UniProtKB - O93449 (TGFB1_ONCMY)
Transforming growth factor beta-1 proprotein
tgfb1
Functioni
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- transforming growth factor beta receptor binding Source: InterPro
GO - Biological processi
- positive regulation of cell division Source: UniProtKB-KW
Keywordsi
Molecular function | Growth factor, Mitogen |
Names & Taxonomyi
Protein namesi | Recommended name: Transforming growth factor beta-1 proproteinCleaved into the following 2 chains: |
Gene namesi | Name:tgfb1 |
Organismi | Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) |
Taxonomic identifieri | 8022 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Protacanthopterygii › Salmoniformes › Salmonidae › Salmoninae › Oncorhynchus |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: InterPro
Keywords - Cellular componenti
Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000445551 | 21 – 271 | Latency-associated peptideBy similarityAdd BLAST | 251 | |
ChainiPRO_0000033781 | 272 – 382 | Transforming growth factor beta-1By similarityAdd BLAST | 111 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 26 | Interchain (with C-? in LTBP1 TB3 domain); in inactive formBy similarity | ||
Glycosylationi | 76 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 116 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 125 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 215 | Interchain (with C-217)By similarity | ||
Disulfide bondi | 217 | Interchain (with C-215)By similarity | ||
Disulfide bondi | 278 ↔ 286 | By similarity | ||
Disulfide bondi | 285 ↔ 348 | By similarity | ||
Disulfide bondi | 314 ↔ 379 | By similarity | ||
Disulfide bondi | 318 ↔ 381 | By similarity | ||
Disulfide bondi | 347 | InterchainBy similarity |
Post-translational modificationi
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinExpressioni
Tissue specificityi
Interactioni
Subunit structurei
Latency-associated peptide: Homodimer; disulfide-linked. Latency-associated peptide:
Interacts with Transforming growth factor beta-1 (TGF-beta-1) chain; interaction is non-covalent and maintains (TGF-beta-1) in a latent state; each Latency-associated peptide (LAP) monomer interacts with TGF-beta-1 in the other monomer. Transforming growth factor beta-1: Homodimer; disulfide-linked. Transforming growth factor beta-1:
Interacts with TGF-beta receptors (tgfbr1 and tgfbr2), leading to signal transduction.
By similarityGO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- transforming growth factor beta receptor binding Source: InterPro
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 23 – 68 | Straightjacket domainBy similarityAdd BLAST | 46 | |
Regioni | 69 – 264 | Arm domainBy similarityAdd BLAST | 196 | |
Regioni | 218 – 243 | Bowtie tailBy similarityAdd BLAST | 26 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 235 – 237 | Cell attachment siteSequence analysis | 3 |
Domaini
Sequence similaritiesi
Keywords - Domaini
SignalFamily and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR003939, TGFb1 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01424, TGFBETA1 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MRAVCLMLTA LLMLEYVCRS DTMSTCKSLD LELVKRKRIE AIRGQILSKL
60 70 80 90 100
RLPKEPEIDQ EGDTEEVPAS LMSIYNSTVE LSEEQVHTYI PSTQDAEEEA
110 120 130 140 150
YFAKEVHKFN MKQSENTSKH QILFNMSEMR SVLGTDRLLS QAELRLLIKN
160 170 180 190 200
HGLLDDSEQR LELYRGVGDK ARYLKSHFVS KEWANRWVSF DVTQTLNEWL
210 220 230 240 250
QGAGEEQGFQ LKLPCDCGKP MEEFRFKISG MNKLRGNTET LAMKMPSKPH
260 270 280 290 300
ILLMSLPVER HSQLSSRKKR QTTTEEICSD KSESCCVRKL YIDFRKDLGW
310 320 330 340 350
KWIHEPTGYF ANYCIGPCTY IWNTENKYSQ VLALYKHHNP GASAQPCCVP
360 370 380
QVLEPLPIIY YVGRQHKVEQ LSNMIVKSCR CS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 237 | N → D in CAA67685 (PubMed:9722928).Curated | 1 | |
Sequence conflicti | 345 | Q → H in CAA67685 (PubMed:9722928).Curated | 1 | |
Sequence conflicti | 371 – 372 | LS → VP in CAA67685 (PubMed:9722928).Curated | 2 | |
Sequence conflicti | 377 | K → M in CAA67685 (PubMed:9722928).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ007836 Genomic DNA Translation: CAA07707.1 X99303 mRNA Translation: CAA67685.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ007836 Genomic DNA Translation: CAA07707.1 X99303 mRNA Translation: CAA67685.1 |
3D structure databases
SMRi | O93449 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR003939, TGFb1 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01424, TGFBETA1 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TGFB1_ONCMY | |
Accessioni | O93449Primary (citable) accession number: O93449 Secondary accession number(s): Q91217 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | November 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |