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Protein

NF-kappa-B inhibitor-like protein 1

Gene

Nfkbil1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
NF-kappa-B inhibitor-like protein 1
Alternative name(s):
Inhibitor of kappa B-like protein
Short name:
I-kappa-B-like protein
Short name:
IkappaBL
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
Gene namesi
Name:Nfkbil1
Synonyms:Ikbl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1340031 Nfkbil1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000670111 – 381NF-kappa-B inhibitor-like protein 1Add BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei151PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO88995
PRIDEiO88995

PTM databases

PhosphoSitePlusiO88995

Expressioni

Tissue specificityi

High expression found in heart muscle, liver, kidney and skin. Not detected in spleen, lung and brain.

Gene expression databases

BgeeiENSMUSG00000042419 Expressed in 213 organ(s), highest expression level in midbrain
GenevisibleiO88995 MM

Interactioni

Subunit structurei

Interacts with CACTIN (via N-terminal domain); the interaction occurs in a proinflammatory-independent manner.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035452

Structurei

3D structure databases

ProteinModelPortaliO88995
SMRiO88995
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati64 – 93ANK 1Add BLAST30
Repeati97 – 134ANK 2Add BLAST38

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IZ7E Eukaryota
ENOG4111NZ2 LUCA
GeneTreeiENSGT00390000013929
HOGENOMiHOG000043101
HOVERGENiHBG048799
InParanoidiO88995
KOiK09256
OMAiQIETWEL
OrthoDBiEOG091G0HSG
PhylomeDBiO88995
TreeFamiTF333242

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR038753 NFKBIL1
PANTHERiPTHR15263 PTHR15263, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O88995-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNPSPQAPE EEASTSVCRP QSCSMASASR RHRRERRFRR YLSAGRLVRA
60 70 80 90 100
QALLQRHPGL DVDAGQPPPL HRACARHDAP ALCLLLRLGA DPAHQDRHGD
110 120 130 140 150
TALHAAARQG PDAYTDFFLP LLSRCPSAMG IKNKDGETPG QILGWGPPWD
160 170 180 190 200
SAEEEEDEEV SKEREWRQKL QGELEDEWQE VIGRFEDDAS RDTQEPESFS
210 220 230 240 250
AWSERLAREH AQKQRQQLEA EGSCRPPRAE GSSHSWRQHE EEQRLFRERA
260 270 280 290 300
RAKEKELCES RARRAQEAQR DKGPEPPRAG PRAEHPRGAE RGSLWRFGDV
310 320 330 340 350
PWPCPGGGDP EAMAAALVAR GPPLEEQGAL KRYLRVQQVR WHPDRFLQRF
360 370 380
RSQIETWELG RVMGAVTALS QALNRHAEAL K
Length:381
Mass (Da):43,202
Last modified:November 1, 1998 - v1
Checksum:i57BD313987CDE868
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti219E → Q in AAH13269 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095902 mRNA Translation: AAC64292.1
AC007080 Genomic DNA Translation: AAD30175.1
AF109719 Genomic DNA Translation: AAC82486.1
BC013269 mRNA Translation: AAH13269.1
CCDSiCCDS28693.1
RefSeqiNP_035039.1, NM_010909.4
UniGeneiMm.300795

Genome annotation databases

EnsembliENSMUST00000048994; ENSMUSP00000035452; ENSMUSG00000042419
GeneIDi18038
KEGGimmu:18038
UCSCiuc008cgv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095902 mRNA Translation: AAC64292.1
AC007080 Genomic DNA Translation: AAD30175.1
AF109719 Genomic DNA Translation: AAC82486.1
BC013269 mRNA Translation: AAH13269.1
CCDSiCCDS28693.1
RefSeqiNP_035039.1, NM_010909.4
UniGeneiMm.300795

3D structure databases

ProteinModelPortaliO88995
SMRiO88995
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035452

PTM databases

PhosphoSitePlusiO88995

Proteomic databases

PaxDbiO88995
PRIDEiO88995

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048994; ENSMUSP00000035452; ENSMUSG00000042419
GeneIDi18038
KEGGimmu:18038
UCSCiuc008cgv.1 mouse

Organism-specific databases

CTDi4795
MGIiMGI:1340031 Nfkbil1

Phylogenomic databases

eggNOGiENOG410IZ7E Eukaryota
ENOG4111NZ2 LUCA
GeneTreeiENSGT00390000013929
HOGENOMiHOG000043101
HOVERGENiHBG048799
InParanoidiO88995
KOiK09256
OMAiQIETWEL
OrthoDBiEOG091G0HSG
PhylomeDBiO88995
TreeFamiTF333242

Miscellaneous databases

PROiPR:O88995
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042419 Expressed in 213 organ(s), highest expression level in midbrain
GenevisibleiO88995 MM

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR038753 NFKBIL1
PANTHERiPTHR15263 PTHR15263, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIKBL1_MOUSE
AccessioniPrimary (citable) accession number: O88995
Secondary accession number(s): Q91X16, Q9R1Y3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: November 1, 1998
Last modified: September 12, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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