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UniProtKB - O94258 (XPOT_SCHPO)
Protein
Exportin-T
Gene
los1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity).
By similarityGO - Molecular functioni
- GTP binding Source: PomBase
- small GTPase binding Source: PomBase
- tRNA binding Source: PomBase
GO - Biological processi
- tRNA processing Source: UniProtKB-KW
- tRNA re-export from nucleus Source: GO_Central
Keywordsi
Molecular function | RNA-binding, tRNA-binding |
Biological process | Transport, tRNA processing |
Names & Taxonomyi
Protein namesi | Recommended name: Exportin-TAlternative name(s): Exportin(tRNA) Karyopherin-beta tRNA exportin |
Gene namesi | Name:los1 ORF Names:SPBP8B7.09c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPBP8B7.09c, los1 |
VEuPathDBi | FungiDB:SPBP8B7.09c |
Subcellular locationi
Cytosol
- cytosol Source: PomBase
Nucleus
- nuclear envelope Source: PomBase
- nuclear matrix Source: PomBase
- nuclear pore Source: GO_Central
- nucleus Source: PomBase
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000343105 | 1 – 978 | Exportin-TAdd BLAST | 978 |
Proteomic databases
MaxQBi | O94258 |
PaxDbi | O94258 |
PTM databases
iPTMneti | O94258 |
Interactioni
Binary interactionsi
O94258
With | #Exp. | IntAct |
---|---|---|
GSP1 [P32835] from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). | 2 | EBI-15799183,EBI-7926 |
GO - Molecular functioni
- small GTPase binding Source: PomBase
Protein-protein interaction databases
BioGRIDi | 277823, 26 interactors |
DIPi | DIP-59297N |
IntActi | O94258, 1 interactor |
STRINGi | 4896.SPBP8B7.09c.1 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O94258 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O94258 |
Family & Domainsi
Sequence similaritiesi
Belongs to the exportin family.Curated
Phylogenomic databases
eggNOGi | KOG2021, Eukaryota |
HOGENOMi | CLU_004414_0_1_1 |
InParanoidi | O94258 |
OMAi | RFSPLCW |
PhylomeDBi | O94258 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR013598, Exportin-1/Importin-b-like IPR045546, Exportin-T_C IPR040017, XPOT |
PANTHERi | PTHR15952, PTHR15952, 1 hit |
Pfami | View protein in Pfam PF19282, Exportin-T, 1 hit PF08389, Xpo1, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
i Sequence
Sequence statusi: Complete.
O94258-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAQDVENAV EAALDPSVGP IIKQQATDFI GSLRSSSTGW KICHEIFSEK
60 70 80 90 100
TKYKPSTRLI CLQTLSEKVR EWNNESNLLE LQMIRDSVWS YIKELSFLDE
110 120 130 140 150
PAYISNAVQH LLTLLFLQLY PSNWNDFFAS LQGVIAASSQ SEFSNFYLKV
160 170 180 190 200
LLSIGDEIAD SLVLKTDVQI QKDNLVKDAI RANDMSDIVS FVYEMMLAYS
210 220 230 240 250
NAKNYGTVGL CLQVYAQWVS WININLIVNE PCMNLLYSFL QIEELRCAAC
260 270 280 290 300
ETMTEIVNKK MKPLEKLNLL NILNLNLFFS KSQEQSTDPN FDEHVAKLIN
310 320 330 340 350
AQGVELVAIK SDPSELSPEL KENCSFQLYN LFPYLIRYLS DDYDETSTAV
360 370 380 390 400
FPFLSDLLVS LRKESSSKEL SASLKEFLKS LLEAIIKKMK YDESQEWDDD
410 420 430 440 450
PDSEEEAEFQ EMRKKLKIFQ DTINSIDSSL FSSYMYSAIT SSLSTAATLS
460 470 480 490 500
PENSWQLIEF ALYETYIFGE GLRGPDAFFN EVDKSPTVLS QILALVTTSQ
510 520 530 540 550
VCRHPHPLVQ LLYMEILVRY ASFFDYESAA IPALIEYFVG PRGIHNTNER
560 570 580 590 600
VRPRAWYLFY RFVKSIKKQV VNYTESSLAM LGDLLNISVS PVTDMDAPVP
610 620 630 640 650
TLNSSIRNSD FNSQLYLFET VGVLISSGNL TPEEQALYCD SLINALIGKA
660 670 680 690 700
NAALSSDLSA LENIISVYCS LMAIGNFAKG FPARGSEEVA WLASFNKASD
710 720 730 740 750
EIFLILDRMG FNEDIRGAVR FTSGRIINVV GPDMLPKVPQ LISILLNSID
760 770 780 790 800
MNELVDVLSF ISQLIHIYKD NMMEITNRML PTLLMRIFSS LSAAPQGTDD
810 820 830 840 850
AVKQNDLRKS YISFILQLLN KGFGSILFTE ENQVYFDPLI NSILHFANLV
860 870 880 890 900
GEPATQKSSI ALVSKMVSLW GGKDGIAGFE NFTLSLTPLC FEMPVNPNFN
910 920 930 940 950
TRDGQSLVVL GELAGLQKII LEKLGDIYKS YLVTVYFPTV NFPDVMASEY
960 970
LQALSNLDSR SFKQFFQKFI QALKSGNV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAA21794.1 |
PIRi | T40803 |
RefSeqi | NP_596516.1, NM_001022437.2 |
Genome annotation databases
EnsemblFungii | SPBP8B7.09c.1; SPBP8B7.09c.1:pep; SPBP8B7.09c |
GeneIDi | 2541311 |
KEGGi | spo:SPBP8B7.09c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAA21794.1 |
PIRi | T40803 |
RefSeqi | NP_596516.1, NM_001022437.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3IBV | X-ray | 3.10 | A/B | 1-978 | [»] | |
3ICQ | X-ray | 3.20 | T/U | 1-978 | [»] | |
SMRi | O94258 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 277823, 26 interactors |
DIPi | DIP-59297N |
IntActi | O94258, 1 interactor |
STRINGi | 4896.SPBP8B7.09c.1 |
PTM databases
iPTMneti | O94258 |
Proteomic databases
MaxQBi | O94258 |
PaxDbi | O94258 |
Genome annotation databases
EnsemblFungii | SPBP8B7.09c.1; SPBP8B7.09c.1:pep; SPBP8B7.09c |
GeneIDi | 2541311 |
KEGGi | spo:SPBP8B7.09c |
Organism-specific databases
PomBasei | SPBP8B7.09c, los1 |
VEuPathDBi | FungiDB:SPBP8B7.09c |
Phylogenomic databases
eggNOGi | KOG2021, Eukaryota |
HOGENOMi | CLU_004414_0_1_1 |
InParanoidi | O94258 |
OMAi | RFSPLCW |
PhylomeDBi | O94258 |
Miscellaneous databases
EvolutionaryTracei | O94258 |
PROi | PR:O94258 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR013598, Exportin-1/Importin-b-like IPR045546, Exportin-T_C IPR040017, XPOT |
PANTHERi | PTHR15952, PTHR15952, 1 hit |
Pfami | View protein in Pfam PF19282, Exportin-T, 1 hit PF08389, Xpo1, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | XPOT_SCHPO | |
Accessioni | O94258Primary (citable) accession number: O94258 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 2008 |
Last sequence update: | May 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families