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Protein

Cell division control protein 6 homolog

Gene

Cdc6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi204 – 211ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • chromatin binding Source: MGI
  • kinase binding Source: MGI

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, DNA replication, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-176187 Activation of ATR in response to replication stress
R-MMU-68689 CDC6 association with the ORC:origin complex
R-MMU-68827 CDT1 association with the CDC6:ORC:origin complex
R-MMU-68867 Assembly of the pre-replicative complex
R-MMU-68949 Orc1 removal from chromatin
R-MMU-68962 Activation of the pre-replicative complex
R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 6 homolog
Alternative name(s):
CDC6-related protein
p62(cdc6)
Gene namesi
Name:Cdc6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1345150 Cdc6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001509801 – 562Cell division control protein 6 homologAdd BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55PhosphoserineBy similarity1
Modified residuei68PhosphothreonineCombined sources1
Modified residuei72PhosphoserineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei129PhosphoserineBy similarity1
Modified residuei421PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO89033
MaxQBiO89033
PaxDbiO89033
PRIDEiO89033

PTM databases

iPTMnetiO89033
PhosphoSitePlusiO89033

Expressioni

Gene expression databases

BgeeiENSMUSG00000017499
CleanExiMM_CDC6
ExpressionAtlasiO89033 baseline and differential
GenevisibleiO89033 MM

Interactioni

Subunit structurei

Interacts with PCNA, ORC1, cyclin-CDK. Interacts with HUWE1. Interacts with ANKRD17. Interacts with GRWD1; origin binding of GRWD1 is dependent on CDC6. Interacts with CDT1; are mutually dependent on one another for loading MCM complexes onto chromatin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204750, 21 interactors
IntActiO89033, 19 interactors
STRINGi10090.ENSMUSP00000091469

Structurei

3D structure databases

ProteinModelPortaliO89033
SMRiO89033
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDC6/cdc18 family.Curated

Phylogenomic databases

eggNOGiKOG2227 Eukaryota
COG1474 LUCA
GeneTreeiENSGT00530000063498
HOGENOMiHOG000045316
HOVERGENiHBG050860
InParanoidiO89033
KOiK02213
PhylomeDBiO89033
TreeFamiTF101051

Family and domain databases

CDDicd08768 Cdc6_C, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR016314 Cdc6/18
IPR015163 Cdc6_C
IPR027417 P-loop_NTPase
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF13401 AAA_22, 1 hit
PF09079 Cdc6_C, 1 hit
PIRSFiPIRSF001767 Cdc6, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM01074 Cdc6_C, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

O89033-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQTRSQTQA TIGFPKKKLS NTLKKPNSRD CEVKLRNVQP VPTTPCVDVK
60 70 80 90 100
LLPLSPRKRL GDDNLCNTPR LSPCSPPKLG KKENGPPRSH TWKGCRLVFD
110 120 130 140 150
DEPTFKASPP KEQDRVRQHQ IRSSSAQRSP ESKADPEQKC PPEKESVCIR
160 170 180 190 200
LFKQEGTCYQ QAKLVLNTAV PDRLPAREQE MGVIRNFLKE HICGKKAGSL
210 220 230 240 250
YLSGAPGTGK TACLSRILQD FKKEVKGFKS ILLNCMSLRS AQAVFPAIAQ
260 270 280 290 300
EIGREELCRP AGKDLMRKLE KHLTAEKGPM IVLVLDEMDQ LDSKGQDVLY
310 320 330 340 350
TLFEWPWLSN SRLVLIGIAN TLDLTDRILP RLEARENCKP QLLNFPPYTR
360 370 380 390 400
NQIAAILQDR LSQVSKDQVL DSAAIQFCAR KVSAVSGDIR KALDVCRRAI
410 420 430 440 450
EIVESDVRSQ TVLKPLSECK SPSESPVPKR VGLAHISQVI SEVDGNRVTL
460 470 480 490 500
SQENTQDSLP LQQKILVCSL LLLTRRLKIK EVTLGKLYEA YSSICRKQQV
510 520 530 540 550
TAVDQSECLS LSGLLESRGL VGLKKNKESR LTKVSLKIEE KEIEHVLNGK
560
AFTGNILAAG LP
Length:562
Mass (Da):62,614
Last modified:July 19, 2004 - v2
Checksum:iCB39D0178FAE4ED7
GO

Sequence cautioni

The sequence CAA08752 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA11110 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti155E → K in BAB28090 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ009559 mRNA Translation: CAA08752.1 Different initiation.
AJ223087 mRNA Translation: CAA11110.1 Different initiation.
AK012192 mRNA Translation: BAB28090.1
AK085020 mRNA Translation: BAC39341.1
AK166003 mRNA Translation: BAE38512.1
BC052434 mRNA Translation: AAH52434.1
CCDSiCCDS25368.1
RefSeqiNP_001020950.1, NM_001025779.1
NP_035929.1, NM_011799.2
UniGeneiMm.20912

Genome annotation databases

EnsembliENSMUST00000092706; ENSMUSP00000090382; ENSMUSG00000017499
GeneIDi23834
KEGGimmu:23834
UCSCiuc007lhu.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCDC6_MOUSE
AccessioniPrimary (citable) accession number: O89033
Secondary accession number(s): Q3TMD0, Q8C3S5, Q9CZT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: June 20, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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