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Protein

Syntaxin-8

Gene

Stx8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi1.F.1.1.4 the synaptosomal vesicle fusion pore (svf-pore) family

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-8
Alternative name(s):
Syntaxin-like protein 3I35
Gene namesi
Name:Stx8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1890156 Stx8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 215CytoplasmicSequence analysisAdd BLAST215
Transmembranei216 – 232Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST17
Topological domaini233 – 236VesicularSequence analysis4

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102181 – 236Syntaxin-8Add BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei160PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated by HECTD3.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO88983
PaxDbiO88983
PeptideAtlasiO88983
PRIDEiO88983

PTM databases

iPTMnetiO88983
PhosphoSitePlusiO88983
SwissPalmiO88983

Expressioni

Gene expression databases

BgeeiENSMUSG00000020903
CleanExiMM_STX8
ExpressionAtlasiO88983 baseline and differential
GenevisibleiO88983 MM

Interactioni

Subunit structurei

Forms a SNARE complex with STX7, VTI1B and VAMP8 which functions in the homotypic fusion of late endosomes. Part of the SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts with VAMP8 (By similarity). Interacts with HECTD3.By similarity1 Publication

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • SNARE binding Source: MGI
  • syntaxin binding Source: MGI
  • ubiquitin protein ligase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi207739, 5 interactors
CORUMiO88983
STRINGi10090.ENSMUSP00000021285

Structurei

3D structure databases

ProteinModelPortaliO88983
SMRiO88983
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 207t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili42 – 65By similarityAdd BLAST24

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3202 Eukaryota
ENOG410ZZA3 LUCA
GeneTreeiENSGT00390000007779
HOGENOMiHOG000031515
HOVERGENiHBG007572
InParanoidiO88983
KOiK08501
OMAiAENIHER
OrthoDBiEOG091G0KM1
PhylomeDBiO88983
TreeFamiTF323262

Family and domain databases

InterProiView protein in InterPro
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
PROSITEiView protein in PROSITE
PS50192 T_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

O88983-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPDPWFSTY DSTCQIAQEI AEKIQERNQC ERRGEKTPKL TLTIRTLLKN
60 70 80 90 100
LKVKIDLLKD LLLRAVSTRQ ITQLEGDRRQ NLLDDLVTRE RLLLASFKNE
110 120 130 140 150
GAEPDLIRSS LMSEEAKRGT PNPWLCEEPE ETRGLGFDEI RQQQQKIIQE
160 170 180 190 200
QDAGLDALSS IISRQKQMGQ EIGNELDEQN EIIDDLANLV ENTDEKLRTE
210 220 230
ARRVTLVDRK STSCGMIMVI LLLLVAIVVV AVWPTN
Length:236
Mass (Da):26,925
Last modified:November 1, 1998 - v1
Checksum:iEAE1D9D150C2EF2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093064 mRNA Translation: AAC64149.1
AF036716 mRNA Translation: AAC95286.1
AB040054 mRNA Translation: BAB20500.1
AK003297 mRNA Translation: BAB22698.1
AL669842, AL663076 Genomic DNA Translation: CAI24774.1
BC048167 mRNA Translation: AAH48167.1
BC048479 mRNA Translation: AAH48479.1
CCDSiCCDS24863.1
RefSeqiNP_061238.1, NM_018768.2
UniGeneiMm.3973

Genome annotation databases

EnsembliENSMUST00000021285; ENSMUSP00000021285; ENSMUSG00000020903
GeneIDi55943
KEGGimmu:55943
UCSCiuc007jnj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSTX8_MOUSE
AccessioniPrimary (citable) accession number: O88983
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 1, 1998
Last modified: June 20, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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