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Protein

Complement component C1q receptor

Gene

Cd93

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion. Marker for early multipotent hematopoietic precursor cells. May play a role in cell-cell interactions during hematopoietic and vascular development.

GO - Molecular functioni

GO - Biological processi

  • cell-cell adhesion Source: UniProtKB

Keywordsi

Molecular functionReceptor
Biological processCell adhesion
LigandLectin

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component C1q receptor
Alternative name(s):
C1q/MBL/SPA receptor
Short name:
C1qR(p)
Short name:
C1qRp
Cell surface antigen AA4
Complement component 1 q subcomponent receptor 1
Lymphocyte antigen 68
Short name:
Ly-68
CD_antigen: CD93
Gene namesi
Name:Cd93
Synonyms:Aa4, C1qr1, C1qrp, Ly68
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:106664 Cd93

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 572ExtracellularSequence analysisAdd BLAST550
Transmembranei573 – 593HelicalSequence analysisAdd BLAST21
Topological domaini594 – 644CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001736823 – 644Complement component C1q receptorAdd BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi140 ↔ 164By similarity
Disulfide bondi261 ↔ 272By similarity
Disulfide bondi268 ↔ 282By similarity
Disulfide bondi284 ↔ 297By similarity
Disulfide bondi303 ↔ 314By similarity
Disulfide bondi308 ↔ 325By similarity
Glycosylationi322N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi327 ↔ 340By similarity
Disulfide bondi346 ↔ 355By similarity
Disulfide bondi351 ↔ 364By similarity
Disulfide bondi366 ↔ 380By similarity
Disulfide bondi386 ↔ 397By similarity
Disulfide bondi393 ↔ 406By similarity
Disulfide bondi408 ↔ 422By similarity
Disulfide bondi428 ↔ 440By similarity
Disulfide bondi436 ↔ 449By similarity
Disulfide bondi451 ↔ 464By similarity
Modified residuei619PhosphoserineBy similarity1
Modified residuei636PhosphotyrosineCombined sources1

Post-translational modificationi

N- and O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO89103
MaxQBiO89103
PaxDbiO89103
PeptideAtlasiO89103
PRIDEiO89103

PTM databases

iPTMnetiO89103
PhosphoSitePlusiO89103

Expressioni

Tissue specificityi

Expressed in lung, heart and bone marrow. Expressed at lower level in ovary, whole embryo and fetal liver. Not detected in brain, adult liver or thymus. Highly expressed in peritoneal cavity and bone marrow macrophages. Not detected in epithelial cells.

Developmental stagei

First detectable in day 9 embryos, in the endocardium and vascular endothelium in the anterior part of the embryo. Expression in endothelial cells, initially restricted to aorta, omphalomesenteric and umbilical arteries, later extends to subcardinal veins, intersomitic arteries and perineural vessels. On day 10, detectable in the entire embryo.

Gene expression databases

BgeeiENSMUSG00000027435 Expressed in 248 organ(s), highest expression level in brain blood vessel
CleanExiMM_CD93
GenevisibleiO89103 MM

Interactioni

Subunit structurei

Interacts with C1QBP; the association may represent a cell surface C1q receptor.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiO89103, 1 interactor
MINTiO89103
STRINGi10090.ENSMUSP00000096876

Structurei

3D structure databases

ProteinModelPortaliO89103
SMRiO89103
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 173C-type lectinPROSITE-ProRule annotationAdd BLAST143
Domaini257 – 298EGF-like 1PROSITE-ProRule annotationAdd BLAST42
Domaini299 – 341EGF-like 2PROSITE-ProRule annotationAdd BLAST43
Domaini342 – 381EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini382 – 423EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini424 – 465EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJQN Eukaryota
ENOG410ZKXP LUCA
GeneTreeiENSGT00930000150853
HOGENOMiHOG000232038
HOVERGENiHBG050751
InParanoidiO89103
KOiK06702
OMAiHYFLCKE
OrthoDBiEOG091G04OD
PhylomeDBiO89103
TreeFamiTF330714

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR026823 cEGF
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
PfamiView protein in Pfam
PF12662 cEGF, 1 hit
PF07645 EGF_CA, 2 hits
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SM00181 EGF, 5 hits
SM00179 EGF_CA, 5 hits
SUPFAMiSSF56436 SSF56436, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS50041 C_TYPE_LECTIN_2, 1 hit
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O89103-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAISTGLFLL LGLLGQPWAG AAADSQAVVC EGTACYTAHW GKLSAAEAQH
60 70 80 90 100
RCNENGGNLA TVKSEEEARH VQQALTQLLK TKAPLEAKMG KFWIGLQREK
110 120 130 140 150
GNCTYHDLPM RGFSWVGGGE DTAYSNWYKA SKSSCIFKRC VSLILDLSLT
160 170 180 190 200
PHPSHLPKWH ESPCGTPEAP GNSIEGFLCK FNFKGMCRPL ALGGPGRVTY
210 220 230 240 250
TTPFQATTSS LEAVPFASVA NVACGDEAKS ETHYFLCNEK TPGIFHWGSS
260 270 280 290 300
GPLCVSPKFG CSFNNGGCQQ DCFEGGDGSF RCGCRPGFRL LDDLVTCASR
310 320 330 340 350
NPCSSNPCTG GGMCHSVPLS ENYTCRCPSG YQLDSSQVHC VDIDECQDSP
360 370 380 390 400
CAQDCVNTLG SFHCECWVGY QPSGPKEEAC EDVDECAAAN SPCAQGCINT
410 420 430 440 450
DGSFYCSCKE GYIVSGEDST QCEDIDECSD ARGNPCDSLC FNTDGSFRCG
460 470 480 490 500
CPPGWELAPN GVFCSRGTVF SELPARPPQK EDNDDRKEST MPPTEMPSSP
510 520 530 540 550
SGSKDVSNRA QTTGLFVQSD IPTASVPLEI EIPSEVSDVW FELGTYLPTT
560 570 580 590 600
SGHSKPTHED SVSAHSDTDG QNLLLFYILG TVVAISLLLV LALGILIYHK
610 620 630 640
RRAKKEEIKE KKPQNAADSY SWVPERAESQ APENQYSPTP GTDC
Length:644
Mass (Da):69,354
Last modified:November 1, 1998 - v1
Checksum:iEB4351648BF8635A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074856 Genomic DNA Translation: AAC63274.1
AF081789 mRNA Translation: AAC62649.1
AF099939, AF099938 Genomic DNA Translation: AAD47906.1
AK079060 mRNA Translation: BAC37518.1
AK155060 mRNA Translation: BAE33020.1
AL935149 Genomic DNA Translation: CAM26726.1
CCDSiCCDS16839.1
RefSeqiNP_034870.1, NM_010740.3
UniGeneiMm.681

Genome annotation databases

EnsembliENSMUST00000099269; ENSMUSP00000096876; ENSMUSG00000027435
GeneIDi17064
KEGGimmu:17064
UCSCiuc008mte.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074856 Genomic DNA Translation: AAC63274.1
AF081789 mRNA Translation: AAC62649.1
AF099939, AF099938 Genomic DNA Translation: AAD47906.1
AK079060 mRNA Translation: BAC37518.1
AK155060 mRNA Translation: BAE33020.1
AL935149 Genomic DNA Translation: CAM26726.1
CCDSiCCDS16839.1
RefSeqiNP_034870.1, NM_010740.3
UniGeneiMm.681

3D structure databases

ProteinModelPortaliO89103
SMRiO89103
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO89103, 1 interactor
MINTiO89103
STRINGi10090.ENSMUSP00000096876

PTM databases

iPTMnetiO89103
PhosphoSitePlusiO89103

Proteomic databases

EPDiO89103
MaxQBiO89103
PaxDbiO89103
PeptideAtlasiO89103
PRIDEiO89103

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099269; ENSMUSP00000096876; ENSMUSG00000027435
GeneIDi17064
KEGGimmu:17064
UCSCiuc008mte.1 mouse

Organism-specific databases

CTDi22918
MGIiMGI:106664 Cd93

Phylogenomic databases

eggNOGiENOG410IJQN Eukaryota
ENOG410ZKXP LUCA
GeneTreeiENSGT00930000150853
HOGENOMiHOG000232038
HOVERGENiHBG050751
InParanoidiO89103
KOiK06702
OMAiHYFLCKE
OrthoDBiEOG091G04OD
PhylomeDBiO89103
TreeFamiTF330714

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

PROiPR:O89103
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027435 Expressed in 248 organ(s), highest expression level in brain blood vessel
CleanExiMM_CD93
GenevisibleiO89103 MM

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR026823 cEGF
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
PfamiView protein in Pfam
PF12662 cEGF, 1 hit
PF07645 EGF_CA, 2 hits
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SM00181 EGF, 5 hits
SM00179 EGF_CA, 5 hits
SUPFAMiSSF56436 SSF56436, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS50041 C_TYPE_LECTIN_2, 1 hit
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiC1QR1_MOUSE
AccessioniPrimary (citable) accession number: O89103
Secondary accession number(s): A2AVY5, Q3U2X0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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