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Protein

Probable phospholipid-transporting ATPase C887.12

Gene

SPBC887.12

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids.Curated

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTranslocase
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-6798695 Neutrophil degranulation
R-SPO-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase C887.12 (EC:7.6.2.1)
Gene namesi
ORF Names:SPBC887.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC887.12
PomBaseiSPBC887.12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 183CytoplasmicBy similarityAdd BLAST183
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 208LumenalBy similarity4
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 406CytoplasmicBy similarityAdd BLAST177
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Topological domaini428 – 451LumenalBy similarityAdd BLAST24
Transmembranei452 – 472HelicalSequence analysisAdd BLAST21
Topological domaini473 – 974CytoplasmicBy similarityAdd BLAST502
Transmembranei975 – 995HelicalSequence analysisAdd BLAST21
Topological domaini996 – 998LumenalBy similarity3
Transmembranei999 – 1019HelicalSequence analysisAdd BLAST21
Topological domaini1020 – 1051CytoplasmicBy similarityAdd BLAST32
Transmembranei1052 – 1072HelicalSequence analysisAdd BLAST21
Topological domaini1073 – 1086LumenalBy similarityAdd BLAST14
Transmembranei1087 – 1107HelicalSequence analysisAdd BLAST21
Topological domaini1108 – 1115CytoplasmicBy similarity8
Transmembranei1116 – 1136HelicalSequence analysisAdd BLAST21
Topological domaini1137 – 1148LumenalBy similarityAdd BLAST12
Transmembranei1149 – 1169HelicalSequence analysisAdd BLAST21
Topological domaini1170 – 1258CytoplasmicBy similarityAdd BLAST89

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003141121 – 1258Probable phospholipid-transporting ATPase C887.12Add BLAST1258

Proteomic databases

MaxQBiO94296
PaxDbiO94296
PRIDEiO94296

PTM databases

iPTMnetiO94296

Interactioni

Protein-protein interaction databases

STRINGi4896.SPBC887.12.1

Structurei

3D structure databases

ProteinModelPortaliO94296
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000202528
InParanoidiO94296
KOiK14802
OMAiGMSCKLI
OrthoDBiEOG092C0BQ4
PhylomeDBiO94296

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

O94296-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARDVDNKQN AKRISRDEDE DEFAGESMVG RTLDNPFLGE DEFEDIFGSE
60 70 80 90 100
SQYISSSGQN STNPFLADTR IENSPLGSES KANQLNKQGT NVNHIEIPLR
110 120 130 140 150
DFNDPTQPES FLPPPKNTFT SRIKKIKNLF KKEKKQVKPE DLGPRQIILN
160 170 180 190 200
DYSANHFLHN AVSTCKYSAF TFLPKFLKEQ FSKYANLFFL FTAVVQQIPG
210 220 230 240 250
ITPVNRYTTI GPMLIVLSVS GIKEIMEDIK RKKQDQELNE SPCYVLQGTG
260 270 280 290 300
FVEKQWKDVV VGDIVKIVSE TFFPADLVLL SSSEPEGLCY IETANLDGET
310 320 330 340 350
NLKIKQALPE TAGLLKPVEL GQLSGEVKSE QPNNNLYTFD ATLKLLPSDR
360 370 380 390 400
ELPLSPDQLL LRGAQLRNTP WVYGIVVFTG HESKLMKNTT ETPIKRTSVE
410 420 430 440 450
KQVNSQILFL LCIFVFLCFA SSLGALIHRS VYGSALSYVK YTSNRAGMFF
460 470 480 490 500
KGLLTFWILY SNLVPISLFV TFELVRYIQA QLISSDLDMY NEETDTPAAC
510 520 530 540 550
RTSSLVEELG QVGYIFSDKT GTLTRNQMEF RQCTIAGVAY ADVIPEDRQF
560 570 580 590 600
TSEDLDSDMY IYDFDTLKEN LKHSENASLI HQFLLVLSIC HTVIPEYDES
610 620 630 640 650
TNSIKYQASS PDEGALVKGA ASIGYKFLAR KPHLVTVSIF GKDESYELLH
660 670 680 690 700
ICEFNSTRKR MSIVFRCPDG KIRLYVKGAD TVIMERLASD NPYLQTTIHH
710 720 730 740 750
LEDYATVGLR TLCIAMREVP EDEYQRWSTV FETAASSLVD RAQKLMDAAE
760 770 780 790 800
EIEKDLILLG ATAIEDRLQD GVPDTISTLQ TAGIKIWVLT GDRQETAINI
810 820 830 840 850
GMSCKLIDED MGLVIVNEET KEATAESVMA KLSSIYRNEA TTGNVESMAL
860 870 880 890 900
VIDGVSLTYA LDFSLERRFF ELASLCRAVI CCRVSPLQKA LIVKMVKRNT
910 920 930 940 950
GEVLLAIGDG ANDVPMIQAA HVGVGISGME GLQAVRSSDF SISQFCYLKK
960 970 980 990 1000
LLLVHGSWCY QRLSKLILYS FYKNIALYMT QFWYAFCNAF SGQVIFESWS
1010 1020 1030 1040 1050
ISLYNVLFTV LPPVVIGIFD QFVSAGQLFQ YPQLYQLGQR SEFFNLKRFW
1060 1070 1080 1090 1100
SWITNGFYHS LLLFLCSIAV FYYDGPNKDG LASGHWVWGT TLYAAILATV
1110 1120 1130 1140 1150
LGKAALISNH WTQYTVIATL GSFLLWIVFM PIYAVAAPAI GFSKEYYGII
1160 1170 1180 1190 1200
PHLYGNLKFW ASLLVLPTIA LMRDFVWKYS SRMYYPEEYH YVQEIQKYNV
1210 1220 1230 1240 1250
TDYRPRIVGF HKAIRKIRQM QRMRKQRGYA FSQGEEDQSR ILDAYDTTHT

RGAYGEMR
Length:1,258
Mass (Da):142,379
Last modified:May 1, 1999 - v1
Checksum:i9128B7BFD692B022
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA21897.1
PIRiT40737
RefSeqiNP_596486.1, NM_001022406.2

Genome annotation databases

EnsemblFungiiSPBC887.12.1; SPBC887.12.1:pep; SPBC887.12
GeneIDi2541239
KEGGispo:SPBC887.12

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA21897.1
PIRiT40737
RefSeqiNP_596486.1, NM_001022406.2

3D structure databases

ProteinModelPortaliO94296
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4896.SPBC887.12.1

PTM databases

iPTMnetiO94296

Proteomic databases

MaxQBiO94296
PaxDbiO94296
PRIDEiO94296

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC887.12.1; SPBC887.12.1:pep; SPBC887.12
GeneIDi2541239
KEGGispo:SPBC887.12

Organism-specific databases

EuPathDBiFungiDB:SPBC887.12
PomBaseiSPBC887.12

Phylogenomic databases

HOGENOMiHOG000202528
InParanoidiO94296
KOiK14802
OMAiGMSCKLI
OrthoDBiEOG092C0BQ4
PhylomeDBiO94296

Enzyme and pathway databases

ReactomeiR-SPO-6798695 Neutrophil degranulation
R-SPO-936837 Ion transport by P-type ATPases

Miscellaneous databases

PROiPR:O94296

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01652 ATPase-Plipid, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiYOOC_SCHPO
AccessioniPrimary (citable) accession number: O94296
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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Main funding by: National Institutes of Health

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