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Protein

C1q-related factor

Gene

C1ql1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses.1 Publication

GO - Molecular functioni

  • signaling receptor binding Source: MGI

GO - Biological processi

  • maintenance of synapse structure Source: MGI
  • motor learning Source: MGI
  • neuron remodeling Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
C1q-related factor
Alternative name(s):
C1q and tumor necrosis factor-related protein 14
Short name:
C1q/TNF-related protein 14
Short name:
CTRP14
Complement component 1 Q subcomponent-like 1
Gene namesi
Name:C1ql1
Synonyms:C1qrf, Crf, Ctrp14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1344400 C1ql1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi28C → A: Does not affect heterooligomerization with C1QL4; when associated with A-32. 1 Publication1
Mutagenesisi32C → A: Does not affect heterooligomerization with C1QL4; when associated with A-28. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000000352817 – 258C1q-related factorAdd BLAST242

Proteomic databases

PaxDbiO88992
PeptideAtlasiO88992
PRIDEiO88992

PTM databases

PhosphoSitePlusiO88992

Expressioni

Tissue specificityi

Expressed in brainstem. More abundant in areas of the nervous system involved in motor function, such as the Purkinje cells of the cerebellum, the accessory olivary nucleus, the pons and the red nucleus.

Gene expression databases

BgeeiENSMUSG00000045532 Expressed in 81 organ(s), highest expression level in lens of camera-type eye
CleanExiMM_C1QL1
GenevisibleiO88992 MM

Interactioni

Subunit structurei

Interacts with ADGRB3 (PubMed:21262840). Forms heterooligomers with C1QL4, when proteins are coexpressed; this interaction does not occur after secretion (PubMed:23449976).2 Publications

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-61402N
STRINGi10090.ENSMUSP00000050469

Structurei

Secondary structure

1258
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO88992
SMRiO88992
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 115Collagen-likeAdd BLAST49
Domaini125 – 258C1qPROSITE-ProRule annotationAdd BLAST134

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IFA6 Eukaryota
ENOG4111FAZ LUCA
GeneTreeiENSGT00760000119052
HOGENOMiHOG000085653
HOVERGENiHBG108220
InParanoidiO88992
OMAiGTDASHY
OrthoDBiEOG091G0UOF
TreeFamiTF329591

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR008160 Collagen
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00386 C1q, 1 hit
PF01391 Collagen, 1 hit
PRINTSiPR00007 COMPLEMNTC1Q
SMARTiView protein in SMART
SM00110 C1Q, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88992-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLVLVVLIP VLVSSGGPDG HYEMLGTCRM VCDPYPARGP GAGARSDGGD
60 70 80 90 100
ALSEQSGAPP PSTLVQGPQG KPGRTGKPGP PGPPGDRGPP GPVGPPGEKG
110 120 130 140 150
EPGKPGPPGL PGSGGSGAIS TATYTTVPRV AFYAGLKNPH EGYEVLKFDD
160 170 180 190 200
VVTNLGNNYD AASGKFTCNI PGTYFFTYHV LMRGGDGTSM WADLCKNGQV
210 220 230 240 250
RASAIAQDAD QNYDYASNSV ILHLDAGDEV FIKLDGGKAH GGNSNKYSTF

SGFIIYSD
Length:258
Mass (Da):26,500
Last modified:October 3, 2012 - v2
Checksum:i3C769203069B2137
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52L → V in AAC64187 (PubMed:9878755).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095155 mRNA Translation: AAC64187.1
AL731670 Genomic DNA Translation: CAM25117.1
CH466558 Genomic DNA Translation: EDL34162.1
CCDSiCCDS25509.1
RefSeqiNP_035925.2, NM_011795.2
UniGeneiMm.57154

Genome annotation databases

EnsembliENSMUST00000057849; ENSMUSP00000050469; ENSMUSG00000045532
GeneIDi23829
KEGGimmu:23829
UCSCiuc007lsz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095155 mRNA Translation: AAC64187.1
AL731670 Genomic DNA Translation: CAM25117.1
CH466558 Genomic DNA Translation: EDL34162.1
CCDSiCCDS25509.1
RefSeqiNP_035925.2, NM_011795.2
UniGeneiMm.57154

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D7YX-ray1.44A125-258[»]
4QQ2X-ray1.80A/B/C122-258[»]
ProteinModelPortaliO88992
SMRiO88992
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61402N
STRINGi10090.ENSMUSP00000050469

PTM databases

PhosphoSitePlusiO88992

Proteomic databases

PaxDbiO88992
PeptideAtlasiO88992
PRIDEiO88992

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057849; ENSMUSP00000050469; ENSMUSG00000045532
GeneIDi23829
KEGGimmu:23829
UCSCiuc007lsz.2 mouse

Organism-specific databases

CTDi10882
MGIiMGI:1344400 C1ql1

Phylogenomic databases

eggNOGiENOG410IFA6 Eukaryota
ENOG4111FAZ LUCA
GeneTreeiENSGT00760000119052
HOGENOMiHOG000085653
HOVERGENiHBG108220
InParanoidiO88992
OMAiGTDASHY
OrthoDBiEOG091G0UOF
TreeFamiTF329591

Miscellaneous databases

PROiPR:O88992
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045532 Expressed in 81 organ(s), highest expression level in lens of camera-type eye
CleanExiMM_C1QL1
GenevisibleiO88992 MM

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR008160 Collagen
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00386 C1q, 1 hit
PF01391 Collagen, 1 hit
PRINTSiPR00007 COMPLEMNTC1Q
SMARTiView protein in SMART
SM00110 C1Q, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC1QRF_MOUSE
AccessioniPrimary (citable) accession number: O88992
Secondary accession number(s): A2AH89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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