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Protein

Metallothionein A

Gene

mta

Organism
Parachaenichthys charcoti (Charcot's dragonfish) (Chaenichthys charcoti)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi4Divalent metal cation; cluster B1
Metal bindingi6Divalent metal cation; cluster B1
Metal bindingi12Divalent metal cation; cluster B1
Metal bindingi14Divalent metal cation; cluster B1
Metal bindingi18Divalent metal cation; cluster B1
Metal bindingi20Divalent metal cation; cluster B1
Metal bindingi23Divalent metal cation; cluster B1
Metal bindingi25Divalent metal cation; cluster B1
Metal bindingi28Divalent metal cation; cluster B1
Metal bindingi32Divalent metal cation; cluster A1
Metal bindingi33Divalent metal cation; cluster A1
Metal bindingi35Divalent metal cation; cluster A1
Metal bindingi36Divalent metal cation; cluster A1
Metal bindingi40Divalent metal cation; cluster A1
Metal bindingi43Divalent metal cation; cluster A1
Metal bindingi47Divalent metal cation; cluster A1
Metal bindingi49Divalent metal cation; cluster A1
Metal bindingi54Divalent metal cation; cluster A1
Metal bindingi58Divalent metal cation; cluster A1
Metal bindingi59Divalent metal cation; cluster A1

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein A
Short name:
MT-A
Short name:
MT-I
Gene namesi
Name:mta
Synonyms:mt
OrganismiParachaenichthys charcoti (Charcot's dragonfish) (Chaenichthys charcoti)
Taxonomic identifieri36187 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesNotothenioideiBathydraconidaeParachaenichthys

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001973051 – 60Metallothionein AAdd BLAST60

Proteomic databases

PRIDEiO93450

Structurei

3D structure databases

ProteinModelPortaliO93450
SMRiO93450
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 28BetaAdd BLAST28
Regioni29 – 60AlphaAdd BLAST32

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit

Sequencei

Sequence statusi: Complete.

O93450-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPCECSKSG NCNCGGSCTC TNCSCKSCKK SCCPCCPSGC TKCASGCVCK
60
GKTCDTSCCQ
Length:60
Mass (Da):6,032
Last modified:November 1, 1998 - v1
Checksum:iE87731CE264C424A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007950 mRNA Translation: CAA07785.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007950 mRNA Translation: CAA07785.1

3D structure databases

ProteinModelPortaliO93450
SMRiO93450
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO93450

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMTA_PARCR
AccessioniPrimary (citable) accession number: O93450
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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