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Protein

Cystatin-F

Gene

Cst7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei36Reactive site1

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI25.007

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-F
Alternative name(s):
Cystatin-7
Cystatin-like metastasis-associated protein
Short name:
CMAP
Leukocystatin
Gene namesi
Name:Cst7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1298217 Cst7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000664719 – 144Cystatin-FAdd BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 109By similarity
Disulfide bondi123 ↔ 143By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO89098
PaxDbiO89098
PRIDEiO89098

PTM databases

PhosphoSitePlusiO89098

Expressioni

Gene expression databases

BgeeiENSMUSG00000068129 Expressed in 63 organ(s), highest expression level in bone marrow
CleanExiMM_CST7
GenevisibleiO89098 MM

Interactioni

Protein-protein interaction databases

IntActiO89098, 1 interactor
MINTiO89098
STRINGi10090.ENSMUSP00000086606

Structurei

3D structure databases

ProteinModelPortaliO89098
SMRiO89098
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi80 – 84Secondary area of contact5

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J26J Eukaryota
ENOG41121KX LUCA
GeneTreeiENSGT00900000140934
HOGENOMiHOG000112134
HOVERGENiHBG009556
InParanoidiO89098
KOiK13903
OMAiDNCDFQT
OrthoDBiEOG091G0TP1

Family and domain databases

CDDicd00042 CY, 1 hit
InterProiView protein in InterPro
IPR027214 Cystatin
IPR000010 Cystatin_dom
PANTHERiPTHR11413 PTHR11413, 1 hit
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit
SMARTiView protein in SMART
SM00043 CY, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O89098-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWLAILLALC CLTSDTHGAR PPDFCSKDLI SSVKPGFPKT IETNNPGVLK
60 70 80 90 100
AARHSVEKFN NCTNDIFLFK ESHVSKALVQ VVKGLKYMLE VKIGRTTCRK
110 120 130 140
TMHHQLDNCD FQTNPALKRT LYCYSEVWVI PWLHSFEVPV LLCQ
Length:144
Mass (Da):16,380
Last modified:November 1, 1998 - v1
Checksum:iB5837334C1B4A89C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031826 Genomic DNA Translation: AAC40140.1
AF031825 mRNA Translation: AAC40139.1
CCDSiCCDS16857.2
RefSeqiNP_034107.2, NM_009977.3
UniGeneiMm.12965

Genome annotation databases

EnsembliENSMUST00000089200; ENSMUSP00000086606; ENSMUSG00000068129
GeneIDi13011
KEGGimmu:13011
UCSCiuc008muc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031826 Genomic DNA Translation: AAC40140.1
AF031825 mRNA Translation: AAC40139.1
CCDSiCCDS16857.2
RefSeqiNP_034107.2, NM_009977.3
UniGeneiMm.12965

3D structure databases

ProteinModelPortaliO89098
SMRiO89098
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO89098, 1 interactor
MINTiO89098
STRINGi10090.ENSMUSP00000086606

Protein family/group databases

MEROPSiI25.007

PTM databases

PhosphoSitePlusiO89098

Proteomic databases

EPDiO89098
PaxDbiO89098
PRIDEiO89098

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089200; ENSMUSP00000086606; ENSMUSG00000068129
GeneIDi13011
KEGGimmu:13011
UCSCiuc008muc.2 mouse

Organism-specific databases

CTDi8530
MGIiMGI:1298217 Cst7

Phylogenomic databases

eggNOGiENOG410J26J Eukaryota
ENOG41121KX LUCA
GeneTreeiENSGT00900000140934
HOGENOMiHOG000112134
HOVERGENiHBG009556
InParanoidiO89098
KOiK13903
OMAiDNCDFQT
OrthoDBiEOG091G0TP1

Miscellaneous databases

PROiPR:O89098
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068129 Expressed in 63 organ(s), highest expression level in bone marrow
CleanExiMM_CST7
GenevisibleiO89098 MM

Family and domain databases

CDDicd00042 CY, 1 hit
InterProiView protein in InterPro
IPR027214 Cystatin
IPR000010 Cystatin_dom
PANTHERiPTHR11413 PTHR11413, 1 hit
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit
SMARTiView protein in SMART
SM00043 CY, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYTF_MOUSE
AccessioniPrimary (citable) accession number: O89098
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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