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UniProtKB - O94258 (XPOT_SCHPO)

Entry version 124 (23 Feb 2022)
Sequence version 1 (01 May 1999)
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Protein

Exportin-T

Gene

los1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding, tRNA-binding
Biological processTransport, tRNA processing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exportin-T
Alternative name(s):
Exportin(tRNA)
Karyopherin-beta
tRNA exportin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:los1
ORF Names:SPBP8B7.09c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Schizosaccharomyces pombe database

More...PomBasei		SPBP8B7.09c, los1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:SPBP8B7.09c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003431051 – 978Exportin-TAdd BLAST978

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		O94258

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O94258

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O94258

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		277823, 26 interactors

Database of interacting proteins

More...DIPi		DIP-59297N

Protein interaction database and analysis system

More...IntActi		O94258, 1 interactor

STRING: functional protein association networks

More...STRINGi		4896.SPBP8B7.09c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1978
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O94258

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O94258

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2021, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004414_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O94258

Identification of Orthologs from Complete Genome Data

More...OMAi		RFSPLCW

Database for complete collections of gene phylogenies

More...PhylomeDBi		O94258

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR013598, Exportin-1/Importin-b-like
IPR045546, Exportin-T_C
IPR040017, XPOT

The PANTHER Classification System

More...PANTHERi		PTHR15952, PTHR15952, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF19282, Exportin-T, 1 hit
PF08389, Xpo1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O94258-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAQDVENAV EAALDPSVGP IIKQQATDFI GSLRSSSTGW KICHEIFSEK 
        60         70         80         90        100
TKYKPSTRLI CLQTLSEKVR EWNNESNLLE LQMIRDSVWS YIKELSFLDE 
       110        120        130        140        150
PAYISNAVQH LLTLLFLQLY PSNWNDFFAS LQGVIAASSQ SEFSNFYLKV 
       160        170        180        190        200
LLSIGDEIAD SLVLKTDVQI QKDNLVKDAI RANDMSDIVS FVYEMMLAYS 
       210        220        230        240        250
NAKNYGTVGL CLQVYAQWVS WININLIVNE PCMNLLYSFL QIEELRCAAC 
       260        270        280        290        300
ETMTEIVNKK MKPLEKLNLL NILNLNLFFS KSQEQSTDPN FDEHVAKLIN 
       310        320        330        340        350
AQGVELVAIK SDPSELSPEL KENCSFQLYN LFPYLIRYLS DDYDETSTAV 
       360        370        380        390        400
FPFLSDLLVS LRKESSSKEL SASLKEFLKS LLEAIIKKMK YDESQEWDDD 
       410        420        430        440        450
PDSEEEAEFQ EMRKKLKIFQ DTINSIDSSL FSSYMYSAIT SSLSTAATLS 
       460        470        480        490        500
PENSWQLIEF ALYETYIFGE GLRGPDAFFN EVDKSPTVLS QILALVTTSQ 
       510        520        530        540        550
VCRHPHPLVQ LLYMEILVRY ASFFDYESAA IPALIEYFVG PRGIHNTNER 
       560        570        580        590        600
VRPRAWYLFY RFVKSIKKQV VNYTESSLAM LGDLLNISVS PVTDMDAPVP 
       610        620        630        640        650
TLNSSIRNSD FNSQLYLFET VGVLISSGNL TPEEQALYCD SLINALIGKA 
       660        670        680        690        700
NAALSSDLSA LENIISVYCS LMAIGNFAKG FPARGSEEVA WLASFNKASD 
       710        720        730        740        750
EIFLILDRMG FNEDIRGAVR FTSGRIINVV GPDMLPKVPQ LISILLNSID 
       760        770        780        790        800
MNELVDVLSF ISQLIHIYKD NMMEITNRML PTLLMRIFSS LSAAPQGTDD 
       810        820        830        840        850
AVKQNDLRKS YISFILQLLN KGFGSILFTE ENQVYFDPLI NSILHFANLV 
       860        870        880        890        900
GEPATQKSSI ALVSKMVSLW GGKDGIAGFE NFTLSLTPLC FEMPVNPNFN 
       910        920        930        940        950
TRDGQSLVVL GELAGLQKII LEKLGDIYKS YLVTVYFPTV NFPDVMASEY 
       960        970 
LQALSNLDSR SFKQFFQKFI QALKSGNV
Length:978
Mass (Da):110,114
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2875E1DBAE818829
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA21794.1

Protein sequence database of the Protein Information Resource

More...PIRi		T40803

NCBI Reference Sequences

More...RefSeqi		NP_596516.1, NM_001022437.2

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		SPBP8B7.09c.1; SPBP8B7.09c.1:pep; SPBP8B7.09c

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2541311

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		spo:SPBP8B7.09c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA21794.1
PIRiT40803
RefSeqiNP_596516.1, NM_001022437.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IBVX-ray3.10A/B1-978[»]
3ICQX-ray3.20T/U1-978[»]
SMRiO94258
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi277823, 26 interactors
DIPiDIP-59297N
IntActiO94258, 1 interactor
STRINGi4896.SPBP8B7.09c.1

PTM databases

iPTMnetiO94258

Proteomic databases

MaxQBiO94258
PaxDbiO94258

Genome annotation databases

EnsemblFungiiSPBP8B7.09c.1; SPBP8B7.09c.1:pep; SPBP8B7.09c
GeneIDi2541311
KEGGispo:SPBP8B7.09c

Organism-specific databases

PomBaseiSPBP8B7.09c, los1
VEuPathDBiFungiDB:SPBP8B7.09c

Phylogenomic databases

eggNOGiKOG2021, Eukaryota
HOGENOMiCLU_004414_0_1_1
InParanoidiO94258
OMAiRFSPLCW
PhylomeDBiO94258

Miscellaneous databases

EvolutionaryTraceiO94258

Protein Ontology

More...PROi		PR:O94258

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR013598, Exportin-1/Importin-b-like
IPR045546, Exportin-T_C
IPR040017, XPOT
PANTHERiPTHR15952, PTHR15952, 1 hit
PfamiView protein in Pfam
PF19282, Exportin-T, 1 hit
PF08389, Xpo1, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXPOT_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O94258
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: May 1, 1999
Last modified: February 23, 2022
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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