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Protein

A-kinase anchor protein 3

Gene

Akap3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.By similarity

GO - Molecular functioni

  • protein kinase A binding Source: MGI

GO - Biological processi

  • blastocyst hatching Source: MGI
  • protein localization Source: MGI
  • regulation of protein kinase A signaling Source: GO_Central
  • transmembrane receptor protein serine/threonine kinase signaling pathway Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase anchor protein 3
Short name:
AKAP-3
Alternative name(s):
A-kinase anchor protein 110 kDa
Short name:
AKAP 110
Protein kinase A-anchoring protein 3
Short name:
PRKA3
Gene namesi
Name:Akap3
Synonyms:Akap110
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1341149 Akap3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000645271 – 864A-kinase anchor protein 3Add BLAST864

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei206PhosphoserineBy similarity1
Modified residuei405PhosphoserineBy similarity1
Modified residuei406PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO88987
PaxDbiO88987
PeptideAtlasiO88987
PRIDEiO88987

PTM databases

iPTMnetiO88987
PhosphoSitePlusiO88987

Expressioni

Gene expression databases

BgeeiENSMUSG00000030344 Expressed in 26 organ(s), highest expression level in testis
CleanExiMM_AKAP3
GenevisibleiO88987 MM

Interactioni

Subunit structurei

Interacts with ROPN1 AND ROPN1L.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
BrapQ99MP83EBI-9033539,EBI-10818333

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198050, 1 interactor
IntActiO88987, 2 interactors
STRINGi10090.ENSMUSP00000093091

Structurei

3D structure databases

ProteinModelPortaliO88987
SMRiO88987
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni125 – 138PKA-RII subunit binding domainAdd BLAST14

Domaini

RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

Sequence similaritiesi

Belongs to the AKAP110 family.Curated

Phylogenomic databases

eggNOGiENOG410IEV9 Eukaryota
ENOG411183Z LUCA
GeneTreeiENSGT00420000029845
HOGENOMiHOG000220883
HOVERGENiHBG050478
InParanoidiO88987
KOiK16520
OMAiMTYANSV
OrthoDBiEOG091G0209
TreeFamiTF105403

Family and domain databases

InterProiView protein in InterPro
IPR020799 AKAP_110
IPR018292 AKAP_110_C
IPR018459 RII_binding_1
IPR008382 SPHK1-interactor_AKAP_110
PANTHERiPTHR10226 PTHR10226, 1 hit
PfamiView protein in Pfam
PF05716 AKAP_110, 1 hit
PF10522 RII_binding_1, 1 hit
SMARTiView protein in SMART
SM00807 AKAP_110, 1 hit

Sequencei

Sequence statusi: Complete.

O88987-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADRVDWLQS QSGVCKVGVY SPGDNQHQDW KMDTSTDPVR VLSWLRKDLE
60 70 80 90 100
KSTAGFQDSR FKPGESSFVE EVAYPVDQRK GFCVDYYNTT NKGSPGRLHF
110 120 130 140 150
EMSHKENPSQ GLISHVGNGG SIDEVSFYAN RLTNLVIAMA RKEINEKIHG
160 170 180 190 200
AENKCVHQSL YMGDEPTPHK SLSTVASELV NETVTACSKN ISSDKAPGSG
210 220 230 240 250
DRASGSSQAP GLRYTSTLKI KESTKEGKCP DDKPGTKKSF FYKEVFESRN
260 270 280 290 300
AGDAKEGGRS LPGDQKLFRT SPDNRPDDFS NSISQGIMTY ANSVVSDMMV
310 320 330 340 350
SIMKTLKIQV KDTTIATILL KKVLMKHAKE VVSDLIDSFM KNLHGVTGSL
360 370 380 390 400
MTDTDFVSAV KRSFFSHGSQ KATDIMDAML GKLYNVMFAK KFPENIRRAR
410 420 430 440 450
DKSESYSLIS TKSRAGDPKL SNLNFAMKSE SKLKENLFST CKLEKEKTCA
460 470 480 490 500
ETLGEHIIKE GLHMWHKSQQ KSPGLERAAK LGNAPQEVSF ECPDPCEANP
510 520 530 540 550
PHQPQPPENF ANFMCDSDSW AKDLIVSALL LIQYHLAQGG KMDAQSFLEA
560 570 580 590 600
AASTNFPTNK PPPPSPVVQD ECKLKSPPHK ICDQEQTEKK DLMSVIFNFI
610 620 630 640 650
RNLLSETIFK SSRNCESNVH EQNTQEEEIH PCERPKTPCE RPITPPAPKF
660 670 680 690 700
CEDEEATGGA LSGLTKMVAN QLDNCMNGQM VEHLMDSVMK LCLIIAKSCD
710 720 730 740 750
SPLSELGEEK CGDASRPNSA FPDNLYECLP VKGTGTAEAL LQNAYLTIHN
760 770 780 790 800
ELRGLSGQPP EGCEIPKVIV SNHNLADTVQ NKQLQAVLQW VAASELNVPI
810 820 830 840 850
LYFAGDDEGI QEKLLQLSAT AVEKGRSVGE VLQSVLRYEK ERQLDEAVGN
860
VTRLQLLDWL MANL
Length:864
Mass (Da):95,556
Last modified:June 28, 2011 - v2
Checksum:i3E24E63327BC4E78
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti215T → M in AAC63369 (PubMed:10319321).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093406 mRNA Translation: AAC63369.1
CH466523 Genomic DNA Translation: EDK99845.1
BC100458 mRNA Translation: AAI00459.1
CCDSiCCDS20558.1
RefSeqiNP_033780.2, NM_009650.2
UniGeneiMm.87748

Genome annotation databases

EnsembliENSMUST00000095440; ENSMUSP00000093091; ENSMUSG00000030344
ENSMUST00000202574; ENSMUSP00000144405; ENSMUSG00000030344
ENSMUST00000202878; ENSMUSP00000143794; ENSMUSG00000030344
GeneIDi11642
KEGGimmu:11642
UCSCiuc009dvf.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093406 mRNA Translation: AAC63369.1
CH466523 Genomic DNA Translation: EDK99845.1
BC100458 mRNA Translation: AAI00459.1
CCDSiCCDS20558.1
RefSeqiNP_033780.2, NM_009650.2
UniGeneiMm.87748

3D structure databases

ProteinModelPortaliO88987
SMRiO88987
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198050, 1 interactor
IntActiO88987, 2 interactors
STRINGi10090.ENSMUSP00000093091

PTM databases

iPTMnetiO88987
PhosphoSitePlusiO88987

Proteomic databases

MaxQBiO88987
PaxDbiO88987
PeptideAtlasiO88987
PRIDEiO88987

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095440; ENSMUSP00000093091; ENSMUSG00000030344
ENSMUST00000202574; ENSMUSP00000144405; ENSMUSG00000030344
ENSMUST00000202878; ENSMUSP00000143794; ENSMUSG00000030344
GeneIDi11642
KEGGimmu:11642
UCSCiuc009dvf.2 mouse

Organism-specific databases

CTDi10566
MGIiMGI:1341149 Akap3

Phylogenomic databases

eggNOGiENOG410IEV9 Eukaryota
ENOG411183Z LUCA
GeneTreeiENSGT00420000029845
HOGENOMiHOG000220883
HOVERGENiHBG050478
InParanoidiO88987
KOiK16520
OMAiMTYANSV
OrthoDBiEOG091G0209
TreeFamiTF105403

Miscellaneous databases

PROiPR:O88987
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030344 Expressed in 26 organ(s), highest expression level in testis
CleanExiMM_AKAP3
GenevisibleiO88987 MM

Family and domain databases

InterProiView protein in InterPro
IPR020799 AKAP_110
IPR018292 AKAP_110_C
IPR018459 RII_binding_1
IPR008382 SPHK1-interactor_AKAP_110
PANTHERiPTHR10226 PTHR10226, 1 hit
PfamiView protein in Pfam
PF05716 AKAP_110, 1 hit
PF10522 RII_binding_1, 1 hit
SMARTiView protein in SMART
SM00807 AKAP_110, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAKAP3_MOUSE
AccessioniPrimary (citable) accession number: O88987
Secondary accession number(s): Q497M9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 28, 2011
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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