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Protein

Histone H2A

Gene

H2AFY

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2AUniRule annotation
Gene namesi
Name:H2AFYImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotation, NucleusUniRule annotation

Expressioni

Gene expression databases

BgeeiENSGALG00000006360 Expressed in 11 organ(s), highest expression level in testis
ExpressionAtlasiO93325 baseline and differential

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotation

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 85HistoneInterPro annotationAdd BLAST81
Domaini89 – 123Histone_H2A_CInterPro annotationAdd BLAST35

Sequence similaritiesi

Belongs to the histone H2A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IV3A Eukaryota
KOG1756 Eukaryota
KOG2633 Eukaryota
COG2110 LUCA
COG5262 LUCA
GeneTreeiENSGT00910000143981
HOVERGENiHBG009342
PhylomeDBiO93325

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

O93325-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSRGGKKKS TKTSRSAKAG VIFPVGRMLR YIKKGHPKYR IGVGAPVYMA
60 70 80 90 100
AVLEYLTAEI LELAGNAARD NKKGRVTPRH ILLAVANDEE LNQLLKGVTI
110 120 130 140 150
ASGGVLPNIH PELLAKKRGS KGKLEAIITP PPAKKAKSPS QKKTVSKKTG
160 170 180 190 200
GKKGARKSKK KQGEVSKSAS ADSTTEGTPA DGFTVLSTKS LFLGQKEALW
210 220
KRKAARSLWK LSLSFGKRTG PWT
Length:223
Mass (Da):23,929
Last modified:November 1, 1998 - v1
Checksum:iC4426B57F56AA69E
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O93327H2AY_CHICK
Core histone macro-H2A.1
H2AFY
372Annotation score:
A0A1D5P7L3A0A1D5P7L3_CHICK
Core histone macro-H2A.1
H2AFY
321Annotation score:
A0A1D5P9Z6A0A1D5P9Z6_CHICK
Core histone macro-H2A.1
H2AFY
324Annotation score:
A0A1D5PAG4A0A1D5PAG4_CHICK
Core histone macro-H2A.1
H2AFY
304Annotation score:
A0A1L1RUV5A0A1L1RUV5_CHICK
Core histone macro-H2A.1
H2AFY
146Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000380 Genomic DNA No translation available.
AF058444 mRNA Translation: AAC28845.1
UniGeneiGga.3138

Genome annotation databases

EnsembliENSGALT00000073747; ENSGALP00000048860; ENSGALG00000040141

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000380 Genomic DNA No translation available.
AF058444 mRNA Translation: AAC28845.1
UniGeneiGga.3138

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000073747; ENSGALP00000048860; ENSGALG00000040141

Phylogenomic databases

eggNOGiENOG410IV3A Eukaryota
KOG1756 Eukaryota
KOG2633 Eukaryota
COG2110 LUCA
COG5262 LUCA
GeneTreeiENSGT00910000143981
HOVERGENiHBG009342
PhylomeDBiO93325

Gene expression databases

BgeeiENSGALG00000006360 Expressed in 11 organ(s), highest expression level in testis
ExpressionAtlasiO93325 baseline and differential

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO93325_CHICK
AccessioniPrimary (citable) accession number: O93325
Secondary accession number(s): A0A1D5P815, F1P461
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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