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Protein

Protein lin-7 homolog C

Gene

Lin7c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

GO - Molecular functioni

GO - Biological processi

  • exocytosis Source: UniProtKB-KW
  • morphogenesis of an epithelial sheet Source: MGI
  • neurotransmitter secretion Source: MGI
  • protein localization to basolateral plasma membrane Source: GO_Central
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-212676 Dopamine Neurotransmitter Release Cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lin-7 homolog C
Short name:
Lin-7C
Short name:
mLin7C
Alternative name(s):
Mammalian lin-seven protein 3
Short name:
MALS-3
Vertebrate lin-7 homolog 3
Short name:
Veli-3
Gene namesi
Name:Lin7c
Synonyms:Mals3, Veli3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1330839 Lin7c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001896302 – 197Protein lin-7 homolog CAdd BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO88952
MaxQBiO88952
PaxDbiO88952
PeptideAtlasiO88952
PRIDEiO88952

PTM databases

iPTMnetiO88952
PhosphoSitePlusiO88952

Expressioni

Tissue specificityi

Expressed in the kidney; particularly in the outer medullary collecting duct.1 Publication

Gene expression databases

BgeeiENSMUSG00000027162 Expressed in 286 organ(s), highest expression level in central nervous system
CleanExiMM_LIN7C
GenevisibleiO88952 MM

Interactioni

Subunit structurei

Forms two exclusive ternary complexes with CASK and APBA1 or CASKIN1 (By similarity). Can also interact with other modular proteins containing protein-protein interaction domains like MPP5, MPP6, MPP7, DLG1, DLG2 and DLG3 through its L27 domain. Interacts with DLG4 and GRIN2B as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain. The association of LIN7A with cadherin and beta-catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains. Associates with KIF17 via APBA1. Interacts with HTR4. Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C) (By similarity). Interacts with MAPK12.By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Kcnma1Q084604EBI-821316,EBI-1633915

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204516, 41 interactors
IntActiO88952, 25 interactors
STRINGi10090.ENSMUSP00000028583

Structurei

3D structure databases

ProteinModelPortaliO88952
SMRiO88952
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 65L27PROSITE-ProRule annotationAdd BLAST56
Domaini93 – 175PDZPROSITE-ProRule annotationAdd BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi2 – 13Kinase interacting siteBy similarityAdd BLAST12

Domaini

The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.By similarity
The PDZ domain regulates endocytosis and recycling of the receptor at the membrane.By similarity
The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes.1 Publication

Sequence similaritiesi

Belongs to the lin-7 family.Curated

Phylogenomic databases

eggNOGiKOG3550 Eukaryota
ENOG410XP5T LUCA
GeneTreeiENSGT00550000074581
HOGENOMiHOG000285929
HOVERGENiHBG052329
InParanoidiO88952
KOiK19931
OMAiRRQQNNF
OrthoDBiEOG091G0PR4
PhylomeDBiO88952
TreeFamiTF316850

Family and domain databases

InterProiView protein in InterPro
IPR014775 L27_C
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR017365 LIN7
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF02828 L27, 1 hit
PF00595 PDZ, 1 hit
PIRSFiPIRSF038039 Lin-7_homologue, 1 hit
SMARTiView protein in SMART
SM00569 L27, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF101288 SSF101288, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51022 L27, 1 hit
PS50106 PDZ, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88952-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALGEPVRL ERDICRAIEL LEKLQRSGEV PPQKLQALQR VLQSEFCNAV
60 70 80 90 100
REVYEHVYET VDISSSPEVR ANATAKATVA AFAASEGHSH PRVVELPKTE
110 120 130 140 150
EGLGFNIMGG KEQNSPIYIS RIIPGGIADR HGGLKRGDQL LSVNGVSVEG
160 170 180 190
EHHEKAVELL KAAQGKVKLV VRYTPKVLEE MESRFEKMRS AKRRQQT
Length:197
Mass (Da):21,834
Last modified:January 1, 1999 - v2
Checksum:i7410FBFA3BD24F45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087695 mRNA Translation: AAC78483.1
AF173083 mRNA Translation: AAD48502.1
AK015399 mRNA Translation: BAB29830.1
AK078923 mRNA Translation: BAC37462.1
BC046966 mRNA Translation: AAH46966.1
CCDSiCCDS16509.1
RefSeqiNP_035829.1, NM_011699.3
UniGeneiMm.235300
Mm.478053

Genome annotation databases

EnsembliENSMUST00000028583; ENSMUSP00000028583; ENSMUSG00000027162
GeneIDi22343
KEGGimmu:22343
UCSCiuc008lmo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087695 mRNA Translation: AAC78483.1
AF173083 mRNA Translation: AAD48502.1
AK015399 mRNA Translation: BAB29830.1
AK078923 mRNA Translation: BAC37462.1
BC046966 mRNA Translation: AAH46966.1
CCDSiCCDS16509.1
RefSeqiNP_035829.1, NM_011699.3
UniGeneiMm.235300
Mm.478053

3D structure databases

ProteinModelPortaliO88952
SMRiO88952
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204516, 41 interactors
IntActiO88952, 25 interactors
STRINGi10090.ENSMUSP00000028583

PTM databases

iPTMnetiO88952
PhosphoSitePlusiO88952

Proteomic databases

EPDiO88952
MaxQBiO88952
PaxDbiO88952
PeptideAtlasiO88952
PRIDEiO88952

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028583; ENSMUSP00000028583; ENSMUSG00000027162
GeneIDi22343
KEGGimmu:22343
UCSCiuc008lmo.1 mouse

Organism-specific databases

CTDi55327
MGIiMGI:1330839 Lin7c

Phylogenomic databases

eggNOGiKOG3550 Eukaryota
ENOG410XP5T LUCA
GeneTreeiENSGT00550000074581
HOGENOMiHOG000285929
HOVERGENiHBG052329
InParanoidiO88952
KOiK19931
OMAiRRQQNNF
OrthoDBiEOG091G0PR4
PhylomeDBiO88952
TreeFamiTF316850

Enzyme and pathway databases

ReactomeiR-MMU-212676 Dopamine Neurotransmitter Release Cycle

Miscellaneous databases

ChiTaRSiLin7c mouse
PROiPR:O88952
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027162 Expressed in 286 organ(s), highest expression level in central nervous system
CleanExiMM_LIN7C
GenevisibleiO88952 MM

Family and domain databases

InterProiView protein in InterPro
IPR014775 L27_C
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR017365 LIN7
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF02828 L27, 1 hit
PF00595 PDZ, 1 hit
PIRSFiPIRSF038039 Lin-7_homologue, 1 hit
SMARTiView protein in SMART
SM00569 L27, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF101288 SSF101288, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51022 L27, 1 hit
PS50106 PDZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLIN7C_MOUSE
AccessioniPrimary (citable) accession number: O88952
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: January 1, 1999
Last modified: November 7, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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