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Protein

Intermediate conductance calcium-activated potassium channel protein 4

Gene

Kcnn4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.2 Publications

GO - Molecular functioni

  • calcium-activated potassium channel activity Source: MGI
  • calmodulin binding Source: GO_Central
  • Intermediate conductance calcium-activated potassium channel activity Source: MGI
  • potassium channel activity Source: MGI
  • protein phosphatase binding Source: MGI
  • small conductance calcium-activated potassium channel activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Ion channel
Biological processImmunity, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1296052 Ca2+ activated K+ channels

Names & Taxonomyi

Protein namesi
Recommended name:
Intermediate conductance calcium-activated potassium channel protein 4
Short name:
SK4
Short name:
SKCa 4
Short name:
SKCa4
Alternative name(s):
IK1
KCa3.1
KCa4
Gene namesi
Name:Kcnn4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1277957 Kcnn4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 50Helical; Name=Segment S1Sequence analysisAdd BLAST21
Transmembranei59 – 79Helical; Name=Segment S2Sequence analysisAdd BLAST21
Transmembranei105 – 121Helical; Name=Segment S3Sequence analysisAdd BLAST17
Transmembranei141 – 161Helical; Name=Segment S4Sequence analysisAdd BLAST21
Transmembranei205 – 225Helical; Name=Segment S5Sequence analysisAdd BLAST21
Intramembranei239 – 259Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Transmembranei263 – 283Helical; Name=Segment S6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001550181 – 425Intermediate conductance calcium-activated potassium channel protein 4Add BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei356PhosphohistidineBy similarity1

Post-translational modificationi

Phosphorylation at His-356 by NDKB activates the channel, and conversely it's dephosphorylation by PHPT1 inhibits the channel.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO89109
MaxQBiO89109
PaxDbiO89109
PRIDEiO89109

PTM databases

iPTMnetiO89109
PhosphoSitePlusiO89109

Expressioni

Gene expression databases

BgeeiENSMUSG00000054342 Expressed in 208 organ(s), highest expression level in parotid gland
ExpressionAtlasiO89109 baseline and differential
GenevisibleiO89109 MM

Interactioni

Subunit structurei

Heterotetramer of potassium channel proteins (Probable). Interacts with MTMR6 (By similarity).By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000133065

Structurei

3D structure databases

ProteinModelPortaliO89109
SMRiO89109
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni284 – 345Calmodulin-bindingBy similarityAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi413 – 416Poly-Gln4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3684 Eukaryota
ENOG410XT9D LUCA
GeneTreeiENSGT00500000044784
HOGENOMiHOG000276908
HOVERGENiHBG052241
InParanoidiO89109
KOiK04945
OMAiAEMLWFG
OrthoDBiEOG091G09X0
PhylomeDBiO89109
TreeFamiTF315015

Family and domain databases

InterProiView protein in InterPro
IPR004178 CaM-bd_dom
IPR036122 CaM-bd_dom_sf
IPR015449 K_chnl_Ca-activ_SK
IPR013099 K_chnl_dom
PANTHERiPTHR10153 PTHR10153, 1 hit
PfamiView protein in Pfam
PF02888 CaMBD, 1 hit
PF07885 Ion_trans_2, 1 hit
PF03530 SK_channel, 1 hit
SMARTiView protein in SMART
SM01053 CaMBD, 1 hit
SUPFAMiSSF81327 SSF81327, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O89109-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGELVTGLG ALRRRKRLLE QEKRVAGWAL VLAGTGIGLM VLHAEMLWFL
60 70 80 90 100
GCKWVLYLLL VKCLITLSTA FLLCLIVVFH AKEVQLFMTD NGLRDWRVAL
110 120 130 140 150
TRRQVAQILL ELLVCGVHPV PLRSPHCALA GEATDAQPWP GFLGEGEALL
160 170 180 190 200
SLAMLLRLYL VPRAVLLRSG VLLNASYRSI GALNQVRFRH WFVAKLYMNT
210 220 230 240 250
HPGRLLLGLT LGLWLTTAWV LSVAERQAVN ATGHLTDTLW LIPITFLTIG
260 270 280 290 300
YGDVVPGTMW GKIVCLCTGV MGVCCTALLV AVVARKLEFN KAEKHVHNFM
310 320 330 340 350
MDIHYAKEMK ESAARLLQEA WMYYKHTRRK DSRAARRHQR KMLAAIHTFR
360 370 380 390 400
QVRLKHRKLR EQVNSMVDIS KMHMILCDLQ LGLSSSHRAL EKRIDGLAGK
410 420
LDALTELLGT ALQQQQLPEP SQEAT
Length:425
Mass (Da):47,784
Last modified:November 1, 1998 - v1
Checksum:iDCD2FC86BDD69A73
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RP82A0A0U1RP82_MOUSE
Intermediate conductance calcium-ac...
Kcnn4 mCG_22845
104Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti181G → E in BAB27283 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042487 mRNA Translation: AAC32051.1
AF072884 mRNA Translation: AAC32829.1
AK010943 mRNA Translation: BAB27283.1
AK155910 mRNA Translation: BAE33499.1
BC010274 mRNA Translation: AAH10274.1
CCDSiCCDS20948.1
RefSeqiNP_001156982.1, NM_001163510.1
NP_032459.3, NM_008433.4
XP_006539626.1, XM_006539563.3
UniGeneiMm.9911

Genome annotation databases

EnsembliENSMUST00000171904; ENSMUSP00000133065; ENSMUSG00000054342
ENSMUST00000205428; ENSMUSP00000146012; ENSMUSG00000054342
GeneIDi16534
KEGGimmu:16534
UCSCiuc009fpk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042487 mRNA Translation: AAC32051.1
AF072884 mRNA Translation: AAC32829.1
AK010943 mRNA Translation: BAB27283.1
AK155910 mRNA Translation: BAE33499.1
BC010274 mRNA Translation: AAH10274.1
CCDSiCCDS20948.1
RefSeqiNP_001156982.1, NM_001163510.1
NP_032459.3, NM_008433.4
XP_006539626.1, XM_006539563.3
UniGeneiMm.9911

3D structure databases

ProteinModelPortaliO89109
SMRiO89109
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000133065

PTM databases

iPTMnetiO89109
PhosphoSitePlusiO89109

Proteomic databases

EPDiO89109
MaxQBiO89109
PaxDbiO89109
PRIDEiO89109

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000171904; ENSMUSP00000133065; ENSMUSG00000054342
ENSMUST00000205428; ENSMUSP00000146012; ENSMUSG00000054342
GeneIDi16534
KEGGimmu:16534
UCSCiuc009fpk.2 mouse

Organism-specific databases

CTDi3783
MGIiMGI:1277957 Kcnn4

Phylogenomic databases

eggNOGiKOG3684 Eukaryota
ENOG410XT9D LUCA
GeneTreeiENSGT00500000044784
HOGENOMiHOG000276908
HOVERGENiHBG052241
InParanoidiO89109
KOiK04945
OMAiAEMLWFG
OrthoDBiEOG091G09X0
PhylomeDBiO89109
TreeFamiTF315015

Enzyme and pathway databases

ReactomeiR-MMU-1296052 Ca2+ activated K+ channels

Miscellaneous databases

ChiTaRSiKcnn4 mouse
PROiPR:O89109
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054342 Expressed in 208 organ(s), highest expression level in parotid gland
ExpressionAtlasiO89109 baseline and differential
GenevisibleiO89109 MM

Family and domain databases

InterProiView protein in InterPro
IPR004178 CaM-bd_dom
IPR036122 CaM-bd_dom_sf
IPR015449 K_chnl_Ca-activ_SK
IPR013099 K_chnl_dom
PANTHERiPTHR10153 PTHR10153, 1 hit
PfamiView protein in Pfam
PF02888 CaMBD, 1 hit
PF07885 Ion_trans_2, 1 hit
PF03530 SK_channel, 1 hit
SMARTiView protein in SMART
SM01053 CaMBD, 1 hit
SUPFAMiSSF81327 SSF81327, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCNN4_MOUSE
AccessioniPrimary (citable) accession number: O89109
Secondary accession number(s): Q3U1J8, Q9CY39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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