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Protein

RNA-binding protein 3

Gene

Rbm3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation.1 Publication

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: GO_Central
  • poly(U) RNA binding Source: GO_Central
  • ribosomal large subunit binding Source: MGI
  • RNA binding Source: GO_Central
  • small ribosomal subunit rRNA binding Source: GO_Central
  • translation repressor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 3
Alternative name(s):
RNA-binding motif protein 3
Gene namesi
Name:Rbm3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1099460 Rbm3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817531 – 153RNA-binding protein 3Add BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47Omega-N-methylarginineCombined sources1
Modified residuei103Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei103Dimethylated arginine; alternateBy similarity1
Modified residuei103Omega-N-methylarginine; alternateCombined sources1
Modified residuei103Omega-N-methylated arginine; alternateBy similarity1
Modified residuei118Omega-N-methylarginineCombined sources1
Modified residuei128Omega-N-methylarginineCombined sources1
Modified residuei133PhosphoserineCombined sources1
Modified residuei143PhosphoserineBy similarity1
Modified residuei151PhosphotyrosineBy similarity1

Post-translational modificationi

Arg-103 is dimethylated, probably to asymmetric dimethylarginine.By similarity
Phosphorylated.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiO89086
PaxDbiO89086
PeptideAtlasiO89086
PRIDEiO89086

2D gel databases

REPRODUCTION-2DPAGEiIPI00130883

PTM databases

iPTMnetiO89086
PhosphoSitePlusiO89086

Expressioni

Gene expression databases

BgeeiENSMUSG00000031167 Expressed in 219 organ(s), highest expression level in thymus
CleanExiMM_RBM3
ExpressionAtlasiO89086 baseline and differential
GenevisibleiO89086 MM

Interactioni

Subunit structurei

Interacts with RPL4. Associates with the 60S ribosomal subunits in an RNA-independent manner.

Protein-protein interaction databases

BioGridi202821, 3 interactors
IntActiO89086, 3 interactors
MINTiO89086
STRINGi10090.ENSMUSP00000038964

Structurei

3D structure databases

ProteinModelPortaliO89086
SMRiO89086
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 84RRMPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi88 – 145Gly-richAdd BLAST58

Phylogenomic databases

eggNOGiENOG410IQVN Eukaryota
ENOG410YRZ9 LUCA
GeneTreeiENSGT00710000106295
HOGENOMiHOG000276232
HOVERGENiHBG107480
InParanoidiO89086
KOiK13186
PhylomeDBiO89086

Family and domain databases

CDDicd12449 RRM_CIRBP_RBM3, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034278 RBM3/CIRBP_RRM
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O89086-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSEEGKLFV GGLNFNTDEQ ALEDHFSSFG PISEVVVVKD RETQRSRGFG
60 70 80 90 100
FITFTNPEHA SDAMRAMNGE SLDGRQIRVD HAGKSARGSR GGAFGGRGRS
110 120 130 140 150
YSRGGGDQGY GSGRYDSRPG GYGYGYGRSR DYSGSQGGYD RYSGGNYRDN

YDN
Length:153
Mass (Da):16,605
Last modified:November 1, 1998 - v1
Checksum:iC54A66A1A9E4FF3D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BG13Q8BG13_MOUSE
RNA-binding protein 3
Rbm3
154Annotation score:
S4R2M6S4R2M6_MOUSE
MCG116386, isoform CRA_c
Rbm3 mCG_116386
90Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016424 mRNA Translation: BAA32060.1
AY052560 mRNA Translation: AAL10707.1
BC006580 mRNA Translation: AAH06580.1
CCDSiCCDS52988.1
RefSeqiNP_001159882.1, NM_001166410.2
NP_001159883.1, NM_001166411.2
UniGeneiMm.128512
Mm.360569

Genome annotation databases

EnsembliENSMUST00000115615; ENSMUSP00000111277; ENSMUSG00000031167
ENSMUST00000115619; ENSMUSP00000111282; ENSMUSG00000031167
ENSMUST00000115621; ENSMUSP00000111284; ENSMUSG00000031167
GeneIDi19652
KEGGimmu:19652
UCSCiuc009sob.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016424 mRNA Translation: BAA32060.1
AY052560 mRNA Translation: AAL10707.1
BC006580 mRNA Translation: AAH06580.1
CCDSiCCDS52988.1
RefSeqiNP_001159882.1, NM_001166410.2
NP_001159883.1, NM_001166411.2
UniGeneiMm.128512
Mm.360569

3D structure databases

ProteinModelPortaliO89086
SMRiO89086
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202821, 3 interactors
IntActiO89086, 3 interactors
MINTiO89086
STRINGi10090.ENSMUSP00000038964

PTM databases

iPTMnetiO89086
PhosphoSitePlusiO89086

2D gel databases

REPRODUCTION-2DPAGEiIPI00130883

Proteomic databases

EPDiO89086
PaxDbiO89086
PeptideAtlasiO89086
PRIDEiO89086

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115615; ENSMUSP00000111277; ENSMUSG00000031167
ENSMUST00000115619; ENSMUSP00000111282; ENSMUSG00000031167
ENSMUST00000115621; ENSMUSP00000111284; ENSMUSG00000031167
GeneIDi19652
KEGGimmu:19652
UCSCiuc009sob.3 mouse

Organism-specific databases

CTDi5935
MGIiMGI:1099460 Rbm3

Phylogenomic databases

eggNOGiENOG410IQVN Eukaryota
ENOG410YRZ9 LUCA
GeneTreeiENSGT00710000106295
HOGENOMiHOG000276232
HOVERGENiHBG107480
InParanoidiO89086
KOiK13186
PhylomeDBiO89086

Miscellaneous databases

PROiPR:O89086
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031167 Expressed in 219 organ(s), highest expression level in thymus
CleanExiMM_RBM3
ExpressionAtlasiO89086 baseline and differential
GenevisibleiO89086 MM

Family and domain databases

CDDicd12449 RRM_CIRBP_RBM3, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034278 RBM3/CIRBP_RRM
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRBM3_MOUSE
AccessioniPrimary (citable) accession number: O89086
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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