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Protein

Glucosamine-6-phosphate isomerase 1

Gene

Gnpda1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).By similarity

Catalytic activityi

Alpha-D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei72Proton acceptor; for enolization stepBy similarity1
Active sitei141For ring-opening stepBy similarity1
Active sitei143Proton acceptor; for ring-opening stepBy similarity1
Active sitei148For ring-opening stepBy similarity1

GO - Molecular functioni

  • glucosamine-6-phosphate deaminase activity Source: UniProtKB
  • identical protein binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

ReactomeiR-MMU-70171 Glycolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Glucosamine-6-phosphate isomerase 1 (EC:3.5.99.6)
Alternative name(s):
Glucosamine-6-phosphate deaminase 1
Short name:
GNPDA 1
Short name:
GlcN6P deaminase 1
Oscillin
Gene namesi
Name:Gnpda1
Synonyms:Gnpi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1347054 Gnpda1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001601241 – 289Glucosamine-6-phosphate isomerase 1Add BLAST289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei161PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO88958
PaxDbiO88958
PeptideAtlasiO88958
PRIDEiO88958

PTM databases

iPTMnetiO88958
PhosphoSitePlusiO88958

Expressioni

Tissue specificityi

Widely expressed. Detected in brain, liver, kidney, muscle, ovary, testis, spermatids and spermatozoa. In spermatids, located close to the developing acrosome vesicle. In spermatozoa, found close to the acrosomal region.1 Publication

Gene expression databases

BgeeiENSMUSG00000052102 Expressed in 34 organ(s), highest expression level in adult mammalian kidney
CleanExiMM_GNPDA1
ExpressionAtlasiO88958 baseline and differential
GenevisibleiO88958 MM

Interactioni

Subunit structurei

Homohexamer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiO88958, 1 interactor
MINTiO88958
STRINGi10090.ENSMUSP00000069081

Structurei

3D structure databases

ProteinModelPortaliO88958
SMRiO88958
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3148 Eukaryota
COG0363 LUCA
GeneTreeiENSGT00390000014316
HOGENOMiHOG000064979
HOVERGENiHBG002546
InParanoidiO88958
KOiK02564
OMAiSYHYFMK
OrthoDBiEOG091G0LJF
TreeFamiTF300841

Family and domain databases

CDDicd01399 GlcN6P_deaminase, 1 hit
HAMAPiMF_01241 GlcN6P_deamin, 1 hit
InterProiView protein in InterPro
IPR006148 Glc/Gal-6P_isomerase
IPR004547 Glucosamine6P_isomerase
IPR018321 Glucosamine6P_isomerase_CS
IPR037171 NagB/RpiA_transferase-like
PANTHERiPTHR11280 PTHR11280, 1 hit
PfamiView protein in Pfam
PF01182 Glucosamine_iso, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR00502 nagB, 1 hit
PROSITEiView protein in PROSITE
PS01161 GLC_GALNAC_ISOMERASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O88958-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLIILEHYS QASEWAAKYI RNRIIQFNPG PDKYFTLGLP TGSTPLGCYQ
60 70 80 90 100
KLIEYYKNGD LSFQYVKTFN MDEYVGLPRD HPESYHSFMW NNFFKHIDIH
110 120 130 140 150
PENTHILDGN AADLQAECDA FEEKIQAAGG IELFVGGIGP DGHIAFNEPG
160 170 180 190 200
SSLVSRTRVK TLAMDTILAN ARFFDGDLAK VPTMALTVGV GTVMDAKEVM
210 220 230 240 250
ILITGAHKAF ALYKAIEEGV NHMWTVSAFQ QHPRTVFVCD EDATLELKVK
260 270 280
TVKYFKGLML VHNKLVDPLY SIKEKEIQKS QSAKKPYSD
Length:289
Mass (Da):32,549
Last modified:October 3, 2012 - v3
Checksum:i4778C0E0D74EBBB8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z0R5D3Z0R5_MOUSE
Glucosamine-6-phosphate isomerase 1
Gnpda1
124Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87S → F in AAC36739 (PubMed:10481053).Curated1
Sequence conflicti91N → D in AAC36739 (PubMed:10481053).Curated1
Sequence conflicti171A → G in AAC36739 (PubMed:10481053).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF088903 mRNA Translation: AAC36739.1
AF160355 mRNA Translation: AAD42233.1
AC134576 Genomic DNA No translation available.
AC152450 Genomic DNA No translation available.
CH466528 Genomic DNA Translation: EDL10078.1
BC014800 mRNA Translation: AAH14800.1
CCDSiCCDS29201.1
RefSeqiNP_036067.2, NM_011937.2
UniGeneiMm.22374

Genome annotation databases

EnsembliENSMUST00000063814; ENSMUSP00000069081; ENSMUSG00000052102
GeneIDi26384
KEGGimmu:26384
UCSCiuc008esi.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF088903 mRNA Translation: AAC36739.1
AF160355 mRNA Translation: AAD42233.1
AC134576 Genomic DNA No translation available.
AC152450 Genomic DNA No translation available.
CH466528 Genomic DNA Translation: EDL10078.1
BC014800 mRNA Translation: AAH14800.1
CCDSiCCDS29201.1
RefSeqiNP_036067.2, NM_011937.2
UniGeneiMm.22374

3D structure databases

ProteinModelPortaliO88958
SMRiO88958
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88958, 1 interactor
MINTiO88958
STRINGi10090.ENSMUSP00000069081

PTM databases

iPTMnetiO88958
PhosphoSitePlusiO88958

Proteomic databases

EPDiO88958
PaxDbiO88958
PeptideAtlasiO88958
PRIDEiO88958

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063814; ENSMUSP00000069081; ENSMUSG00000052102
GeneIDi26384
KEGGimmu:26384
UCSCiuc008esi.2 mouse

Organism-specific databases

CTDi10007
MGIiMGI:1347054 Gnpda1

Phylogenomic databases

eggNOGiKOG3148 Eukaryota
COG0363 LUCA
GeneTreeiENSGT00390000014316
HOGENOMiHOG000064979
HOVERGENiHBG002546
InParanoidiO88958
KOiK02564
OMAiSYHYFMK
OrthoDBiEOG091G0LJF
TreeFamiTF300841

Enzyme and pathway databases

ReactomeiR-MMU-70171 Glycolysis

Miscellaneous databases

ChiTaRSiGnpda1 mouse
PROiPR:O88958
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052102 Expressed in 34 organ(s), highest expression level in adult mammalian kidney
CleanExiMM_GNPDA1
ExpressionAtlasiO88958 baseline and differential
GenevisibleiO88958 MM

Family and domain databases

CDDicd01399 GlcN6P_deaminase, 1 hit
HAMAPiMF_01241 GlcN6P_deamin, 1 hit
InterProiView protein in InterPro
IPR006148 Glc/Gal-6P_isomerase
IPR004547 Glucosamine6P_isomerase
IPR018321 Glucosamine6P_isomerase_CS
IPR037171 NagB/RpiA_transferase-like
PANTHERiPTHR11280 PTHR11280, 1 hit
PfamiView protein in Pfam
PF01182 Glucosamine_iso, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR00502 nagB, 1 hit
PROSITEiView protein in PROSITE
PS01161 GLC_GALNAC_ISOMERASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGNPI1_MOUSE
AccessioniPrimary (citable) accession number: O88958
Secondary accession number(s): Q91WJ4, Q9R188
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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