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Protein

Fibroblast growth factor 18

Gene

Fgf18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-MMU-109704 PI3K Cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-190322 FGFR4 ligand binding and activation
R-MMU-190371 FGFR3b ligand binding and activation
R-MMU-190372 FGFR3c ligand binding and activation
R-MMU-190375 FGFR2c ligand binding and activation
R-MMU-5654221 Phospholipase C-mediated cascade, FGFR2
R-MMU-5654227 Phospholipase C-mediated cascade, FGFR3
R-MMU-5654228 Phospholipase C-mediated cascade, FGFR4
R-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654695 PI-3K cascade:FGFR2
R-MMU-5654699 SHC-mediated cascade:FGFR2
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654704 SHC-mediated cascade:FGFR3
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654710 PI-3K cascade:FGFR3
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5654719 SHC-mediated cascade:FGFR4
R-MMU-5654720 PI-3K cascade:FGFR4
R-MMU-5654727 Negative regulation of FGFR2 signaling
R-MMU-5654732 Negative regulation of FGFR3 signaling
R-MMU-5654733 Negative regulation of FGFR4 signaling
R-MMU-5658623 FGFRL1 modulation of FGFR1 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 18
Short name:
FGF-18
Alternative name(s):
zFGF5
Gene namesi
Name:Fgf18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1277980 Fgf18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000000899128 – 207Fibroblast growth factor 18Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi109 ↔ 127By similarity
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO89101
PRIDEiO89101

PTM databases

PhosphoSitePlusiO89101

Expressioni

Gene expression databases

BgeeiENSMUSG00000057967 Expressed in 210 organ(s), highest expression level in forelimb
CleanExiMM_FGF18
ExpressionAtlasiO89101 baseline and differential
GenevisibleiO89101 MM

Interactioni

Subunit structurei

Interacts with FGFR3 and FGFR4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020507

Structurei

3D structure databases

ProteinModelPortaliO89101
SMRiO89101
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00730000110785
HOGENOMiHOG000115986
HOVERGENiHBG005659
InParanoidiO89101
KOiK04358
OMAiMFVAEEN
OrthoDBiEOG091G0NQH
PhylomeDBiO89101
TreeFamiTF331233

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028289 FGF18
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF124 PTHR11486:SF124, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O89101-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYSAPSACTC LCLHFLLLCF QVQVLAAEEN VDFRIHVENQ TRARDDVSRK
60 70 80 90 100
QLRLYQLYSR TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK
110 120 130 140 150
GKETEFYLCM NRKGKLVGKP DGTSKECVFI EKVLENNYTA LMSAKYSGWY
160 170 180 190 200
VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK GQAELQKPFK YTTVTKRSRR

IRPTHPG
Length:207
Mass (Da):23,921
Last modified:November 1, 1998 - v1
Checksum:iCD5F987B271628B8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SQB3Q5SQB3_MOUSE
Fibroblast growth factor
Fgf18
98Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075291 mRNA Translation: AAC62239.1
AB004639 mRNA Translation: BAA31980.1
AF211187 mRNA Translation: AAF22976.1
CCDSiCCDS24531.1
RefSeqiNP_032031.1, NM_008005.2
UniGeneiMm.339812

Genome annotation databases

EnsembliENSMUST00000020507; ENSMUSP00000020507; ENSMUSG00000057967
GeneIDi14172
KEGGimmu:14172
UCSCiuc007ikc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075291 mRNA Translation: AAC62239.1
AB004639 mRNA Translation: BAA31980.1
AF211187 mRNA Translation: AAF22976.1
CCDSiCCDS24531.1
RefSeqiNP_032031.1, NM_008005.2
UniGeneiMm.339812

3D structure databases

ProteinModelPortaliO89101
SMRiO89101
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020507

PTM databases

PhosphoSitePlusiO89101

Proteomic databases

PaxDbiO89101
PRIDEiO89101

Protocols and materials databases

DNASUi14172
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020507; ENSMUSP00000020507; ENSMUSG00000057967
GeneIDi14172
KEGGimmu:14172
UCSCiuc007ikc.2 mouse

Organism-specific databases

CTDi8817
MGIiMGI:1277980 Fgf18

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00730000110785
HOGENOMiHOG000115986
HOVERGENiHBG005659
InParanoidiO89101
KOiK04358
OMAiMFVAEEN
OrthoDBiEOG091G0NQH
PhylomeDBiO89101
TreeFamiTF331233

Enzyme and pathway databases

ReactomeiR-MMU-109704 PI3K Cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-190322 FGFR4 ligand binding and activation
R-MMU-190371 FGFR3b ligand binding and activation
R-MMU-190372 FGFR3c ligand binding and activation
R-MMU-190375 FGFR2c ligand binding and activation
R-MMU-5654221 Phospholipase C-mediated cascade, FGFR2
R-MMU-5654227 Phospholipase C-mediated cascade, FGFR3
R-MMU-5654228 Phospholipase C-mediated cascade, FGFR4
R-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654695 PI-3K cascade:FGFR2
R-MMU-5654699 SHC-mediated cascade:FGFR2
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654704 SHC-mediated cascade:FGFR3
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654710 PI-3K cascade:FGFR3
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5654719 SHC-mediated cascade:FGFR4
R-MMU-5654720 PI-3K cascade:FGFR4
R-MMU-5654727 Negative regulation of FGFR2 signaling
R-MMU-5654732 Negative regulation of FGFR3 signaling
R-MMU-5654733 Negative regulation of FGFR4 signaling
R-MMU-5658623 FGFRL1 modulation of FGFR1 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Miscellaneous databases

PROiPR:O89101
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057967 Expressed in 210 organ(s), highest expression level in forelimb
CleanExiMM_FGF18
ExpressionAtlasiO89101 baseline and differential
GenevisibleiO89101 MM

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028289 FGF18
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF124 PTHR11486:SF124, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFGF18_MOUSE
AccessioniPrimary (citable) accession number: O89101
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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