Ccl20

Functionⁱ

Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:9862452, PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (By similarity). Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation (PubMed:19050256). Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (PubMed:24638065). Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (PubMed:10064080).1 PublicationBy similarity6 Publications

GO - Molecular functionⁱ

CCR6 chemokine receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20068036
CCR chemokine receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine activity Source: MGI
cytokine activity
Source: MGI
Inferred from direct assayⁱ
- 9862452

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium-mediated signaling using intracellular calcium source Source: UniProtKB
cell chemotaxis Source: UniProtKB
cellular response to interferon-gamma
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to interleukin-1
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to tumor necrosis factor
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine-mediated signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemotaxis
Source: UniProtKB
Inferred from direct assayⁱ
- 20068036
G protein-coupled receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
inflammatory response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
lymphocyte chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
monocyte chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neutrophil chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of ERK1 and ERK2 cascade
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of GTPase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of interleukin-1 alpha biosynthetic process Source: MGI
positive regulation of nitric-oxide synthase biosynthetic process Source: MGI
positive regulation of T cell migration
Source: MGI
Inferred from sequence orthologyⁱ
- 23620790
T cell migration
Source: UniProtKB
Inferred from direct assayⁱ
- 19050256
- 24638065
thymocyte migration
Source: UniProtKB
Inferred from direct assayⁱ
- 24638065

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine
Biological process	Chemotaxis, Inflammatory response

Enzyme and pathway databases

Reactomeⁱ	R-MMU-380108 Chemokine receptors bind chemokines R-MMU-418594 G alpha (i) signalling events

Reactomeⁱ

R-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: C-C motif chemokine 20 Alternative name(s): Beta-chemokine exodus-1 CC chemokine LARC CC chemokine ST38 Liver and activation-regulated chemokine Macrophage inflammatory protein 3 alpha Short name: MIP-3-alpha Small-inducible cytokine A20
Gene namesⁱ	Name:Ccl20 Synonyms:Larc, Scya20
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:1329031 Ccl20

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 27	1 PublicationAdd BLAST		27
ChainⁱPRO_0000005218	28 – 97	C-C motif chemokine 20Add BLAST		70

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	33 ↔ 59	1 Publication
Disulfide bondⁱ	34 ↔ 75	1 Publication

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PaxDbⁱ	O89093
PRIDEⁱ	O89093

Expressionⁱ

Tissue specificityⁱ

Thymic medulla (at protein level). Prominently expressed in the small intestine, colon and appendix. Also found in thymus, spleen, lymph node and lung. The long form might be dominant in intestinal, and the short form in lymphoid tissues. Expressed by IL17 producing helper T-cells (Th17).2 Publications

Inductionⁱ

By lipopolysaccharide (LPS), TNF-alpha and interleukin-1. IFN-gamma alone showed no effect, but potentiated the effect of TNF. Induced synergistically by TGFB1 and IL6, which requires STAT3, RORC and IL21.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000026166 Expressed in 22 organ(s), highest expression level in jejunum
CleanExⁱ	MM_CCL20
ExpressionAtlasⁱ	O89093 baseline and differential
Genevisibleⁱ	O89093 MM

Interactionⁱ

GO - Molecular functionⁱ

CCR6 chemokine receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20068036
CCR chemokine receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine activity Source: MGI
cytokine activity
Source: MGI
Inferred from direct assayⁱ
- 9862452

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000109064

STRINGⁱ

10090.ENSMUSP00000109064

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	34 – 37	Combined sources	4
Helixⁱ	44 – 46	Combined sources	3
Beta strandⁱ	47 – 53	Combined sources	7
Beta strandⁱ	55 – 58	Combined sources	4
Beta strandⁱ	63 – 76	Combined sources	14
Helixⁱ	81 – 93	Combined sources	13

Show more details

3D structure databases

ProteinModelPortalⁱ	O89093
SMRⁱ	O89093
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

O89093

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the intercrine beta (chemokine CC) family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J2BK Eukaryota ENOG410ZGME LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000064223
HOGENOMⁱ	HOG000036685
HOVERGENⁱ	HBG017871
InParanoidⁱ	O89093
KEGG Orthology (KO) More...KOⁱ	K14625
OMAⁱ	CCLRYTE
PhylomeDBⁱ	O89093
TreeFamⁱ	TF334888

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01119 Chemokine_CC_DCCL, 1 hit
InterProⁱ	View protein in InterPro IPR039809 Chemokine_b/g/d IPR000827 Chemokine_CC_CS IPR034133 Chemokine_CC_DCCL IPR001811 Chemokine_IL8-like_dom IPR036048 Interleukin_8-like_sf
PANTHERⁱ	PTHR12015 PTHR12015, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00048 IL8, 1 hit
SMARTⁱ	View protein in SMART SM00199 SCY, 1 hit
SUPFAMⁱ	SSF54117 SSF54117, 1 hit
PROSITEⁱ	View protein in PROSITE PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform Long (identifier: O89093-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MACGGKRLLF LALAWVLLAH LCSQAEAASN YDCCLSYIQT PLPSRAIVGF 
        60         70         80         90 
TRQMADEACD INAIIFHTKK RKSVCADPKQ NWVKRAVNLL SLRVKKM

Length:97

Mass (Da):10,826

Last modified:November 1, 1998 - v1

Checksum:ⁱ6E0C73C8AC80AB0A

GO

Isoform Short (identifier: O89093-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
28-28: Missing.

« Hide

        10         20         30         40         50
MACGGKRLLF LALAWVLLAH LCSQAEASNY DCCLSYIQTP LPSRAIVGFT 
        60         70         80         90 
RQMADEACDI NAIIFHTKKR KSVCADPKQN WVKRAVNLLS LRVKKM

Show »

Length:96

Mass (Da):10,755

Checksum:ⁱA5236C18BC0E09DB

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F8WHA7	F8WHA7_MOUSE		C-C motif chemokine C-C motif chemokine	Ccl20	102	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_001062	28	Missing in isoform Short. Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF053313 mRNA Translation: AAC78295.1 AJ007862 Genomic DNA Translation: CAA07714.1 AF099052 mRNA Translation: AAC78680.1 AJ222694 mRNA Translation: CAA10948.1 AB015136 mRNA Translation: BAA76955.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35632.1 [O89093-1] CCDS78638.1 [O89093-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001153210.1, NM_001159738.1 [O89093-2] NP_058656.1, NM_016960.2 [O89093-1]
UniGeneⁱ	Mm.116739

Genome annotation databases

Ensemblⁱ	ENSMUST00000113437; ENSMUSP00000109064; ENSMUSG00000026166 [O89093-1] ENSMUST00000186832; ENSMUSP00000139923; ENSMUSG00000026166 [O89093-2]
GeneIDⁱ	20297
KEGGⁱ	mmu:20297
UCSC genome browser More...UCSCⁱ	uc007bsk.2 mouse [O89093-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O89093	C-C motif chemokine		MOUSE		97	UniRef100_O89093
UPI0000111ACC		MOUSE		70
O89093-2	C-C motif chemokine		MOUSE		96	UniRef100_Q642U4

Protein	Similar proteins		Species	Score	Length	Source
O89093	C-C motif chemokine		MOUSE		97	UniRef90_O89093
UPI000A30DFDC		MUSPA		102
C-C motif chemokine		MOUSE		102
C-C motif chemokine		MOUSE		96
Isoform Short of C-C motif chemokine 20		MOUSE		96
+1

Protein	Similar proteins		Species	Score	Length	Source
O89093	C-C motif chemokine		MOUSE		97	UniRef50_O89093
C-C motif chemokine		NOMLE		96
UPI000A30DFDC		MUSPA		102
UPI00032B0193		OCHPR		126
UPI000D185EFE		DESRO		112
+9

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF053313 mRNA Translation: AAC78295.1 AJ007862 Genomic DNA Translation: CAA07714.1 AF099052 mRNA Translation: AAC78680.1 AJ222694 mRNA Translation: CAA10948.1 AB015136 mRNA Translation: BAA76955.1
CCDSⁱ	CCDS35632.1 [O89093-1] CCDS78638.1 [O89093-2]
RefSeqⁱ	NP_001153210.1, NM_001159738.1 [O89093-2] NP_058656.1, NM_016960.2 [O89093-1]
UniGeneⁱ	Mm.116739

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1HA6	NMR	-	A	28-97	[»]
ProteinModelPortalⁱ	O89093
SMRⁱ	O89093
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000109064

STRINGⁱ

10090.ENSMUSP00000109064

Proteomic databases

PaxDbⁱ	O89093
PRIDEⁱ	O89093

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000113437; ENSMUSP00000109064; ENSMUSG00000026166 [O89093-1] ENSMUST00000186832; ENSMUSP00000139923; ENSMUSG00000026166 [O89093-2]
GeneIDⁱ	20297
KEGGⁱ	mmu:20297
UCSCⁱ	uc007bsk.2 mouse [O89093-1]

Organism-specific databases

CTDⁱ	6364
MGIⁱ	MGI:1329031 Ccl20

Phylogenomic databases

eggNOGⁱ	ENOG410J2BK Eukaryota ENOG410ZGME LUCA
GeneTreeⁱ	ENSGT00530000064223
HOGENOMⁱ	HOG000036685
HOVERGENⁱ	HBG017871
InParanoidⁱ	O89093
KOⁱ	K14625
OMAⁱ	CCLRYTE
PhylomeDBⁱ	O89093
TreeFamⁱ	TF334888

Enzyme and pathway databases

Reactomeⁱ	R-MMU-380108 Chemokine receptors bind chemokines R-MMU-418594 G alpha (i) signalling events

Reactomeⁱ

R-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Miscellaneous databases

EvolutionaryTraceⁱ	O89093
Protein Ontology More...PROⁱ	PR:O89093
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000026166 Expressed in 22 organ(s), highest expression level in jejunum
CleanExⁱ	MM_CCL20
ExpressionAtlasⁱ	O89093 baseline and differential
Genevisibleⁱ	O89093 MM

Family and domain databases

CDDⁱ	cd01119 Chemokine_CC_DCCL, 1 hit
InterProⁱ	View protein in InterPro IPR039809 Chemokine_b/g/d IPR000827 Chemokine_CC_CS IPR034133 Chemokine_CC_DCCL IPR001811 Chemokine_IL8-like_dom IPR036048 Interleukin_8-like_sf
PANTHERⁱ	PTHR12015 PTHR12015, 1 hit
Pfamⁱ	View protein in Pfam PF00048 IL8, 1 hit
SMARTⁱ	View protein in SMART SM00199 SCY, 1 hit
SUPFAMⁱ	SSF54117 SSF54117, 1 hit
PROSITEⁱ	View protein in PROSITE PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CCL20_MOUSE
Accessionⁱ	O89093Primary (citable) accession number: O89093 Secondary accession number(s): Q9Z1X3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	November 1, 1998
	Last modified:	November 7, 2018
	This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - O89093 (CCL20_MOUSE)

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C-C motif chemokine 20

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ