UniProtKB - O89093 (CCL20_MOUSE)
C-C motif chemokine 20
Ccl20
Functioni
Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:9862452, PubMed:20068036).
The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases (PubMed:21376174).
CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (By similarity).
Involved in the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation (PubMed:19050256).
Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (PubMed:24638065).
Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636).
May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (PubMed:10064080).
1 PublicationBy similarity6 PublicationsGO - Molecular functioni
- CCR6 chemokine receptor binding Source: UniProtKB
- CCR chemokine receptor binding Source: GO_Central
- chemokine activity Source: MGI
- cytokine activity Source: MGI
GO - Biological processi
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: MGI
- calcium-mediated signaling using intracellular calcium source Source: UniProtKB
- cell chemotaxis Source: UniProtKB
- cellular response to interferon-gamma Source: GO_Central
- cellular response to interleukin-1 Source: GO_Central
- cellular response to tumor necrosis factor Source: GO_Central
- chemokine-mediated signaling pathway Source: GO_Central
- chemotaxis Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: GO_Central
- inflammatory response Source: GO_Central
- killing of cells of another organism Source: MGI
- lymphocyte chemotaxis Source: GO_Central
- monocyte chemotaxis Source: GO_Central
- neutrophil chemotaxis Source: GO_Central
- positive regulation of ERK1 and ERK2 cascade Source: GO_Central
- positive regulation of GTPase activity Source: GO_Central
- positive regulation of interleukin-1 alpha production Source: MGI
- positive regulation of nitric-oxide synthase biosynthetic process Source: MGI
- positive regulation of T cell migration Source: MGI
- T cell migration Source: UniProtKB
- thymocyte migration Source: UniProtKB
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis, Inflammatory response |
Enzyme and pathway databases
Reactomei | R-MMU-380108, Chemokine receptors bind chemokines R-MMU-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: C-C motif chemokine 20Alternative name(s): Beta-chemokine exodus-1 CC chemokine LARC CC chemokine ST38 Liver and activation-regulated chemokine Macrophage inflammatory protein 3 alpha Short name: MIP-3-alpha Small-inducible cytokine A20 |
Gene namesi | Name:Ccl20 Synonyms:Larc, Scya20 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1329031, Ccl20 |
VEuPathDBi | HostDB:ENSMUSG00000026166 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: MGI
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | 1 PublicationAdd BLAST | 27 | |
ChainiPRO_0000005218 | 28 – 97 | C-C motif chemokine 20Add BLAST | 70 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 33 ↔ 59 | 1 Publication | ||
Disulfide bondi | 34 ↔ 75 | 1 Publication |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | O89093 |
ProteomicsDBi | 283734 [O89093-1] 283735 [O89093-2] |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000026166, Expressed in jejunum and 45 other tissues |
Genevisiblei | O89093, MM |
Interactioni
GO - Molecular functioni
- CCR6 chemokine receptor binding Source: UniProtKB
- CCR chemokine receptor binding Source: GO_Central
- chemokine activity Source: MGI
- cytokine activity Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000109064 |
Miscellaneous databases
RNActi | O89093, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | O89093 |
BMRBi | O89093 |
SMRi | O89093 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O89093 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S776, Eukaryota |
GeneTreei | ENSGT01030000234602 |
HOGENOMi | CLU_141716_3_3_1 |
InParanoidi | O89093 |
OMAi | FDCCLQY |
PhylomeDBi | O89093 |
TreeFami | TF334888 |
Family and domain databases
CDDi | cd01119, Chemokine_CC_DCCL, 1 hit |
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR034133, Chemokine_CC_DCCL IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MACGGKRLLF LALAWVLLAH LCSQAEAASN YDCCLSYIQT PLPSRAIVGF
60 70 80 90
TRQMADEACD INAIIFHTKK RKSVCADPKQ NWVKRAVNLL SLRVKKM
The sequence of this isoform differs from the canonical sequence as follows:
28-28: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8WHA7 | F8WHA7_MOUSE | C-C motif chemokine | Ccl20 | 102 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001062 | 28 | Missing in isoform Short. Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF053313 mRNA Translation: AAC78295.1 AJ007862 Genomic DNA Translation: CAA07714.1 AF099052 mRNA Translation: AAC78680.1 AJ222694 mRNA Translation: CAA10948.1 AB015136 mRNA Translation: BAA76955.1 |
CCDSi | CCDS35632.1 [O89093-1] CCDS78638.1 [O89093-2] |
RefSeqi | NP_001153210.1, NM_001159738.1 [O89093-2] NP_058656.1, NM_016960.2 [O89093-1] |
Genome annotation databases
Ensembli | ENSMUST00000113437; ENSMUSP00000109064; ENSMUSG00000026166 [O89093-1] ENSMUST00000186832; ENSMUSP00000139923; ENSMUSG00000026166 [O89093-2] |
GeneIDi | 20297 |
KEGGi | mmu:20297 |
UCSCi | uc007bsk.2, mouse [O89093-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF053313 mRNA Translation: AAC78295.1 AJ007862 Genomic DNA Translation: CAA07714.1 AF099052 mRNA Translation: AAC78680.1 AJ222694 mRNA Translation: CAA10948.1 AB015136 mRNA Translation: BAA76955.1 |
CCDSi | CCDS35632.1 [O89093-1] CCDS78638.1 [O89093-2] |
RefSeqi | NP_001153210.1, NM_001159738.1 [O89093-2] NP_058656.1, NM_016960.2 [O89093-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1HA6 | NMR | - | A | 28-97 | [»] | |
AlphaFoldDBi | O89093 | |||||
BMRBi | O89093 | |||||
SMRi | O89093 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000109064 |
Proteomic databases
PaxDbi | O89093 |
ProteomicsDBi | 283734 [O89093-1] 283735 [O89093-2] |
Protocols and materials databases
Antibodypediai | 20171, 688 antibodies from 38 providers |
DNASUi | 20297 |
Genome annotation databases
Ensembli | ENSMUST00000113437; ENSMUSP00000109064; ENSMUSG00000026166 [O89093-1] ENSMUST00000186832; ENSMUSP00000139923; ENSMUSG00000026166 [O89093-2] |
GeneIDi | 20297 |
KEGGi | mmu:20297 |
UCSCi | uc007bsk.2, mouse [O89093-1] |
Organism-specific databases
CTDi | 6364 |
MGIi | MGI:1329031, Ccl20 |
VEuPathDBi | HostDB:ENSMUSG00000026166 |
Phylogenomic databases
eggNOGi | ENOG502S776, Eukaryota |
GeneTreei | ENSGT01030000234602 |
HOGENOMi | CLU_141716_3_3_1 |
InParanoidi | O89093 |
OMAi | FDCCLQY |
PhylomeDBi | O89093 |
TreeFami | TF334888 |
Enzyme and pathway databases
Reactomei | R-MMU-380108, Chemokine receptors bind chemokines R-MMU-418594, G alpha (i) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 20297, 2 hits in 75 CRISPR screens |
EvolutionaryTracei | O89093 |
PROi | PR:O89093 |
RNActi | O89093, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026166, Expressed in jejunum and 45 other tissues |
Genevisiblei | O89093, MM |
Family and domain databases
CDDi | cd01119, Chemokine_CC_DCCL, 1 hit |
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR034133, Chemokine_CC_DCCL IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CCL20_MOUSE | |
Accessioni | O89093Primary (citable) accession number: O89093 Secondary accession number(s): Q9Z1X3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | November 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families