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Protein

Protein lin-7 homolog B

Gene

Lin7b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface.1 Publication

GO - Molecular functioni

  • L27 domain binding Source: GO_Central
  • PDZ domain binding Source: MGI
  • protein domain specific binding Source: MGI

GO - Biological processi

  • exocytosis Source: UniProtKB-KW
  • neurotransmitter secretion Source: MGI
  • protein localization to basolateral plasma membrane Source: GO_Central
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-212676 Dopamine Neurotransmitter Release Cycle
R-MMU-5666185 RHO GTPases Activate Rhotekin and Rhophilins

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lin-7 homolog B
Short name:
Lin-7B
Alternative name(s):
Mammalian lin-seven protein 2
Short name:
MALS-2
Vertebrate lin-7 homolog 2
Short name:
Veli-2
Gene namesi
Name:Lin7b
Synonyms:Mals2, Veli2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1330858 Lin7b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001896271 – 207Protein lin-7 homolog BAdd BLAST207

Proteomic databases

MaxQBiO88951
PaxDbiO88951
PeptideAtlasiO88951
PRIDEiO88951

PTM databases

iPTMnetiO88951
PhosphoSitePlusiO88951

Expressioni

Tissue specificityi

Expressed in the kidney; predominantly in the vasa recta.2 Publications

Gene expression databases

BgeeiENSMUSG00000003872 Expressed in 146 organ(s), highest expression level in facial nucleus
CleanExiMM_LIN7B
ExpressionAtlasiO88951 baseline and differential
GenevisibleiO88951 MM

Interactioni

Subunit structurei

Forms two exclusive ternary complexes with CASK and APBA1 or CASKIN1. Can also interact with other modular proteins containing protein-protein interaction domains like MPP5, MPP6, MPP7, DLG1, DLG2 and DLG3 through its L27 domain. Interacts with DLG4 and GRIN2B as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain. The association of LIN7A with cadherin and beta-catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains. Associates with KIF17 via APBA1. Interacts with ASIC3. Interacts with RTKN (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204515, 1 interactor
IntActiO88951, 5 interactors
MINTiO88951
STRINGi10090.ENSMUSP00000003971

Structurei

Secondary structure

1207
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO88951
SMRiO88951
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO88951

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 65L27PROSITE-ProRule annotationAdd BLAST56
Domaini93 – 175PDZPROSITE-ProRule annotationAdd BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1 – 13Kinase interacting siteBy similarityAdd BLAST13

Domaini

The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.By similarity
The PDZ domain regulates endocytosis and recycling of the receptor at the membrane.By similarity
The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes.By similarity

Sequence similaritiesi

Belongs to the lin-7 family.Curated

Phylogenomic databases

eggNOGiKOG3550 Eukaryota
ENOG410XP5T LUCA
GeneTreeiENSGT00550000074581
HOGENOMiHOG000285929
HOVERGENiHBG052329
InParanoidiO88951
KOiK19931
OMAiRQQHTSY
OrthoDBiEOG091G0PR4
PhylomeDBiO88951
TreeFamiTF316850

Family and domain databases

InterProiView protein in InterPro
IPR014775 L27_C
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR017365 LIN7
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF02828 L27, 1 hit
PF00595 PDZ, 1 hit
PIRSFiPIRSF038039 Lin-7_homologue, 1 hit
SMARTiView protein in SMART
SM00569 L27, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF101288 SSF101288, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51022 L27, 1 hit
PS50106 PDZ, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O88951-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALVEPLGL ERDVSRAVEL LERLQRSGEL PPQKLQALQR VLQSRFCSAI
60 70 80 90 100
REVYEQLYDT LDITGSAEVR AHATAKATVA AFTASEGHAH PRVVELPKTD
110 120 130 140 150
EGLGFNIMGG KEQNSPIYIS RVIPGGVADR HGGLKRGDQL LSVNGVSVEG
160 170 180 190 200
EHHEKAVELL KAAQGSVKLV VRYTPRVLEE MEARFEKMRS ARRRQQHHSY

TSLESRG
Length:207
Mass (Da):22,914
Last modified:January 1, 1999 - v2
Checksum:iBC6B6754B8C89F03
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GQX6A0A1B0GQX6_MOUSE
Protein lin-7 homolog B
Lin7b
52Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087694 mRNA Translation: AAC78482.1
AF173082 mRNA Translation: AAD48501.1
BC031780 mRNA Translation: AAH31780.1
CCDSiCCDS21239.1
RefSeqiNP_035828.1, NM_011698.1
UniGeneiMm.20472

Genome annotation databases

EnsembliENSMUST00000003971; ENSMUSP00000003971; ENSMUSG00000003872
GeneIDi22342
KEGGimmu:22342
UCSCiuc009guv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087694 mRNA Translation: AAC78482.1
AF173082 mRNA Translation: AAD48501.1
BC031780 mRNA Translation: AAH31780.1
CCDSiCCDS21239.1
RefSeqiNP_035828.1, NM_011698.1
UniGeneiMm.20472

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y74NMR-A/C8-64[»]
ProteinModelPortaliO88951
SMRiO88951
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204515, 1 interactor
IntActiO88951, 5 interactors
MINTiO88951
STRINGi10090.ENSMUSP00000003971

PTM databases

iPTMnetiO88951
PhosphoSitePlusiO88951

Proteomic databases

MaxQBiO88951
PaxDbiO88951
PeptideAtlasiO88951
PRIDEiO88951

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003971; ENSMUSP00000003971; ENSMUSG00000003872
GeneIDi22342
KEGGimmu:22342
UCSCiuc009guv.1 mouse

Organism-specific databases

CTDi64130
MGIiMGI:1330858 Lin7b

Phylogenomic databases

eggNOGiKOG3550 Eukaryota
ENOG410XP5T LUCA
GeneTreeiENSGT00550000074581
HOGENOMiHOG000285929
HOVERGENiHBG052329
InParanoidiO88951
KOiK19931
OMAiRQQHTSY
OrthoDBiEOG091G0PR4
PhylomeDBiO88951
TreeFamiTF316850

Enzyme and pathway databases

ReactomeiR-MMU-212676 Dopamine Neurotransmitter Release Cycle
R-MMU-5666185 RHO GTPases Activate Rhotekin and Rhophilins

Miscellaneous databases

EvolutionaryTraceiO88951
PROiPR:O88951
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003872 Expressed in 146 organ(s), highest expression level in facial nucleus
CleanExiMM_LIN7B
ExpressionAtlasiO88951 baseline and differential
GenevisibleiO88951 MM

Family and domain databases

InterProiView protein in InterPro
IPR014775 L27_C
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR017365 LIN7
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF02828 L27, 1 hit
PF00595 PDZ, 1 hit
PIRSFiPIRSF038039 Lin-7_homologue, 1 hit
SMARTiView protein in SMART
SM00569 L27, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF101288 SSF101288, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51022 L27, 1 hit
PS50106 PDZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLIN7B_MOUSE
AccessioniPrimary (citable) accession number: O88951
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: January 1, 1999
Last modified: November 7, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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