Krueppel-like factor 10

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• core promoter sequence-specific DNA binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.4

    "Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork."
    Hirota T., Kon N., Itagaki T., Hoshina N., Okano T., Fukada Y.
    Genes Cells 15:111-121(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION, PHOSPHORYLATION.
• DNA binding Source: MGI <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Mammalian SP/KLF transcription factors: bring in the family."
    Suske G., Bruford E., Philipsen S.
    Genomics 85:551-556(2005) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI

GO - Biological processⁱ

• bone mineralization Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro."
    Subramaniam M., Gorny G., Johnsen S.A., Monroe D.G., Evans G.L., Fraser D.G., Rickard D.J., Rasmussen K., van Deursen J.M., Turner R.T., Oursler M.J., Spelsberg T.C.
    Mol. Cell. Biol. 25:1191-1199(2005) [PubMed] [Europe PMC] [Abstract]
• cellular response to peptide Source: Ensembl
• cellular response to starvation Source: UniProtKBInferred from direct assayⁱ
  • Ref.4

    "Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork."
    Hirota T., Kon N., Itagaki T., Hoshina N., Okano T., Fukada Y.
    Genes Cells 15:111-121(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION, PHOSPHORYLATION.
• circadian rhythm Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • Ref.4

    "Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork."
    Hirota T., Kon N., Itagaki T., Hoshina N., Okano T., Fukada Y.
    Genes Cells 15:111-121(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION, PHOSPHORYLATION.
• negative regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • Ref.4

    "Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork."
    Hirota T., Kon N., Itagaki T., Hoshina N., Okano T., Fukada Y.
    Genes Cells 15:111-121(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION, PHOSPHORYLATION.
• positive regulation of osteoclast differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro."
    Subramaniam M., Gorny G., Johnsen S.A., Monroe D.G., Evans G.L., Fraser D.G., Rickard D.J., Rasmussen K., van Deursen J.M., Turner R.T., Oursler M.J., Spelsberg T.C.
    Mol. Cell. Biol. 25:1191-1199(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: MGI
• regulation of circadian rhythm Source: UniProtKB
• regulation of transcription, DNA-templated Source: MGIInferred from mutant phenotypeⁱ
  • "TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro."
    Subramaniam M., Gorny G., Johnsen S.A., Monroe D.G., Evans G.L., Fraser D.G., Rickard D.J., Rasmussen K., van Deursen J.M., Turner R.T., Oursler M.J., Spelsberg T.C.
    Mol. Cell. Biol. 25:1191-1199(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• somatic stem cell population maintenance Source: MGIInferred from direct assayⁱ
  • "A functional screen to identify novel effectors of hematopoietic stem cell activity."
    Deneault E., Cellot S., Faubert A., Laverdure J.P., Frechette M., Chagraoui J., Mayotte N., Sauvageau M., Ting S.B., Sauvageau G.
    Cell 137:369-379(2009) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MLNFGASLQQ ASEGKMELIS EKPREGMHPW DKAEQSDFEA VEALMSMSCD 
        60         70         80         90        100
WKSHFKKYLE NRPVTPVSDT SEDDSLLPGT PDLQTVPAFC LTPPYSPSDF 
       110        120        130        140        150
EPSQGSNLTA SAPSTGHFKS FSDAAKPPGA TPFKEEEKNP LAAPPLPKAQ 
       160        170        180        190        200
ATSVIRHTAD AQLCNHQSCP VKAASILNYQ DNSFRRRTHG NVEATRKNIP 
       210        220        230        240        250
CAAVSPNRSK PEPSTVSDGD EKAGAALYDF AVPSSETVIC RSQPAPSSPV 
       260        270        280        290        300
QKSVLVSSPT VSTGGVPPLP VICQMVPLPA NNSLVSTVVP STPPSQPPAV 
       310        320        330        340        350
CSPVLFMGTQ VPEGTVVFVV PQPVVQSPRP PVVSPSGTRL SPIAPAPGFS 
       360        370        380        390        400
PSAARVTPQI DSSRVRSHIC SHPGCGKTYF KSSHLKAHVR THTGEKPFSC 
       410        420        430        440        450
SWKGCERRFA RSDELSRHRR THTGEKKFAC PMCDRRFMRS DHLTKHARRH 
       460        470 
LSAKKLPNWQ MEVSKLNDIA LPPTPASAQ                        

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot