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Protein

Coronin-1A

Gene

Coro1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.1 Publication

GO - Molecular functioni

  • actin binding Source: MGI
  • actin filament binding Source: MGI
  • actin monomer binding Source: MGI
  • cytoskeletal protein binding Source: UniProtKB
  • identical protein binding Source: MGI
  • myosin heavy chain binding Source: MGI
  • phosphatidylinositol 3-kinase binding Source: MGI
  • protein C-terminus binding Source: MGI
  • protein homodimerization activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-1A
Alternative name(s):
Coronin-like protein A
Short name:
Clipin-A
Coronin-like protein p57
Tryptophan aspartate-containing coat protein
Short name:
TACO
Gene namesi
Name:Coro1a
Synonyms:Coro1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1345961 Coro1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000509212 – 461Coronin-1AAdd BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2Phosphoserine; by PKCBy similarity1
Modified residuei412Phosphoserine; by PKC1 Publication1
Modified residuei418PhosphothreonineCombined sources1
Modified residuei422PhosphoserineCombined sources1

Post-translational modificationi

phosphorylation at Ser-412 by PKC strongly down-regulates the association with actin.By similarity
Polyubiquitinated by RNF128 with 'Lys-48'-linked chains, leading to proteasomal degradation.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO89053
PaxDbiO89053
PeptideAtlasiO89053
PRIDEiO89053

PTM databases

iPTMnetiO89053
PhosphoSitePlusiO89053
SwissPalmiO89053

Expressioni

Tissue specificityi

Expressed in spleen, lymph nodes, thymus, brain and at very lower levels in lung. Also expressed in cells of the lymphoid/myeloid lineage. Not expressed in Kuffper cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000030707 Expressed in 260 organ(s), highest expression level in thymus
CleanExiMM_CORO1A
ExpressionAtlasiO89053 baseline and differential
GenevisibleiO89053 MM

Interactioni

Subunit structurei

Binds actin.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
GNASP630922EBI-6665847,EBI-1047114From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198732, 3 interactors
IntActiO89053, 3 interactors
MINTiO89053
STRINGi10090.ENSMUSP00000032949

Structurei

Secondary structure

1461
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO89053
SMRiO89053
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO89053

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati13 – 63WD 1PROSITE-ProRule annotation1 PublicationAdd BLAST51
Repeati73 – 110WD 2PROSITE-ProRule annotation1 PublicationAdd BLAST38
Repeati123 – 160WD 3PROSITE-ProRule annotation1 PublicationAdd BLAST38
Repeati164 – 204WD 4PROSITE-ProRule annotation1 PublicationAdd BLAST41
Repeati207 – 251WD 5PROSITE-ProRule annotation1 PublicationAdd BLAST45
Repeati258 – 296WD 6PROSITE-ProRule annotation1 PublicationAdd BLAST39
Repeati302 – 349WD 7PROSITE-ProRule annotation1 PublicationAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili424 – 4612 PublicationsAdd BLAST38

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0303 Eukaryota
ENOG410XQAD LUCA
GeneTreeiENSGT00760000119195
HOGENOMiHOG000166356
HOVERGENiHBG059978
InParanoidiO89053
KOiK13882
OMAiCYDDIRI
OrthoDBiEOG091G03H5
PhylomeDBiO89053
TreeFamiTF314280

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR029508 CORO1A
IPR015505 Coronin
IPR015048 DUF1899
IPR015049 Trimer_CC
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10856 PTHR10856, 1 hit
PTHR10856:SF18 PTHR10856:SF18, 1 hit
PfamiView protein in Pfam
PF08953 DUF1899, 1 hit
PF08954 Trimer_CC, 1 hit
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM01166 DUF1899, 1 hit
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

O89053-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRQVVRSSK FRHVFGQPAK ADQCYEDVRV SQTTWDSGFC AVNPKFMALI
60 70 80 90 100
CEASGGGAFL VLPLGKTGRV DKNVPLVCGH TAPVLDIAWC PHNDNVIASG
110 120 130 140 150
SEDCTVMVWE IPDGGLVLPL REPVITLEGH TKRVGIVAWH PTAQNVLLSA
160 170 180 190 200
GCDNVILVWD VGTGAAVLTL GPDVHPDTIY SVDWSRDGAL ICTSCRDKRV
210 220 230 240 250
RVIEPRKGTV VAEKDRPHEG TRPVHAVFVS EGKILTTGFS RMSERQVALW
260 270 280 290 300
DTKHLEEPLS LQELDTSSGV LLPFFDPDTN IVYLCGKGDS SIRYFEITSE
310 320 330 340 350
APFLHYLSMF SSKESQRGMG YMPKRGLEVN KCEIARFYKL HERKCEPIAM
360 370 380 390 400
TVPRKSDLFQ EDLYPPTAGP DPALTAEEWL GGRDAGPLLI SLKDGYVPPK
410 420 430 440 450
SRELRVNRGL DSARRRATPE PSGTPSSDTV SRLEEDVRNL NAIVQKLQER
460
LDRLEETVQA K
Length:461
Mass (Da):50,989
Last modified:January 23, 2007 - v5
Checksum:i9098F53757C5318D
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UYK8G3UYK8_MOUSE
Coronin
Coro1a
389Annotation score:
D3YW57D3YW57_MOUSE
Coronin
Coro1a
233Annotation score:
D3YXM2D3YXM2_MOUSE
Coronin
Coro1a
116Annotation score:
G3UX53G3UX53_MOUSE
Coronin
Coro1a
113Annotation score:
A0A0U1RPY8A0A0U1RPY8_MOUSE
Coronin
Coro1a
246Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125I → V in AAD32703 (PubMed:9778037).Curated1
Sequence conflicti125I → V in AAH02136 (PubMed:15489334).Curated1
Sequence conflicti299S → F in AAH53398 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143955 mRNA Translation: AAD32703.1
AF047388 mRNA Translation: AAD31082.1
AF495468 mRNA Translation: AAM18514.1
BC002136 mRNA Translation: AAH02136.1
BC053398 mRNA Translation: AAH53398.1
U89399 mRNA Translation: AAC36506.1
CCDSiCCDS21840.1
RefSeqiNP_001288303.1, NM_001301374.1
NP_034028.1, NM_009898.3
XP_006507347.1, XM_006507284.3
XP_006507348.1, XM_006507285.3
UniGeneiMm.290482

Genome annotation databases

EnsembliENSMUST00000032949; ENSMUSP00000032949; ENSMUSG00000030707
ENSMUST00000106364; ENSMUSP00000101972; ENSMUSG00000030707
GeneIDi12721
KEGGimmu:12721
UCSCiuc009jsk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143955 mRNA Translation: AAD32703.1
AF047388 mRNA Translation: AAD31082.1
AF495468 mRNA Translation: AAM18514.1
BC002136 mRNA Translation: AAH02136.1
BC053398 mRNA Translation: AAH53398.1
U89399 mRNA Translation: AAC36506.1
CCDSiCCDS21840.1
RefSeqiNP_001288303.1, NM_001301374.1
NP_034028.1, NM_009898.3
XP_006507347.1, XM_006507284.3
XP_006507348.1, XM_006507285.3
UniGeneiMm.290482

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AKFX-ray1.20A/B/C430-461[»]
2AQ5X-ray1.75A1-402[»]
2B4EX-ray2.30A1-402[»]
ProteinModelPortaliO89053
SMRiO89053
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198732, 3 interactors
IntActiO89053, 3 interactors
MINTiO89053
STRINGi10090.ENSMUSP00000032949

PTM databases

iPTMnetiO89053
PhosphoSitePlusiO89053
SwissPalmiO89053

Proteomic databases

EPDiO89053
PaxDbiO89053
PeptideAtlasiO89053
PRIDEiO89053

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032949; ENSMUSP00000032949; ENSMUSG00000030707
ENSMUST00000106364; ENSMUSP00000101972; ENSMUSG00000030707
GeneIDi12721
KEGGimmu:12721
UCSCiuc009jsk.2 mouse

Organism-specific databases

CTDi11151
MGIiMGI:1345961 Coro1a

Phylogenomic databases

eggNOGiKOG0303 Eukaryota
ENOG410XQAD LUCA
GeneTreeiENSGT00760000119195
HOGENOMiHOG000166356
HOVERGENiHBG059978
InParanoidiO89053
KOiK13882
OMAiCYDDIRI
OrthoDBiEOG091G03H5
PhylomeDBiO89053
TreeFamiTF314280

Miscellaneous databases

ChiTaRSiCoro1a mouse
EvolutionaryTraceiO89053
PROiPR:O89053
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030707 Expressed in 260 organ(s), highest expression level in thymus
CleanExiMM_CORO1A
ExpressionAtlasiO89053 baseline and differential
GenevisibleiO89053 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR029508 CORO1A
IPR015505 Coronin
IPR015048 DUF1899
IPR015049 Trimer_CC
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10856 PTHR10856, 1 hit
PTHR10856:SF18 PTHR10856:SF18, 1 hit
PfamiView protein in Pfam
PF08953 DUF1899, 1 hit
PF08954 Trimer_CC, 1 hit
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM01166 DUF1899, 1 hit
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOR1A_MOUSE
AccessioniPrimary (citable) accession number: O89053
Secondary accession number(s): Q7TMU0, Q9R1Y8, Q9R288
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 166 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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