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Protein

Coatomer subunit epsilon

Gene

Cope

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit epsilon
Alternative name(s):
Epsilon-coat protein
Short name:
Epsilon-COP
Gene namesi
Name:Cope
Synonyms:Cope1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1891702 Cope

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938521 – 308Coatomer subunit epsilonAdd BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineBy similarity1
Modified residuei45PhosphoserineBy similarity1
Modified residuei99PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by PKA.By similarity
Polyubiquitinated by RCHY1 in the presence of androgen, leading to proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO89079
MaxQBiO89079
PaxDbiO89079
PeptideAtlasiO89079
PRIDEiO89079

2D gel databases

REPRODUCTION-2DPAGEiO89079

PTM databases

iPTMnetiO89079
PhosphoSitePlusiO89079
SwissPalmiO89079

Expressioni

Gene expression databases

BgeeiENSMUSG00000055681 Expressed in 296 organ(s), highest expression level in ear vesicle
CleanExiMM_COPE
ExpressionAtlasiO89079 baseline and differential
GenevisibleiO89079 MM

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

Protein-protein interaction databases

BioGridi208506, 1 interactor
CORUMiO89079
IntActiO89079, 1 interactor
STRINGi10090.ENSMUSP00000071078

Structurei

3D structure databases

ProteinModelPortaliO89079
SMRiO89079
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COPE family.Curated

Phylogenomic databases

eggNOGiKOG3081 Eukaryota
ENOG410XS5P LUCA
GeneTreeiENSGT00390000003478
HOGENOMiHOG000205825
HOVERGENiHBG002201
InParanoidiO89079
KOiK17268
OMAiDAFHIYQ
OrthoDBiEOG091G0KHF
PhylomeDBiO89079
TreeFamiTF313390

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR006822 Coatomer_esu
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR10805 PTHR10805, 1 hit
PIRSFiPIRSF016478 Coatomer_esu, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O89079-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPPVPGAVS GGSGEVDELF DVKNAFYIGS YQQCINEAQR VKLSSPEREV
60 70 80 90 100
ERDVFLYRAY LAQRKYGVVL DEIKPSSAPE LQAVRMFAEY LASENQRDSI
110 120 130 140 150
VLELDREMSR SVDVTNTTFL LMAASIYFHD QNPDAALRTL HQGDGLECMA
160 170 180 190 200
MTIQILLKLD RLDLARKELK KMQDQDEDAT LTQLATAWVN LAVGGEKLQE
210 220 230 240 250
AYYIFQELAD KCSPTLLLLN GQAACHSAQG RWETAEGVLQ EALDKDSGHP
260 270 280 290 300
ETLINLIVLS QHLGKPPEVT NRYLSQLKDA HRAHPFIKEY QAKENDFDRL

AMQYAPSA
Length:308
Mass (Da):34,567
Last modified:January 23, 2007 - v3
Checksum:i81331BDDB1F99270
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6YFR7F6YFR7_MOUSE
Coatomer subunit epsilon
Cope
234Annotation score:
E9Q6I5E9Q6I5_MOUSE
Coatomer subunit epsilon
Cope
112Annotation score:
D3Z315D3Z315_MOUSE
Coatomer subunit epsilon
Cope
227Annotation score:
F6XIG5F6XIG5_MOUSE
Coatomer subunit epsilon
Cope
116Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti291Q → R in AAC36533 (PubMed:9798653).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039837 mRNA Translation: BAA92384.1
BC009170 mRNA Translation: AAH09170.1
BC083336 mRNA Translation: AAH83336.1
U89427 mRNA Translation: AAC36533.1
CCDSiCCDS22365.1
RefSeqiNP_067513.1, NM_021538.1
UniGeneiMm.28668

Genome annotation databases

EnsembliENSMUST00000066469; ENSMUSP00000071078; ENSMUSG00000055681
GeneIDi59042
KEGGimmu:59042
UCSCiuc009lzx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039837 mRNA Translation: BAA92384.1
BC009170 mRNA Translation: AAH09170.1
BC083336 mRNA Translation: AAH83336.1
U89427 mRNA Translation: AAC36533.1
CCDSiCCDS22365.1
RefSeqiNP_067513.1, NM_021538.1
UniGeneiMm.28668

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5A1Velectron microscopy21.00Q/Z1-308[»]
5A1Yelectron microscopy21.00X/Z1-308[»]
5NZTelectron microscopy17.00E1-308[»]
5NZVelectron microscopy17.30E/O1-308[»]
ProteinModelPortaliO89079
SMRiO89079
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208506, 1 interactor
CORUMiO89079
IntActiO89079, 1 interactor
STRINGi10090.ENSMUSP00000071078

PTM databases

iPTMnetiO89079
PhosphoSitePlusiO89079
SwissPalmiO89079

2D gel databases

REPRODUCTION-2DPAGEiO89079

Proteomic databases

EPDiO89079
MaxQBiO89079
PaxDbiO89079
PeptideAtlasiO89079
PRIDEiO89079

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066469; ENSMUSP00000071078; ENSMUSG00000055681
GeneIDi59042
KEGGimmu:59042
UCSCiuc009lzx.1 mouse

Organism-specific databases

CTDi11316
MGIiMGI:1891702 Cope

Phylogenomic databases

eggNOGiKOG3081 Eukaryota
ENOG410XS5P LUCA
GeneTreeiENSGT00390000003478
HOGENOMiHOG000205825
HOVERGENiHBG002201
InParanoidiO89079
KOiK17268
OMAiDAFHIYQ
OrthoDBiEOG091G0KHF
PhylomeDBiO89079
TreeFamiTF313390

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

ChiTaRSiCope mouse
PROiPR:O89079
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055681 Expressed in 296 organ(s), highest expression level in ear vesicle
CleanExiMM_COPE
ExpressionAtlasiO89079 baseline and differential
GenevisibleiO89079 MM

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR006822 Coatomer_esu
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR10805 PTHR10805, 1 hit
PIRSFiPIRSF016478 Coatomer_esu, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOPE_MOUSE
AccessioniPrimary (citable) accession number: O89079
Secondary accession number(s): Q9JM65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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