UniProtKB - O89091 (KLF10_MOUSE)
Krueppel-like factor 10
Klf10
Functioni
Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. May play a role in the cell cycle regulation (By similarity).
Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis.
By similarity2 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 368 – 392 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 398 – 422 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 428 – 450 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- core promoter sequence-specific DNA binding Source: UniProtKB
- DNA binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- bone mineralization Source: MGI
- cellular response to starvation Source: UniProtKB
- circadian rhythm Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of osteoclast differentiation Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of circadian rhythm Source: UniProtKB
- regulation of transcription, DNA-templated Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- somatic stem cell population maintenance Source: MGI
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Krueppel-like factor 10Alternative name(s): GDNF-inducible factor Transcription factor GIF Short name: mGIF Transforming growth factor-beta-inducible early growth response protein 1 Short name: TGFB-inducible early growth response protein 1 Short name: TIEG-1 |
Gene namesi | Name:Klf10 Synonyms:Gdnfif, Tieg, Tieg1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1101353, Klf10 |
VEuPathDBi | HostDB:ENSMUSG00000037465 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Chemistry databases
ChEMBLi | CHEMBL4523155 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047178 | 1 – 479 | Krueppel-like factor 10Add BLAST | 479 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 183 | PhosphoserineBy similarity | 1 | |
Modified residuei | 248 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | O89091 |
PeptideAtlasi | O89091 |
PRIDEi | O89091 |
ProteomicsDBi | 263617 |
PTM databases
iPTMneti | O89091 |
PhosphoSitePlusi | O89091 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000037465, Expressed in pineal body and 300 other tissues |
ExpressionAtlasi | O89091, baseline and differential |
Genevisiblei | O89091, MM |
Interactioni
Binary interactionsi
O89091
With | #Exp. | IntAct |
---|---|---|
Itch [Q8C863] | 4 | EBI-10949150,EBI-851782 |
Protein-protein interaction databases
BioGRIDi | 204195, 3 interactors |
IntActi | O89091, 1 interactor |
STRINGi | 10090.ENSMUSP00000073690 |
Miscellaneous databases
RNActi | O89091, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 94 – 145 | DisorderedSequence analysisAdd BLAST | 52 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 97 – 118 | Polar residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 368 – 392 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 398 – 422 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 428 – 450 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159405 |
HOGENOMi | CLU_046370_1_0_1 |
InParanoidi | O89091 |
OMAi | CQPMVFM |
OrthoDBi | 582598at2759 |
PhylomeDBi | O89091 |
TreeFami | TF315506 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MLNFGASLQQ ASEGKMELIS EKPREGMHPW DKAEQSDFEA VEALMSMSCD
60 70 80 90 100
WKSHFKKYLE NRPVTPVSDT SEDDSLLPGT PDLQTVPAFC LTPPYSPSDF
110 120 130 140 150
EPSQGSNLTA SAPSTGHFKS FSDAAKPPGA TPFKEEEKNP LAAPPLPKAQ
160 170 180 190 200
ATSVIRHTAD AQLCNHQSCP VKAASILNYQ DNSFRRRTHG NVEATRKNIP
210 220 230 240 250
CAAVSPNRSK PEPSTVSDGD EKAGAALYDF AVPSSETVIC RSQPAPSSPV
260 270 280 290 300
QKSVLVSSPT VSTGGVPPLP VICQMVPLPA NNSLVSTVVP STPPSQPPAV
310 320 330 340 350
CSPVLFMGTQ VPEGTVVFVV PQPVVQSPRP PVVSPSGTRL SPIAPAPGFS
360 370 380 390 400
PSAARVTPQI DSSRVRSHIC SHPGCGKTYF KSSHLKAHVR THTGEKPFSC
410 420 430 440 450
SWKGCERRFA RSDELSRHRR THTGEKKFAC PMCDRRFMRS DHLTKHARRH
460 470
LSAKKLPNWQ MEVSKLNDIA LPPTPASAQ
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8C900 | Q8C900_MOUSE | Krueppel-like factor 10 | Klf10 Tieg1 | 434 | Annotation score: | ||
A0A2I3BRS7 | A0A2I3BRS7_MOUSE | Krueppel-like factor 10 | Klf10 | 464 | Annotation score: | ||
A0A2I3BPZ3 | A0A2I3BPZ3_MOUSE | Krueppel-like factor 10 | Klf10 | 151 | Annotation score: | ||
A0A2I3BQ59 | A0A2I3BQ59_MOUSE | Krueppel-like factor 10 | Klf10 | 176 | Annotation score: | ||
A0A2I3BRQ2 | A0A2I3BRQ2_MOUSE | Krueppel-like factor 10 | Klf10 | 71 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF064088 mRNA Translation: AAC16734.1 AF049880 Genomic DNA Translation: AAC77797.1 AF049879 mRNA Translation: AAC77796.1 BC003316 mRNA Translation: AAH03316.1 |
CCDSi | CCDS27438.1 |
RefSeqi | NP_038720.1, NM_013692.3 |
Genome annotation databases
Ensembli | ENSMUST00000074043; ENSMUSP00000073690; ENSMUSG00000037465 |
GeneIDi | 21847 |
KEGGi | mmu:21847 |
UCSCi | uc007vnr.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF064088 mRNA Translation: AAC16734.1 AF049880 Genomic DNA Translation: AAC77797.1 AF049879 mRNA Translation: AAC77796.1 BC003316 mRNA Translation: AAH03316.1 |
CCDSi | CCDS27438.1 |
RefSeqi | NP_038720.1, NM_013692.3 |
3D structure databases
SMRi | O89091 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204195, 3 interactors |
IntActi | O89091, 1 interactor |
STRINGi | 10090.ENSMUSP00000073690 |
Chemistry databases
ChEMBLi | CHEMBL4523155 |
PTM databases
iPTMneti | O89091 |
PhosphoSitePlusi | O89091 |
Proteomic databases
PaxDbi | O89091 |
PeptideAtlasi | O89091 |
PRIDEi | O89091 |
ProteomicsDBi | 263617 |
Protocols and materials databases
Antibodypediai | 26326, 297 antibodies from 34 providers |
DNASUi | 21847 |
Genome annotation databases
Ensembli | ENSMUST00000074043; ENSMUSP00000073690; ENSMUSG00000037465 |
GeneIDi | 21847 |
KEGGi | mmu:21847 |
UCSCi | uc007vnr.2, mouse |
Organism-specific databases
CTDi | 7071 |
MGIi | MGI:1101353, Klf10 |
VEuPathDBi | HostDB:ENSMUSG00000037465 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159405 |
HOGENOMi | CLU_046370_1_0_1 |
InParanoidi | O89091 |
OMAi | CQPMVFM |
OrthoDBi | 582598at2759 |
PhylomeDBi | O89091 |
TreeFami | TF315506 |
Miscellaneous databases
BioGRID-ORCSi | 21847, 2 hits in 62 CRISPR screens |
ChiTaRSi | Klf10, mouse |
PROi | PR:O89091 |
RNActi | O89091, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037465, Expressed in pineal body and 300 other tissues |
ExpressionAtlasi | O89091, baseline and differential |
Genevisiblei | O89091, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KLF10_MOUSE | |
Accessioni | O89091Primary (citable) accession number: O89091 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families