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UniProtKB - O94454 (CSN5_SCHPO)
Protein
COP9 signalosome complex subunit 5
Gene
csn5
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 118 | Zinc; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 120 | Zinc; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 131 | Zinc; catalyticPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- isopeptidase activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
- metalloendopeptidase activity Source: InterPro
- metallopeptidase activity Source: GO_Central
- NEDD8-specific protease activity Source: PomBase
GO - Biological processi
- protein deneddylation Source: PomBase
Keywordsi
Molecular function | Hydrolase, Metalloprotease, Protease |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-SPO-6781823, Formation of TC-NER Pre-Incision Complex |
Protein family/group databases
MEROPSi | M67.A01 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:csn5 ORF Names:SPAC1687.13c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAC1687.13c, csn5 |
VEuPathDBi | FungiDB:SPAC1687.13c |
Subcellular locationi
Cytosol
- cytosol Source: PomBase
Nucleus
- COP9 signalosome Source: PomBase
- nucleus Source: PomBase
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Nucleus, SignalosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000194856 | 1 – 299 | COP9 signalosome complex subunit 5Add BLAST | 299 |
Proteomic databases
MaxQBi | O94454 |
PaxDbi | O94454 |
Interactioni
Subunit structurei
Component of the COP9 signalosome (CSN) complex.
By similarityProtein-protein interaction databases
BioGRIDi | 278029, 32 interactors |
STRINGi | 4896.SPAC1687.13c.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 172 | MPNPROSITE-ProRule annotationAdd BLAST | 138 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 118 – 131 | JAMM motifPROSITE-ProRule annotationAdd BLAST | 14 |
Domaini
The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity).By similarity
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1554, Eukaryota |
HOGENOMi | CLU_053034_2_0_1 |
InParanoidi | O94454 |
OMAi | KMTMHAR |
PhylomeDBi | O94454 |
Family and domain databases
InterProi | View protein in InterPro IPR037740, CSN5 IPR000555, JAMM/MPN+_dom IPR037518, MPN |
PANTHERi | PTHR10410:SF6, PTHR10410:SF6, 1 hit |
Pfami | View protein in Pfam PF01398, JAB, 1 hit |
SMARTi | View protein in SMART SM00232, JAB_MPN, 1 hit |
PROSITEi | View protein in PROSITE PS50249, MPN, 1 hit |
i Sequence
Sequence statusi: Complete.
O94454-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNNQLENVFR FDEEKERAKI RESPWKHDPE FFRSVKISAV ALLKMLRHVS
60 70 80 90 100
QGMPLEVMGY VQGKVEGASL IILDSFALPV EGTETRVNAH EEAQEYSVQY
110 120 130 140 150
HTLCKSVYRH ENVIGWYHSH PNYGCWLSGV DVETQRQNQK YQDPFVAVVL
160 170 180 190 200
DPKRSLESPY VNIGAFRTYP VGNDGSIRTK SRHHPSVLFK NLPSSKIEDA
210 220 230 240 250
GAHAEAYYSL PITYFHSKAE KKVTEFLRNR NWSRSITECS ILQNNEFLHD
260 270 280 290
SEKLIDHLIH ETGNNELPVA SAYEQSKACC NELSTFLSQI DVQDKLFKE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAA22607.1 |
PIRi | T37756 |
RefSeqi | NP_593131.1, NM_001018527.2 |
Genome annotation databases
EnsemblFungii | SPAC1687.13c.1; SPAC1687.13c.1:pep; SPAC1687.13c |
GeneIDi | 2541529 |
KEGGi | spo:SPAC1687.13c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAA22607.1 |
PIRi | T37756 |
RefSeqi | NP_593131.1, NM_001018527.2 |
3D structure databases
SMRi | O94454 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 278029, 32 interactors |
STRINGi | 4896.SPAC1687.13c.1 |
Protein family/group databases
MEROPSi | M67.A01 |
Proteomic databases
MaxQBi | O94454 |
PaxDbi | O94454 |
Genome annotation databases
EnsemblFungii | SPAC1687.13c.1; SPAC1687.13c.1:pep; SPAC1687.13c |
GeneIDi | 2541529 |
KEGGi | spo:SPAC1687.13c |
Organism-specific databases
PomBasei | SPAC1687.13c, csn5 |
VEuPathDBi | FungiDB:SPAC1687.13c |
Phylogenomic databases
eggNOGi | KOG1554, Eukaryota |
HOGENOMi | CLU_053034_2_0_1 |
InParanoidi | O94454 |
OMAi | KMTMHAR |
PhylomeDBi | O94454 |
Enzyme and pathway databases
Reactomei | R-SPO-6781823, Formation of TC-NER Pre-Incision Complex |
Miscellaneous databases
PROi | PR:O94454 |
Family and domain databases
InterProi | View protein in InterPro IPR037740, CSN5 IPR000555, JAMM/MPN+_dom IPR037518, MPN |
PANTHERi | PTHR10410:SF6, PTHR10410:SF6, 1 hit |
Pfami | View protein in Pfam PF01398, JAB, 1 hit |
SMARTi | View protein in SMART SM00232, JAB_MPN, 1 hit |
PROSITEi | View protein in PROSITE PS50249, MPN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CSN5_SCHPO | |
Accessioni | O94454Primary (citable) accession number: O94454 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2003 |
Last sequence update: | May 1, 1999 | |
Last modified: | April 7, 2021 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families