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UniProtKB - O94511 (YN67_SCHPO)
Protein
Putative enoyl reductase C646.07c
Gene
SPBC646.07c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Catalytic activityi
- EC:1.3.1.38
GO - Molecular functioni
- enoyl-[acyl-carrier-protein] reductase activity Source: PomBase
- oxidoreductase activity Source: GO_Central
- trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC
GO - Biological processi
- fatty acid elongation Source: PomBase
- very long-chain fatty acid biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Lipid biosynthesis, Lipid metabolism |
Ligand | NADP |
Enzyme and pathway databases
Reactomei | R-SPO-75876, Synthesis of very long-chain fatty acyl-CoAs |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:SPBC646.07c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPBC646.07c |
VEuPathDBi | FungiDB:SPBC646.07c |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: PomBase
- endoplasmic reticulum membrane Source: PomBase
Mitochondrion
- mitochondrion Source: PomBase
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 84 | CytoplasmicSequence analysisAdd BLAST | 84 | |
Transmembranei | 85 – 105 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 106 – 157 | LumenalSequence analysisAdd BLAST | 52 | |
Transmembranei | 158 – 178 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 179 – 186 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 187 – 207 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 208 – 223 | LumenalSequence analysisAdd BLAST | 16 | |
Transmembranei | 224 – 246 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 247 – 250 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 251 – 268 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 269 – 295 | LumenalSequence analysisAdd BLAST | 27 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317698 | 1 – 295 | Putative enoyl reductase C646.07cAdd BLAST | 295 |
Proteomic databases
MaxQBi | O94511 |
PaxDbi | O94511 |
PTM databases
iPTMneti | O94511 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 277585, 3 interactors |
STRINGi | 4896.SPBC646.07c.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the steroid 5-alpha reductase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1639, Eukaryota |
HOGENOMi | CLU_059260_0_0_1 |
InParanoidi | O94511 |
OMAi | WVTCPNY |
PhylomeDBi | O94511 |
Family and domain databases
InterProi | View protein in InterPro IPR001104, 3-oxo-5_a-steroid_4-DH_C IPR039357, SRD5A/TECR IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR10556, PTHR10556, 1 hit |
Pfami | View protein in Pfam PF02544, Steroid_dh, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50244, S5A_REDUCTASE, 1 hit |
i Sequence
Sequence statusi: Complete.
O94511-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSITLSSRGR KIRKLPKSLE FPLDGSIDKL RDEVSSVTRL PVERLRFSTA
60 70 80 90 100
DGTTLLPNTT LRKYGVGPGA TIWVKDLGPQ IGWRTVFMIE YLGPLVIHLF
110 120 130 140 150
FILNYKWIYR KDYNLCLNQK IAFVLVMLHF MKREYESIFV HRFSLATMPL
160 170 180 190 200
RNIFKNCAHY HLLSGLFLAY FIYGPWHAND YIKPNHLLFL IVGWAFAVLS
210 220 230 240 250
NFRTHIILRD LRPAGSKKRV IPTGYGFNLV SFPNYFFESL GWLFFALLTK
260 270 280 290
SWASWIFLFV GSAQMFVWAK KKHARYLKEF PNYPRSRKIM IPFFL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAA22811.1 |
PIRi | T40583 |
RefSeqi | NP_595365.1, NM_001021273.2 |
Genome annotation databases
EnsemblFungii | SPBC646.07c.1; SPBC646.07c.1:pep; SPBC646.07c |
GeneIDi | 2541070 |
KEGGi | spo:SPBC646.07c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAA22811.1 |
PIRi | T40583 |
RefSeqi | NP_595365.1, NM_001021273.2 |
3D structure databases
SMRi | O94511 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 277585, 3 interactors |
STRINGi | 4896.SPBC646.07c.1 |
PTM databases
iPTMneti | O94511 |
Proteomic databases
MaxQBi | O94511 |
PaxDbi | O94511 |
Genome annotation databases
EnsemblFungii | SPBC646.07c.1; SPBC646.07c.1:pep; SPBC646.07c |
GeneIDi | 2541070 |
KEGGi | spo:SPBC646.07c |
Organism-specific databases
PomBasei | SPBC646.07c |
VEuPathDBi | FungiDB:SPBC646.07c |
Phylogenomic databases
eggNOGi | KOG1639, Eukaryota |
HOGENOMi | CLU_059260_0_0_1 |
InParanoidi | O94511 |
OMAi | WVTCPNY |
PhylomeDBi | O94511 |
Enzyme and pathway databases
Reactomei | R-SPO-75876, Synthesis of very long-chain fatty acyl-CoAs |
Miscellaneous databases
PROi | PR:O94511 |
Family and domain databases
InterProi | View protein in InterPro IPR001104, 3-oxo-5_a-steroid_4-DH_C IPR039357, SRD5A/TECR IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR10556, PTHR10556, 1 hit |
Pfami | View protein in Pfam PF02544, Steroid_dh, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50244, S5A_REDUCTASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | YN67_SCHPO | |
Accessioni | O94511Primary (citable) accession number: O94511 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | May 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families