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Entry version 122 (25 May 2022)
Sequence version 1 (01 May 1999)
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Protein

PWWP domain-containing protein2

Gene

pdp2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PWWP domain-containing protein2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pdp2
ORF Names:SPBC215.07c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPBC215.07c, pdp2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPBC215.07c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001167681 – 568PWWP domain-containing protein2Add BLAST568

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O94312

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O94312

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O94312

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
277178, 21 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPBC215.07c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1568
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
O94312

Biological Magnetic Resonance Data Bank

More...
BMRBi
O94312

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O94312

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O94312

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini125 – 189PWWPPROSITE-ProRule annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 126DisorderedSequence analysisAdd BLAST126
Regioni213 – 340DisorderedSequence analysisAdd BLAST128
Regioni465 – 568DisorderedSequence analysisAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 23Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi24 – 49Polar residuesSequence analysisAdd BLAST26
Compositional biasi51 – 89Basic and acidic residuesSequence analysisAdd BLAST39
Compositional biasi90 – 104Polar residuesSequence analysisAdd BLAST15
Compositional biasi105 – 121Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi229 – 245Acidic residuesSequence analysisAdd BLAST17
Compositional biasi268 – 311Polar residuesSequence analysisAdd BLAST44
Compositional biasi465 – 487Polar residuesSequence analysisAdd BLAST23
Compositional biasi488 – 502Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi515 – 541Basic and acidic residuesSequence analysisAdd BLAST27

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S5RN, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_032844_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O94312

Identification of Orthologs from Complete Genome Data

More...
OMAi
IVCDEEM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O94312

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05840, SPBC215_ISWI_like, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...
IDEALi
IID50183

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035503, IOC4-like_PWWP
IPR000313, PWWP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00855, PWWP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00293, PWWP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50812, PWWP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O94312-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEIKDSSVK DENPGKQEES SIAVESREMS TATNNSKNIE TTSSNGAEDI
60 70 80 90 100
KIQRDVGDDK DLDDKEANDK SSKGLEEESD SKDRKTIETD QPSNNIGDIK
110 120 130 140 150
SQKSEKSNGN ARKETKQSER VNYKPGMRVL TKMSGFPWWP SMVVTESKMT
160 170 180 190 200
SVARKSKPKR AGTFYPVIFF PNKEYLWTGS DSLTPLTSEA ISQFLEKPKP
210 220 230 240 250
KTASLIKAYK MAQSTPDLDS LSVPSSESEV SEEESDQEMS EPSPIEEDYN
260 270 280 290 300
DTKARRITRK GTKKKTVTFD PSLESVPQKR LNASSNVSSN PAKKTRVSPR
310 320 330 340 350
RSTAASKKKS PSSKRASSDE IEKDKEEEEG SVANEEDVAK RTFHSREQSL
360 370 380 390 400
LFLRHKLQSS LLSPKQDLSQ VDYKLVHNYL DKLANFQGID VPLIQKTKIA
410 420 430 440 450
VVVRKIFSLA GLPKENEDEV KSICGDILEN RWKSLLQEIS SQKQLSTDAS
460 470 480 490 500
QTQDASIANE NETEIASLDE GSESKPTPSP PAEQLTDQKQ NEDNEDKVKA
510 520 530 540 550
DSNGPTQNEN ETADASKDMI SEEKSSKDAD NSLEVAGKDF AEDGTEQTPN
560
LAEPEDGVAA VDLSTGQK
Length:568
Mass (Da):62,825
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD54F73C9F6E51991
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA22121.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T39897

NCBI Reference Sequences

More...
RefSeqi
NP_596684.1, NM_001022607.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC215.07c.1; SPBC215.07c.1:pep; SPBC215.07c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2540653

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC215.07c

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA22121.1
PIRiT39897
RefSeqiNP_596684.1, NM_001022607.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H3ZNMR-A118-225[»]
AlphaFoldDBiO94312
BMRBiO94312
SMRiO94312
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi277178, 21 interactors
STRINGi4896.SPBC215.07c.1

PTM databases

iPTMnetiO94312

Proteomic databases

MaxQBiO94312
PaxDbiO94312

Genome annotation databases

EnsemblFungiiSPBC215.07c.1; SPBC215.07c.1:pep; SPBC215.07c
GeneIDi2540653
KEGGispo:SPBC215.07c

Organism-specific databases

PomBaseiSPBC215.07c, pdp2
VEuPathDBiFungiDB:SPBC215.07c

Phylogenomic databases

eggNOGiENOG502S5RN, Eukaryota
HOGENOMiCLU_032844_0_0_1
InParanoidiO94312
OMAiIVCDEEM
PhylomeDBiO94312

Miscellaneous databases

EvolutionaryTraceiO94312

Protein Ontology

More...
PROi
PR:O94312

Family and domain databases

CDDicd05840, SPBC215_ISWI_like, 1 hit
IDEALiIID50183
InterProiView protein in InterPro
IPR035503, IOC4-like_PWWP
IPR000313, PWWP_dom
PfamiView protein in Pfam
PF00855, PWWP, 1 hit
SMARTiView protein in SMART
SM00293, PWWP, 1 hit
PROSITEiView protein in PROSITE
PS50812, PWWP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDP2_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94312
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: May 1, 1999
Last modified: May 25, 2022
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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