Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 63 (16 Oct 2019)
Sequence version 3 (06 Feb 2013)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

1,3-beta-glucan synthase component FKS1

Gene

FKS1

Organism
Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Alternate catalytic subunit of the 1,3-beta-glucan synthase (GS). Synthesizes 1,3-beta-glucan, a major structural component of the yeast cell wall. Involved in cell wall synthesis, maintenance and cell wall remodeling (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell shape, Cell wall biogenesis/degradation

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT48 Glycosyltransferase Family 48

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
1,3-beta-glucan synthase component FKS1 (EC:2.4.1.34)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FKS1
ORF Names:CNAG_06508
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri235443 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000010091 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:CNAG_06508

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei431 – 451HelicalSequence analysisAdd BLAST21
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21
Transmembranei504 – 524HelicalSequence analysisAdd BLAST21
Transmembranei530 – 550HelicalSequence analysisAdd BLAST21
Transmembranei591 – 611HelicalSequence analysisAdd BLAST21
Transmembranei648 – 668HelicalSequence analysisAdd BLAST21
Transmembranei1268 – 1288HelicalSequence analysisAdd BLAST21
Transmembranei1323 – 1343HelicalSequence analysisAdd BLAST21
Transmembranei1422 – 1442HelicalSequence analysisAdd BLAST21
Transmembranei1446 – 1466HelicalSequence analysisAdd BLAST21
Transmembranei1527 – 1547HelicalSequence analysisAdd BLAST21
Transmembranei1563 – 1583HelicalSequence analysisAdd BLAST21
Transmembranei1605 – 1625HelicalSequence analysisAdd BLAST21
Transmembranei1635 – 1655HelicalSequence analysisAdd BLAST21
Transmembranei1704 – 1724HelicalSequence analysisAdd BLAST21
Transmembranei1762 – 1782HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Impairs mitotic growth.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003942171 – 17991,3-beta-glucan synthase component FKS1Add BLAST1799

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O93927

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the 1,3-beta-glucan synthase (GS).

By similarity

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyltransferase 48 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026899 FKS1-like_dom1
IPR003440 Glyco_trans_48

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14288 FKS1_dom1, 1 hit
PF02364 Glucan_synthase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01205 FKS1_dom1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O93927-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYPNPPPPP KGSASFSSSS SDPFNQTNQL PYDSQFPPQH AFAHPSAPNP
60 70 80 90 100
GAGGAGVAPP GQGGQYAPYY DNEPEMGGRW EGGGMGRETW ASESGWSQNE
110 120 130 140 150
PNYPPSDYHG GPGYLPSRAS TPTFEGSNAG HRPRDPYPAW TVDANIPLSK
160 170 180 190 200
EEIEDVLIDL ANKFGFQKDS SRNVYDFLMI QLDSRASRMS PNQALLTLHA
210 220 230 240 250
DYIGGEHANY RKWYFAAQLD LDDAIGAVQN PGLNRVRSVA RRGGKTKNPL
260 270 280 290 300
ATAQEKSLES ATSRWRTAMN NMSQYDRLRQ VALYLLCWGE AAQVRFMPEC
310 320 330 340 350
LCFIFKCADD YYRSPECQNR QEAVPEGLYL RAVIKPLYRF LRDQGYEVVD
360 370 380 390 400
GKFLRRERDH DKVIGYDDVN QLFWYPEGIS RITLNDNTRL VDIPPAQRFM
410 420 430 440 450
KFDRIDWNKV FFKTYLEKRS FFHLLVNFNR IWVLHISVFW FFTAYNAPSI
460 470 480 490 500
YAPSGSTTAT TPMAWSMTGL GGFVATLIMI AATLAEFSYI PTTWNNTSHL
510 520 530 540 550
TRRLIFLLII LAITGGPSIY IAFFNQTGHV ALILGIVQFF CSVVATIAFA
560 570 580 590 600
TLPSGRMFGD RVAGKSRKYL ANQTFTASYP ALGFYPRVAS FLLWFLVFGC
610 620 630 640 650
KFTESYFFLT LSFRDPMKVM NGMKVQNCHD KYFGNGLCTN QPAFALAVMF
660 670 680 690 700
VMDLTLFFLD TFLWYVIWNT VFSIARSFAI GMSIWTPWKD IFARLPKRIY
710 720 730 740 750
AKILATDDME VKYKPKVLVS QVWNAVIISM YREHLLSIEH VQKLLYHQIQ
760 770 780 790 800
SDQPGKRTLR APAFFISQSE KGSKAEFFPK GSEAERRICF FAQSLTTSIP
810 820 830 840 850
APIPVDAMPT FTVLVPHYSE KILLSLREII REEDQNTRVT LLEYLKQLHP
860 870 880 890 900
VEWDNFVRDT KILAEESDAF NGGNPFASDE KEEAKKADDI PFYTIGFKSA
910 920 930 940 950
APEYTLRTRI WASLRAQTLY RTVSGFMNYS KAIKLLYRVE NPEVVQLFGG
960 970 980 990 1000
NTDQLERELE RMARRKFKFV VSMQRYSKFN KEEHENAEFL LRAYPDLQIA
1010 1020 1030 1040 1050
YLDEEPPRKD GGESRIFSAL IDGHSEIMPN GRRRPKFRIE LPGNPILGDG
1060 1070 1080 1090 1100
KSDNQNHAIV FYRGEYLQLI DANQDNYLEE CLKIRNVLGE FEEFKVSTQS
1110 1120 1130 1140 1150
PYAAQGHADF AKFPVAILGA REYIFSENIG ILGDIAAGKE QTFGTLAARS
1160 1170 1180 1190 1200
LSYIGGKLHY GHPDFLNAIY MNTRGGVSKA QKGLHLNEDI FAGMLAFGRG
1210 1220 1230 1240 1250
GRIKHSEYYQ CGKGRDLGFG TILNFQTKIG TGMGEQMLSR EYYYLGTQLP
1260 1270 1280 1290 1300
IDRFLTFYYG HPGFHINNIL VMMSVQVFML ALVFLGTLNK QLTVCRYSSG
1310 1320 1330 1340 1350
GDILPGQSGC YNLVPVFKWI KRCIISIFIV FWIAFVPLFV QELTERGTGR
1360 1370 1380 1390 1400
AILRLCKHFL SLSPVFEVFS TQIYMHSILN DLTFGGARYI ATGRGFATTR
1410 1420 1430 1440 1450
ISFSILYSRF AGPSIYLGMR TLVLLLFITL TVWVPHLIYF WITVVGLCVA
1460 1470 1480 1490 1500
PFLFNPHQFA IADFIIDYRE FLRWMSRGNS RTHANSWVGY CRLSRTRVTG
1510 1520 1530 1540 1550
FKRKRLGLPS EKLSSDVPRA PWKAILIGEI IGPICLAILF VICYLFIKSF
1560 1570 1580 1590 1600
AVDGQIQPGL VRIAIIALGP IVWNMALLIT LFLISVFLGP CLNSYTHQFG
1610 1620 1630 1640 1650
ATMAALAHFG AVAGMLVFFE LLWFLELWNT SHAVLGIIAV ISVQRCIFKF
1660 1670 1680 1690 1700
LIAVFLSREF KHDETNRAWW TGVWFNRGLG SHALSQPARE FVVKTIEMGL
1710 1720 1730 1740 1750
YSADFIACHL LLALLTIPMF IPYFDRVHAT MLFWLAPNQQ IRPPIYSFRQ
1760 1770 1780 1790
RSQRRKIVFK YGLLYLIIQG IFIALIVVPI IFKDVAGLTP KSVPFNGII
Length:1,799
Mass (Da):204,372
Last modified:February 6, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE3D5290290DD48EC
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD11794 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1333I → M in AAD11794 (PubMed:9882657).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF102882 Genomic DNA Translation: AAD11794.1 Frameshift.
CP003832 Genomic DNA Translation: AFR98738.1

NCBI Reference Sequences

More...
RefSeqi
XP_012053533.1, XM_012198143.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
AFR98738; AFR98738; CNAG_06508

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23889702

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102882 Genomic DNA Translation: AAD11794.1 Frameshift.
CP003832 Genomic DNA Translation: AFR98738.1
RefSeqiXP_012053533.1, XM_012198143.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

CAZyiGT48 Glycosyltransferase Family 48

PTM databases

SwissPalmiO93927

Genome annotation databases

EnsemblFungiiAFR98738; AFR98738; CNAG_06508
GeneIDi23889702

Organism-specific databases

EuPathDBiFungiDB:CNAG_06508

Family and domain databases

InterProiView protein in InterPro
IPR026899 FKS1-like_dom1
IPR003440 Glyco_trans_48
PfamiView protein in Pfam
PF14288 FKS1_dom1, 1 hit
PF02364 Glucan_synthase, 1 hit
SMARTiView protein in SMART
SM01205 FKS1_dom1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFKS1_CRYNH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O93927
Secondary accession number(s): J9VWV0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: February 6, 2013
Last modified: October 16, 2019
This is version 63 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again