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Protein

Synaptophysin-like protein 2

Gene

Sypl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes.By similarity

GO - Biological processi

  • cellular calcium ion homeostasis Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptophysin-like protein 2
Alternative name(s):
Mitsugumin-29
Short name:
Mg29
Gene namesi
Name:Sypl2
Synonyms:Mg29
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1328311 Sypl2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 116VesicularSequence analysisAdd BLAST62
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 150CytoplasmicSequence analysisAdd BLAST13
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 213VesicularSequence analysisAdd BLAST42
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 264CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001791671 – 264Synaptophysin-like protein 2Add BLAST264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO89104
PaxDbiO89104
PRIDEiO89104

PTM databases

iPTMnetiO89104
PhosphoSitePlusiO89104

Expressioni

Tissue specificityi

Expressed abundantly in skeletal muscle and at lower levels in the kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000027887 Expressed in 71 organ(s), highest expression level in quadriceps femoris
CleanExiMM_SYPL2
GenevisibleiO89104 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029486

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 238MARVELPROSITE-ProRule annotationAdd BLAST209

Sequence similaritiesi

Belongs to the synaptophysin/synaptobrevin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF8N Eukaryota
ENOG4111ZDM LUCA
GeneTreeiENSGT00390000010039
HOVERGENiHBG006681
InParanoidiO89104
OMAiNRVQYEM
OrthoDBiEOG091G0ZEI

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
IPR001285 Synaptophysin/porin
PANTHERiPTHR10306 PTHR10306, 1 hit
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PRINTSiPR00220 SYNAPTOPHYSN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

Sequencei

Sequence statusi: Complete.

O89104-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSTESPGRT SDKSPRQQVD RLLLGLRWQR LEEPLGFIKV LQWLFAIFAF
60 70 80 90 100
GSCGSYSGET GALVLCNNEA KDVSSIIVLF GYPFRLYQVQ YEMPLCDQDS
110 120 130 140 150
TSKTMNLMGD FSAPAEFFVT LGIFSFFYTM AALVIYLRFH KLYTENKRFP
160 170 180 190 200
LVDFCVTVSF TFFWLVAAAA WGKGLTDVKG ATRPSSLTAA MSVCHGEEAV
210 220 230 240 250
CSAGATPSMG LANLSVLFGF INFFLWAGNC WFVFKETPWH GQGQDQGQGP
260
SQESAAEQGA VEKQ
Length:264
Mass (Da):29,224
Last modified:November 1, 1998 - v1
Checksum:i5CB8A169533B6704
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010144 Genomic DNA Translation: BAA32531.1
AB010140 mRNA Translation: BAA32530.1
BC030038 mRNA Translation: AAH30038.1
CCDSiCCDS57253.1
RefSeqiNP_032622.1, NM_008596.1
UniGeneiMm.316885

Genome annotation databases

EnsembliENSMUST00000141387; ENSMUSP00000116756; ENSMUSG00000027887
GeneIDi17306
KEGGimmu:17306
UCSCiuc008qyn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010144 Genomic DNA Translation: BAA32531.1
AB010140 mRNA Translation: BAA32530.1
BC030038 mRNA Translation: AAH30038.1
CCDSiCCDS57253.1
RefSeqiNP_032622.1, NM_008596.1
UniGeneiMm.316885

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029486

PTM databases

iPTMnetiO89104
PhosphoSitePlusiO89104

Proteomic databases

MaxQBiO89104
PaxDbiO89104
PRIDEiO89104

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000141387; ENSMUSP00000116756; ENSMUSG00000027887
GeneIDi17306
KEGGimmu:17306
UCSCiuc008qyn.1 mouse

Organism-specific databases

CTDi284612
MGIiMGI:1328311 Sypl2

Phylogenomic databases

eggNOGiENOG410IF8N Eukaryota
ENOG4111ZDM LUCA
GeneTreeiENSGT00390000010039
HOVERGENiHBG006681
InParanoidiO89104
OMAiNRVQYEM
OrthoDBiEOG091G0ZEI

Miscellaneous databases

PROiPR:O89104
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027887 Expressed in 71 organ(s), highest expression level in quadriceps femoris
CleanExiMM_SYPL2
GenevisibleiO89104 MM

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
IPR001285 Synaptophysin/porin
PANTHERiPTHR10306 PTHR10306, 1 hit
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PRINTSiPR00220 SYNAPTOPHYSN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYPL2_MOUSE
AccessioniPrimary (citable) accession number: O89104
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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