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Protein

Lysophospholipase 2

Gene

PLB2

Organism
Candida albicans (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase 2 (EC:3.1.1.5)
Alternative name(s):
CaPLB2
Phospholipase B 2
Gene namesi
Name:PLB2
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002463118 – 608Lysophospholipase 2Add BLAST591

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi259N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi365N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi450N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi464N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi491N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi572N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliO93795
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 564PLA2cPROSITE-ProRule annotationAdd BLAST535

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR002642 LysoPLipase_cat_dom
PfamiView protein in Pfam
PF01735 PLA2_B, 1 hit
SMARTiView protein in SMART
SM00022 PLAc, 1 hit
SUPFAMiSSF52151 SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS51210 PLA2C, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O93795-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVWQSILLF LVGCVLSKSP TNLYTPGYVQ CPEGKLTRSS LDGINSNEKA
60 70 80 90 100
YIDRRYANAK SELSRFLHNA KMVDFDVDGF LNSNPTIGLA FSGGGYRAML
110 120 130 140 150
AGAGELLALD SRATNPSVLS GILQSSSYIV GLSGGSWLVG SLASNDLIPV
160 170 180 190 200
DQLLREDKLW DIQNSLVAYY GVNIVRNTAM WGNINLQVQT KQLAGFTVSI
210 220 230 240 250
TDVYGRALSH QLLTNFDNQG ASFLWSDVTE TTSFQNNEMP YPILAALGRE
260 270 280 290 300
PNTVLMNFNS TVFELTPYEV GSWDPSLRSF VDTKYIGTRL DDGAPVSKRC
310 320 330 340 350
VNGFDNAGFF MGTSSSLFNI VLQQLNNMPI PPFLKELISK FTLDPVEKLN
360 370 380 390 400
IDIAQYNPNP FHKSNNSDTK IAQSRTLYLA DGGEDGQNVP LLPLIHRKVS
410 420 430 440 450
AIFAFDQSAD KNNWPDGSAL IKTFERQFSS QGDGIAFPYV PDQNTFRNTN
460 470 480 490 500
LTSKPTFFGC DAQNLTSLTE NIYDVPVVIY LANRPFTYFS NISTFKLKYS
510 520 530 540 550
DTERQGMISN GYDVASRLNG KLDNEWAACV GCAIIRREQE RLGIEQTEQC
560 570 580 590 600
KKCFENYCWD GTIYKGEPLG DNFSDEGLTT SAAYYNSNNV AGINDGGIAL

VKRDDLSN
Length:608
Mass (Da):67,220
Last modified:May 1, 1999 - v1
Checksum:i0ABEA2C878CD8610
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010809 Genomic DNA Translation: BAA36162.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010809 Genomic DNA Translation: BAA36162.1

3D structure databases

ProteinModelPortaliO93795
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR002642 LysoPLipase_cat_dom
PfamiView protein in Pfam
PF01735 PLA2_B, 1 hit
SMARTiView protein in SMART
SM00022 PLAc, 1 hit
SUPFAMiSSF52151 SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS51210 PLA2C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLB2_CANAX
AccessioniPrimary (citable) accession number: O93795
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 1, 1999
Last modified: May 10, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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