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Protein

Vesicle transport through interaction with t-SNAREs homolog 1A

Gene

Vti1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be concerned with increased secretion of cytokines associated with cellular senescence.1 Publication

GO - Molecular functioni

  • SNAP receptor activity Source: MGI
  • SNARE binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6811438 Intra-Golgi traffic
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle transport through interaction with t-SNAREs homolog 1A
Alternative name(s):
Vesicle transport v-SNARE protein Vti1-like 2
Vti1-rp2
Gene namesi
Name:Vti1a
Synonyms:Vti1, Vti1l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1855699 Vti1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 192CytoplasmicSequence analysisAdd BLAST192
Transmembranei193 – 213Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini214 – 217VesicularSequence analysis4

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002182261 – 217Vesicle transport through interaction with t-SNAREs homolog 1AAdd BLAST217

Proteomic databases

EPDiO89116
MaxQBiO89116
PaxDbiO89116
PeptideAtlasiO89116
PRIDEiO89116

PTM databases

iPTMnetiO89116
PhosphoSitePlusiO89116

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000024983 Expressed in 243 organ(s), highest expression level in brain
ExpressionAtlasiO89116 baseline and differential
GenevisibleiO89116 MM

Interactioni

Subunit structurei

Interacts with distinct SNARE complexes that contain either STX5 or STX6. Interacts with NAPA and, to a lesser extent, with NAPG. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207331, 2 interactors
IntActiO89116, 2 interactors
MINTiO89116
STRINGi10090.ENSMUSP00000093644

Structurei

Secondary structure

1217
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO89116
SMRiO89116
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO89116

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili31 – 92Sequence analysisAdd BLAST62
Coiled coili112 – 178Sequence analysisAdd BLAST67

Sequence similaritiesi

Belongs to the VTI1 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1666 Eukaryota
ENOG4111J90 LUCA
GeneTreeiENSGT00530000063466
HOGENOMiHOG000116573
HOVERGENiHBG104027
InParanoidiO89116
KOiK08493
OMAiVESHRAE
OrthoDBiEOG091G0L3Z
PhylomeDBiO89116
TreeFamiTF312874

Family and domain databases

Gene3Di1.20.58.400, 1 hit
InterProiView protein in InterPro
IPR027027 GOSR2/Membrin/Bos1
IPR010989 SNARE
IPR000727 T_SNARE_dom
IPR038407 v-SNARE_N_sf
IPR007705 Vesicle_trsprt_v-SNARE_N
PfamiView protein in Pfam
PF05008 V-SNARE, 1 hit
PIRSFiPIRSF028865 Membrin-2, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O89116-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSDFEGYEQ DFAVLTAEIT SKIARVPRLP PDEKKQMVAN VEKQLEEARE
60 70 80 90 100
LLEQMDLEVR EIPPQSRGMY SNRMRSYKQE MGKLETDFKR SRIAYSDEVR
110 120 130 140 150
NELLGDAGNS SENQRAHLLD NTERLERSSR RLEAGYQIAV ETEQIGQEML
160 170 180 190 200
ENLSHDREKI QRARDRLRDA DANLGKSSRI LTGMLRRIIQ NRILLVILGI
210
IVVIAILTAI AFFVKGH
Length:217
Mass (Da):24,986
Last modified:November 1, 1998 - v1
Checksum:i3FD7B7A5A16E3522
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5FWJ7Q5FWJ7_MOUSE
Vesicle transport through interacti...
Vti1a mCG_140667
224Annotation score:
A0A286YDF2A0A286YDF2_MOUSE
Vesicle transport through interacti...
Vti1a
197Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035823 mRNA Translation: AAC32049.1
AF035209 mRNA Translation: AAC23482.1
AK004751 mRNA Translation: BAB23532.1
AK028646 mRNA Translation: BAC26046.1
BC019386 mRNA Translation: AAH19386.1
CCDSiCCDS29910.1
RefSeqiNP_001280615.1, NM_001293686.1
NP_058558.1, NM_016862.4
UniGeneiMm.258637
Mm.451075
Mm.451214

Genome annotation databases

EnsembliENSMUST00000095950; ENSMUSP00000093644; ENSMUSG00000024983
GeneIDi53611
KEGGimmu:53611
UCSCiuc008hxw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035823 mRNA Translation: AAC32049.1
AF035209 mRNA Translation: AAC23482.1
AK004751 mRNA Translation: BAB23532.1
AK028646 mRNA Translation: BAC26046.1
BC019386 mRNA Translation: AAH19386.1
CCDSiCCDS29910.1
RefSeqiNP_001280615.1, NM_001293686.1
NP_058558.1, NM_016862.4
UniGeneiMm.258637
Mm.451075
Mm.451214

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VCSNMR-A6-94[»]
ProteinModelPortaliO89116
SMRiO89116
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207331, 2 interactors
IntActiO89116, 2 interactors
MINTiO89116
STRINGi10090.ENSMUSP00000093644

PTM databases

iPTMnetiO89116
PhosphoSitePlusiO89116

Proteomic databases

EPDiO89116
MaxQBiO89116
PaxDbiO89116
PeptideAtlasiO89116
PRIDEiO89116

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095950; ENSMUSP00000093644; ENSMUSG00000024983
GeneIDi53611
KEGGimmu:53611
UCSCiuc008hxw.2 mouse

Organism-specific databases

CTDi143187
MGIiMGI:1855699 Vti1a

Phylogenomic databases

eggNOGiKOG1666 Eukaryota
ENOG4111J90 LUCA
GeneTreeiENSGT00530000063466
HOGENOMiHOG000116573
HOVERGENiHBG104027
InParanoidiO89116
KOiK08493
OMAiVESHRAE
OrthoDBiEOG091G0L3Z
PhylomeDBiO89116
TreeFamiTF312874

Enzyme and pathway databases

ReactomeiR-MMU-6811438 Intra-Golgi traffic
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

ChiTaRSiVti1a mouse
EvolutionaryTraceiO89116
PROiPR:O89116
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024983 Expressed in 243 organ(s), highest expression level in brain
ExpressionAtlasiO89116 baseline and differential
GenevisibleiO89116 MM

Family and domain databases

Gene3Di1.20.58.400, 1 hit
InterProiView protein in InterPro
IPR027027 GOSR2/Membrin/Bos1
IPR010989 SNARE
IPR000727 T_SNARE_dom
IPR038407 v-SNARE_N_sf
IPR007705 Vesicle_trsprt_v-SNARE_N
PfamiView protein in Pfam
PF05008 V-SNARE, 1 hit
PIRSFiPIRSF028865 Membrin-2, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVTI1A_MOUSE
AccessioniPrimary (citable) accession number: O89116
Secondary accession number(s): Q545P9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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