52
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Topological domaini351 – 372CytoplasmicSequence analysisAdd BLAST22
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 404LumenalSequence analysisAdd BLAST11
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Topological domaini426 – 457CytoplasmicSequence analysisAdd BLAST32
Transmembranei458 – 480HelicalSequence analysisAdd BLAST23
Topological domaini481 – 483LumenalSequence analysis3
Transmembranei484 – 503HelicalSequence analysisAdd BLAST20
Topological domaini504 – 514CytoplasmicSequence analysisAdd BLAST11
Transmembranei515 – 535HelicalSequence analysisAdd BLAST21
Topological domaini536 – 545LumenalSequence analysis10
Transmembranei546 – 566HelicalSequence analysisAdd BLAST21
Topological domaini567 – 862CytoplasmicSequence analysisAdd BLAST296

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000037262026 – 862Uncharacterized membrane protein C1322.03Add BLAST837

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O94543

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94543

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
275643, 8 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPCC1322.03.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni668 – 717DisorderedSequence analysisAdd BLAST50
Regioni815 – 862DisorderedSequence analysisAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi668 – 707Polar residuesSequence analysisAdd BLAST40
Compositional biasi837 – 852Basic and acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502R2RV, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_356839_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O94543

Identification of Orthologs from Complete Genome Data

More...
OMAi
READVYH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O94543

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010308, TRP_C
IPR040241, TRP_Flc/Pkd2-like
IPR032800, TRP_N

The PANTHER Classification System

More...
PANTHERi
PTHR31145, PTHR31145, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06011, TRP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01320, TRP_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O94543-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPRPYSVFL FLHIVFYSLL SAVNGSPSLD YFETCSNFVP RAGIPTFSPY
60 70 80 90 100
AVIKNFDEVN RMYYIQVVGN LSGVITIVGG NGSHIHAASV YSETYALGKL
110 120 130 140 150
VTSNTTKLCD VVMDPHSFEV PIKCPWAAGS AAFMVKVPFK STLSDYSKYE
160 170 180 190 200
LTTLTTRVIV VDGTPEKNVI TCMKFGLSTT LYYFYPVISY LVVVSLAYVS
210 220 230 240 250
FSIIYALFLN PWTGSLDPFK SIFNFNMDPD ALRLTSLGFF DFVQYLQFAV
260 270 280 290 300
STAQVSVMFP KFYINIMAAL SWGTALFRFP IFSEPAEYQF ADFADLSVAS
310 320 330 340 350
SSYADYLPKS YGMYSFLDSI GIGTACWLPF LIVMVIYLFA ALFVALLVIF
360 370 380 390 400
LKWLMSRIFN ETIAETRWDT WSFIAGSLIR LYFLTYFPTV AYMSFQFVAP
410 420 430 440 450
PTGYEIIPVL WFIFFGIFIP VYLYMNLAFV EPSSKLLEDQ TYLHLFGSIY
460 470 480 490 500
NSFREERVMF WIFPIAVQFM RGITVGVIGS SGSAQLAIFF ILEVANVVAY
510 520 530 540 550
AYVRPHFPQT SMNTLNTFIS TMRLITVILM IPLDPRLKVL GISRDLLAYA
560 570 580 590 600
ILFIHIMVCI LFLLLSTQRF MEVSARLLGA KSESKGVPLD RPFGWARVFG
610 620 630 640 650
INELRRRRLK DPYSNGNTMM FDHSTYNSNE MSVPLTPVSV CSNSLKKDGE
660 670 680 690 700
AAPPKLFVQT NCIPPVTQAS SLVPSKNNTA SSSSLMLDSP VTPSSPYSTS
710 720 730 740 750
QGYSFYRPPK PKSSVRKRDM DQLRALQLDF LNNKPNLLRH DVNYAVREAD
760 770 780 790 800
VYHPHVDTSI DSLSQISSQP FEMRPTAIPP PPKNAFQRAW QIVQSTAKSI
810 820 830 840 850
WHSDPPKESE KGFVVLRSRP RPNLQKPLPQ LHIEPSRDEQ YSMERKKTDD
860
SLAESAWSIP HP
Length:862
Mass (Da):97,438
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36C83CA6C6B88CA8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA22856.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T40934

NCBI Reference Sequences

More...
RefSeqi
NP_588131.1, NM_001023121.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPCC1322.03.1; SPCC1322.03.1:pep; SPCC1322.03

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2539071

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPCC1322.03

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA22856.1
PIRiT40934
RefSeqiNP_588131.1, NM_001023121.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi275643, 8 interactors
STRINGi4896.SPCC1322.03.1

Protein family/group databases

TCDBi1.A.4.9.4, the transient receptor potential ca(2+) channel (trp-cc) family

Proteomic databases

MaxQBiO94543
PaxDbiO94543

Genome annotation databases

EnsemblFungiiSPCC1322.03.1; SPCC1322.03.1:pep; SPCC1322.03
GeneIDi2539071
KEGGispo:SPCC1322.03

Organism-specific databases

PomBaseiSPCC1322.03
VEuPathDBiFungiDB:SPCC1322.03

Phylogenomic databases

eggNOGiENOG502R2RV, Eukaryota
HOGENOMiCLU_356839_0_0_1
InParanoidiO94543
OMAiREADVYH
PhylomeDBiO94543

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O94543

Family and domain databases

InterProiView protein in InterPro
IPR010308, TRP_C
IPR040241, TRP_Flc/Pkd2-like
IPR032800, TRP_N
PANTHERiPTHR31145, PTHR31145, 1 hit
PfamiView protein in Pfam
PF06011, TRP, 1 hit
SMARTiView protein in SMART
SM01320, TRP_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYCD3_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94543
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 1, 1999
Last modified: June 2, 2021
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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